Methods for Diagnosing Prostate Cancer and Predicting Prostate Cancer Relapse

ABSTRACT

The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression.

PRIORITY CLAIM

This application is a continuation of United Sates Ser. No. 13/619,556, filed Sep. 14, 2012, which claims priority to U.S. Provisional Application No. 61/535,240, filed Sep. 15, 2011, the contents of each of which is hereby incorporated by reference in its entirety herein, and to each of which priority is claimed.

GRANT SUPPORT

This invention was made with government support under Grant No. RO1-CA098249 awarded by the National Cancer Institute. The government has certain rights in the invention.

1. INTRODUCTION

The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a subject having prostate cancer is at increased risk for relapse or rapid relapse.

2. BACKGROUND OF THE INVENTION

Prostate cancer is one of the most common and lethal malignancies in men: The annual mortality rate reached 32,000 in the US in 2009 (1-3). Previous cytogenetic and other genome studies suggest a clear link between genome abnormalities and the prostate cancer (4-9). Currently, several treatment options are available for prostate cancer patients including watchful waiting, radiation, hormonal/chemo-therapy and radical prostatectomy. Gleason's grading alone or in combination with other clinical indicators such as serum prostate specific antigen levels and pathological or clinical staging has been the guiding tool in selecting these treatment options. Significant numbers of prostate cancer patients, however, experienced relapse after surgical resection of the prostate gland. There is clearly a need for better prediction of the behavior of prostate cancer.

3. SUMMARY OF THE INVENTION

The present invention relates to methods and compositions for diagnosing prostate cancer and/or determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. It is based, at least in part, on the results of a comprehensive genome analysis on 241 prostate cancer samples (104 prostate cancer, 85 matched bloods, 49 matched benign prostate tissues adjacent to cancer, and 3 cell lines) which indicate that (i) genome copy number variation (CNV) occurred in both cancer and non-cancer tissues, and (ii) CNV predicts prostate cancer progression.

Armed with the present invention, the health care practitioner is better able to advise a prostate cancer patient whether or not to undergo more aggressive forms of therapy or whether watchful waiting would be an appropriate recommendation, where in subjects at higher risk more aggressive forms of therapy may be recommended, including but not limited to prostate resection, antiandrogen therapy, radiotherapy and/or chemotherapy.

4. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1A-D. Deletion and amplification of segments of genomes in blood, benign prostate tissues adjacent to cancer, and prostate cancer samples, (A) Histograms of genome deletion (blue) or amplification (red) of blood (B), benign prostate tissues adjacent to tumor (AT), and tumor (T) in 23 pairs of human chromosomes. (B) Box plot of number of genes overlapping with CNV per sample. Outliers in B and AT samples are indicated. (C) Venn diagram of deleted or amplified genes occurring in at least one sample overlapping between B, AT and T. (D) The spectrum of genes that are amplified or deleted in B, AT, tumors that did not relapse (Tnone), tumors that relapsed and had PSADT at or after 15th months of radical prostatectomy (Tslow), and tumors that relapsed and had PSADT within 4 months of radical prostatectomy (Tfast).

FIG. 2A-C. Genome copy variation in prostate cancer predicts relapse. (A) Histograms of genome deletion (blue) or amplification (red) of Tnone, Tslow and Tfast in 23 pairs of human chromosomes. (B) Receiver operating characteristic (ROC) curves of predicting prostate cancer relapse. The prostate cancer were separated into a group that relapsed within 5 years of prostatectomy (n=75) and a group that did not relapse (n=27). Prediction using gene deletions or amplifications unique to relapsing group generated through “leave-one-out” analysis was carried out to produce the ROC chart. The dotted line represents random prediction baseline. The broken line represents prediction generated from Gleason's grading. (C) ROC curves of predicting prostate cancer fast relapse. The prostate cancer were separated into a group that had PSADT within 4 months of prostatectomy (n=33) and a group that did not (n=69). Prediction using gene deletions or amplifications unique to fast relapsing group generated through “leave-one-out” analysis was carried out to produce the ROC chart. The dotted line represents random prediction baseline. The broken line represents prediction generated from Gleason's grading.

FIG. 3A-D. Genome copy variation in benign prostate tissues adjacent to cancer predicts prostate cancer relapse. (A) Histograms of genome deletion (blue) or amplification (red) of AT no relapse, AT relapse, AT not fast relapse, AT fast relapse in 23 pairs of human chromosomes. (B) ROC curves of AT predicting prostate cancer relapse. The AT samples were separated into a group that relapsed within 5 years of prostatectomy (n=21) and a group that did not relapse (n=28). Prediction using gene deletions or amplifications unique to relapsing group generated through “leave-one-out” analysis was carried out to produce the ROC chart. The dotted line represents random prediction baseline. (C) ROC curves of AT predicting prostate cancer fast relapse. The AT samples were separated into a group that had PSADT within 4 months of prostatectomy (n=8) and a group that did not (n=41). Prediction using gene deletions or amplifications unique to fast relapsing group generated through “leave-one-out” analysis was carried out to produce the ROC chart. The dotted line represents random prediction baseline.

FIG. 4A-D. Median size variation of CNV of blood and tumor samples predicts prostate cancer relapse and fast relapse. (A) ROC curves of CNV median size of B predicting prostate cancer relapse. The B samples were separated as described in (A). Prediction using various CNV median sizes was carried out to produce the ROC chart. The dotted line represents random prediction baseline. The optimal prediction rates for CNV median size of B model are 86% (57/66) sensitivity and 61% (11/18) specificity. (B) ROC curves of CNV median size of B predicting prostate cancer fast relapse. The B samples were separated into a group that had PSADT within 4 months of prostatectomy (n=31) and a group that did not (n=53). Prediction using various CNV median sizes was carried out to produce the ROC chart. The dotted line represents random prediction baseline. The optimal prediction rates for CNV median size of B model are 68% (21/31) sensitivity and 70% (37/53) specificity. (C) ROC curves of predicting prostate cancer relapse using median sizes of CNV from T samples. The prostate cancer were separated into a group that relapsed within 5 years of prostatectomy (n=75) and a group that did not relapse (n=27). Prediction using various CNV median sizes was carried out to produce the ROC chart. The dotted line represents random prediction baseline. The broken line represents prediction generated from Gleason's grading. The optimal prediction rates for CNV median size of T model are 71% (53/75) sensitivity and 89% (24/27) specificity. (D) ROC curves of predicting prostate cancer fast relapse using CNV median sizes from T samples. The prostate cancer were separated into a group that had PSADT within 4 months of prostatectomy (n=33) and a group that did not (n=69). Prediction using various CNV median sizes was carried out to produce the ROC chart. The dotted line represents random prediction baseline. The broken line represents prediction generated from Gleason's grading. The optimal prediction rates for CNV median size of T model are 61% (20/33) sensitivity and 90% (62/69) specificity.

FIG. 5A-D, (A.) Percent overlap of genome segment abnormalities of B, AT, and T, comparing results of study for FIG. 1 and further experiments including additional samples. (B.) Percent deletions with loss of heterozygosity. (C.) Results of quantitative PCR analysis for genes ARL17B, SCAPER, EPHA3 and ERBB4. (D) Sensitivity versus specificity.

FIG. 6A-D. (A,B) Sensitivity versus specificity in B samples, (C,D) Sensitivity versus specificity in T samples.

FIG. 7A-B, Sensitivity versus specificity in AT samples (A) and (B).

FIG. 8A-D. (A,B) Sensitivity versus specificity in B samples. (C,D) Sensitivity versus specificity in T samples.

FIG. 9A-D. (A), (B), (C) and (D) Sensitivity versus specificity in B samples.

FIG. 10A-F. Sensitivity versus specificity in T samples (A,D), B samples (C,F), and AT samples (B,E).

5. DETAILED DESCRIPTION OF THE INVENTION

In certain non-limiting embodiments, the present invention provides for methods and compositions for diagnosing prostate cancer in a subject. In other non-limiting embodiments, the present invention provides for methods and compositions for determining whether a prostate cancer patient is at increased risk of suffering a relapse, or a rapid relapse, of his cancer. In other non-limiting embodiments, the present invention provides for methods and compositions for determining whether a prostate cancer patient is at decreased risk of suffering a relapse, or a rapid relapse, of his cancer (in other words, is at increased risk or has an increased likelihood of not suffering a relapse).

A “prostate cancer patient” is a subject having or who has had a carcinoma of the prostate. The use of the term “patient” does not suggest that the subject has received any treatment for the cancer, but rather that the subject has at some point come to the attention of the healthcare system. Said patient/subject, prior to or contemporaneous with the practicing of the invention, may be untreated for prostate cancer or may have received treatment, including but not limited to surgical, chemotherapeutic, antiandrogen, or radiologic treatment.

“Increased risk” means an increased likelihood that relapse will occur relative to other prostate cancer patients. In particular non-limiting embodiments, there is a statistically validated increase in the likelihood of relapse or rapid relapse relative to subjects without relapse or rapid relapse with a p value of 0.003 for relapse and <0.001 for fast relapse when using “gene specific” CNV of prostate cancer samples, 0.04 for relapse and 0.015 for fast relapse when using “gene specific” CNV of AT samples, <0.001 for relapse and 0.001 for fast relapse when using median sizes of CNV of blood samples from prostate cancer patients, <0.001 for both relapse and fast relapse when using “median sizes” CNV of prostate cancer samples, and 0.004 for relapse when using “mean sizes” of CNV of AT samples.

“Relapse,” as that term is used herein, refers to a clinical course including one or more of the following: (i) where the cancer had been removed or put into remission, a recurrence of prostate cancer at the original site or occurrence at a new site, including metastatic spread; (ii) where the cancer had not been removed or put into remission, extension of the cancer and/or metastatic spread; (iii) whether or not the cancer had been treated, an advancement in the clinical grade, for example the Gleasons grade, of the cancer; and/or a prostate specific antigen (“PSA”) doubling time of 15 months or longer.

By “rapid”, or “relapse quickly”, it is meant that relapse occurs within a period of 5 years. In certain embodiments, patients suffering a rapid relapse also manifest a PSA doubling time of 3 months or less or 4 months or less.

In particular, non-limiting embodiments, the method of the invention may be performed as follows. One or more sample may be obtained from a subject. For example, the sample may be a sample of malignant tumor (or presumptively malignant tumor, where a diagnosis has not yet been made) tissue (e.g., microdissection may be performed to achieve a tumor purity of at least about 70 percent or at least about 80 percent or greater than 80%). As another example, a sample may be tissue adjacent a malignant tumor tissue (e.g., prostate tissue that is not identified as tumor located in a prostate gland that contains tumor; in certain non-limiting embodiments the adjacent tissue is non-malignant prostate tissue located at least 3 mm from tumor tissue). As another example, a sample may be a tissue sample which is considered by a skilled artisan to appear abnormal (microscopically and/or macroscopically) and is to be tested to determine whether it is cancerous. As another example, a sample may be a blood sample that contains at least some nucleated cells (to serve as a source of DNA, e.g., whole blood or buffy coat). Multiple samples may be prepared for a single subject; for example, samples of tumor (meaning malignant) tissue, tissue adjacent tumor tissue, and blood may be prepared and the results of analysis of each may be compared.

For example, DNA may be extracted from a sample, for example using a Qiagen tissue kit or other method known in the art. Then genotyping may be performed to identify CNVs across the genome or a portion of the genome, for example, by fragmenting the DNA using restriction enzymes, ligated with adaptors, amplifying the fragments using primers that correspond to the adaptor sequences (for example, Genome wide human snp NSP/STY assay kit, Affymetrix, CA), optionally performing an additional fragmentation step, labeling the amplified (optionally further fragmented) DNA product, and then hybridizing the resulting labeled DNA with a plurality of test DNA molecules representative of the genome or a genome portion of interest, for example, but not limited to, as provided in an array such as Affymetrix Genome-Wide Human SNP Array 6.0, under appropriate conditions (for example as described by the array manufacturer). The results may then be interpreted to determine the number or approximate number of CNVs in the genome or portion thereof. For example, Partek Genome Suite 6.6™ or a Affymetrix Genotyping Console may be used.

In one set of non-limiting embodiments of the invention, the number of CNVs across the genome are determined. The present invention provides for a method of diagnosing a prostate cancer in a subject comprising determining the number and/or size of CNVs in a tumor sample, a sample of tissue adjacent a tumor, and/or in a blood sample, where if the number and/or size of CNVs exceeds a particular threshold, a diagnosis of prostate cancer is indicated. The present invention also provides for a method of determining that a prostate cancer patient is at increased risk for relapse or rapid relapse comprising determining the number and/or size of CNVs in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the number and/or size of CNVs exceeds a particular threshold, the subject is deemed at risk for relapse or rapid relapse.

In another set of non-limiting embodiments of the invention, CNV of one or more particular gene or chromosome or chromosome region is determined. In specific, non-limiting embodiments of the invention, genes for which CNVs may be determined may include one or more of the genes listed in Tables 2-5, where a CNV in one of the genes listed is indicative of increased risk of relapse (in Table 2 based on a prostate cancer tissue sample or in Table 4 based on tissue adjacent to prostate cancer tissue) or rapid relapse (in Table 3 based on a prostate cancer tissue sample or in Table 5 based on tissue adjacent to prostate cancer tissue). The present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse or rapid relapse comprising determining the number and/or size of CNVs of a specific gene as listed in Table 2, 3, 4 or 5 in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the number of CNVs for the gene exceeds a particular threshold, a diagnosis of prostate cancer is indicated and/or the subject is deemed at risk for relapse or rapid relapse.

For clarity of description and not by way of limitation, the detailed description of the invention is divided into the following subsections:

(i) Diagnosis based on CNV number and size; (ii) Assessment of risk based on CNV number and size; (iii) Assessment of risk based on CNV of particular genes; and

(iv) Kits. 5.1 Diagnosis Based on CNV Number and Size

In non-limiting embodiments of the invention, the number of CNVs across the genome are determined. CNV may be detected using methodology known in the art, including the hybridization to gene arrays and the analysis of the results of hybridization using software that determines copy number variation, including, but not limited to, the method using Affymetrix products described above. In non-limiting embodiments of the invention, the entire genome or a portion thereof may be analyzed; for example, in a subset of non-limiting embodiments, the chromosome region for which CNVs is determined is one or more of 8p, 13p, 16p, 17p, and/or 8q.

In certain non-limiting embodiments, the present invention provides for a method of diagnosing a prostate cancer in a subject comprising determining the number and/or size of CNVs in DNA from a tumor sample, a sample of tissue adjacent a tumor, and/or in a blood sample, where if the number and/or size of CNVs exceeds a particular threshold, a diagnosis of prostate cancer is indicated.

In a tissue, CNV in at least about 90 loci, each locus being at least 10 kb in length, is consistent with a diagnosis of prostate cancer rather than benign tissue. Accordingly, the present invention provides for a method of diagnosing a prostate cancer in a subject comprising determining the number and size of CNVs in DNA from a tumor or prostate tissue sample, where if the number of CNVs exceeds 90 loci, each locus being at least 10 kb in length, a diagnosis of prostate cancer is indicated.

In a blood sample, CNV in at least 4 loci, each locus being at least 10 kb in length, is consistent with a diagnosis of prostate cancer rather than no malignancy. Accordingly, the present invention provides for a method of diagnosing a prostate cancer in a subject, where said subject is a male having one or more of the following clinical findings: increased serum prostate specific antigen, enlarged prostate on physical exam, difficulty urinating and/or urinary retention, comprising determining the number and/or size of CNVs in DNA from a blood sample from the subject, where if the number of CNVs exceeds 4 loci, each locus being at least 10 kb in length, a diagnosis of prostate cancer is indicated.

In a tissue or a blood sample, a deletion of at least 3 megabases in one or more of the following chromosome regions is consistent with a diagnosis of prostate cancer rather than benign tissue: 8p, 13p, 16q, and/or 17p. Deletions in these regions can be deduced from CNV information. Accordingly, the present invention provides for a method of diagnosing a prostate cancer in a subject comprising determining the presence of deletions in one or more of chromosome regions 8p, 13p, 16q, and/or 17p in DNA from a prostate tissue or a blood sample from the subject, where if there is a deletion of at least 3 megabases in one or more of these regions, a diagnosis of prostate cancer is indicated.

In a tissue or a blood sample, an amplification of a locus in chromosome region 8q and/or X is consistent with a diagnosis of prostate cancer rather than benign tissue. Amplification in these regions can be deduced using CNV information. Accordingly, the present invention provides for a method of diagnosing a prostate cancer in a subject comprising determining the presence of amplification in one or more of chromosome regions 8q and X in DNA from a prostate tissue or a blood sample from the subject, where if there is amplification of a locus in one or more of these regions, a diagnosis of prostate cancer is indicated.

If a diagnosis of prostate cancer is indicated, a healthcare provider may optionally take the further step of recommending and/or performing a further diagnostic test, such as a biopsy or prostate ultrasound, and/or recommending and/or performing a therapeutic procedure, for example but not limited to surgical excision, radiotherapy, and/or chemotherapy.

5.2 Assessment of Risk Based on CNV Size

In non-limiting embodiments of the invention, CNVs across the genome are determined. CNV may be detected using methodology known in the art, including the hybridization to gene arrays and the analysis of the results of hybridization using software that determines copy number variation, including, but not limited to, the method using Affymetrix products described above. In non-limiting embodiments of the invention, the entire genome or a portion thereof may be analyzed; for example, in a subset of non-limiting embodiments, the chromosome region for which CNVs is determined is one or more of 8p, 13p, 16p, 17p, and/or 8q.

In non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse or rapid relapse comprising determining the size of CNVs in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the size of CNVs is less than a particular threshold, the patient is deemed to be at decreased risk for relapse or rapid relapse.

In non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse or rapid relapse comprising determining the mean and/or median size of CNVs in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the mean or median size of CNVs is less than a particular threshold, the patient is deemed to be at decreased risk for relapse or rapid relapse.

In non-limiting embodiments, the present invention may utilize the average (mean) size of CNV to assess the likelihood that a prostate cancer will relapse. CNV size may be determined using the same genotyping analysis techniques as described above and as are known in the art. In particular non-limiting embodiments of the invention, using the Partek software described above, segments with copy number change may be obtained (including amplification and deletions), and those with the criteria p<0.001, length >2000 bp and >10 markers, may be selected and then the mean length of the CNVs thus identified may be determined.

In certain non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse comprising determining the size of CNVs in DNA from a blood sample from the patient, where if the average (i.e., mean) size of CNVs is 40 kb or less or 33 kb or less, the patient is deemed to be at decreased risk for relapse.

In certain non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse comprising determining the size of CNVs in DNA from a sample of tissue adjacent a prostate cancer from the patient, where if the mean size of CNVs is 95 kb or less or 81.1 kb or less, the patient is deemed to be at decreased risk for relapse.

In certain non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse comprising determining, the size of CNVs in DNA from a sample of prostate cancer tissue from the patient, where if the mean size of CNVs is 385 kb or less or 105 kb or less, the patient is deemed to be at decreased risk for relapse.

In further non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse or rapid relapse comprising determining the mean or median size of CNVs in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the mean or median size of CNVs exceeds a particular threshold, the patient is deemed to be at increased risk for relapse or rapid relapse.

In one non-limiting embodiment, in a blood sample from a prostate cancer patient, an average (mean) CNV size of 70 kb or more, is consistent with a likelihood that the prostate cancer will relapse. Accordingly, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining the mean size of CNVs in DNA from a blood sample from the patient, where if the average (i.e., mean) size of CNVs is 70 kb or more, the patient is deemed to be at increased risk for relapse.

In other non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining the mean size of CNVs in DNA from a sample of tissue adjacent to prostate cancer from the patient, where if the mean size of CNVs is 246 kb or more, the patient is deemed to be at increased risk for relapse.

In other non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining the mean size of CNVs in DNA from a sample of prostate cancer tissue from the patient, where if the mean size of CNVs is 817 kb or more, the patient is deemed to be at increased risk for relapse.

In other non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for rapid relapse comprising determining the mean size of CNVs in DNA from a sample of prostate cancer tissue from the patient, where if the mean size of CNVs is 1060 kb or more, the patient is deemed to be at increased risk for rapid relapse.

In further non-limiting embodiments, the present invention may utilize the median size of CNV to assess the likelihood that a prostate cancer will relapse. CNV size may be determined using the same genotyping analysis techniques as described above and as are known in the art. In particular non-limiting embodiments of the invention, using the Partek software described above, segments with copy number change may be obtained (including amplification and deletions), and those with the criteria p<0.001, length >2000 bp and >10 markers, may be selected and then the median length of the CNVs thus identified may be determined.

In one non-limiting embodiment, in a blood sample from a prostate cancer patient, a median CNV size of about 17 kb or less is consistent with a likelihood that the prostate cancer will not relapse. Accordingly, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse comprising determining the median size of CNVs in a blood sample, where if the median size of CNVs is 17 kb or less, the subject is deemed to be at decreased risk for relapse.

In certain non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse comprising determining the median size of CNVs in DNA from a sample of tissue adjacent to a prostate cancer from the patient, where if the median size of CNVs is 16 kb or less, the patient is deemed to be at decreased risk for relapse.

In certain non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at decreased risk for relapse comprising determining the median size of CNVs in DNA from a sample of prostate cancer tissue from the patient, where if the median size of CNVs is 185 kb or less, the patient is deemed to be at decreased risk for relapse.

In certain other non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining the median size of CNVs in DNA from a blood sample from the patient, where if the median size of CNVs is 23 kb or more, the patient is deemed to be at increased risk for relapse.

In other non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining the median size of CNVs in DNA from a sample of tissue adjacent to prostate cancer from the patient, where if the median size of CNVs is 17384 or more or 18 kb or more, the patient is deemed to be at increased risk for relapse.

In other non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for rapid relapse comprising determining the median size of CNVs in DNA from a sample of tissue adjacent to prostate cancer from the patient, where if the median size of CNVs is 32651 bp or more, or 33 kb or more, the patient is deemed to be at increased risk for rapid relapse.

In other non-limiting embodiments, the present invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining the median size of CNVs in DNA from a sample of prostate cancer tissue from the patient, where if the median size of CNVs is 647 kb or more, the patient is deemed to be at increased risk for relapse.

If is determined that the patient is at increased risk for relapse or rapid relapse, a healthcare provider may optionally take the further step of recommending and/or performing frequent monitoring of the patient for recurrence (e.g., a PSA test or imaging (e.g. ultrasound, CT scan, MRI or PET scan)) and/or recommending and/or performing a therapeutic procedure, for example but not limited to surgical excision, radiotherapy, and/or chemotherapy.

5.3 Assessment of Risk by CNV of Particular Genes

In non-limiting embodiments of the invention, the number of CNVs across the genome are determined, CNV may be detected using methodology known in the art, including the hybridization to gene arrays and the analysis of the results of hybridization using software that determines copy number variation, including, but not limited to, the method using Affymetrix products described above. In non-limiting embodiments of the invention, the entire genome or a portion thereof may be analyzed; for example, in a subset of non-limiting embodiments, the chromosome region for which CNVs is determined is one or more of 8p, 13p, 16p, 17p, and/or 8q. Further, the CNV of particular genes may be determined and utilized as set forth in this section.

In further non-limiting embodiments, a CNV in a gene in a prostate cancer tissue from a subject, where the gene is listed in Table 2, indicates that the subject is likely to relapse. In further non-limiting embodiments, a CNV in a gene in a prostate cancer tissue from a subject, where the gene is listed in Table 3, indicates that the subject is likely to experience rapid relapse.

In further non-limiting embodiments, a CNV in a gene in a tissue adjacent to prostate cancer tissue from a subject, where the gene is listed in Table 4, indicates that the subject is likely to relapse. In further non-limiting embodiments, a CNV in a gene in a tissue adjacent a prostate cancer tissue from a subject, where the gene is listed in Table 5, indicates that the subject is likely to experience rapid relapse.

In on set of non-limiting embodiments, the present invention provides for a gene-based prediction in any one or more of four scenarios: relapse or fast relapse prediction in tumor (T) or tissues adjacent to tumor (AT). According to this set of embodiments, the methods for these four scenarios are the same except for the gene lists used are different. In particular, for each scenario, two gene lists are utilized: one list for genes amplified (list “a”) and one list for genes deleted (list “b”). Using Partek, the copy number change status of each gene for each sample could be determined; the status could be amplified, deleted or unchanged.

For a given T sample, the number of genes in list “a” that are amplified and the number of genes in list “b” that arc deleted are counted, and the number of amplified genes in list “a” may be designated “a” and the number of deleted genes in list “b” may be designated “b”. Genes in list “a” for relapse include HECTD1, MIR1827, UBXN8, SMAP1, C6orf147, DDX43, SLC17A5, LRRIQ4, LRRC31, SAMD7, LOC100128164, SEC62, GPR160, and PHC3. Genes in list “b” for relapse include SLC7A5, CA5A, BANP, ZFPM1, ZC3H18, IL17C, CYBA, MVD, MGC23284, SNAI3, RNF166, GALNS, TRAPPC2L, CBFA2T3, ACSF3, C16orf81, CDH15, ANKRD11, SPG7, RPL13, SNORD68, CDK10, SPATA2L, C16orf7, ZNF276, SYT16, GRIN2B, BCAT1, OVC1, BEYLA, GPR125, and GBA3. If the number (a+b) is larger than a pre-set cutoff C (i.e. a+b>C), the corresponding sample is assigned the risk designation relapse or fast relapse, depending upon the list that is drawn from. In a particular non-limiting embodiment, in a+b>C, C=0 meaning that the threshold is 0 so that if a or b is a non-zero number, there is an increased risk of relapse.

In non-limiting embodiments, the invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining whether a gene is amplified or whether a gene is deleted in DNA from a sample of prostate cancer tissue from the patient, wherein (a) if one or more gene is amplified from the group consisting of HECTD1, MIR1827, UBXN8, SMAP1, C6orf147, DDX43, SLC17A5, LRRIQ4, LRRC31, SAMD7, LOC100128164, SEC62, GPR160, and PHC3 and/or (b) if one or more gene is deleted from the group consisting of SLC7A5, CA5A, BANP, ZFPM1, ZC3H18, IL17C, CYBA, MVD, MGC23284, SNAI3, RNF166, GALNS, TRAPPC2L, CBFA2T3, ACSF3, C16orf81, CDH15, ANKRD11, SPG7, RPL13, SNORD68, CDK10, SPATA2L, C16orf7, ZNF276, SYT16, GRIN2B, BCAT1, OVCH1, BEYLA, GPR125, and GBA3, then the patient is deemed to be at increased risk for relapse.

In other non-limiting embodiments, genes in list “a” for rapid relapse include BRMS1L, KCNMB4, MIR548A1, ORC3L, SDAD1, CXCL9, ART3, CXCL10, CXCL11, Genes in list “b” for rapid relapse include GALNTL1, FLJ44817, KIAA0247, LOC100289511, SFRS5, SLC10A1, SLC8A3, SNGRD56B, PABPC3, MTMR6, ATP8A2, NAV2, ZC3H12C, FDX1, ARHGAP20, C11orf88, LAYN, and CD28. In a particular non-limiting embodiment, in a+b>C, C=0, meaning that the threshold is 0 so that if a or b is a non-zero number, there is an increased risk of rapid relapse.

In non-limiting embodiments, the invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining whether a gene is amplified or whether a gene is deleted in DNA from a sample of prostate cancer tissue from the patient, wherein (a) if one or more gene is amplified from the group consisting of BRMS1L, KCNMB4, MIR548A1, ORC3L, SDAD1, CXCL9, ART3, CXCL10, and CXCL11 and/or (b) if one or more gene is deleted from the group consisting of GALNTL1, FLJ44817, KIAA0247, LOC100289511, SFRS5, SLC10A1, SLC8A3, SNORD56B, PABPC3, MTMR6, ATP8A2, NAV2, ZC3H12C, FDX1, ARHGAP20, C11 orf88, LAYN, CD28, then the patient is deemed to be at increased risk for rapid relapse.

In related embodiments applied to AT, two gene lists are utilized: one list for genes amplified (list “c”) and one list for genes deleted (list “d”). Using Partek, the copy number change status of each gene for each sample could be determined; the status could be amplified, deleted or unchanged. For a given T sample, the number of genes in list “c” that arc amplified and the number of genes in list “d” that are deleted are counted, and the number of amplified genes in list “c” may be designated “c” and the number of deleted genes in list “d” may be designated “d”. Genes in list “c” for relapse include DZIP1, ZHX2, DERL1, WDR67, COL22A1, BHLHE40 and, in a non-limiting embodiment, there is no gene in list “d”. In a particular non-limiting embodiment, in a+b>C, C=0 meaning that the threshold is 0 so that if c or d is a non-zero number, there is a likelihood of relapse. In other non-limiting embodiments applied to AT, genes in list “c” for rapid relapse include MAGEL2, NDN, RSU1, ADC Y2, UBE2E1 and genes in list “d” for rapid relapse based on AT include RPL23AP82, RABL2B, CA10, C13orf36, SMAD9, ALG5, RETNLB, TRAT1, GUCA1C, MORC1. In a particular non-limiting embodiment, in a+b>C, C=1 meaning that the threshold is 1 so that if the sum of c and d is greater than one, there is a likelihood of rapid relapse,

In non-limiting embodiments, the invention provides for a method of determining that a prostate cancer patient is at increased risk for relapse comprising determining whether a gene is amplified in DNA from a sample of tissue adjacent to prostate cancer tissue from the patient, wherein if one or more genes is amplified from the group consisting of DZIP1, ZHX2, DERL1, WDR67, COL22A1, BHLHE40 then the patient is deemed to be at increased risk for relapse.

In non-limiting embodiments, the invention provides for a method of determining that a prostate cancer patient is at increased risk for rapid relapse comprising determining whether a gene is amplified or whether a gene is deleted in DNA from a sample of tissue adjacent to prostate cancer tissue from the patient, wherein (a) if one or more genes is amplified from the group consisting of MAGEL2, NDN, RSU1, ADCY2, UBE2E1 and/or (b) one or more genes is deleted from the group consisting of RPL23AP82, RABL2B, CA10, C13orf36, SMAD9, ALG5, RETNLB, TRAT1, GUCA1C, MORC1, wherein the total number of genes amplified from the group listed in (a) and/or deleted from the group listed in (b) is greater than or equal to 2, then the patient is deemed to be at increased risk for rapid relapse.

If is determined that the patient is at increased risk for relapse or rapid relapse, a healthcare provider may optionally take the further step of recommending and/or performing frequent monitoring of the patient for recurrence (e.g., a PSA test or imaging (e.g. ultrasound, CT scan, MRI or PET scan), digital rectal exam) and/or recommending and/or performing a therapeutic procedure, for example but not limited to surgical excision, radiotherapy, and/or chemotherapy.

If is determined that the patient is at decreased risk for relapse, a healthcare provider may optionally take the further step of recommending that the patient not seek imminent further treatment and/or performing frequent monitoring of the patient for recurrence (e.g., a PSA test or imaging (e.g. ultrasound, CT scan, MRI or PET scan), digital rectal exam) (“watchful waiting”).

5.4 Kits

In non-limiting embodiments, the present invention provides for kits that may be used to practice the invention. Such kits may include an array comprising nucleic acid representing at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 15, at least 20, at least 30, at least 40, or at least 50 of the following genes, where the genes listed below constitute up to 50 percent or up to 60 percent or up to 70 percent or up to 80 percent or up to 90 percent or up to 95 percent or up to 100 percent of the total set of genes represented in the array:

genes listed in Table 2;

genes listed in Table 3;

genes listed in Table 4;

genes listed in Table 5;

HECTD1, MIR1827, UBXN8, SMAP1, C6orf147, DDX43, SLC17A5, LRRIQ4, LRRC31, SAMD7, LOCI00128164, SEC62, GPR160, PHC3, SLC7A5, CA5A, BANP, ZFPM1, ZC3H18, IL17C, CYBA, MVD, MGC23284, SNAI3, RNF166, GALNS, TRAPPC2L, CBFA2T3, ACSF3, C16orf81, CDH15, ANKRD11, SPG7, RPL13, SNORD68, CDK10, SPATA2L, C16orf7, ZNF276, SYT16, GRIN2B, BCAT1, OVCH1, BEYLA, GPR125, GBA3, BRMS1L, KCNMB4, MIR548A1, ORC3L, SDAD1, CXCL9, ART3, CXCL10, CXCL11, GALNTL1, FL344817, KIAA0247, LOC100289511, SFRS5, SLC10A1, SLC8A3, SNORD56B, PABPC3, MTMR6, ATP8A2, NAV2, ZC3H12C, FDX1, ARHGAP20, C11orf88, LAYN, CD28 DZIP1, ZHX2, DERL1, WDR67, COL22A1, BHLHE40, MAGEL2, NDN, RSU1, ADCY2, UBE2E1, RPL23AP82, RABL2B, CA10, C13orf36, SMAD9, ALG5, RETNLB, TRAT1, GUCA1C, and MORC1.

For example, but not by way of limitation, an array may comprise sets of genes as listed above for lists “a”, “b”, “c” and/or “d”.

Such kits may optionally comprise software, or Internet access to software, in electronically readable form, that determines the number and size of CNVs in the genes represented in the array, and optionally software, or internet access to software, in electronically readable form, that determines whether CNVs in a DNA sample exceed or fall below a threshold set forth herein that indicates an increased risk of relapse or an increased risk of rapid relapse of prostate cancer.

6. EXAMPLE Genome Abnormalities Precede Prostate Cancer and Predict Clinical Relapse

6.1 Materials and Methods

Tissue Processing, DNA Extraction, Amplicon Generation, Labeling, Hybridization, Washing and Scanning of SNP 6.0 Chips.

Prostate cancer samples were obtained from the University of Pittsburgh Medical Center Tissue Bank, Pittsburgh, Pa. These samples were collected from 1998 to 2009. To make the analysis balance, samples of short prostate specific antigen doubling time (“PSADT”) (<4 months), long PSADT (>15 months), and no relapse (cancer free for >5 years after radical prostatectomy) each were made to constitute approximately one third of the total number. Whenever possible, nonrelapse samples were chosen to match pathological stages and Gleason grades of relapse samples. A total of 214 samples were from whites, whereas 5 samples were from African Americans and 19 samples were from patients with an unknown race. The patients whom these samples were obtained from either experienced relapse or had no relapse for at least 5 years, based on chemical (serum PSA) and radiological evidence. Frozen tissues were used for blood, prostate cancer, and benign prostate tissue adjacent to cancer. Clinical follow-up was conducted by office examination record, blood PSA survey, and radiographical follow-up. These follow-up visits were performed for up to a 10-year period after the patient underwent a radical prostatectomy. The protocol was approved by the Institutional Review Board. For prostate cancer, microdissection was performed to achieve tumor purity >80%. For benign prostate tissues adjacent to cancer, benign tissues away from prostate cancer (at least 3 mm) were microdissected. Whenever available, whole blood or buffy coat from the same patients was used as a normal control. PC3, DU145, and LNCaP cells were obtained from American Type Culture Collection Inc. (Manassas, Va.) in 2000, 2001, and 2007, respectively. The genomes of these cell lines were tested for short tandem repeat DNA profiling on eight different loci (CSF1PO, D13S317, D16S539, D5S818, D7S820, THO1, TPOX, and vWA) of the genomes by PCR using the following sets of primers:

(SEQ ID NO: 1) CSF1PO, 5′-AACCTGAGTCTGCCAAGGACTAGC-3′ and (SEQ ID NO: 2) 5′-TTCCACACACCACTGGCCATCTTC-3′; (SEQ ID NO: 3) D13S317, 5′-ACAGAAGTCTGGGATGTGGA-3′ and (SEQ ID NO: 4) 5′-GCCCAAAAAGACAGACAGAA-3′; (SEQ ID NO: 5) D16S539, 5′-GATCCCAAGCTCTTCCTCTT-3′ and (SEQ ID NO: 6) 5-ACGTTTGTGTGTGCATCTGT-3′; (SEQ ID NO: 7) D5S818, 5′-GGGTGATTTTCCTCTTTGGT-3′ and (SEQ ID NO: 8) 5′-TGATTCCAATCATAGCCACA-3′; (SEQ ID NO: 9) D7S820, 5′-TGTCATAGTTTAGAACGAACTAACG-3′ and (SEQ ID NO: 10) 5′-CTGAGGTATCAAAAACTCAGAGG-3′; (SEQ ID NO: 11) TH01, 5′-GTGGGCTGAAAAGCTCCCGATTAT-3′ and (SEQ ID NO: 12) 5′-ATTCAAAGGGTATCTGGGCTCTGG-3′; (SEQ ID NO: 13) TPOX, 5′-CTGGCACAGAACAGGCACTTAGG-3′ and (SEQ ID NO: 14) 5′-GGAGGAACTGGGAACCACACAGGT-3′; and (SEQ ID NO: 15) vWA, 5′-CCCTAGTGGATGATAAGAATAATCAGTATG-3′ and (SEQ ID N): 16) 5′-GGACAGATGATAAATACATAGGATGGATGG-3′. These cell lines were authenticated because the short tandem repeat profiles of the cell lines have a perfect match with those published by American Type Culture Collection Inc, DNA was then extracted using a Qiagen tissue kit (Qiagen, Valencia, Calif.). Detailed case information is shown in Tables 1A-D. Genome DNA (500 ng), was digested with Sty1 and Nsp1 for 2 hours at 37° C. The digested DNA was purified and ligated with primer/adaptors at 16° C. for 12 to 16 hours. Amplicons were generated by performing PCR using primers provided by the manufacturer (Affymetrix, Santa Clara, Calif.) on the ligation products using the following program: 94° C. for 3 minutes and then 35 cycles of 94° C. for 30 seconds, 60° C. for 45 seconds, and 65° C. for 1 minute. This was followed by extension at 68° C. for 7 minutes. The PCR products were then purified and digested with DNaseI for 35 minutes at 37° C. to fragment the amplified DNA. The fragmented DNA was then labeled with biotinylated nucleotide through terminal deoxynucleotide transferase for 4 hours at 37° C. Fragmented DNA, 250 μg, was hybridized with a pre-equilibrated Affymetrix SNP 6.0 chip at 50° C. for 18 hours. Procedures of washing and scanning of SNP 6.0 chips followed the manuals provided by Affymetrix.

SYBR-Green Real Time Quantitation PCR:

LightCycler FastStart DNA Master SYBR-Green I kit was used for real time PCR amplification. The reaction was carried out in a MasterCycler Realplex™ (Eppendorf, Hauppauge, N.Y.). A quantitation standard curve of normal male DNA from 50,000 to 500,000 copies of genome was generated using known amounts of template copies. Twenty nanograms of genomic DNA were used for all of the experimental and control samples. Tag DNA polymerase was activated with a 2 min pre-incubation step at 94° C. Amplification of the following primers was performed:

ARL17B (ACTGTCATAGCAGTGCTGAGG(SEQ ID NO: 17)/ ACTTACCTACTGTAGGGACGG SEQ ID NO: 18), SCAPER (AGGAAGGCCTATTCGTTCTCG SEQ ID NO: 19/ GAACAGTATGGGAGGAGTTCG(SEQ ID NO: 20), WWOX (GCCAGTTGATGTGACAACTGC(SEQ ID NO: 21)/ CAGCTGAGAGTGGTTTCTTTGC(SEQ ID NO: 22)), EPHA3 (ATCAGGACTTACCAGGTGTGC(SEQ ID NO: 23)/ ACCGTGTCTGGAAACATAGCC(SEQ ID NO: 24)), and ERBB4 (AGTGGCCTGTCCTTGCTTATC(SEQ ID NO: 25)/ CAGAGCAACAATTCTGACCGG(SEQ ID NO: 26)) with 35 cycles of the following program: 94° C. for 30 s, 62° C. for 30 s, and 68° C. for 3 min. Realplex™ data software was used to quantify and to fit the data with a standard curve. A separate β-actin (TCTTTGCACTTTCTGCATGTCCCC (SEQ ID NO: 27)/GTCCATCACGATGCCAGTGGTAC (SEQ ID NO:28)) DNA quantification was also performed as an internal control for each analysis.

Statistical Analysis:

Two hundred forty-one cell files were analyzed with the Genotyping console 4.0 from Affymetrix, Inc, for quality control analysis. Samples with QC call above 80% and QC contrast ratio above 0.4 were admitted into the analysis. To analyze CNV, cell files were imported into Partek GenorneSuite 6.6 to generate copy number from raw intensity. To plot the histograms, GC adjust was performed. Deletion or amplification of genomes were analyzed by first limiting to the regions with p-value less than 0.05/total number of regions detected, i.e. family-wise error rate (FWER) is controlled using Bonferroni's correction (10). The selected regions were subsequently filtered by limiting to the regions with at least 100 markers and 10 kb. The regions were then mapped to known genes. For a subset of the sample (i.e. tumor or relapse with rapid progression), the frequencies of amplification/deletion are calculated on the gene level. The frequencies were plotted to the genome corresponding to the gene locations.

Prediction Analysis and ROC Curve:

The following prediction analysis for the comparison of (1) non-relapse versus fast-relapse+slow-relapse); (2) non-relapse+slow-relapse versus fast-relapse was performed. A test sample was first left out from prediction model construction. The remaining samples were used as the training set. Loci with more than r %, amplification or r % deletion in the case group but none locus aberration in the control group were selected as predictive loci. To predict the left-out test sample, the percentage of locus aberration (amplification or deletion) among the identified predictive loci was calculated. The test sample was predicted as a case if the percent of aberration is greater than p % threshold, and control otherwise. The “leave-one-out” cross-validation was repeated until each sample was left out and predicted. In this prediction scheme, r is a parameter that determines the number of predictive loci used in the model. For a given r, the threshold p % was varied to locus rate an ROC curve with sensitivity/specificity trade-off. We selected r that produced the best “area under curve” (AUC)(11). To report the best sensitivity and specificity trade-off and overall accuracy rate, we chose the threshold p % such that the Youden index (sensitivity+specificity-1) is maximized. This criterion gave equal importance to sensitivity and specificity. To further evaluate whether the prediction result is better than obtained by random, AUC was used as a test statistics, and permutation analysis was performed to assess the statistical significance. Specifically, class labels (case and control) were randomly shuffled and AUC calculation was performed. Such permutations were repeated for 1000 times to generate the null distribution. The p-value was calculated as the percentage that the 1000 null AUCs from permutation are greater than the observed AUC. The genes that are overlapped with the loci used in the test and the frequency of utilization are listed in Tables 2-5. For Gleason score prediction, the ROC curve was generated by varying Gleason score threshold. AUC and its associated p-value were similarly calculated. For CNV size prediction, CNV was limited to >2 kb, p<0.001 and >10 markers. The ROC curve was generated by varying sizes of CNV threshold. AUC and its associated p-value were similarly calculated.

Prediction Analysis for Blood Versus Tumor:

To predict blood versus tumor, the total number of aberrations in each sample was counted instead of the predictive locus selection described above. The ROC curve, AUC and the associated p-value were similarly generated.

6.2 Results

The SNP 6.0 chip hybridization results were analyzed through Partek Genome Suite 6.6™, using blood (B) samples as normal references. As shown in histograms of FIG. 1A, abnormalities of genome in copy number can be found in all chromosomes in prostate cancer. An average of 91.6 loci (minimum of 10 kb) per sample involving 1092 genes were identified either amplified or deleted in prostate cancer genomes as determined by more than 100 markers, p<5.5×10⁻⁹ (Bonferroni correction, FIG. 1B). Deletions of large segments of (>3 megabases) chromosome 8p, 13p, 16q and 17p occurred with high frequencies, while amplification of 8q and X chromosomes occurred in a subset of prostate cancer samples. Similar amplification and deletion of the same regions also occurred in benign prostate tissues adjacent to cancer, albeit with smaller sizes and lower frequency. Unexpectedly, the blood of prostate cancer patients contains significant abnormalities in genomes (1329 genes total, or 4.4 loci and 32.6 genes/sample). Most of these abnormalities are not unique and are overlapped with those of prostate cancer samples (FIG. 1C). Prostate cancers were then sub-divided based on clinical behavior: those with no relapse after prostatectomy (Tnone); those with relapse and slow increase in serum prostate specific antigen (PSA, doubling in more than 15 months) (Tslow); those with relapse and rapid increase in serum PSA (doubling in less than 4 months) (Tfast). The kinetics of PSA increase after prostatectomy is predictive of prostate-cancer specific death, with rapid increases highly associated with lethal prostate cancer(12). The spectrum of locus abnormalities increases from blood to prostate cancer in an incremental fashion: the least in blood to the most in rapidly progressive prostate cancer (Tfast) (FIG. 1D).

To assess the reproducibility of these analyses, a large set of reference normal samples (n=800) available to public through Partek, Inc. was used. This re-analysis showed genome segment abnormalities of B, AT and T overlapped at least 93 percent between these two analyses (FIG. 5A). In addition, a third analysis using a different set of normal samples (GeneSpring GX11, n=265) was performed, showing that 94% to 99% of the amplified or deleted genome segments from B, AT and T overlap with those obtained from Partek Genome Suite analyses using blood as baseline (FIG. 5A). Affymetrix SNP6.0 contains separate probe sets for SNP and CNV detection. The majority of large genome deletions are accompanied with loss of heterozygosity (LOH). Profiles of LOH for B, AT and T samples were generated to validate the deletions detected by CNV analysis. Genome deletion frequently accompanied LOH (91% to 98%), with average matches for B, AT and T ranging from 93% to 96% (FIG. 5B). This suggests that the analyses are reproducible and robust.

Five loci from chromosomes 16, 17, 3, 2 and 15 with deletions of at least 10 kb and overlapping with nearby genes were selected for quantitative-PCR analysis. As shown in FIG. 5C, a deletion by Q-PCR was found in 4 of 5 samples predicted to have a deletion in the region overlapping with ARL17B, a gene homologous to ADP-ribosylation factor located at 17q2113. Similar confirmation was found in Q-PCR of SCAPER, the S-phase cyclin A-associated protein in the ER located at 15q2414 (5 of 5 samples), of WWOX, WW domain containing oxidoreductase located at 16q2315-17 (5 of 5 samples), of EPHA3 or ephrin receptor 3, a protein tyrosine receptor frequently mutated in a variety of human cancers 18-20 (4 of 5 samples), and of ERBB4 or v-erb-a erythroblastic leukemia viral oncogene homolog 421,22 (5 of 5 samples) in blood samples from prostate cancer patients. The concordance rate of Q-PCR and copy number analysis was 92%. Our analysis indicates that copy number variation is not limited to prostate cancer or benign prostate tissue adjacent to cancer, but is also found in blood from prostate cancer patients.

To investigate whether the CNV profiles of B, AT and T are distinctive from each other, classification analysis was performed to predict genomes of blood versus those of prostate cancer, by aggregating genome loci that have differential amplification or deletion proportion between blood and prostate cancer (see methods for more detail). The prediction accuracy under unbiased “leave-one-out” cross-validation (23) was 89% for blood (76/85) and 94% for prostate cancer (98/104). The overall accuracy was 92% (174/189, FIG. 5D). To investigate whether AT is genetically more related to cancer or “normal” tissues, the CNV profiles of B and T samples were constructed into a logistic regression model as “normal” and “prostate cancer” training sets, respectively. This model was then utilized to classify each of the 49 AT samples as either “normal” or “prostate cancer”. Such analysis predicts that 42 of 49 (86%) putatively benign prostate tissue is “cancer”, while only 7 of the AT tissues were classified as “normal”. All prostate cancer cell lines were classified as “cancer”. These analyses clearly indicate that majority of AT samples have copy number profiles similar to prostate cancer's rather than to normal's, resembling a field effect similarly found for gene expression profiling (24).

The vast majority of prostate cancers are not lethal (25). Prediction analysis with “leave-one-out” cross-validation based on loci that have significant proportion of amplification or deletion in the group of relapse but none in the non-relapsed group was performed. The resulting Receiver Operating Characteristic curves (ROC) were generated by varying sensitivity-specificity trade-off (FIGS. 2A,B). The cutoff that generates the best Youden index (i.e. sensitivity+specificity−1) has an accuracy of 73% (74/102, ROC p=0.003, positive prediction=76% [57/75], negative prediction=63% [17/27]) for relapse prediction. Gleason's grading has been a strong predictor of recurrence but in this analysis it was statistically insignificant from baseline (ROC p=0.32) and much worse than CNV analysis.

Prostate cancers with rapid progression, as defined by rates of PSA rise, are lethal 1(2,26), Those with PSA doubling time (PSADT)<4 months after relapse and those who died of prostate cancer were compared to those with PSADT>15 months or having no relapse. A similar prediction with “Leave-One-Out” cross-validation analysis was performed to examine the accuracy of CNV profiling (see the genes listed in TABLE 3) in predicting rapidly progressing prostate cancer. As shown in FIG. 2C, the accuracy of predicting rapid progression was 75% (p<0.001) with positive and negative predictive value of 58% and 83%, respectively. In contrast, the histology of the cancer, as defined by Gleason grading, failed to achieve >50% predictive values simultaneously on positive and negative predictions (ROC p=0.074).

Since the genome alterations in AT are most similar to those of T, the CNV of AT to predict relapse was examined using cross-validation. As shown in FIGS. 3A and 3C, the CNV profile of AT is moderately predictive of prostate cancer relapse: a sensitivity of 76% and a specificity at 56% (ROC p=0.041) were observed. Surprisingly, the CNV profile of AT is more accurate in predicting fast relapse (88% sensitivity and 75% specificity, p=0.015, FIGS. 3 B&D). Using the same approach, the CNV profiles from B failed to generate a ROC statistically different from baseline in predicting relapse or fast relapse. However, our analysis showed that the average and median sizes of CNV are significantly larger in blood samples (70 Kb and 23 kb, respectively) from patients with relapse than those without (40 kb and 17 kb). Based on the sizes of CNV, highly statistically significant ROCs were generated (FIGS. 4A-B), predicting 81% (p<0.001) relapse and 69% (p=0.001) fast relapse correctly through median CNV sizes. The CNV size correlation with relapse was also found in T (817 kb mean and 647 kb median for relapse vs. 385 kb and 185 kb for non-relapse) and AT samples (246 kb mean and 18 kb median for relapse vs. 95 kb and 16 kb for non-relapse), suggesting a larger CNV size a common feature for prostate cancer relapse regardless tissues. Both median and mean sizes of CNV from T and B, and mean size of CNV from AT predict prostate cancer relapse, while mean and median sizes of CNV from T and B predict fast relapse (FIGS. 4A-D, 6A-D and 7A-B). Interestingly, similar relapse prediction results were also replicated using the sizes of either amplified or deleted loci of blood (FIGS. 8A-D and 9A-D).

To rule out aging being a factor in our analysis, correlation analyses between our gene-specific or size-based model and the patient age were performed, and revealed no significant correlation between age and our prediction methods, Age did not predict outcomes (FIG. 10A-F).

To investigate the reproducibility of our prediction models, we collected an additional 25 samples, including 10 tumors, 10 benign tissues adjacent to tumors, and 5 blood samples from patients with prostate cancer. These experiments and analyses were performed in a separate time period and by different personnel. By using a genespecific model, we correctly predicted 7 of 10 relapse and 8 of 10 short PSADT from tumor samples, whereas we correctly predicted 7 of 10 for both relapse and short PSADT from AT samples. By using mean size of CNV from tumor, we correctly predicted 7 of 10 cases of both relapse and short PSADT, 7 of 10 for relapse from AT, and 4 of 5 for relapse and 4 of 5 for short PSADT from blood. By using median size of CNV from tumors, we correctly predicted 6 of 10 for relapse and 7 of 10 for short PSADT, whereas from blood, we correctly predicted 5 of 5 for relapse and 4 of 5 for short PSADT. Taken together, the gene-specific CNV model has an overall prediction rate of 72.5% in the replication data set, similar to those found in the first set of data. The mean CNV sizes of blood, tumor, and benign prostate tissues have an overall prediction rate of 72% for relapse, and the mean CNV sizes of blood and tumor samples have an overall prediction rate of 73% for short PSADT, whereas the median CNV sizes of blood and tumor have overall prediction rates of 73% for relapse and 80% for short PSADT. These results are also similar to those found in the original study, reflecting good consistency and reproducibility of our prediction models.

6.3 Discussion

Genome-wide analyses of prostate cancer using other methodologies were performed previously (27-30). However, there was no attempt to construct a model to predict the prognosis of prostate cancer. The genome abnormality found in blood from prostate cancer patients in this study is novel. Even though a tiny amount (<0.1% of blood cell population) of circulating tumor cells may exist in the blood sample (31, 32), the stringency of CNV analysis (>30% contamination to be detected) ruled out contamination of tumor cells in the blood as a contending interpretation. Analysis of some of the previously published matched normal samples of other malignancies (33,34) also reveals significant CNV. This suggests that CNV is widely present in tissues of patients carrying malignancies. However, it is unclear whether healthy individuals carry these abnormalities. The CNV of blood may be somatic and acquired through aging; this alteration would tend to be random and spontaneous. Alternatively, genome copy number abnormalities may occur at germ line level. To distinguish these two possibilities, longitudinal blood samples of the same aging individual could identify if CNV is accumulated. Independent of the mechanism, however, genome CNV correlates with the eventual behavior of prostate cancer. This is observed in the primary prostate cancer, in the histologically normal tissue from a prostate gland containing cancer and in the blood of prostate cancer patient. The field effect of genome alterations appears to extend beyond the organ to the entire host.

Conceivably, CNV analysis offers a better option than Gleason's grading in predicting the behavior of prostate cancer not only because of a better prediction rate on the tumor samples, but also its applicability to non-tumor tissues. There are several salient potentials for clinical application using the CNV tests: For a patient being diagnosed of prostate cancer, CNV analysis done on the blood or perhaps other normal tissues from the patient would eliminate the need for additional invasive procedure to decide a treatment mode. For a patient already having a radical prostatectomy, the CNV analysis on tumor or blood sample may help to decide whether additional treatment is warranted to prevent relapse. When morphology becomes in-determinate in a biopsy sample, the gene specific CNV field effect in benign prostate tissues may help to obtain a firmer diagnosis. The main limitation of the genome CNV analysis for clinical test is its requirement of high quality genome DNA. Formalin-fixed paraffin-embedded tissues may not be suitable. When gene specific CNV prediction is performed, a training set containing samples with known outcome is required for the prediction (while there is no need of training set when size of CNV analysis is performed). Despite these limitations, CNV analysis on the genome of blood, normal prostate or tumor tissues of the prostate cancer patients holds promise to become a more efficient and accurate way to predict the behavior of prostate cancer.

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Kim J H, Dhanasekaran S M, Mehra R, et al: Integrative analysis     of genomic aberrations associated with prostate cancer progression.     Cancer Res 67:8229-39, 2007 -   28. Zhao H, Kim Y, Wang P, et al: Genome-wide characterization of     gene expression variations and DNA copy number changes in prostate     cancer cell lines. Prostate 63:187-97, 2005 -   29. Ren B, Yu G, Tseng G C, et al: MCM7 amplification and     overexpression are associated with prostate cancer progression.     Oncogene 25:1090-8, 2006 -   30. Liu W, Laitinen S, Khan S, et al: Copy number analysis indicates     monoclonal origin of lethal metastatic prostate cancer. Nat Med     15:559-65, 2009 -   31. Cristofanilli M, Budd G T, Ellis M J, et al: Circulating tumor     cells, disease progression, and survival in metastatic breast     cancer, N Engl J Med 351:781-91, 2004 -   32. Moreno J G, Croce C M, Fischer R, et al: Detection of     hematogenous micrometastasis in patients with prostate cancer.     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Various publications are cited herein, the contents of which are hereby incorporated by reference in their entireties.

TABLE 1A Case pathology grading, Clinical outcome and Age Relapse Relapse Gleason's Sample Type Relapse Fast Simple Grade Age LNCaP C 5772T T none nf n 7 60 s 3806T T Du145 C 20968T T slow nf y 7 50 s 15463T T none nf n 7 60 s 8629T T none nf n 6 50 s PC3 C 28685T T slow nf y 7 50 s 11423T T slow nf y 7 70 s 11462T T slow nf y 7 50 s 25265T T none nf n 7 60 s 25313T T none nf n 8 50 s 2671T T slow nf y 7 60 s 6647T T slow nf y 7 40 s 9122T T none nf n 7 50 s 678T T none nf n 9 70 s 7270T T none nf n 9 70 s 28925N N 50 s 1199T T slow nf y 8 50 s 27086T T none nf n 6 50 s 562T T none nf n 6 60 s 34N N Nnone Nnf Nn 50 s 36N N Nnone Nnf Nn 50 s 9122N N Nnone Nnf Nn 50 s 28278T T none nf n 7 50 s 2691T T none nf n 7 50 s 8629N N Nnone Nnf Nn 50 s 8378T T none nf n 7 60 s 8432T T none nf n 7 50 s 6837T T slow nf y 6 70 s 7943N N Nnone Nnf Nn 60 s 8741T T none nf n 6 60 s 34T T none nf n 7 50 s 14878T T none nf n 8 60 s 25313N N Nnone Nnf Nn 50 s 678N N Nnone Nnf Nn 70 s GB195T T slow nf y 7 60 s HB591T T fast f y 7 60 s IB071T T fast f y 7 60 s JB426T T fast f y 7 60 s PR079T T slow nf y 7 60 s PR521T T slow nf y 7 50 s TP08-S00530T T fast f y 7 60 s TP09-S0006T T fast f y 8 50 s 16464T T slow nf y 7 60 s 16947T T slow nf y 8 70 s DB237T T slow nf y 6 70 s FB94T T slow nf y 7 60 s JB378T T slow nf y 6 60 s PR151T T slow nf y 7 60 s PR304T T slow nf y 8 60 s PR311T T slow nf y 8 60 s 2644T T slow nf y 9 50 s 19381T T none nf n 6 50 s 7943T T none nf n 7 60 s TP09-S0420T T fast f y 7 50 s 18176N N Nslow Nnf Ny 50 s 19381N N Nnone Nnf Nn 50 s IB071N N Nfast Nf Ny 60 s JB426N N Nfast Nf Ny 60 s PR304N N Nslow Nnf Ny 60 s 2644N N Nslow Nnf Ny 50 s 15733N N Nnone Nnf Nn 50 s 15875N N Nnone Nnf Nn 40 s PR310T T fast f y 7 60 s 29671T T slow nf y 7 60 s 15733T T none nf n 7 50 s 18176T T slow nf y 6 50 s 5772N N Nnone Nnf Nn 60 s 7504T T none nf n 9 70 s 28925T T 7 50 s 15875T T none nf n 7 40 s 15922T T none nf n 7 60 s 28278N N Nnone Nnf Nn 50 s 4308T T none nf n 6 60 s 7504N N Nnone Nnf Nn 70 s JB197T T fast f y 7 50 s TP08-S00268N N Nfast Nf Ny 60 s TP08-S00268T T fast f y 7 60 s TP09-S0420N N Nfast Nf Ny 50 s 1199B B Bslow Bnf By 50 s 9122B B Bnone Bnf Bn 50 s 18176B B Bslow Bnf By 50 s 25313B B Bnone Bnf Bn 50 s 6634B B Bnone Bnf Bn 50 s 678B B Bnone Bnf Bn 70 s 7504B B Bnone Bnf Bn 70 s 16464B B Bnone Bnf Bn 60 s 4336B B Bslow Bnf By 60 s 28685B B Bslow Bnf By 50 s 4851B B Bnone Bnf Bn 60 s 1942B B Bfast Bf By 60 s 13563B B Bnone Bnf Bn 70 s TP09-S0420B B Bfast Bf By 50 s TP08-S00268B B Bfast Bf By 60 s DB237B B Bslow Bnf By 70 s PR151B B Bslow Bnf By 60 s 13745B B 60 s TP09-S0006B B Bfast Bf By 50 s PR331B B Bslow Bnf By 60 s 28685B2 B Bslow Bnf By 50 s IB071B B Bfast Bf By 60 s PR304B B Bslow Bnf By 60 s JB426B B Bfast Bf By 60 s 7270B B Bnone Bnf Bn 70 s 27086B B Bnone Bnf Bn 50 s TP09-S0420B2 B Bfast Bf By 50 s DB237B2 B Bslow Bnf By 70 s PR151B2 B Bslow Bnf By 60 s PR310B B Bfast Bf By 60 s FB586B B Bslow Bnf By 50 s 6634B2 B Bnone Bnf Bn 50 s JB378B B Bslow Bnf By 60 s FB94B B Bslow Bnf By 60 s GB195B B Bslow Bnf By 60 s PR490B B Bslow Bnf By 60 s PR303B B Bslow Bnf By 70 s PR018B B Bslow Bnf By 60 s TP08-S00542B B Bfast Bf By 50 s GB400B B Bfast Bf By 60 s HB603B B Bfast Bf By 60 s DB237N N Nslow Nnf Ny 70 s 11423N N Nslow Nnf Ny 70 s 25265N N Nnone Nnf Nn 60 s 8378N N Nnone Nnf Nn 60 s 8432N N Nnone Nnf Nn 50 s 15463N N Nnone Nnf Nn 60 s 27086N N Nnone Nnf Nn 50 s 4308N N Nnone Nnf Nn 60 s 562N N Nnone Nnf Nn 60 s FB183T T slow nf y 7 60 s GB400T T fast f y 7 60 s HB021T T fast f y 6 50 s HB261T T none nf n 7 50 s HB312T T slow nf y 8 70 s HB526T T fast f y 6 60 s HB951T T fast f y 7 60 s IB134T T none nf n 9 70 s IB273T T fast f y 7 50 s IB298T T slow nf y 7 60 s 20968N N Nslow Nnf Ny 50 s 6647N N Nslow Nnf Ny 40 s 15922N N Nnone Nnf Nn 60 s 8741N N Nnone Nnf Nn 60 s FB183N N Nslow Nnf Ny 60 s HB526N N Nfast Nf Ny 60 s HB568T T fast f y 7 60 s PR236T T fast f y 10 60 s PR300T T fast f y 7 50 s PR303N N Nslow Nnf Ny 70 s PR434T T slow nf y 7 60 s TPG8-S00542N N Nfast Nf Ny 50 s FB120T T slow nf y 7 60 s FB174T T fast f y 7 60 s HB603T T slow nf y 7 60 s IB113T T slow nf y 7 70 s IB483T T fast f y 7 50 s IB684T T slow nf y 7 60 s KB170T T fast f y 7 70 s PR018T T slow nf y 7 60 s PR151N N Nslow Nnf Ny 60 s PR303T T slow nf y 6 70 s PR311N N Nslow Nnf Ny 60 s 11462N N Nslow Nnf Ny 50 s 29671N N Nslow Nnf Ny 60 s 14878N N Nnone Nnf Nn 60 s 16464N N Nnone Nnf Nn 60 s PR521B B Bslow Bnf By 50 s PR363B B Bslow Bnf By 60 s FB174B B Bfast Bf By 60 s FB421B B Bfast Bf By 60 s FB421T T fast f y 7 60 s HB033T T none nf n 7 50 s HB526N2 N Nfast Nf Ny 60 s IB113B B Bslow Bnf By 70 s IB483T2 T fast f y 7 50 s TP08-S00542T T fast f y 7 50 s TP09-S0006N N Nfast Nf Ny 50 s PR079B B Bslow Bnf By 60 s FB183B B Bslow Bnf By 60 s FB120B B Bslow Bnf By 60 s HB305B B Bfast Bf By 60 s HB305T T fast f y 6 60 s IB362T T slow nf y 7 50 s IB684B B Bslow Bnf By 60 s JB770B B Bfast Bf By 60 s JB770T T fast f y 8 60 s TP10-S093B B Bslow Bnf By 60 s TP10-S093T T slow nf y 7 60 s TP09-S0408B B Bfast Bf By 70 s TP09-S0408T T fast f y 8 70 s 2691N N Nnone Nnf Nn 50 s 28278N2 N Nnone Nnf Nn 50 s 4336T T slow nf y 6 60 s 6634N N Nnone Nnf Nn 50 s 6837T2 T slow nf y 6 70 s 7221T T fast f y 7 50 s 4308B B Bnone Bnf Bn 60 s 5396B B Bnone Bnf Bn 60 s 9122B2 B Bnone Bnf Bn 50 s TP08-S00530B B Bfast Bf By 60 s 562B B Bnone Bnf Bn 60 s KB170B B Bfast Bf By 70 s IB298B B Bslow Bnf By 60 s HB591B B Bfast Bf By 60 s HB261B B Bnone Bnf Bn 50 s PR300B B Bfast Bf By 50 s PR236B B Bfast Bf By 60 s PR434B B Bslow Bnf By 60 s HB568B B Bfast Bf By 60 s IB134B B Bnone Bnf Bn 70 s IB483B B Bfast Bf By 50 s HB526B B Bfast Bf By 60 s HB021B B Bfast Bf By 50 s HB312B B Bslow Bnf By 70 s HB033B B Bnone Bnf Bn 50 s FB238T T slow nf y 7 60 s FB493T T slow nf y 6 50 s HB207T T fast f y 9 60 s HB235T T slow nf y 9 60 s HB504T T fast f y 8 50 s IB112T T slow nf y 7 60 s IB136T T fast f y 8 50 s PR306T T slow nf y 7 60 s TP10-S0638T T fast f y 10 50 s HB235B B Bslow Bnf By 60 s PR375B B Bfast Bf By 50 s FB238B B Bslow Bnf By 60 s IB136B B Bfast Bf By 50 s TP09-S0721B B Bfast Bf By 50 s HB504B B Bfast Bf By 50 s IB112B B Bslow Bnf By 60 s HB207B B Bfast Bf By 60 s PR306B B Bslow Bnf By 60 s TP09-S0638B B Bfast Bf By 50 s HB46B B Bslow Bnf By 60 s FB493B B Bslow Bnf By 50 s HB46T T slow nf y 8 60 s PR375T T fast f y 7 50 s TP09-S0721T T fast f y 10 50 s

TABLE 1B Clinical and Pathological Characteristics of Prostate Cancer Samples Relapse Status None Long PSADT Short PSADT (n = 28) (n = 42) (n = 33) Mean Age 56.07 59.29 56.06 (P = 0.0783) Cancer Stage (P = 0.0224) pT1 3 (2.9) 1 (1.0) 0 (0) pT2 10 (9.7) 9 (8.7) 7 (6.8) pT3a 7 (6.8) 18 (17.5) 6 (5.8) pT3b 8 (7.8) 14 (13.6) 20 (19.4) Gleason grade (P = 0.6569) 6 6 (5.8) 8 (7.8) 3 (2.9) 7 16 (15.5) 26 (25.2) 21 (20.4) 8-10 6 (5.8) 8 (7.8) 9 (8.7) Race (P = 0.2349) Black 1 2 0 Unknown 4 1 2 White 23 39 31 Median follow-up 154 124.8 54.8 (months) Median time to NA 47.355 1.87 progression (months) Median PSADT NA 23.2 3.21 (months) Mean preoperative 8.61 12.31 10.79 PSA (P = 0.42) Data are given as number (percentage) of the 103 samples unless otherwise indicated. NA = not applicable

TABLE 1C Clinical and Pathological Characteristics of Prostate Tissues Adjacent to Tumor Relapse Status None Long PSADT Short PSADT (n = 28) (n = 13) (n = 8) Mean Age 55 57.69 56.06 (P = 0.554) Cancer Stage (P = 0.541) pT1 3 (6.1) 0 (0) 0 (0) pT2 11 (22.4) 4 (8.2) 3 (6.1) pT3a 7 (14.3) 6 (12.2) 1 (2.0) pT3b 7 (14.3) 3 (6.1) 4 (8.2) Gleason grade (P = 0.9849) 5 1 (2.0) 0 (0) 0 (0) 6 7 (14.3) 3 (6.1) 2 (4.1) 7 16 (32.7) 7 (14.3) 5 (10.2) 8-10 4 (8.2) 3 (6.1) 1 (2.0) Race (P = 0.08387) Black 0 1 0 Unknown 6 0 0 White 22 12 8 Median follow up 155 149 29.205 (months) Median time to NA 54.6 3.09 progression (months) Median (PSADT) NA 26.9 2.46 months Mean preoperative 8.23 12.98 6.3 PSA (P = 0.074) Data are given as number (percentage) of the 49 samples unless otherwise indicated. NA = not applicable

TABLE 1D Clinical and Pathological Characteristics of Blood Samples from Patients with Prostate Cancer Relapse Status None Long PSADT Short PSADT (n = 18) (n = 35) (n = 31) Mean age 58.33 59.43 56.77 (P = 0.268) Cancer Stage (P = 0.003893) pT1 5 (6.0) 1 (1.2) 0 (0) pT2 6 (7.1) 12 (14.3) 6 (7.1) pT3a 1 (1.2) 10 (11.9) 5 (6.0) pT3b 6 (7.1) 12 (14.3) 20 (23.8) Gleason grade (P = 0.2248) 6 5 (6.0) 8 (9.5) 3 (3.6) 7 7 (8.3) 21 (25.0) 18 (21.4) 8-10 6 (7.1) 6 (7.1) 10 (11.9) Race (P = 0.08387) Black 0 1 0 Unknown 3 1 2 White 15 33 29 Median follow up 152 109.14 54.8 (months) Median time to NA 47.27 3.23 progression (months) Median PSADT NA 26 3.21 (months) Mean preoperative 10.48 12.17 10.87 PSA (P = 0.868) Data are given as number (percentage) of the 84 samples unless otherwise indicated. NA = not applicable

TABLE 2 Gene list for predicting prostate cancer relapse using prostate cancer tissue freq. freq. freq. freq. freq. Gene. chromo- cyto- Tran- Tran- Symbol use amp. c

del. ca

amp. c

del. co

Sym

son

band script.

script. end psiTPTE22 1 0.106667 0.133333 0.444444 0 psiTPTE22 22 22q11.1 15462801 15509721 XKR3 1 0.133333 0.133333 0.481481 0 XKR3 22 22q11.1 15644306 15682585 DNAL4 1 0.413333 0.133333 0.777778 0 DNAL4 22 22q13.1 37504459 37520108 BRD1 1 0.48 0.12 0.814815 0 BRD1 22 22q13.33 48552941 48604457 LOC90834 1 0.48 0.12 0.814815 0 LOC90834 22 22q13.33 48557542 48559963 ZBED4 1 0.48 0.12 0.814815 0 ZBED4 22 22q13.33 48633501 48669731 ALG12 1 0.48 0.12 0.814815 0 ALG12 22 22q13.33 48682857 48698111 CRELD2 1 0.48 0.12 0.814815 0 CRELD2 22 22q13.33 48698287 48707191 PIM3 1 0.48 0.12 0.814815 0 PIM3 22 22q13.33 48740147 48743724 IL17REL 1 0.48 0.12 0.814815 0 IL17REL 22 22q13.33 48775069 48793183 TTLL8 1 0.48 0.12 0.814815 0 TTLL8 22 22q13.33 48795679 48835183 PANX2 1 0.48 0.12 0.814815 0 PANX2 22 22q13.33 48951287 48960851 TRABD 1 0.48 0.12 0.814815 0 TRABD 22 22q13.33 48966487 48980155 SELO 1 0.48 0.12 0.814815 0 SELO 22 22q13.33 48981535 48998173 TUBGCP6 1 0.48 0.12 0.814815 0 TUBGCP6 22 22q13.33 48998245 49025528 KIF16B 1 0.106667 0.12 0.074074 0 KIF16B 20 20p12.1 16200749 16502079 PCSK2 1 0.146667 0.133333 0.222222 0 PCSK2 20 20p12.1 17155631 17413223 LGALS13 1 0.333333 0.145667 0.740741 0 LGALS13 19 19q13.2 44785009 44789955 LGALS14 1 0.346667 0.12 0.740741 0 LGALS14 19 19q13.2 44886786 44891929 CLC 1 0.346667 0.12 0.740741 0 CLC 19 19q13.2 44913735 44920509 RPH3AL 1 0.48 0.12 0.814815 0 RPH3AL 17 17p13.3 62294 202577 VPS53 1 0.48 0.12 0.777778 0 VPS53 17 17p13.3 361480 564847 GEMIN4 1 0.48 0.12 0.777778 0 GEMIN4 17 17p13.3 594411 602252 ELP2P 1 0.48 0.12 0.777778 0 ELP2P 17 17p13.3 602650 605327 NXN 1 0.466667 0.133333 0.777778 0 NXN 17 17p13.3 649335 829761 TIMM22 1 0.466667 0.133333 0.777778 0 TIMM22 17 17p13.3 847107 852141 ABR 1 0.466667 0.133333 0.777778 0 ABR 17 17p13.3 853509 959075 YWHAE 1 0.453333 0.133333 0.777778 0 YWHAE 17 17p13.3 1194586 1250307 CRK 1 0.453333 0.133333 0.777778 0 CRK 17 17p13.3 1272208 1306295 INPP5K 1 0.466667 0.133333 0.777778 0 INPP5K 17 17p13.3 1344622 1366933 LOC10030

1 0.466667 0.133333 0.777778 0 LOC10030

17 17p13.3 1366963 1368139 PITPNA 1 0.466667 0.133333 0.777778 0 PITPNA 17 17p13.3 1368033 1412861 PRPF8 1 0.466667 0.133333 0.777778 0 PRPF8 17 17p13.3 1500673 1534927 WDR81 1 0.466667 0.133333 0.777778 0 WDR81 17 17p13.3 1566567 1588644 SERPINF2 1 0.466667 0.133333 0.777778 0 SERPINF2 17 17p13.3 1592880 1605310 SERPINF1 1 0.466667 0.133333 0.777778 0 SERPINF1 17 17p13.3 1612009 1527619 SMYD4 1 0.466667 0.133333 0.777778 0 SMYD4 17 17p13.3 1629579 1679926 RPA1 1 0.466667 0.133333 0.777778 0 RPA1 17 17p13.3 1680023 1749599 RTN4RL1 1 0.466667 0.133333 0.777778 0 RTN4RL1 17 17p13.3 1784721 1874929 SMG6 1 0.466667 0.133333 0.777778 0 SMG6 17 17p13.3 1909883 2153564 SRR 1 0.453333 0.133333 0.777778 0 SRR 17 17p13.3 2153998 2175304 METT10D 1 0.413333 0.133333 0.740741 0 METT10D 17 17p13.3 2266098 2361951 PAFAH1B1 1 0.413333 0.133333 0.740741 0 PAFAH1B1 17 17p13.3 2443673 2535660 KIAA0664 1 0.426667 0.133333 0.740741 0 KIAA0664 17 17p13.3 2539430 2561678 RAP1GAP2 1 0.426667 0.133333 0.740741 0 RAP1GAP2 17 17p13.3 2646482 2887786 OR3A2 1 0.28 0.146667 0.740741 0 OR3A2 17 17p13.3 3127934 3129019 TRPV3 1 0.413333 0.133333 0.740741 0 TRPV3 17 17p13.3 3363236 3408040 TRPV1 1 0.413333 0.133333 0.740741 0 TRPV1 17 17p13.3 3415490 3447086 SHPK 1 0.413333 0.133333 0.740741 0 SHPK 17 17p13.3 3458305 3486366 CTNS 1 0.413333 0.133333 0.740741 0 CTNS 17 17p13.3 3486511 3513147 TMEM93 1 0.413333 0.133333 0.740741 0 TMEM93 17 17p13.3 3518839 3519712 P2RX5 1 0.413333 0.133333 0.740741 0 P2RX5 17 17p13.3 3523271 3546333 ITGAE 1 0.413333 0.133333 0.740741 0 ITGAE 17 17p13.3 3564568 3651287 GSG2 1 0.413333 0.133333 0.740741 0 GSG2 17 17p13.3 3573946 3576742 C17orf85 1 0.4 0.133333 0.740741 0 C17orf85 17 17p13.2 3661209 3696290 CAMKK1 1 0.413333 0.146667 0.777778 0 CAMKK1 17 17p13.2 3710366 3743087 P2RX1 1 0.413333 0.133333 0.777778 0 P2RX1 17 17p13.2 3746634 3766710 CDRT15P 1 0.106667 0.146667 0.296296 0 CDRT15P 17 17p12 13868540 13869641 MIR1288 1 0.32 0.12 0.481481 0 MIR1288 17 17p11.2 16126053 16126128 TRPV2 1 0.346667 0.12 0.518519 0 TRPV2 17 17p11.2 16259613 16281043 NCRNA001 1 0.346667 0.12 0.518519 0 NCRNA001 17 17p11.2 16283026 16286064 SNORD49B 1 0.346667 0.12 0.518519 0 SNORD498 17 17p11.2 16283548 16283596 SNORD49A 1 0.346667 0.12 0.518519 0 SNORD49A 17 17p11.2 16284075 16284146 SNORD65 1 0.346667 0.12 0.518519 0 SNORD65 17 17p11.2 16285265 16285338 C17orf76 1 0.346667 0.12 0.518519 0 C17orf76 17 17p11.2 16286053 16336206 ZNF287 1 0.346667 0.12 0.518519 0 ZNF287 17 17p11.2 16394356 16413246 MPP3 1 0.466667 0.12 0.777778 0 MPP3 17 17q21.31 39233693 39266065 CD300LG 1 0.466667 0.12 0.777778 0 CD300LG 17 17q21.31 39280042 39291128 MPP2 1 0.466667 0.12 0.777778 0 MPP2 17 17q21.31 39308253 39340640 PPY 1 0.466667 0.133333 0.777778 0 PPY 17 17q21.31 39373698 39375360 PYY 1 0.466667 0.133333 0.777778 0 PYY 17 17q21.31 39385633 39437364 NAGS 1 0.466667 0.133333 0.777778 0 NAGS 17 17q21.31 39437558 39441963 TMEM101 1 0.466667 0.133333 0.777778 0 TMEM101 17 17q21.31 39444082 39447872 LSM12 1 0.466667 0.133333 0.777778 0 LSM12 17 17q21.31 39467530 39500514 G6PC3 1 0.466667 0.133333 0.777778 0 G6PC3 17 17q21.31 39503624 39509238 HDAC5 1 0.466667 0.133333 0.777778 0 HDAC5 17 17q21.31 39509647 39556541 C17orf53 1 0.466667 0.133333 0.777778 0 C17orf53 17 17q21.31 39574852 39595371 ASB16 1 0.466667 0.133333 0.777778 0 ASB16 17 17q21.31 39603600 39611978 C17orf65 1 0.466667 0.133333 0.777778 0 C17orf65 17 17q21.31 39608878 39619609 TMUB2 1 0.466667 0.133333 0.777778 0 TMUB2 17 17q21.31 39619880 39624626 ATXN7L3 1 0.466667 0.133333 0.777778 0 ATXN7L3 17 17q21.31 39624699 39631056 UBTF 1 0.466667 0.133333 0.777778 0 UBTF 17 17q21.31 39637927 39653777 SLC4A1 1 0.466667 0.133333 0.777778 0 SLC4A1 17 17q21.31 39681284 39701029 SLC25A39 1 0.466667 0.12 0.777778 0 SLC25A39 17 17q21.31 39752519 39757744 GRN 1 0.466667 0.12 0.777778 0 GRN 17 17q21.31 39778017 39785997 FAM171A2 1 0.466667 0.12 0.777778 0 FAM171A2 17 17q21.31 39786627 39796762 ITGA2B 1 0.466667 0.12 0.777778 0 ITGA2B 17 17q21.31 39805076 39822400 GPATCH8 1 0.466667 0.12 0.777778 0 GPATCH8 17 17q21.31 39828176 39936329 FZD2 1 0.426667 0.12 0.777778 0 FZD2 17 17q21.31 39990451 39992434 C17orf104 1 0.453333 0.12 0.777778 0 C17orf104 17 17q21.31 40089288 40108690 ADAM11 1 0.48 0.12 0.777778 0 ADAM11 17 17q21.31 40192094 40214741 HIGD1B 1 0.466667 0.12 0.777778 0 HIGD1B 17 17q21.31 40280805 40283375 EFTUD2 1 0.466667 0.12 0.777778 0 EFTUD2 17 17q21.31 40283181 40332520 KIF18B 1 0.48 0.12 0.777778 0 KIF18B 17 17q21.31 40358974 40380609 C1QL1 1 0.48 0.12 0.777778 0 C1QL1 17 17q21.31 40392587 40401171 DCAKD 1 0.48 0.12 0.777778 0 DCAKD 17 17q21.31 40456232 40484505 NMT1 1 0.48 0.12 0.777778 0 NMT1 17 17q21.31 40494206 40541909 PLCD3 1 0.48 0.12 0.777778 0 PLCD3 17 17q21.31 40544534 40565418 ACBD4 1 0.48 0.12 0.777778 0 ACBD4 17 17q21.31 40565493 40577325 HEXIM1 1 0.48 0.12 0.777778 0 HEXIM1 17 17q21.31 40580467 40585252 HEXIM2 1 0.48 0.12 0.777778 0 HEXIM2 17 17q21.31 40594047 40603190 FMNL1 1 0.48 0.12 0.777778 0 FMNL1 17 17q21.31 40655075 40680467 LOC10013

1 0.48 0.12 0.777778 0 LOC10013

17 17q21.31 40681086 40701780 C17orf46 1 0.48 0.12 0.777778 0 C17orf46 17 17q21.31 40687543 40695263 MAP3K14 1 0.48 0.12 0.777778 0 MAP3K14 17 17q21.31 40696271 40750198 ARHGAP27 1 0.48 0.12 0.777778 0 ARHGAP27 17 17q21.31 40827051 40839233 TNRC6A 1 0.32 0.12 0.666667 0 TNRC6A 16 16p12.1 24648550 24745049 FLI30679 1 0.413333 0.133333 0.666667 0 FLI30679 16 16q24.1 85146427 85148407 FOXC2 1 0.413333 0.133333 0.666667 0 FOXC2 16 16q24.1 85158358 85160037 FBXO31 1 0.426667 0.146667 0.665667 0 FBXO31 16 16q24.2 85920445 85974896 ZCCHC14 1 0.426667 0.146667 0.666667 0 ZCCHC14 16 16q24.2 85997353 86082962 JPH3 1 0.426667 0.173333 0.666667 0 JPH3 16 16q24.2 86194000 86289263 SLC7A5 1 0.426667 0.186667 0.666667 0 SLC7A5 16 16q24.2 86421130 86460602 CA5A 1 0.426667 0.186667 0.666667 0 CA5A 16 16q24.2 86479126 86527614 BANP 1 0.426667 0.186667 0.666667 0 BANP 16 16q24.2 86542539 86668426 ZFPM1 1 0.44 0.2 0.666667 0 ZFPM1 16 16q24.2 87047515 87129076 ZC3H18 1 0.44 0.2 0.666667 0 ZC3H18 16 16q24.2 87164290 87225873 IL17C 1 0.44 0.2 0.703704 0 IL17C 16 16q24.3 87232502 87234384 CYBA 1 0.44 0.2 0.703704 0 CYBA 16 16q24.3 87237198 87244959 MVD 1 0.44 0.2 0.703704 0 MVD 16 16q24.3 87245849 87256997 MGC23284 1 0.44 0.2 0.703704 0 MGC23284 16 16q24.3 87257282 87281054 SNAI3 1 0.44 0.2 0.703704 0 SNAI3 16 16q24.3 87271591 87280384 RNF166 1 0.44 0.2 0.703704 0 RNF166 16 16q24.3 87290410 87300302 GALNS 1 0.466667 0.2 0.703704 0 GALNS 16 16q24.3 87407643 87450876 TRAPPC2L 1 0.466667 0.2 0.703704 0 TRAPPC2L 16 16q24.3 87451007 87455022 CBFA2T3 1 0.466667 0.2 0.703704 0 CBFA2T3 16 16q24.3 87468768 87570903 ACSF3 1 0.466667 0.2 0.703704 0 ACSF3 16 16q24.3 87687755 87748499 C16orf81 1 0.466667 0.2 0.703704 0 C16orf81 16 16q24.3 87753129 87757585 CDH15 1 0.466667 0.2 0.703704 0 CDH15 16 16q24.3 87765664 87789402 ANKRD11 1 0.48 0.2 0.703704 0 ANKRD11 16 16q24.3 87861536 88084471 SPG7 1 0.48 0.186667 0.703704 0 SPG7 16 16q24.3 88102306 88151676 RPL13 1 0.48 0.186667 0.703704 0 RPL13 16 16q24.3 88154591 88157350 SNORD68 1 0.48 0.186667 0.703704 0 SNORD68 16 16q24.3 88155339 88155411 CDK10 1 0.48 0.186667 0.703704 0 CDK10 16 16q24.3 88280577 88290273 SPATA2L 1 0.48 0.186667 0.703704 0 SPATA2L 16 16q24.3 88290266 88295601 C16orf7 1 0.48 0.186667 0.703704 0 C16orf7 16 16q24.3 88301042 88314896 ZNF276 1 0.48 0.186667 0.703704 0 ZNF276 16 16q24.3 88314894 88334834 SPIRE2 1 0.48 0.173333 0.740741 0 SPIRE2 16 16q24.3 88422403 88465229 TUBB3 1 0.48 0.16 0.740741 0 TUBB3 16 16q24.3 88517246 88530007 DEF8 1 0.48 0.16 0.740741 0 DEF8 16 16q24.3 88542652 88553276 CENPBD1 1 0.48 0.16 0.740741 0 CENPBD1 16 16q24.3 88563702 88566444 OR11H4 1 0.08 0.12 0.111111 0 OR11H4 14 14q11.2 19780791 19781766 G2E3 1 0.026667 0.173333 0 0 G2E3 14 14q12 30098080 30158798 SCFD1 1 0.026667 0.133333 0 0 SCFD1 14 14q12 30161272 30274770 COCH 1 0.053333 0.133333 0 0 COCH 14 14q12 30413492 30429574 STRN3 1 0.16 0.053333 0 0 STRN3 14 14q12 30432756 30565359 AP4S1 1 0.173333 0.053333 0 0 AP4S1 14 14q12 30564434 30632390 HECTD1 1 0.186667 0.053333 0 0 HECTD1 14 14q12 30639075 30746441 AKAP6 1 0.04 0.146667 0 0 AKAP6 14 14q13.1 31868230 32372020 NPAS3 1 0.093333 0.133333 0 0 NPAS3 14 14q13.1 32478210 33343133 SAV1 1 0.12 0.013333 0 0.037037 SAV1 14 14q22.1 50170110 50204774 NIN 1 0.12 0 0 0.037037 NIN 14 14q22.1 50256231 50367590 BMP4 1 0.04 0.133333 0.037037 0 BMP4 14 14q22.2 53486205 53493305 SYT16 1 0.013333 0.2 0.037037 0 SYT16 14 14q23.2 61532294 61638181 GPHN 1 0.08 0.173333 0.185185 0 GPHN 14 14q23.3 66043878 66718279 ERH 1 0.186667 0.133333 0.333333 0 ERH 14 14q24.1 68916593 68934775 SMOC1 1 0.186667 0.12 0.333333 0 SMOC1 14 14q24.2 69415896 69568837 NRXN3 1 0.066667 0.173333 0.222222 0 NRXN3 14 14q24.3 77939846 79400514 LOC100101 1 0.106667 0.16 0.259259 0 LOC100101 13 13q12.11 18734941 18817114 TSC22D1 1 0.12 0.226667 0 0.111111 TSC22D1 13 13q14.11 43905655 44048702 RCBTB1 1 0.12 0.253333 0 0.148148 RCBTB1 13 13q14.3 49004083 49057721 ARL11 1 0.12 0.253333 0 0.148148 ARL11 13 13q14.3 49100625 49105733 EBPL 1 0.12 0.253333 0 0.148148 EBPL 13 13q14.3 49132811 49163625 KPNA3 1 0.12 0.253333 0 0.148148 KPNA3 13 13q14.3 49171445 49265057 LOC22042

1 0.12 0.253333 0 0.148148 LOC22042

13 13q14.3 49362546 49365518 C13orf1 1 0.12 0.253333 0 0.148148 C13orf1 13 13q14.3 49384843 49408627 NDUFA9 1 0.213333 0.133333 0.592593 0 NDUFA9 12 12p13.32 4628544 4666661 VWF 1 0.226667 0.133333 0.592593 0 VWF 12 12p13.31 5928301 6104098 GABARAPL 1 0.146667 0.133333 0.111111 0 GABARAPL 12 12p13.2 10256756 10266992 ETV6 1 0.066667 0.16 0.111111 0 ETV6 12 12p13.2 11694055 11939593 BCL2L14 1 0.173333 0.146667 0.148148 0 BCL2L14 12 12p13.2 12115145 12143895 LRP6 1 0.16 0.146667 0.148148 0 LRP6 12 12p13.2 12160228 12311079 MANSC1 1 0.16 0.146667 0.148148 0 MANSC1 12 12p13.2 12373485 12394437 LOH12CR2 1 0.16 0.146667 0.148148 0 LOH12CR2 12 12p13.2 12399611 12401269 LOH12CR1 1 0.16 0.146667 0.148148 0 LOH12CR1 12 12p13.2 12401287 12511106 DUSP16 1 0.133333 0.146667 0.111111 0 DUSP16 12 12p13.2 12520098 12606585 CREBL2 1 0.106667 0.16 0.074074 0 CREBL2 12 12p13.1 12656098 12689309 GPR19 1 0.106667 0.16 0.074074 0 GPR19 12 12p13.1 12705263 12740389 CDKN1B 1 0.106667 0.16 0.074074 0 CDKN1B 12 12p13.1 12761569 12766573 APOLD1 1 0.106667 0.16 0.074074 0 APOLD1 12 12p13.1 12770118 12835667 MIR613 1 0.106667 0.16 0.074074 0 MIR613 12 12p13.1 12808850 12808944 DDX47 1 0.133333 0.146667 0.074074 0 DDX47 12 12p13.1 12857547 12874183 RPL13AP2

1 0.133333 0.146667 0.074074 0 RPL13AP2

12 12p13.1 12919678 12920337 GPRC5A 1 0.133333 0.146667 0.074074 0 GPRC5A 12 12p13.1 12935223 12957868 MIR614 1 0.133333 0.146667 0.074074 0 MIR614 12 12p13.1 12960030 12960120 GPRC5D 1 0.133333 0.146667 0.074074 0 GPRC5D 12 12p13.1 12984976 12994586 HEBP1 1 0.133333 0.146667 0.074074 0 HEBP1 12 12p13.1 13019066 13044489 KIAA1467 1 0.12 0.146667 0.074074 0 KIAA1467 12 12p13.1 13088582 13127651 GRIN2B 1 0 0.186667 0.037037 0 GRIN2B 12 12p13.1 13605677 14024290 ST8SIA1 1 0.013333 0.16 0 0 ST8SIA1 12 12p12.1 22237592 22378916 KIAA0528 1 0.066667 0.146667 0.037037 0 KIAA0528 12 12p12.1 22492785 22588720 ETNK1 1 0.066667 0.146667 0.037037 0 ETNK1 12 12p12.1 22669343 22688617 BCAT1 1 0.013333 0.213333 0.037037 0 BCAT1 12 12p12.1 24855546 24993576 CASC1 1 0.066667 0.16 0 0 CASC1 12 12p12.1 25152490 25239362 IFLTD1 1 0.013333 0.12 0.037037 0 IFLTD1 12 12p12.1 25520283 25597446 OVCH1 1 0 0.213333 0 0 OVCH1 12 12p11.22 29471756 29541887 TMTC1 1 0.013333 0.12 0 0 TMTC1 12 12p11.22 29545024 29828960 FAM60A 1 0.186667 0.12 0.222222 0 FAM60A 12 12p11.21 31324794 31370389 SRGAP1 1 0.146667 0.04 0 0 SRGAP1 12 12q14.2 62524808 62827881 RASSF3 1 0.16 0.013333 0 0.037037 RASSF3 12 12q14.2 63290560 63375460 UHRF1BP1

1 0.133333 0.093333 0 0 UHRF1BP1

12 12q23.1 98954994 99060774 MIR1827 1 0.213333 0.026667 0 0 MIR1827 12 12q23.1 99107793 99107859 SCYL2 1 0.145667 0.026667 0 0 SCYL2 12 12q23.1 99185680 99258046 SLC17A8 1 0.133333 0.026667 0 0 SLC17A8 12 12q23.1 99274988 99339968 NR1H4 1 0.146667 0.026667 0 0 NR1H4 12 12q23.1 99391810 99481775 GAS2L3 1 0.146667 0.026667 0 0 GAS2L3 12 12q23.1 99491620 99542817 SLC5A8 1 0.106667 0.133333 0.111111 0 SLC5A8 12 12q23.2   1E+08   1E+08 PAH 1 0.093333 0.12 0.148148 0 PAH 12 12q23.2 1.02E+08 1.02E+08 C12orf42 1 0.106667 0.12 0.148148 0 C12orf42 12 12q23.2 1.02E+08 1.02E+08 BTBD10 1 0.093333 0.12 0.148148 0 BTBD10 11 11p15.2 13366132 13441415 OR5B12 1 0.08 0.133333 0.148148 0 OR5B12 11 11q12.1 57963256 57964201 LPXN 1 0.08 0.133333 0.148148 0 LPXN 11 11q12.1 58050922 58102216 RAB30 1 0.12 0.04 0 0 RAB30 11 11q14.1 82370126 82460533 CCDC90B 1 0.053333 0.12 0 0 CCDC90B 11 11q14.1 82650150 82675026 FAT3 1 0.04 0.173333 0 0 FAT3 11 11q14.3 91724910 92269284 BIRC3 1 0.133333 0.066667 0 0.074074 BIRC3 11 11q22.2 1.02E+08 1.02E+08 MMP7 1 0.12 0.066667 0 0.074074 MMP7 11 11q22.2 1.02E+08 1.02E+08 DDX10 1 0.066667 0.16 0.111111 0 DDX10 11 11q22.3 1.08E+08 1.08E+08 FRMPD2 1 0.226667 0.16 0.37037 0 FRMPD2 10 10q11.22 49034608 49152948 ERCC6 1 0.226667 0.173333 0.333333 0 ERCC6 10 10q11.23 50334497 50417154 PGBD3 1 0.226667 0.173333 0.333333 0 PGBD3 10 10q11.23 50393250 50402333 SGMS1 1 0.133333 0.133333 0.222222 0 SGMS1 10 10q11.23 51735351 52053744 FAM13C 1 0.12 0.133333 0 0.074074 FAM13C 10 10q21.1 60675896 60792359 ARID5B 1 0.146667 0.026667 0 0 ARID5B 10 10q21.2 63331449 63526710 ADO 1 0.146667 0.04 0 0 ADO 10 10q21.2 64234522 64238246 EGR2 1 0.146667 0.04 0 0 EGR2 10 10q21.2 64241766 64246133 JMJD1C 1 0.173333 0.026667 0 0 JMJD1C 10 10q21.2 64596994 64698989 REEP3 1 0.173333 0.04 0 0 REEP3 10 10q21.3 64951129 65051979 SLC24A2 1 0.026667 0.173333 0.037037 0 SLC24A2 9 9p22.1 19505978 19776927 MLLT3 1 0.026667 0.133333 0 0 MLLT3 9 9p21.3 20334968 20612515 IFNA13 1 0.04 0.146667 0 0 IFNA13 9 9p21.3 21357371 21358076 IFNA1 1 0.026667 0.16 0 0 IFNA1 9 9p21.3 21430440 21431316 LOC55420

1 0.026667 0.16 0 0 LOC55420

9 9p21.3 21444267 21549698 IFNE 1 0.026667 0.16 0 0 IFNE 9 9p21.3 21470841 21472313 1-Dec 1 0.12 0.133333 0.333333 0 1-Dec 9 9q33.1 1.17E+08 1.17E+08 PAPPA 1 0.093333 0.12 0.259259 0 PAPPA 9 9q33.1 1.18E+08 1.18E+08 TUBBP5 1 0.573333 0.12 0.851852 0 TUBBP5 9 9q34.3  1.4E+08  1.4E+08 TMEM66 1 0.12 0.36 0 0.185185 TMEM66 8 8p12 30040173 30060192 LEPROTL1 1 0.12 0.36 0 0.185185 LEPROTL1 8 8p12 30072464 30114755 MBOAT4 1 0.12 0.36 0 0.185185 MBOAT4 8 8p12 30108729 30121743 DCTN6 1 0.12 0.36 0 0.185185 DCTN6 8 8p12 30133355 30160603 RBPMS 1 0.133333 0.36 0 0.185185 RBPMS 8 8p12 30361486 30549277 UBXN8 1 0.186667 0.373333 0 0.185185 UBXN8 8 8p12 30721232 30744063 TEX15 1 0.133333 0.386667 0 0.222222 TEX15 8 8p12 30808602 30826076 BEYLA 1 0.173333 0.186667 0.185185 0 BEYLA 8 8q11.1 47871673 47886573 NKAIN3 1 0.106667 0.133333 0.111111 0 NKAIN3 8 8q12.3 63324055 64066183 STEAP1 1 0.146667 0.12 0 0.185185 STEAP1 7 7q21.13 89621625 89632078 GTPBP10 1 0.12 0.053333 0 0.074074 GTPBP10 7 7q21.13 89813926 89854587 CLDN12 1 0.12 0.053333 0 0.074074 CLDN12 7 7q21.13 89870732 89883205 ENPP5 1 0.04 0.133333 0.111111 0 ENPP5 6 6p12.3 46235721 46246677 CYP39A1 1 0.04 0.12 0.074074 0 CYP39A1 6 6p12.3 46525404 46728483 MEP1A 1 0.04 0.12 0.074074 0 MEP1A 6 6p12.3 46869053 46915479 SMAP1 1 0.186667 0.146667 0 0.185185 SMAP1 6 6q13 71434200 71628438 C6orf147 1 0.2 0.186667 0 0.111111 C6orf147 6 6q13 74040583 74076810 DDX43 1 0.186667 0.186667 0 0.111111 DDX43 6 6q13 74161006 74184004 MTO1 1 0.173333 0.2 0 0.111111 MTO1 6 6q13 74228175 74267901 SLC17A5 1 0.186667 0.186667 0 0.111111 SLC17A5 6 6q13 74359823 74420459 CD109 1 0.12 0.16 0 0.111111 CD109 6 6q13 74462229 74594761 MYO6 1 0.146667 0.173333 0 0.222222 MYO6 6 6q14.1 76515629 76685975 GABRR1 1 0.12 0.2 0 0.185185 GABRR1 6 6q15 89943942 89984216 GABRR2 1 0.133333 0.2 0 0.185185 GABRR2 6 6q15 90023958 90081687 RRAGD 1 0.133333 0.2 0 0.185185 RRAGD 6 6q15 90131056 90178715 ANKRD6 1 0.12 0.2 0 0.185185 ANKRD6 6 6q15 90199616 90400125 GJA1 1 0.133333 0.213333 0 0.296296 GJA1 6 6q22.31 1.22E+08 1.22E+08 ARHGAP18 1 0.013333 0.146667 0.037037 0 ARHGAP18 6 6q22.33  1.3E+08  1.3E+08 C6orf191 1 0.013333 0.133333 0 0 C6orf191 6 6q22.33  1.3E+08  1.3E+08 L3MBTL3 1 0.013333 0.133333 0 0 L3MBTL3 6 6q23.1  1.3E+08 1.31E+08 SAMD3 1 0.026667 0.12 0 0 SAMD3 6 6q23.1 1.31E+08 1.31E+08 RPS12 1 0.146667 0.026667 0 0 RPS12 6 6q23.2 1.33E+08 1.33E+08 SNORD101 1 0.146667 0.026667 0 0 SNORD101 6 6q23.2 1.33E+08 1.33E+08 SNORD100 1 0.133333 0.04 0 0 SNORD100 6 6q23.2 1.33E+08 1.33E+08 SNORA33 1 0.133333 0.04 0 0 SNORA33 6 6q23.2 1.33E+08 1.33E+08 EYA4 1 0 0.133333 0 0 EYA4 6 6q23.2 1.34E+08 1.34E+08 AHI1 1 0 0.146667 0 0 AHI1 6 6q23.3 1.36E+08 1.36E+08 ADAT2 1 0 0.133333 0 0 ADAT2 6 6q24.2 1.44E+08 1.44E+08 CKMT2 1 0.12 0.093333 0 0.037037 CKMT2 5 5q14.1 80564895 80597974 DMXL1 1 0.16 0.106667 0 0.111111 DMXL1 5 5q23.1 1.18E+08 1.19E+08 LARS 1 0.16 0 0 0.037037 LARS 5 5q32 1.45E+08 1.46E+08 RBM27 1 0.16 0 0 0.037037 RBM27 5 5q32 1.46E+08 1.46E+08 ZNF718 1 0.253333 0.133333 0.703704 0 ZNF718 4 4p16.3 43277 146491 MIR572 1 0.04 0.12 0.074074 0 MIR572 4 4p15.33 10979549 10979643 C1QTNF7 1 0.013333 0.133333 0 0 C1QTNF7 4 4p15.33 14950658 15056889 CD38 1 0.12 0.053333 0 0 CD38 4 4p15.32 15389029 15459805 FGFBP1 1 0.133333 0.053333 0 0 FGFBP1 4 4p15.32 15546290 15549070 PROM1 1 0.133333 0.053333 0 0 PROM1 4 4p15.32 15578947 15694693 TAPT1 1 0.026667 0.146667 0 0 TAPT1 4 4p15.32 15771226 15837260 FLJ39653 1 0.026667 0.146667 0 0 FLJ39653 4 4p15.32 15837384 15868909 LDB2 1 0.026667 0.133333 0 0 LDB2 4 4p15.32 16112262 16509523 QDPR 1 0.146667 0.04 0 0 QDPR 4 4p15.32 17097118 17122956 CLRN2 1 0.146667 0.04 0 0 CLRN2 4 4p15.32 17125886 17137826 LAP3 1 0.146667 0.04 0 0 LAP3 4 4p15.32 17188025 17218689 FAM184B 1 0.146667 0.04 0 0 FAM184B 4 4p15.32 17242809 17392234 DCAF16 1 0.146667 0.04 0 0 DCAF16 4 4p15.32 17411376 17421480 GPR125 1 0.026667 0.226667 0 0 GPR125 4 4p15.31 21998097 22126771 GBA3 1 0.026667 0.213333 0 0 GBA3 4 4p15.31 22303646 22430291 PARM1 1 0.04 0.146667 0 0 PARM1 4 4q13.3 76077322 76194348 FRAS1 1 0.026667 0.12 0 0 FRAS1 4 4q21.21 79197748 79586810 SLC10A6 1 0.12 0.026667 0 0 SLC10A6 4 4q21.3 87963645 87989441 AFF1 1 0.146667 0.013333 0 0 AFF1 4 4q21.3 88075178 88281230 KLHL8 1 0.12 0.013333 0 0 KLHL8 4 4q22.1 88301238 88360699 HSD17B13 1 0.12 0.013333 0 0 HSD17B13 4 4q22.1 88443965 88463081 HSD17B11 1 0.12 0.013333 0 0 HSD17B11 4 4q22.1 88476715 88531480 NUDT9 1 0.12 0.013333 0 0 NUDT9 4 4q22.1 88562759 88598524 SPARCL1 1 0.12 0.013333 0 0 SPARCL1 4 4q22.1 88613512 88669680 PHF17 1 0.133333 0.08 0 0.185185 PHF17 4 4q28.2  1.3E+08  1.3E+08 HHIP 1 0.04 0.12 0 0 HHIP 4 4q31.22 1.46E+08 1.46E+08 TBC1D5 1 0.053333 0.16 0.148148 0 TBC1D5 3 3p24.3 17173659 17759245 LOC285401 1 0.013333 0.146667 0.037037 0 LOC285401 3 3p14.2 63063404 63085776 SYNPR 1 0.026667 0.133333 0.037037 0 SYNPR 3 3p14.2 63238954 63577638 SNTN 1 0.013333 0.12 0.037037 0 SNTN 3 3p14.2 63613384 63625932 SUCLG2 1 0.013333 0.146667 0.037037 0 SUCLG2 3 3p14.1 67507833 67787729 FAM19A4 1 0 0.133333 0.037037 0 FAM19A4 3 3p14.1 68863607 69064402 MINA 1 0.173333 0.173333 0 0.259259 MINA 3 3q11.2 99143351 99173915 TM4SF4 1 0.173333 0 0 0.037037 TM4SF4 3 3q25.1 1.51E+08 1.51E+08 WWTR1 1 0.133333 0 0 0.037037 WWTR1 3 3q25.1 1.51E+08 1.51E+08 SERP1 1 0.12 0 0 0 SERP1 3 3q25.1 1.52E+08 1.52E+08 EIF2A 1 0.12 0 0 0 EIF2A 3 3q25.1 1.52E+08 1.52E+08 SELT 1 0.12 0 0 0 SELT 3 3q25.1 1.52E+08 1.52E+08 FAM194A 1 0.12 0 0 0 FAM194A 3 3q25.1 1.52E+08 1.52E+08 SIAH2 1 0.12 0 0 0 SIAH2 3 3q25.1 1.52E+08 1.52E+08 KPNA4 1 0.053333 0.146667 0.037037 0 KPNA4 3 3q26.1 1.62E+08 1.62E+08 LRRIQ4 1 0.226667 0.013333 0 0.037037 LRRIQ4 3 3q26.2 1.71E+08 1.71E+08 LRRC31 1 0.226667 0.013333 0 0.037037 LRRC31 3 3q26.2 1.71E+08 1.71E+08 SAMD7 1 0.226667 0.013333 0 0.037037 SAMD7 3 3q26.2 1.71E+08 1.71E+08 LOC10012

1 0.226667 0.013333 0 0.037037 LOC10012

3 3q26.2 1.71E+08 1.71E+08 SEC62 1 0.226667 0.013333 0 0.037037 SEC62 3 3q26.2 1.71E+08 1.71E+08 GPR160 1 0.24 0.013333 0 0.037037 GPR160 3 3q26.2 1.71E+08 1.71E+08 PHC3 1 0.226667 0.013333 0 0.037037 PHC3 3 3q26.2 1.71E+08 1.71E+08 KCNMB2 1 0.053333 0.133333 0.037037 0 KCNMB2 3 3q26.32  1.8E+08  1.8E+08 CCDC50 1 0.133333 0.12 0 0.074074 CCDC50 3 3q28 1.93E+08 1.93E+08 MIR217 1 0 0.133333 0 0 MIR217 2 2p16.1 56063606 56063716 MIR216A 1 0 0.133333 0 0 MIR216A 2 2p16.1 56069590 56069699 MIR216B 1 0 0.133333 0 0 MIR216B 2 2p16.1 56081354 56081435 CCDC85A 1 0 0.173333 0 0 CCDC85A 2 2p16.1 56264762 56466814 NCRNA001 1 0.026667 0.12 0.074074 0 NCRNA001 2 2q21.2 1.33E+08 1.33E+08 B3GALT1 1 0.013333 0.133333 0.037037 0 B3GALT1 2 2q24.3 1.68E+08 1.68E+08 ABCB11 1 0 0.16 0.074074 0 ABCB11 2 2q31.1 1.69E+08  1.7E+08 MTX2 1 0.013333 0.133333 0.074074 0 MTX2 2 2q31.1 1.77E+08 1.77E+08 ELAVL4 1 0.08 0.16 0.333333 0 ELAVL4 1 1p33 50286273 50440128 LOC72946

1 0.04 0.133333 0.148148 0 LOC72946

1 1p32.1 59370198 59385068 FGGY 1 0.053333 0.12 0.111111 0 FGGY 1 1p32.1 59535213 60000991 HOOK1 1 0.04 0.146667 0.111111 0 HOOK1 1 1p32.1 60053121 60114639 C1orf87 1 0.053333 0.146667 0.111111 0 C1orf87 1 1p32.1 60228654 60312015 RPE65 1 0.026667 0.133333 0.074074 0 RPE65 1 1p31.3 68667095 68688231 ANKRD13C 1 0.133333 0.08 0 0.074074 ANKRD13C 1 1p31.1 70497273 70593006 HHLA3 1 0.133333 0.08 0 0.074074 HHLA3 1 1p31.1 70593081 70606294 CTH 1 0.146667 0.066667 0 0.074074 CTH 1 1p31.1 70549543 70677842 DDAH1 1 0.013333 0.16 0.037037 0 DDAH1 1 1p22.3 85556757 85816635 COL24A1 1 0.013333 0.146667 0.037037 0 COL24A1 1 1p22.3 85967504 86394710 CLCA2 1 0.026667 0.173333 0 0 CLCA2 1 1p22.3 86662357 86694829 CLCA1 1 0.026667 0.173333 0 0 CLCA1 1 1p22.3 86707114 86738563 CLCA3P 1 0.013333 0.16 0 0 CLCA3P 1 1p22.3 86872547 86893647 SH3GLB1 1 0.013333 0.146667 0 0 SH3GLB1 1 1p22.3 86942845 86986456 GBP7 1 0.04 0.12 0.037037 0 GBP7 1 1p22.2 89370022 89414312 GBP4 1 0.04 0.12 0.037037 0 GBP4 1 1p22.2 89419419 89437222 LOC40075

1 0.026667 0.133333 0.037037 0 LOC40075

1 1p22.2 89645826 89663082 LRRC8B 1 0.013333 0.146667 0.037037 0 LRRC8B 1 1p22.2 89762985 89836007 LRRC8C 1 0.013333 0.12 0.111111 0 LRRC8C 1 1p22.2 89871232 89957682 LRRC8D 1 0.026667 0.12 0.074074 0 LRRC8D 1 1p22.2 90059161 90174576 EVI5 1 0.066667 0.12 0.111111 0 EVI5 1 1p22.1 92746841 93030550 C1orf114 1 0.013333 0.146667 0.037037 0 C1orf114 1 1q24.2 1.68E+08 1.68E+08 F5 1 0 0.12 0.037037 0 F5 1 1q24.2 1.68E+08 1.68E+08 SELP 1 0 0.133333 0.037037 0 SELP 1 1q24.2 1.68E+08 1.68E+08 SELL 1 0 0.133333 0.037037 0 SELL 1 1q24.2 1.68E+08 1.68E+08 SELE 1 0.026667 0.12 0.037037 0 SELE 1 1q24.2 1.68E+08 1.68E+08 C4BPA 1 0.146667 0.12 0.555556 0 C4BPA 1 1q32.2 2.05E+08 2.05E+08 MIR548F3 1 0.04 0.146667 0.074074 0 MIR548F3 1 1q41 2.13E+08 2.13E+08 CHRM3 1 0.026667 0.146667 0.037037 0 CHRM3 1 1q43 2.38E+08 2.38E+08 FMN2 1 0.026667 0.133333 0.074074 0 FMN2 1 1q43 2.38E+08 2.39E+08 GAB4 0.921569 0.333333 0.106667 0.518519 0 GAB4 22 22q11.1 15822827 15869113 CECR6 0.921569 0.453333 0.106667 0.740741 0 CECR6 22 22q11.1 15977189 15982258 CECR5 0.921569 0.453333 0.106667 0.740741 0 CECR5 22 22q11.1 15998410 16026178 CECR4 0.921569 0.453333 0.106667 0.740741 0 CECR4 22 22q11.1 16020279 16026335 CECR1 0.921569 0.453333 0.106667 0.740741 0 CECR1 22 22q11.1 16040192 16060546 LOC64685

0.921569 0.426667 0.106667 0.740741 0 LOC64685

22 22q13.1 37304071 37382581 ATF4 0.921569 0.453333 0.106667 0.814815 0 ATF4 22 22q13.1 38246515 38248638 RPS19BP1 0.921569 0.453333 0.106667 0.814815 0 RPS19BP1 22 22q13.1 38255044 38258807 PPARA 0.921569 0.48 0.106667 0.777778 0 PPARA 22 22q13.31 44925163 45018318 TTC38 0.921569 0.48 0.106667 0.777778 0 TTC38 22 22q13.31 45042525 45068570 CELSR1 0.921569 0.48 0.106667 0.777778 0 CELSR1 22 22q13.31 45135395 45311732 HDAC10 0.921569 0.48 0.106667 0.814815 0 HDAC10 22 22q13.33 49025742 49031962 SAPS2 0.921569 0.48 0.106667 0.814815 0 SAPS2 22 22q13.33 49128626 49230381 ADM2 0.921569 0.48 0.106667 0.814815 0 ADM2 22 22q13.33 49266878 49271733 MIOX 0.921569 0.48 0.106667 0.814815 0 MIOX 22 22q13.33 49272079 49275617 LMF2 0.921569 0.48 0.105667 0.814815 0 LMF2 22 22q13.33 49288242 49293002 NCAPH2 0.921569 0.48 0.106667 0.814815 0 NCAPH2 22 22q13.33 49293511 49305058 SCO2 0.921569 0.48 0.106667 0.814815 0 SCO2 22 22q13.33 49308863 49310901 DEFB115 0.921569 0.213333 0.106667 0.518519 0 DEFB115 20 20q11.21 29309128 29311097 UQCR 0.921569 0.506667 0.106667 0.851852 0 UQCR 19 19p13.3 1548154 1556484 TCF3 0.921569 0.506667 0.106667 0.851852 0 TCF3 19 19p13.3 1560293 1601287 COPE 0.921569 0.48 0.106667 0.777778 0 COPE 19 19p13.1 18871323 18891200 DDX49 0.921569 0.48 0.106667 0.777778 0 DDX49 19 19p13.11 18891494 18900437 HOMER3 0.921569 0.48 0.106667 0.777778 0 HOMER3 19 19p13.11 18901010 18912162 CEACAM7 0.921569 0.413333 0.106667 0.814815 0 CEACAM7 19 19q13.2 46869075 46883937 ANKRD30B 0.921569 0.04 0.106667 0.074074 0 ANKRD30B 18 18p11.21 14738239 14842738 CDRT4 0.921569 0.24 0.106667 0.407407 0 CDRT4 17 17p12 15280063 15311651 PIGL 0.921569 0.32 0.106667 0.481481 0 PIGL 17 17p11.2 16051234 16170299 TNFRSF13

0.921569 0.453333 0.106667 0.740741 0 TNFRSF13

17 17p11.2 16783123 16816128 MPRIP 0.921569 0.466667 0.106667 0.740741 0 MPRIP 17 17p11.2 16886832 17029598 PLD6 0.921569 0.466667 0.106667 0.740741 0 PLD6 17 17p11.2 17045036 17050372 FLCN 0.921569 0.466667 0.106667 0.740741 0 FLCN 17 17p11.2 17056252 17081228 COPS3 0.921569 0.466667 0.106667 0.740741 0 COPS3 17 17p11.2 17090864 17125317 NT5M 0.921569 0.466667 0.106667 0.740741 0 NT5M 17 17p11.2 17147405 17191703 MED9 0.921569 0.466667 0.106667 0.740741 0 MED9 17 17p11.2 17321025 17337260 RASD1 0.921569 0.466667 0.106667 0.740741 0 RASD1 17 17p11.2 17338478 17340433 PEMT 0.921569 0.466667 0.106667 0.740741 0 PEMT 17 17p11.2 17349602 17426471 RAI1 0.921569 0.48 0.106667 0.740741 0 RAI1 17 17p11.2 17525512 17555491 SREBF1 0.921569 0.466667 0.106667 0.740741 0 SREBF1 17 17p11.2 17655393 17681051 MIR33B 0.921569 0.466667 0.106667 0.740741 0 MIR33B 17 17p11.2 17657875 17557971 TOM1L2 0.921569 0.466667 0.106667 0.740741 0 TOM1L2 17 17p11.2 17687547 17816510 LRRC48 0.921569 0.466667 0.106667 0.740741 0 LRRC48 17 17p11.2 17816852 17860915 ATPAF2 0.921569 0.466667 0.106667 0.740741 0 ATPAF2 17 17p11.2 17862059 17883206 MYO15A 0.921569 0.48 0.106667 0.740741 0 MYO15A 17 17p11.2 17952745 18023842 ALKBH5 0.921569 0.466667 0.106667 0.740741 0 ALKBH5 17 17p11.2 18027592 18053993 SMCR8 0.921569 0.48 0.106667 0.740741 0 SMCR8 17 17p11.2 18159319 18172096 SHMT1 0.921569 0.48 0.106667 0.740741 0 SHMT1 17 17p11.2 18171912 18207582 EVPLL 0.921569 0.48 0.106667 0.740741 0 EVPLL 17 17p11.2 18221804 18233684 MEOX1 0.921569 0.466667 0.106667 0.777778 0 MEOX1 17 17q21.31 39073284 39094789 SOST 0.921569 0.466667 0.106667 0.777778 0 SOST 17 17q21.31 39186625 39191683 DUSP3 0.921569 0.466667 0.106667 0.777778 0 DUSP3 17 17q21.31 39199015 39211895 HS3ST2 0.921569 0.28 0.106667 0.666667 0 HS3ST2 16 16p12.1 22733361 22835161 PWRN1 0.921569 0.026667 0.106667 0.148148 0 PWRN1 15 15q11.2 22354397 22384018 AQP9 0.921569 0.04 0.106667 0.074074 0 AQP9 15 15q22.1 56217700 56265403 LOC91948 0.921569 0.04 0.106667 0.111111 0 LOC91948 15 15q26.2 96086850 96218664 ABHD12B 0.921569 0.106667 0 0 0.037037 ABHD12B 14 14q22.1 50408628 50441439 PYGL 0.921569 0.106667 0 0 0.037037 PYGL 14 14q22.1 50441686 50480999 PSPC1 0.921569 0.093333 0.106667 0.333333 0 PSPC1 13 13q12.11 19146896 19255084 DHRS12 0.921569 0.106667 0.226667 0 0.148148 DHRS12 13 13q14.3 51240132 51276295 FLI37307 0.921569 0.106667 0.226667 0 0.148148 FLI37307 13 13q14.3 51285484 51317288 ATP7B 0.921569 0.106667 0.226657 0 0.148148 ATP7B 13 13q14.3 51404806 51483632 ALG11 0.921569 0.106667 0.226667 0 0.148148 ALG11 13 13q14.3 51484551 51501782 UTP14C 0.921569 0.106667 0.226667 0 0.148148 UTP14C 13 13q14.3 51496828 51505736 NEK5 0.921569 0.106667 0.226667 0 0.148148 NEK5 13 13q14.3 51536901 51601216 NEK3 0.921569 0.106667 0.226667 0 0.148148 NEK3 13 13q14.3 51604780 51631998 THSD1 0.921569 0.106667 0.226667 0 0.148148 THSD1 13 13q14.3 51849305 51878631 HNRNPA1L 0.921569 0.106667 0.226667 0 0.148148 HNRNPA1L 13 13q14.3 52089606 52115921 LECT1 0.921569 0.106667 0.226667 0 0.148148 LECT1 13 13q14.3 52175400 52211949 ITPR2 0.921569 0.013333 0.106667 0.037037 0 ITPR2 12 12p11.23 26379552 26877399 CSRP2 0.921569 0.106667 0.106667 0 0.111111 CSRP2 12 12q21.2 75776627 75796931 PAWR 0.921569 0.106667 0.12 0 0.296296 PAWR 12 12q21.2 78509876 78608922 NEDD1 0.921569 0.066667 0.106667 0.074074 0 NEDD1 12 12q23.1 95825132 95871593 ANO4 0.921569 0.066667 0.106667 0 0 ANO4 12 12q23.1 99712505   1E+D8 GVIN1 0.921569 0.053333 0.106667 0.037037 0 GVIN1 11 11p15.4 6690954 6699687 APIP 0.921569 0.053333 0.106667 0.074074 0 APIP 11 11p13 34860419 34894516 FAM181B 0.921569 0.04 0.106667 0 0 FAM181B 11 11q14.1 82120694 82122555 HEPHL1 0.921569 0.04 0.106667 0.074074 0 HEPHL1 11 11q21 93394026 93487023 HTR3B 0.921569 0.213333 0.106657 0.37037 0 HTR3B 11 11q23.2 1.13E+08 1.13E+08 FLJ35024 0.921569 0.013333 0.106667 0.037037 0 FLJ35024 9 9p24.2 2525655 2612374 RFX3 0.921569 0.026667 0.106667 0.037037 0 RFX3 9 9p24.2 3214647 3515984 FREM1 0.921569 0.026667 0.106667 0 0 FREM1 9 9p22.3 14727151 14900235 BNC2 0.921569 0.04 0.106667 0.074074 0 BNC2 9 9p22.3 16399501 16860787 TLE4 0.921569 0.053333 0.106667 0.111111 0 TLE4 9 9q21.31 81376698 81531477 RASEF 0.921569 0.093333 0.106667 0.185185 0 RASEF 9 9q21.32 84787137 84867864 CCDC129 0.921569 0.053333 0.106667 0.037037 0 CCDC129 7 7p15.1 31523503 31659829 PDE1C 0.921569 0.053333 0.106667 0.037037 0 PDE1C 7 7p14.3 31795772 32077517 C7orf53 0.921569 0.106667 0.04 0 0.074074 C7orf53 7 7q31.1 1.12E+08 1.12E+08 CAV1 0.921569 0.106667 0.08 0 0.111111 CAV1 7 7q31.2 1.16E+08 1.16E+08 LOC10028

0.921569 0.04 0.106667 0.074074 0 LOC10028

6 6p12.3 46822658 46834901 IBTK 0.921569 0.106667 0.226667 0 0.333333 IBTK 6 6q14.1 82936675 83014168 PNRC1 0.921569 0.106667 0.2 0 0.185185 PNRC1 6 6q15 89847148 89851599 SFRS13B 0.921569 0.106667 0.2 0 0.185185 SFRS13B 6 6q15 89862397 89884520 CD180 0.921569 0.106667 0.146667 0 0.148148 CD180 5 5q13.1 66513860 66528374 ZCCHC9 0.921569 0.106667 0.106667 0 0.037037 ZCCHC9 5 5q14.1 80633158 80644720 ACOT12 0.921569 0.106667 0.106667 0 0.037037 ACOT12 5 5q14.1 80661703 80725745 PJA2 0.921569 0.106667 0.16 0 0.185185 PJA2 5 5q21.3 1.09E+08 1.09E+08 CDS1 0.921569 0.04 0.106667 0 0 CDS1 4 4q21.23 85723081 85791518 PTPN13 0.921569 0.106667 0.053333 0 0 PTPN13 4 4q21.3 87734492 87955353 OSTC 0.921569 0.106667 0 0 0.037037 OSTC 4 4q25  1.1E+08  1.1E+08 GAB1 0.921569 0.013333 0.106667 0 0 GAB1 4 4q31.21 1.44E+08 1.45E+08 SMARCA5 0.921569 0.013333 0.106667 0 0 SMARCA5 4 4q31.21 1.45E+08 1.45E+08 LOC44104

0.921569 0.013333 0.106667 0 0 LOC44104

4 4q31.21 1.45E+08 1.45E+08 FREM3 0.921569 0.013333 0.106667 0 0 FREM3 4 4q31.21 1.45E+08 1.45E+08 SCN10A 0.921569 0.106667 0.106667 0.259259 0 SCN10A 3 3p22.2 38713841 38810506 FHIT 0.921569 0.066667 0.106667 0.148148 0 FHIT 3 3p14.2 59710076 61212174 C3orf49 0.921569 0.026667 0.106667 0.037037 0 C3orf49 3 3p14.1 63780081 63809351 PROS1 0.921569 0.106667 0.173333 0 0.37037 PROS1 3 3q11.2 95074572 95175625 TMEM108 0.921569 0.066667 0.106667 0.074074 0 TMEM108 3 3q22.1 1.34E+08 1.35E+08 GYG1 0.921569 0.106667 0.026667 0 0.074074 GYG1 3 3q24  1.5E+08  1.5E+08 IQCJ 0.921569 0.053333 0.106667 0.037037 0 IQCJ 3 3q25.33  1.6E+08  1.6E+08 NMD3 0.921569 0.106667 0.04 0 0.074074 NMD3 3 3q26.1 1.62E+08 1.62E+08 TBL1XR1 0.921569 0.106667 0.013333 0 0 TBL1XR1 3 3q26.32 1.78E+08 1.78E+08 UTS2D 0.921569 0.106667 0.12 0 0.074074 UTS2D 3 3q28 1.92E+08 1.93E+08 LOC10027

0.921569 0.013333 0.106667 0.074074 0 LOC10027

2 2p22.1 39000093 39056093 SOS1 0.921569 0.013333 0.106667 0.074074 0 SOS1 2 2p22.1 39062194 39201109 GTF2A1L 0.921569 0.04 0.106667 0.222222 0 GTF2A1L 2 2p16.3 48698452 48813791 LHCGR 0.921569 0.04 0.106667 0.222222 0 LHCGR 2 2p16.3 48767417 48836385 ANTXR1 0.921569 0.093333 0.106667 0.222222 0 ANTXR1 2 2p14 69093780 69226999 LYPD1 0.921569 0.04 0.106667 0.074074 0 LYPD1 2 2q21.2 1.33E+08 1.33E+08 NCKAP5 0.921569 0.026667 0.106667 0.074074 0 NCKAP5 2 2q21.2 1.33E+08 1.34E+08 MGAT5 0.921569 0.093333 0.106667 0.148148 0 MGAT5 2 2q21.3 1.35E+08 1.35E+08 RAB3GAP1 0.921569 0.146667 0.106667 0.148148 0 RAB3GAP1 2 2q21.3 1.36E+08 1.36E+08 NEB 0.921569 0.04 0.106667 0.037037 0 NEB 2 2q23.3 1.52E+08 1.52E+08 BAZ2B 0.921569 0.066667 0.106667 0.148148 0 BAZ2B 2 2q24.2  1.6E+08  1.6E+08 LOC10013

0.921569 0.013333 0.106667 0.037037 0 LOC10013

2 2q31.2 1.78E+08 1.78E+08 SLC5A9 0.921569 0.146667 0.106667 0.518519 0 SLC5A9 1 1p33 48460944 48486904 BEND5 0.921569 0.146667 0.106667 0.37037 0 BEND5 1 1p33 48966127 49015135 ORC1L 0.921569 0.28 0.106667 0.481481 0 ORC1L 1 1p32.3 52611089 52642720 C8B 0.921569 0.08 0.106667 0.111111 0 C8B 1 1p32.2 57167471 57204277 DAB1 0.921569 0.08 0.106667 0.111111 0 DAB1 1 1p32.2 57236167 58488800 JUN 0.921569 0.04 0.106667 0.074074 0 JUN 1 1p32.1 59019051 59022374 EFCAB7 0.921569 0.093333 0.106667 0.074074 0 EFCAB7 1 1p31.3 63761601 63810952 CACHD1 0.921569 0.04 0.106667 0.074074 0 CACHD1 1 1p31.3 64709064 64931330 LEPR 0.921569 0.12 0.106667 0.074074 0 LEPR 1 1p31.3 65658836 65873699 LEPROT 0.921569 0.12 0.106667 0.074074 0 LEPROT 1 1p31.3 65658836 65674277 GNG5 0.921569 0.053333 0.106667 0.037037 0 GNG5 1 1p22.3 84736594 84744851 SPATA1 0.921569 0.053333 0.106667 0.037037 0 SPATA1 1 1p22.3 84744562 84804464 CTBS 0.921569 0.04 0.106667 0.037037 0 CTBS 1 1p22.3 84791394 84812752 C1orf180 0.921569 0.04 0.106667 0.037037 0 C1orf180 1 1p22.3 84866501 84873292 SSX2IP 0.921569 0.04 0.106667 0.037037 0 SSX2IP 1 1p22.3 84881978 84928829 LPAR3 0.921569 0.04 0.106667 0.037037 0 LPAR3 1 1p22.3 85051674 95131485 MCOLN2 0.921569 0.04 0.106667 0.037037 0 MCOLN2 1 1p22.3 85163854 85235385 MCOLN3 0.921569 0.026667 0.106667 0.037037 0 MCOLN3 1 1p22.3 85256353 85286758 WDR63 0.921569 0.026667 0.106667 0.037037 0 WDR63 1 1p22.3 85300581 85371409 HS2ST1 0.921569 0.04 0.106667 0 0 HS2ST1 1 1p22.3 87152923 87336713 RBMXL1 0.921569 0.066667 0.106667 0.037037 0 RBMXL1 1 1p22.2 89217728 89231232 TGFBR3 0.921569 0.04 0.106667 0.111111 0 TGPBR3 1 1p22.2 91918490 92124375 ARHGAP29 0.921569 0.066667 0.106667 0.148148 0 ARHGAP29 1 1p22.1 94407051 94475896 MGC4473 0.921569 0.013333 0.106667 0.037037 0 MGC4473 1 1q24.2 1.67E+08 1.67E+08 SLC19A2 0.921569 0.013333 0.106667 0.037037 0 SLC19A2 1 1q24.2 1.68E+08 1.68E+08 C1orf156 0.921569 0.04 0.106667 0.037037 0 C1orf156 1 1q24.2 1.68E+08 1.68E+08 C1orf112 0.921569 0.04 0.106667 0.037037 0 C1orf112 1 1q24.2 1.68E+08 1.68E+08 GORAB 0.921569 0 0.106667 0.037037 0 GORAB 1 1q24.2 1.69E+08 1.69E+08 RNF138P1 0.019608 0.12 0.146667 0.037037 0.037037 RNF138P1 5 5q11.2 54860427 54866128 MTX3 0.019608 0.12 0.133333 0.037037 0.037037 MTX3 5 5q14.1 79308297 73322845 USP33 0.019608 0.133333 0.106667 0.037037 0.037037 USP33 1 1p31.1 77934262 77998126 FAM73A 0.019608 0.133333 0.106667 0.037037 0.037037 FAM73A 1 1p31.1 78017897 78116670 TTTY12 0.009804 0.226667 0.12 0.259259 0.037037 TTTY12 Y Yp11.2 7732965 7738724 CECR7 0.009804 0.32 0.133333 0.481481 0.037037 CECR7 22 22q11.1 15897460 15919683 EP300 0.009804 0.44 0.106667 0.740741 0.037037 EP300 22 22q13.2 39818560 39906028 MOV10L1 0.009804 0.48 0.12 0.777778 0.037037 MOV10L1 22 22q13.33 48870562 48942243 ABCC13 0.009804 0.04 0.146667 0.037037 0.037037 ABCC13 21 21q11.2 14567991 14595564 CYYR1 0.009804 0 0.146667 0 0.037037 CYYR1 21 21q21.3 26760399 26867453 HAO1 0.009804 0.053333 0.186667 0.143148 0.037037 HAO1 20 20p12.3 7811631 7869094 PLCB4 0.009804 0.066667 0.133333 0.074074 0.037037 PLCB4 20 20p12.2 9024932 9409463 PAK7 0.009804 0.106667 0.106667 0.074074 0.037037 PAK7 20 20p12.2 9466037 9767688 SNAP25 0.009804 0.08 0.12 0.074074 0.037037 SNAP25 20 20p12.2 10147477 10236066 BTBD3 0.009804 0.04 0.173333 0.074074 0.037037 BTBD3 20 20p12.2 11819477 11855244 ISM1 0.009804 0.066667 0.146667 0.111111 0.037037 ISM1 20 20p12.1 13150418 13229298 CRNKL1 0.009804 0.24 0.133333 0.481481 0.037037 CRNKL1 20 20p11.23 19963012 19984691 PSG1 0.009804 0.306667 0.133333 0.740741 0.037037 PSG1 19 19q13.31 48063198 48075712 ZNF180 0.009804 0.426667 0.106667 0.814815 0.037037 ZNF180 19 19q13.31 49671699 49696415 ZNF521 0.009804 0.026667 0.12 0.111111 0.037037 ZNF521 18 18q11.2 20895886 21186213 C18orf16 0.009804 0 0.133333 0 0.037037 C18orf16 18 18q11.2 22699270 22769909 CHST9 0.009804 0 0.133333 0 0.037037 CHST9 18 18q11.2 22749595 23019288 MOCOS 0.009804 0.106667 0.093333 0.037037 0.074074 MOCOS 18 18q12.2 32021478 32102684 FHOD3 0.009804 0.106667 0.093333 0.037037 0.037037 FHOD3 18 18q12.2 32131700 32614017 SLC14A2 0.009804 0.213333 0.106667 0.185185 0.037037 SLC14A2 18 18q12.3 41448764 41517059 SLC14A1 0.009804 0.226667 0.106667 0.185185 0.037037 SLC14A1 18 18q12.3 41558090 41586483 SIGLEC15 0.009804 0.226667 0.106667 0.185185 0.037037 SIGLEC15 18 18q12.3 41659543 41676520 KIAA1632 0.009804 0.226667 0.106667 0.185185 0.037037 KIAA1632 18 18q12.3 41681572 41801304 PSTPIP2 0.009804 0.226667 0.12 0.185185 0.037037 PSTPIP2 18 18q21.1 41817500 41906249 ATP5A1 0.009804 0.226667 0.12 0.185185 0.037037 ATP5A1 18 18q21.1 41918108 41938198 HAUS1 0.009804 0.226667 0.12 0.185185 0.037037 HAUS1 18 18q21.1 41938296 41962297 C18orf25 0.009804 0.226667 0.106667 0.222222 0.037037 C18orf25 18 18q21.1 42007986 42100954 RNF165 0.009804 0.253333 0.106667 0.222222 0.037037 RNF165 18 18q21.1 42168185 42294782 LOXHD1 0.009804 0.24 0.106667 0.222222 0.037037 LOXHD1 18 18q21.1 42310935 42393251 ST8SIA5 0.009804 0.24 0.106667 0.222222 0.037037 ST8SIA5 18 18q21.1 42513079 42591038 IER3IP1 0.009804 0.16 0.106667 0.222222 0.037037 IER3IP1 18 18q21.1 42935411 42956744 KIAA0427 0.009804 0.306667 0.106667 0.407407 0.037037 KIAA0427 18 18q21.1 44319425 44643577 SMAD7 0.009804 0.306667 0.106667 0.333333 0.037037 SMAD7 18 18q21.1 44700221 44731080 MYO5B 0.009804 0.24 0.106667 0.259259 0.037037 MYO5B 18 18q21.1 45603154 45975450 CCDC11 0.009804 0.213333 0.106667 0.259259 0.037037 CCDC11 18 18q21.1 46007562 46046864 SKA1 0.009804 0.2 0.12 0.259259 0.037037 SKA1 18 18q21.1 46155390 46174537 MAPK4 0.009804 0.16 0.16 0.259259 0.037037 MAPK4 18 18q21.1 46340482 46512195 MRO 0.009804 0.24 0.106667 0.259259 0.037037 MRO 18 18q21.2 46575488 46605753 ME2 0.009804 0.24 0.106667 0.259259 0.037037 ME2 18 18q21.2 46659430 46730159 ELAC1 0.009804 0.24 0.106667 0.259259 0.037037 ELAC1 18 18q21.2 46748385 46768489 ST8SIA3 0.009804 0.093333 0.133333 0.148148 0.037037 ST8SIA3 18 18q21.31 53170719 53187160 ONECUT2 0.009804 0.093333 0.133333 0.148148 0.037037 ONECUT2 18 18q21.31 53253915 53309529 ATP8B1 0.009804 0.186667 0.133333 0.185185 0.037037 ATP8B1 18 18q21.31 53464657 53550038 NEDD4L 0.009804 0.186667 0.133333 0.148148 0.037037 NEDD4L 18 18q21.31 53862617 54219753 ALPK2 0.009804 0.2 0.12 0.074074 0.037037 ALPK2 18 18q21.31 54299462 54447170 MALT1 0.009804 0.2 0.133333 0.074074 0.037037 MALT1 18 18q21.32 54489598 54568351 ZNF532 0.009804 0.213333 0.12 0.074074 0.037037 ZNF532 18 18q21.32 54681041 54804690 LOC39085

0.009804 0.186667 0.12 0.074074 0.037037 LOC39085

18 18q21.32 54853951 54871427 SEC11C 0.009804 0.146667 0.12 0.074074 0.037037 SEC11C 18 18q21.32 54958105 54977044 CPLX4 0.009804 0.146667 0.133333 0.074074 0.037037 CPLX4 18 18q21.32 55113618 55136862 LMAN1 0.009804 0.146667 0.133333 0.074074 0.037037 LMAN1 18 18q21.32 55146037 55177489 CCBE1 0.009804 0.146667 0.12 0.074074 0.037037 CCBE1 18 18q21.32 55252129 55515625 SOCS6 0.009804 0.106667 0.173333 0.037037 0.222222 SOCS6 18 18q22.2 66107117 66148415 ZNF516 0.009804 0.213333 0.106667 0.185185 0.037037 ZNF516 18 18q23 72200607 72304044 LOC28427

0.009804 0.24 0.106667 0.222222 0.037037 LOC28427

18 18q23 72369600 72400772 ZNF236 0.009804 0.253333 0.106667 0.222222 0.037037 ZNF236 18 18q23 72665104 72811671 C17orf97 0.009804 0.466667 0.12 0.740741 0.037037 C17orf97 17 17p13.3 260434 264802 OR1A2 0.009804 0.266667 0.16 0.703704 0.037037 OR1A2 17 17p13.3 3047563 3048493 ATP2A3 0.009804 0.413333 0.133333 0.740741 0.037037 ATP2A3 17 17p13.2 3773918 3814486 ZZEF1 0.009804 0.36 0.133333 0.740741 0.037037 ZZEF1 17 17p13.2 3854488 3993003 CYB5D2 0.009804 0.4 0.133333 0.740741 0.037037 CYB5D2 17 17p13.2 3993211 4007741 ANKFY1 0.009804 0.4 0.133333 0.740741 0.037037 ANKFY1 17 17p13.2 4013414 4114024 UBE2G1 0.009804 0.4 0.133333 0.740741 0.037037 UBE2G1 17 17p13.2 4119251 4216719 SPNS2 0.009804 0.413333 0.133333 0.740741 0.037037 SPNS2 17 17p13.2 4348878 4389978 SMTNL2 0.009804 0.413333 0.133333 0.740741 0.037037 SMTNL2 17 17p13.2 4434025 4458364 PELP1 0.009804 0.413333 0.133333 0.740741 0.037037 PELP1 17 17p13.2 4521428 4554382 ARRB2 0.009804 0.413333 0.133333 0.740741 0.037037 ARRB2 17 17p13.2 4560538 4571545 MED11 0.009804 0.413333 0.133333 0.740741 0.037037 MED11 17 17p13.2 4581472 4583646 CXCL16 0.009804 0.413333 0.133333 0.740741 0.037037 CXCL16 17 17p13.2 4583577 4589973 ZMYND15 0.009804 0.413333 0.133333 0.740741 0.037037 ZMYND15 17 17p13.2 4590068 4596160 TM4SF5 0.009804 0.413333 0.133333 0.740741 0.037037 TM4SF5 17 17p13.2 4621936 4633254 VMO1 0.009804 0.413333 0.133333 0.740741 0.037037 VMO1 17 17p13.2 4635321 4636470 GLTPD2 0.009804 0.413333 0.133333 0.740741 0.037037 GLTPD2 17 17p13.2 4638994 4640426 PSMB6 0.009804 0.413333 0.133333 0.740741 0.037037 PSMB6 17 17p13.2 4646415 4648749 PLD2 0.009804 0.413333 0.133333 0.740741 0.037037 PLD2 17 17p13.2 4657378 4673695 MINK1 0.009804 0.413333 0.133333 0.740741 0.037037 MINK1 17 17p13.2 4683303 4742135 RNF167 0.009804 0.413333 0.133333 0.740741 0.037037 RNF167 17 17p13.2 4784375 4789263 PFN1 0.009804 0.413333 0.133333 0.740741 0.037037 PFN1 17 17p13.2 4789692 4792571 ENO3 0.009804 0.413333 0.133333 0.740741 0.037037 ENO3 17 17p13.2 4795131 4801149 SPAG7 0.009804 0.413333 0.133333 0.740741 0.037037 SPAG7 17 17p13.2 4803244 4811857 CAMTA2 0.009804 0.413333 0.133333 0.740741 0.037037 CAMTA2 17 17p13.2 4812017 4831656 KIF1C 0.009804 0.413333 0.133333 0.740741 0.037037 KIF1C 17 17p13.2 4842000 4868721 GPR172B 0.009804 0.413333 0.133333 0.740741 0.037037 GPR172B 17 17p13.2 4876621 4879452 ZNF594 0.009804 0.373333 0.133333 0.740741 0.037037 ZNF594 17 17p13.2 5023555 5035903 C17orf87 0.009804 0.373333 0.133333 0.740741 0.037037 C17orf87 17 17p13.2 5054625 5078808 RABEP1 0.009804 0.373333 0.146667 0.740741 0.037037 RABEP1 17 17p13.2 5126282 5229857 C1Q8P 0.009804 0.373333 0.133333 0.740741 0.037037 C1QBP 17 17p13.2 5276823 5283196 DHX33 0.009804 0.373333 0.133333 0.740741 0.037037 DHX33 17 17p13.2 5286315 5312906 DERL2 0.009804 0.36 0.133333 0.740741 0.037037 DERL2 17 17p13.2 5318337 5330219 MIS12 0.009804 0.36 0.133333 0.740741 0.037037 MIS12 17 17p13.2 5330971 5334855 NLRP1 0.009804 0.36 0.133333 0.740741 0.037037 NLRP1 17 17p13.2 5345443 5428557 WSCD1 0.009804 0.386667 0.133333 0.740741 0.037037 WSCD1 17 17p13.2 5914658 5968472 PITPNM3 0.009804 0.4 0.133333 0.740741 0.037037 PITPNM3 17 17p13.2 6295307 6400602 KIAA0753 0.009804 0.36 0.186667 0.740741 0.037037 KIAA0753 17 17p13.2 6422369 6484972 SLC13A5 0.009804 0.4 0.146667 0.740741 0.037037 SLC13A5 17 17p13.2 5528765 6557465 XAF1 0.009804 0.386667 0.146667 0.740741 0.037037 XAF1 17 17p13.2 6599880 6619689 FBXO39 0.009804 0.386667 0.146667 0.740741 0.037037 FBXO39 17 17p13.2 6620276 6631689 TEKT1 0.009804 0.386667 0.146667 0.740741 0.037037 TEKT1 17 17p13.2 6644024 6675785 ALOX12P2 0.009804 0.386667 0.146667 0.740741 0.037037 ALOX12P2 17 17p13.2 6697619 6744393 ALOX12 0.009804 0.413333 0.146667 0.740741 0.037037 ALOX12 17 17p13.1 6840108 6854780 RNASEK 0.009804 0.413333 0.146667 0.740741 0.037037 RNASEK 17 17p13.1 6856522 6858576 C17orf49 0.009804 0.413333 0.146667 0.740741 0.037037 C17orf49 17 17p13.1 6858797 6861563 MIR195 0.009804 0.413333 0.146667 0.740741 0.037037 MIR195 17 17p13.1 6861658 6861745 MIR497 0.009804 0.413333 0.146667 0.740741 0.037037 MIR497 17 17p13.1 6861954 6862066 BCL6B 0.009804 0.413333 0.146667 0.740741 0.037037 BCL6B 17 17p13.1 6867093 6873686 SLC16A13 0.009804 0.413333 0.146667 0.740741 0.037037 SLC16A13 17 17p13.1 6880118 6884164 SLC16A11 0.009804 0.413333 0.146667 0.740741 0.037037 SLC16A11 17 17p13.1 6885673 6887967 ASGR2 0.009804 0.413333 0.146667 0.703704 0.037037 ASGR2 17 17p13.1 6945365 6958853 ASGR1 0.009804 0.413333 0.146667 0.703704 0.037037 ASGR1 17 17p13.1 7017475 7023608 DLG4 0.009804 0.413333 0.145667 0.703704 0.037037 DLG4 17 17p13.1 7033934 7061653 ACADVL 0.009804 0.413333 0.146667 0.703704 0.037037 ACADVL 17 17p13.1 7063877 7069310 MIR324 0.009804 0.413333 0.146667 0.703704 0.037037 MIR324 17 17p13.1 7067340 7067423 DVL2 0.009804 0.413333 0.146667 0.703704 0.037037 DVL2 17 17p13.1 7069385 7078588 PHF23 0.009804 0.413333 0.146667 0.703704 0.037037 PHF23 17 17p13.1 7079071 7083550 GABARAP 0.009804 0.413333 0.146667 0.703704 0.037037 GABARAP 17 17p13.1 7084462 7086478 DULLARD 0.009804 0.413333 0.146667 0.703704 0.037037 DULLARD 17 17p13.1 7087630 7095720 C17orf81 0.009804 0.413333 0.146667 0.703704 0.037037 C17orf81 17 17p13.1 7096096 7103984 CLDN7 0.009804 0.413333 0.146667 0.703704 0.037037 CLDN7 17 17p13.1 7103946 7106520 SLC2A4 0.009804 0.413333 0.146667 0.703704 0.037037 SLC2A4 17 17p13.1 7125778 7132092 YBX2 0.009804 0.413333 0.146667 0.703704 0.037037 YBX2 17 17p13.1 7132295 7138601 WRAP53 0.009804 0.4 0.16 0.703704 0.037037 WRAP53 17 17p13.1 7530114 7547545 EFNB3 0.009804 0.4 0.16 0.703704 0.037037 EFNB3 17 17p13.1 7549245 7555419 DNAH2 0.009804 0.4 0.16 0.703704 0.037037 DNAH2 17 17p13.1 7563764 7677784 KDM6B 0.009804 0.4 0.16 0.703704 0.037037 KDM6B 17 17p13.1 7683960 7698844 TMEM88 0.009804 0.4 0.16 0.703704 0.037037 TMEM88 17 17p13.1 7699109 7700143 LSMD1 0.009804 0.4 0.16 0.703704 0.037037 LSMD1 17 17p13.1 7700728 7701898 CYB5D1 0.009804 0.4 0.16 0.703704 0.037037 CYB5D1 17 17p13.1 7701789 7706326 CHD3 0.009804 0.4 0.16 0.703704 0.037037 CHD3 17 17p13.1 7728848 7756801 SCARNA21 0.009804 0.4 0.16 0.703704 0.037037 SCARNA21 17 17p13.1 7750166 7750304 LOC28402

0.009804 0.4 0.16 0.703704 0.037037 LOC28402

17 17p13.1 7757366 7759991 KCNAB3 0.009804 0.4 0.16 0.703704 0.037037 KCNAB3 17 17p13.1 7766752 7773479 TRAPPC1 0.009804 0.4 0.16 0.703704 0.037037 TRAPPC1 17 17p13.1 7774388 7776043 CNTROB 0.009804 0.4 0.16 0.703704 0.037037 CNTROB 17 17p13.1 7776198 7793622 GUCY2D 0.009804 0.4 0.16 0.703704 0.037037 GUCY2D 17 17p13.1 7846713 7864384 ALOX12B 0.009804 0.4 0.146667 0.703704 0.037037 ALOX12B 17 17p13.1 7916679 7931747 ALOXE3 0.009804 0.4 0.146667 0.703704 0.037037 ALOXE3 17 17p13.1 7939943 7962586 HES7 0.009804 0.4 0.146667 0.703704 0.037037 HES7 17 17p13.1 7964633 7968136 PER1 0.009804 0.4 0.146667 0.703704 0.037037 PER1 17 17p13.1 7984513 7996479 VAMP2 0.009804 0.4 0.146667 0.703704 0.037037 VAMP2 17 17p13.1 8003190 8007019 TMEM107 0.009804 0.4 0.146667 0.703704 0.037037 TMEM107 17 17p13.1 8017021 8020440 C17orf59 0.009804 0.4 0.146667 0.703704 0.037037 C17orf59 17 17p13.1 8032376 8034290 AURKB 0.009804 0.4 0.146667 0.703704 0.037037 AURKB 17 17p13.1 8048774 8054609 C17orf44 0.009804 0.4 0.146667 0.703704 0.037037 C17orf44 17 17p13.1 8064673 8068087 C17orf68 0.009804 0.4 0.146667 0.703704 0.037037 C17orf68 17 17p13.1 8068864 8092139 PFAS 0.009804 0.4 0.146667 0.703704 0.037037 PFAS 17 17p13.1 8093321 8114534 SLC25A35 0.009804 0.4 0.146667 0.703704 0.037037 SLC25A35 17 17p13.1 8131807 8138896 RANGRF 0.009804 0.4 0.146667 0.703704 0.037037 RANGRF 17 17p13.1 8132714 8134131 ARHGEF15 0.009804 0.4 0.146667 0.703704 0.037037 ARHGEF15 17 17p13.1 8154315 8166555 LOC10012

0.009804 0.4 0.133333 0.703704 0.037037 LOC10012

17 17p13.1 8202456 8204585 KRBA2 0.009804 0.4 0.133333 0.703704 0.037037 KRBA2 17 17p13.1 8212698 8215584 RPL26 0.009804 0.4 0.133333 0.703704 0.037037 RPL26 17 17p13.1 8221559 8227291 RNF222 0.009804 0.4 0.133333 0.703704 0.037037 RNF222 17 17p13.1 8234750 8241870 NDEL1 0.009804 0.4 0.133333 0.703704 0.037037 NDEL1 17 17p13.1 8279904 8312207 MYH10 0.009804 0.4 0.133333 0.703704 0.037037 MYH10 17 17p13.1 8318255 8474762 CCDC42 0.009804 0.4 0.12 0.703704 0.037037 CCDC42 17 17p13.1 8573972 8588880 SPDYE4 0.009804 0.4 0.12 0.703704 0.037037 SPDYE4 17 17p13.1 8597149 8602603 MFSD6L 0.009804 0.373333 0.146667 0.703704 0.037037 MFSD6L 17 17p13.1 8641153 8643393 PIK3R6 0.009804 0.373333 0.146667 0.703704 0.037037 PIK3R6 17 17p13.1 8646780 8711720 PIK3R5 0.009804 0.4 0.12 0.666667 0.037037 PIK3R5 17 17p13.1 8722959 8809750 NTN1 0.009804 0.386667 0.12 0.666667 0.037037 NTN1 17 17p13.1 8865584 9088043 STX8 0.009804 0.386667 0.12 0.666667 0.037037 STX8 17 17p13.1 9094513 9420001 WDR16 0.009804 0.386667 0.12 0.592593 0.037037 WDR16 17 17p13.1 9420669 9487502 USP43 0.009804 0.386667 0.12 0.592593 0.037037 USP43 17 17p13.1 5489675 9573729 GLP2R 0.009804 0.373333 0.106667 0.555556 0.037037 GLP2R 17 17p13.1 9670106 9733748 GAS7 0.009804 0.386667 0.106667 0.555556 0.037037 GAS7 17 17p13.1 9754651 9870349 MYH13 0.009804 0.36 0.106667 0.555556 0.037037 MYH13 17 17p13.1 10144908 10217048 C17orf39 0.009804 0.466667 0.106667 0.703704 0.037037 C17orf39 17 17p11.2 17883336 17912444 ACLY 0.009804 0.466667 0.106667 0.703704 0.037037 ACLY 17 17q21.2 37276705 37328799 KCNJ16 0.009804 0.106667 0.146667 0.296296 0.037037 KCNJ16 17 17q24.3 65583021 65643342 IRF8 0.009804 0.36 0.133333 0.62963 0.037037 IRF8 16 16q24.1 84490275 84513713 MAP1LC3B 0.009804 0.426667 0.146667 0.62963 0.037037 MAP1LC3B 16 16q24.2 85983302 85995881 KLHDC4 0.009804 0.426667 0.186667 0.62963 0.037037 KLHDC4 16 16q24.2 86298919 86357044 FANCA 0.009804 0.48 0.186667 0.703704 0.037037 FANCA 16 16q24.3 88331460 88410567 MEIS2 0.009804 0.013333 0.133333 0.037037 0.037037 MEIS2 15 15q14 34970524 35180793 SPRED1 0.009804 0.026667 0.146667 0.037037 0.037037 SPRED1 15 15q14 36332344 36436743 SHC4 0.009804 0.013333 0.106667 0.037037 0.037037 SHC4 15 15q21.1 46903227 47042934 ATP8B4 0.009804 0.013333 0.133333 0.074074 0.037037 ATP8B4 15 15q21.2 47937727 48198712 PIGB 0.009804 0.12 0.026667 0.037037 0 PIGB 15 15q21.3 53398425 53435139 CCPG1 0.009804 0.12 0.026667 0.037037 0 CCPG1 15 15q21.3 53434730 53487835 MIR628 0.009804 0.12 0.026667 0.037037 0 MIR628 15 15q21.3 53452430 53452525 DYX1C1 0.009804 0.12 0.026667 0.037037 0 DYX1C1 15 15q21.3 53497246 53587725 PYGO1 0.009804 0.12 0.026667 0.037037 0 PYGO1 15 15q21.3 53625513 53668343 PRTG 0.009804 0.12 0.026667 0.037037 0 PRTG 15 15q21.3 53691042 53822470 AGBL1 0.009804 0.106667 0.146667 0.296296 0.037037 AGBL1 15 15q25.3 84486246 85373288 MCTP2 0.009804 0.12 0 0.037037 0 MCTP2 15 15q26.2 92642434 92828185 STXBP6 0.009804 0.04 0.16 0.037037 0.037037 STXBP6 14 14q12 24351144 24588936 PRKD1 0.009804 0.04 0.2 0 0.037037 PRKD1 14 14q12 29115438 29466651 TRIM9 0.009804 0.106667 0 0.037037 0.037037 TRIM9 14 14q22.1 50511731 50632173 C14orf37 0.009804 0.013333 0.12 0 0.037037 C14orf37 14 14q23.1 57540561 57688601 ACTR10 0.009804 0.106667 0.013333 0.037037 0 ACTR10 14 14q23.1 57736586 57772107 PSMA3 0.009804 0.106667 0.04 0.037037 0 PSMA3 14 14q23.1 57781346 57808480 FLJ31306 0.009804 0.106667 0.04 0.037037 0 FLJ31306 14 14q23.1 57801837 57834609 FLJ43390 0.009804 0.013333 0.213333 0.037037 0.037037 FLJ43390 14 14q23.2 61653828 61664886 KCNH5 0.009804 0.013333 0.2 0.037037 0.037037 KCNH5 14 14q23.2 62243698 62581709 FUT8 0.009804 0.093333 0.106667 0.222222 0.037037 FUT8 14 14q23.3 64947593 65279716 DIO2 0.009804 0.013333 0.186667 0.037037 0.037037 DIO2 14 14q31.1 79733622 79748279 C14orf145 0.009804 0.013333 0.16 0.037037 0.037037 C14orf145 14 14q31.1 80032574 80475638 TSHR 0.009804 0.026667 0.16 0 0.037037 TSHR 14 14q31.1 80491622 80682400 POLR1D 0.009804 0.16 0.12 0.333333 0.037037 POLR1D 13 13q12.2 27094003 27139549 KL 0.009804 0.106667 0.106667 0.037037 0.074074 KL 13 13q13.1 32488571 32538282 STARD13 0.009804 0.106667 0.12 0.037037 0.074074 STARD13 13 13q13.1 32575273 32678188 MIR548F5 0.009804 0.12 0.186667 0.037037 0.111111 MIR548F5 13 13q13.3 34946406 35413383 SMAD9 0.009804 0.146667 0.186667 0.037037 0.111111 SMAD9 13 13q13.3 36320207 36392410 ALG5 0.009804 0.16 0.213333 0.037037 0.111111 ALG5 13 13q13.3 36421310 36471505 LOC64698

0.009804 0.066667 0.24 0.074074 0.037037 LOC64698

13 13q14.11 39819273 39953144 FOXO1 0.009804 0.12 0.226667 0.074074 0.037037 FOXO1 13 13q14.11 40027801 40138735 MIR320D1 0.009804 0.12 0.24 0.074074 0.037037 MIR320D1 13 13q14.11 40199964 40200012 MRPS31 0.009804 0.12 0.24 0.074074 0.037037 MRPS31 13 13q14.11 40201432 40243348 SLC25A15 0.009804 0.12 0.213333 0.074074 0.037037 SLC25A15 13 13q14.11 40261547 40284596 SUGT1L1 0.009804 0.106667 0.213333 0.074074 0.037037 SUGT1L1 13 13q14.11 40269127 40393887 MIR621 0.009804 0.106667 0.213333 0.074074 0.037037 MIR621 13 13q14.11 40282902 40282998 ELF1 0.009804 0.106667 0.213333 0.074074 0.037037 ELF1 13 13q14.11 40404056 40454419 WBP4 0.009804 0.12 0.213333 0.074074 0.037037 WBP4 13 13q14.11 40533697 40556140 KBTBD6 0.009804 0.106667 0.226667 0.074074 0.037037 KBTBD6 13 13q14.11 40599709 40604937 MTRF1 0.009804 0.08 0.226667 0.037037 0.037037 MTRF1 13 13q14.11 40688516 40735714 NARG1L 0.009804 0.08 0.226667 0.037037 0.037037 NARG1L 13 13q14.11 40783341 40830855 KIAA0564 0.009804 0.04 0.266667 0.037037 0.037037 KIAA0564 13 13q14.11 41038961 41433222 DGKH 0.009804 0.013335 0.293333 0.037037 0.037037 DGKH 13 13q14.11 41520889 41701889 NUFIP1 0.009804 0.12 0.24 0.037037 0.111111 NUFIP1 13 13q14.12 44411384 44461614 KIAA1704 0.009804 0.12 0.24 0.037037 0.111111 KIAA1704 13 13q14.12 44461687 44500405 GTF2F2 0.009804 0.12 0.24 0.037037 0.111111 GTF2F2 13 13q14.12 44592631 44756240 KCTD4 0.009804 0.12 0.24 0.037037 0.111111 KCTD4 13 13q14.12 44664988 44673176 TPT1 0.009804 0.12 0.253333 0.037037 0.111111 TPT1 13 13q14.12 44809304 44813298 SNORA31 0.009804 0.12 0.253333 0.037037 0.111111 SNORA31 13 13q14.12 44809615 44809745 LOC10019

0.009804 0.12 0.253333 0.037037 0.111111 LOC10019

13 13q14.12 44813480 44863617 COG3 0.009804 0.12 0.253333 0.037037 0.111111 COG3 13 13q14.12 44937072 45008762 ABCC4 0.009804 0.133333 0.16 0.037037 0.222222 ABCC4 13 13q32.1 94470084 94751689 UBAC2 0.009804 0.2 0.12 0.037037 0.074074 UBAC2 13 13q32.3 98650680 98836753 MIR623 0.009804 0.226667 0.12 0.037037 0.074074 MIR623 13 13q32.3 98806386 98806484 TM9SF2 0.009804 0.146667 0.173333 0.037037 0.074074 TM9SF2 13 13q32.3 98951729 99013278 CLYBL 0.009804 0.186667 0.12 0.037037 0.074074 CLYBL 13 13q32.3 99056920 99347389 PCCA 0.009804 0.16 0.12 0.037037 0.074074 PCCA 13 13q32.3 99539338 99980690 TMTC4 0.009804 0.146667 0.12 0.037037 0.074074 TMTC4 13 13q32.3   1E+08   1E+08 ANKRD10 0.009804 0.293333 0.12 0.444444 0.037037 ANKRD10 13 13q34  1.1E+08  1.1E+08 C13orf28 0.009804 0.4 0.106667 0.62963 0.037037 C13orf28 13 13q34 1.12E+08 1.12E+08 TUBGCP3 0.009804 0.413333 0.12 0.592593 0.037037 TUBGCP3 13 13q34 1.12E+08 1.12E+08 C13orf35 0.009804 0.44 0.12 0.62963 0.037037 C13orf35 13 13q34 1.12E+08 1.12E+08 ATP11A 0.009804 0.44 0.133333 0.666667 0.037037 ATP11A 13 13q34 1.12E+08 1.13E+08 MCF2L 0.009804 0.44 0.133333 0.666667 0.037037 MCF2L 13 13q34 1.13E+08 1.13E+08 F7 0.009804 0.44 0.133333 0.666667 0.037037 F7 13 13q34 1.13E+08 1.13E+08 F10 0.009804 0.44 0.133333 0.666667 0.037037 F10 13 13q34 1.13E+08 1.13E+08 PROZ 0.009804 0.44 0.133333 0.666667 0.037037 PROZ 13 13q34 1.13E+08 1.13E+08 PCID2 0.009804 0.44 0.133333 0.666667 0.037037 PCID2 13 13q34 1.13E+08 1.13E+08 CUL4A 0.009804 0.44 0.133333 0.666667 0.037037 CUL4A 13 13q34 1.13E+08 1.13E+08 LAMP1 0.009804 0.44 0.133333 0.666667 0.037037 LAMP1 13 13q34 1.13E+08 1.13E+08 GRTP1 0.009804 0.44 0.133333 0.666667 0.037037 GRTP1 13 13q34 1.13E+08 1.13E+08 TMCO3 0.009804 0.466667 0.133333 0.62963 0.037037 TMCO3 13 13q34 1.13E+08 1.13E+08 TFDP1 0.009804 0.466667 0.12 0.666667 0.037037 TFDP1 13 13q34 1.13E+08 1.13E+08 GRK1 0.009804 0.466667 0.12 0.666667 0.037037 GRK1 13 13q34 1.13E+08 1.13E+08 FLJ44054 0.009804 0.466667 0.12 0.666667 0.037037 FLJ44054 13 13q34 1.13E+08 1.14E+08 GAS6 0.009804 0.466667 0.12 0.666667 0.037037 GAS6 13 13q34 1.14E+08 1.14E+08 FAM70B 0.009804 0.466667 0.12 0.666667 0.037037 FAM70B 13 13q34 1.14E+08 1.14E+08 RASA3 0.009804 0.466667 0.12 0.666667 0.037037 RASA3 13 13q34 1.14E+08 1.14E+08 CDC16 0.009804 0.466667 0.12 0.666667 0.037037 CDC16 13 13q34 1.14E+08 1.14E+08 ZNF828 0.009804 0.466667 0.12 0.666667 0.037037 ZNF828 13 13q34 1.14E+08 1.14E+08 ACSM4 0.009804 0.146667 0.146667 0.37037 0.037037 ACSM4 12 12p13.31 7348195 7372237 LOC37444

0.009804 0.013333 0.2 0.074074 0.037037 LOC37444

12 12p13.31 9691910 9702276 CLECL1 0.009804 0.013333 0.2 0.037037 0.037037 CLECL1 12 12p13.31 9766358 9777128 CD69 0.009804 0.013333 0.2 0.037037 0.037037 CD69 12 12p13.31 9796351 9804755 CLEC2A 0.009804 0.026667 0.186667 0.037037 0.037037 CLEC2A 12 12p13.31 9957093 9976248 CLEC12A 0.009804 0.013333 0.213333 0.037037 0.037037 CLEC12A 12 12p13.2 10015275 10029462 CLEC1B 0.009804 0.04 0.186667 0.037037 0.037037 CLEC1B 12 12p13.2 10036929 10043167 CLEC12B 0.009804 0.026667 0.213333 0.037037 0.037037 CLEC12B 12 12p13.2 10054498 10062667 CLEC9A 0.009804 0.013333 0.213333 0.037037 0.037037 CLEC9A 12 12p13.2 10074543 10109833 CLEC1A 0.009804 0.013333 0.213333 0.037037 0.037037 CLEC1A 12 12p13.2 10114347 10142873 KLRC1 0.009804 0.013333 0.2 0.037037 0.037037 KLRC1 12 12p13.2 10489904 10497247 STYK1 0.009804 0.013333 0.16 0.037037 0.037037 STYK1 12 12p13.2 10662805 10718159 CSDA 0.009804 0.013333 0.16 0.037037 0.037037 CSDA 12 12p13.2 10742945 10767221 PLBD1 0.009804 0.106667 0.146667 0.074074 0.037037 PLBD1 12 12p13.1 14547864 14612059 GUCY2C 0.009804 0.08 0.146667 0.074074 0.037037 GUCY2C 12 12p13.1 14656836 14740787 PLEKHA5 0.009804 0.053333 0.12 0.037037 0.037037 PLEKHA5 12 12p12.3 19173915 19420599 SOX5 0.009804 0 0.253333 0 0.037037 SOX5 12 12p12.1 23576498 23993905 C12orf67 0.009804 0 0.24 0 0.037037 C12orf67 12 12p12.1 24611165 24628370 CCDC91 0.009804 0.013333 0.253333 0 0.037037 CCDC91 12 12p11.22 28301400 28594367 YAF2 0.009804 0.12 0.04 0.037037 0 YAF2 12 12q12 40837174 40918318 ADAMTS2

0.009804 0.026667 0.16 0.074074 0.037037 ADAMTS2

12 12q12 42034279 42231992 TWF1 0.009804 0.053333 0.106667 0.074074 0.037037 TWF1 12 12q12 42473793 42486446 TMEM117 0.009804 0.053333 0.106667 0.074074 0.037037 TMEM117 12 12q12 42516229 43069809 DBX2 0.009804 0.026667 0.12 0.074074 0.037037 DBX2 12 12q12 43694806 43731150 MON2 0.009804 0.16 0.013333 0.037037 0.037037 MON2 12 12q14.1 61146864 61277631 PPM1H 0.009804 0.173333 0.013333 0.037037 0.037037 PPM1H 12 12q14.1 61324031 61614933 C12orf66 0.009804 0.12 0.026667 0.037037 0 C12orf66 12 12q14.2 62872686 62902344 C12orf56 0.009804 0.12 0.026667 0.037037 0 C12orf56 12 12q14.2 62947032 63070613 TBK1 0.009804 0.146667 0.026667 0.037037 0 TBK1 12 12q14.2 63132204 63182159 GNS 0.009804 0.146667 0.026667 0.037037 0 GNS 12 12q14.2 -1 63393489 63439494 CPM 0.009804 0.106667 0.04 0.037037 0 CPM 12 12q15 67531225 67613247 CPSF6 0.009804 0.16 0.013333 0.037037 0 CPSF6 12 12q15 67919584 67954406 MIR1279 0.009804 0.16 0.013333 0.037037 0 MIR1279 12 12q15 67953204 67953265 FRS2 0.009804 0.146667 0.013333 0.037037 0 FRS2 12 12q15 68150396 68259830 CCT2 0.009804 0.146667 0.013333 0.037037 0 CCT2 12 12q15 68265475 68281625 BEST3 0.009804 0.146667 0.013333 0.037037 0 BEST3 12 12q15 68333656 68379464 ZDHHC17 0.009804 0.106667 0.066667 0.037037 0.111111 ZDHHC17 12 12q21.2 75681935 75771606 WDR51B 0.009804 0.106667 0.066667 0.037037 0.185185 WDR51B 12 12q21.33 88337634 88443909 EEA1 0.009804 0.106667 0.013333 0.037037 0 EEA1 12 12q22 91690416 91847239 NUDT4 0.009804 0.186667 0.013333 0.037037 0 NUDT4 12 12q22 92295832 92321156 NUDT4P1 0.009804 0.186667 0.013333 0.037037 0 NUDT4P1 12 12q22 92295877 92320183 SOCS2 0.009804 0.133333 0.013333 0.037037 0 SOCS2 12 12q22 92487729 92494110 CRADD 0.009804 0.133333 0.013333 0.037037 0 CRADD 12 12q22 92595282 92768663 ANKS1B 0.009804 0.12 0.066667 0.037037 0 ANKS1B 12 12q23.1 97653202 98072604 OR51A7 0.009804 0.053333 0.12 0.037037 0.037037 OR51A7 11 11p15.4 4885175 4886115 OR52A1 0.009804 0.013333 0.133333 0 0.037037 OR52A1 11 11p15.4 5129237 5130176 OR51V1 0.009804 0.013333 0.146667 0 0.037037 OR51V1 11 11p15.4 5177541 5178507 OR51B4 0.009804 0.013333 0.12 0 0.037037 OR51B4 11 11p15.4 5278820 5279753 OR51B5 0.009804 0.013333 0.133333 0 0.037037 OR51B5 11 11p15.4 5320392 5321331 OR51B6 0.009804 0.013333 0.133333 0 0.037037 OR51B6 11 11p15.4 5329314 5330253 UBQLN3 0.009804 0.013333 0.133333 0 0.037037 UBQLN3 11 11p15.4 5485106 5487730 UBQLNL 0.009804 0.013333 0.133333 0 0.037037 UBQLNL 11 11p15.4 5492199 5494533 TRIM6 0.009804 0.173333 0.013333 0.037037 0.037037 TRIM6 11 11p15.4 5573923 5590765 TRIM6-TRI

0.009804 0.173333 0.013333 0.037037 0.037037 TRIM6-TRI

11 11p15.4 5574460 5622200 TRIM34 0.009804 0.173333 0.013333 0.037037 0.037037 TRIM34 11 11p15.4 5597750 5622202 FAM160A2 0.009804 0.12 0.013333 0.037037 0 FAM160A2 11 11p15.4 6189140 6212518 CNGA4 0.009804 0.12 0.013333 0.037037 0 CNGA4 11 11p15.4 6216906 6222284 CCKBR 0.009804 0.12 0.013333 0.037037 0 CCKBR 11 11p15.4 6237542 6249933 PRKCDBP 0.009804 0.133333 0.013333 0.037037 0 PRKCDBP 11 11p15.4 6296752 6298317 SMPD1 0.009804 0.133333 0.013333 0.037037 0 SMPD1 11 11p15.4 6368231 6372803 APBB1 0.009804 0.133333 0.013333 0.037037 0 APBB1 11 11p15.4 6372931 6396877 HPX 0.009804 0.133333 0.013333 0.037037 0 HPX 11 11p15.4 6408844 6418831 TRIM3 0.009804 0.133333 0.013333 0.037037 0 TRIM3 11 11p15.4 6426419 6451782 ARFIP2 0.009804 0.133333 0.013333 0.037037 0 ARFIP2 11 11p15.4 6453502 6459172 FXC1 0.009804 0.133333 0.013333 0.037037 0 FXC1 11 11p15.4 6459253 6462488 DNHD1 0.009804 0.133333 0.013333 0.037037 0 DNHD1 11 11p15.4 6475102 6549829 RRP8 0.009804 0.2 0.013333 0.037037 0.037037 RRP8 11 11p15.4 6577728 6581388 ILK 0.009804 0.2 0.013333 0.037037 0.037037 ILK 11 11p15.4 6581540 6588676 TAF10 0.009804 0.2 0.013333 0.037037 0 TAF10 11 11p15.4 6588649 6590022 TPP1 0.009804 0.2 0.013333 0.037037 0 TPP1 11 11p15.4 6590573 6597269 RBMXL2 0.009804 0.013333 0.146667 0.037037 0.037037 RBMXL2 11 11p15.4 7066741 7068956 SYT9 0.009804 0.013333 0.12 0.037037 0.037037 SYT9 11 11p15.4 7229757 7446847 PDE3B 0.009804 0.04 0.106667 0.074074 0.037037 PDE3B 11 11p15.2 14621845 14850179 FSHB 0.009804 0.013333 0.186667 0.037037 0.037037 FSHB 11 11p14.1 30209139 30213401 MPPED2 0.009804 0.026667 0.173333 0 0.037037 MPPED2 11 11p14.1 30362616 30564507 CSTF3 0.009804 0.16 0.12 0.185185 0.037037 CSTF3 11 11p13 33062706 33139614 OR4C16 0.009804 0.026667 0.2 0.037037 0.037037 OR4C16 11 11q11 55096180 55097113 SPRYD5 0.009804 0.053333 0.186667 0.074074 0.037037 SPRYD5 11 11q11 55407349 55415859 ZFP91 0.009804 0.08 0.133333 0.148148 0.037037 ZFP91 11 11q12.1 58103163 58145092 ZFP91-CNT 0.009804 0.08 0.133333 0.148148 0.037037 ZFP91-CNT 11 11q12.1 58103163 58149780 CNTF 0.009804 0.08 0.133333 0.148148 0.037037 CNTF 11 11q12.1 58146722 58149780 C11orf73 0.009804 0.106667 0.026667 0.037037 0 C11orf73 11 11q14.2 85690901 85734633 ME3 0.009804 0.12 0.026667 0.037037 0 ME3 11 11q14.2 85829798 86060889 GRM5 0.009804 0.04 0.173333 0 0.037037 GRM5 11 11q14.2 87877393 88436465 MTMR2 0.009804 0.026667 0.133333 0.037037 0.037037 MTMR2 11 11q21 95205694 95297020 MAML2 0.009804 0.04 0.12 0.037037 0.037037 MAML2 11 11q21 95351088 95715993 CWF19L2 0.009804 0.053333 0.146667 0.074074 0.037037 CWF19L2 11 11q22.3 1.07E+08 1.07E+08 NCAM1 0.009804 0.106667 0.146667 0.333333 0.037037 NCAM1 11 11q23.1 1.12E+08 1.13E+08 C11orf71 0.009804 0.106667 0.12 0.333333 0.037037 C11orf71 11 11q23.2 1.14E+08 1.14E+08 RBM7 0.009804 0.106667 0.12 0.333333 0.037037 RBM7 11 11q23.2 1.14E+08 1.14E+08 FAM55A 0.009804 0.093333 0.146667 0.296296 0.037037 FAM55A 11 11q23.2 1.14E+08 1.14E+08 FAM55B 0.009804 0.093333 0.146667 0.333333 0.037037 FAM55B 11 11q23.2 1.14E+08 1.14E+08 LOC39995

0.009804 0.093333 0.133333 0.37037 0.037037 LOC39995

11 11q24.1 1.21E+08 1.22E+08 TMEM225 0.009804 0.053333 0.16 0.148148 0.037037 TMEM225 11 11q24.1 1.23E+08 1.23E+08 OR8G2 0.009804 0.053333 0.12 0.074074 0.037037 OR8G2 11 11q24.2 1.24E+08 1.24E+08 OR8D1 0.009804 0.04 0.16 0.111111 0.037037 OR8D1 11 11q24.2 1.24E+08 1.24E+08 OR8D2 0.009804 0.04 0.16 0.111111 0.037037 OR8D2 11 11q24.2 1.24E+08 1.24E+08 OR8B4 0.009804 0.04 0.12 0.111111 0.037037 OR8B4 11 11q24.2 1.24E+08 1.24E+08 OR8A1 0.009804 0.04 0.106667 0.111111 0.037037 OR8A1 11 11q24.2 1.24E+08 1.24E+08 DNAJC1 0.009804 0.106667 0.026667 0.037037 0.074074 DNAJC1 10 10p12.31 22085483 22332657 RTKN2 0.009804 0.066667 0.12 0 0.037037 RTKN2 10 10q21.2 63622959 63698473 ZNF365 0.009804 0.066667 0.12 0 0.037037 ZNF365 10 10q21.2 63803922 63832224 NRG3 0.009804 0.106667 0.106667 0.037037 0.074074 NRG3 10 10q23.1 83625050 84736916 RBM20 0.009804 0.12 0.08 0.037037 0.111111 RBM20 10 10q25.2 1.12E+08 1.13E+08 GLIS3 0.009804 0.013333 0.173333 0.037037 0.037037 GLIS3 9 9p24.2 3814128 4290036 C9orf70 0.009804 0.013333 0.173333 0.037037 0.037037 C9orf70 9 9p24.2 3888646 3891248 NFIB 0.009804 0.026667 0.106667 0 0.037037 NFIB 9 9p22.3 14071847 14303946 ADAMTSL1 0.009804 0.026667 0.16 0.037037 0.037037 ADAMTSL1 9 9p22.2 18464104 18900948 KIAA1797 0.009804 0.026667 0.12 0 0.037037 KIAA1797 9 9p21.3 20648309 20985955 PTPLAD2 0.009804 0.026667 0.146667 0.037037 0.037037 PTPLAD2 9 9p21.3 20996365 21021636 IFNW1 0.009804 0.04 0.146667 0 0.037037 IFNW1 9 9p21.3 21130631 21132145 IFNA21 0.009804 0.04 0.146667 0 0.037037 IFNA21 9 9p21.3 21155636 21156660 MOBKL2B 0.009804 0.133333 0.04 0.037037 0.037037 MOBKL2B 9 9p21.2 27315207 27519851 KIF9 0.009804 0.106667 0 0.037037 0 KIF9 9 9q21.11 72189333 72219394 RORB 0.009804 0.013333 0.146667 0.074074 0.037037 RORB 9 9q21.13 76302072 76491938 LPPR1 0.009804 0.026667 0.133333 0.148148 0.037037 LPPR1 9 9q31.1 1.03E+08 1.03E+08 MRPL50 0.009804 0.04 0.106667 0.111111 0.037037 MRPL50 9 9q31.1 1.03E+08 1.03E+08 ZNF189 0.009804 0.04 0.106667 0.111111 0.037037 ZNF189 9 9q31.1 1.03E+08 1.03E+08 ALDOB 0.009804 0.04 0.12 0.111111 0.037037 ALDOB 9 9q31.1 1.03E+08 1.03E+08 RNF20 0.009804 0.04 0.146667 0.111111 0.037037 RNF20 9 9q31.1 1.03E+08 1.03E+08 GRIN3A 0.009804 0.026667 0.146667 0.111111 0.037037 GRIN3A 9 9q31.1 1.03E+08 1.04E+08 ZNF462 0.009804 0.04 0.146667 0.074074 0.037037 ZNF462 9 9q31.2 1.09E+08 1.09E+08 DBC1 0.009804 0.12 0.106667 0.148148 0.037037 DBC1 9 9q33.1 1.21E+08 1.21E+08 ERICH1 0.009804 0.333333 0.186667 0.518519 0.037037 ERICH1 8 8p23.3 604200 671227 ASAH1 0.009804 0.106667 0.386667 0.037037 0.222222 ASAH1 8 8p22 17958205 17986788 DPYSL2 0.009804 0.106667 0.36 0.037037 0.185185 DPYSL2 8 8p21.2 26491338 26571611 STMN4 0.009804 0.133333 0.346667 0.037037 0.185185 STMN4 8 8p21.2 27149731 27171821 TRIM35 0.009804 0.133333 0.346667 0.037037 0.185185 TRIM35 8 8p21.2 27198321 27224752 PTK2B 0.009804 0.146667 0.346667 0.037037 0.185185 PTK2B 8 8p21.2 27224916 27372821 EPHX2 0.009804 0.146667 0.346667 0.037037 0.185185 EPHX2 8 8p21.1 27404562 27458404 CLU 0.009804 0.146667 0.346667 0.037037 0.185135 CLU 8 8p21.1 27510368 27528245 SCARA3 0.009804 0.12 0.373333 0.037037 0.185185 SCARA3 8 8p21.1 27547496 27586457 CCDC25 0.009804 0.106667 0.346667 0.037037 0.185185 CCDC25 8 8p21.1 27646752 27686090 ESCO2 0.009804 0.106667 0.346667 0.037037 0.185185 ESCO2 8 8p21.1 27687977 27718344 PBK 0.009804 0.146667 0.346667 0.037037 0.185185 PBK 8 8p21.1 27723057 27751269 SCARA5 0.009804 0.173333 0.346667 0.037037 0.185185 SCARA5 8 8p21.1 27783669 27906118 C8orf80 0.009804 0.16 0.346667 0.037037 0.185185 C8orf80 8 8p21.1 27935400 27997308 ELP3 0.009804 0.16 0.346667 0.037037 0.185185 ELP3 8 8p21.1 28006503 28104589 PNOC 0.009804 0.16 0.346667 0.037037 0.185185 PNOC 8 8p21.1 28230568 28256788 FBXO16 0.009804 0.106667 0.346667 0.037037 0.185185 FBXO16 8 8p21.1 28341848 28403704 EXTL3 0.009804 0.106667 0.346667 0.037037 0.185185 EXTL3 8 8p21.1 28615072 28667122 INTS9 0.009804 0.106667 0.346667 0.037037 0.185185 INTS9 8 8p21.1 28681099 28803618 KIF13B 0.009804 0.12 0.36 0.037037 0.185185 KIF13B 8 8p21.1 28980714 29176530 DUSP4 0.009804 0.106667 0.346667 0.037037 0.185185 DUSP4 8 8p21.1 29249537 29262242 FUT10 0.009804 0.16 0.36 0.037037 0.296296 FUT10 8 8p12 33347886 33450207 SNTG1 0.009804 0.12 0.16 0.111111 0.037037 SNTG1 8 8q11.22 50987150 51867981 ST18 0.009804 0.12 0.133333 0.111111 0.037037 ST18 8 8q11.23 53185945 53484993 MIR124-2 0.009804 0.106667 0.133333 0.111111 0.037037 MIR124-2 8 8q12.3 65454260 65454367 C8orf34 0.009804 0.133333 0.146667 0.111111 0.037037 C8orf34 8 8q13.2 69512702 69893812 KCNB2 0.009804 0.133333 0.106667 0.111111 0.037037 KCNB2 8 8q13.3 73612180 74013139 PGCP 0.009804 0.16 0.106667 0.148148 0.037037 PGCP 8 8q22.1 97726675 98224899 C1GALT1 0.009804 0.133333 0.106667 0.111111 0.037037 C1GALT1 7 7p21.3 7188771 7250507 EEPD1 0.009804 0.146667 0.013333 0.037037 0 EEPD1 7 7p14.2 36159361 36307678 ANLN 0.009804 0.16 0 0.037037 0 ANLN 7 7p14.2 36395957 36459926 AOAH 0.009804 0.12 0 0.037037 0 AOAH 7 7p14.2 36519133 36730679 RALA 0.009804 0.133333 0 0.037037 0 RALA 7 7p14.1 39629687 39714243 LOC34911

0.009804 0.146667 0 0.037037 0 LOC34911

7 7p14.1 39739692 39800747 CDK13 0.009804 0.186667 0 0.037037 0 CDK13 7 7p14.1 39956484 40103257 C7orf10 0.009804 0.2 0 0.037037 0 C7orf10 7 7p14.1 40141100 40866883 PION 0.009804 0.133333 0 0.037037 0.074074 PION 7 7q11.23 76778004 76883654 PTPN12 0.009804 0.146667 0.013333 0.037037 0.074074 PTPN12 7 7q11.23 77004709 77107325 TMEM60 0.009804 0.186667 0.013333 0.037037 0.074074 TMEM60 7 7q11.23 77260982 77265684 PHTF2 0.009804 0.186667 0.013333 0.037037 0.074074 PHTF2 7 7q11.23 77266045 77424758 MAGI2 0.009804 0.186667 0 0.037037 0.074074 MAGI2 7 7q21.11 77484310 78920827 SEMA3C 0.009804 0.146667 0.146667 0.037037 0.148148 SEMA3C 7 7q21.11 80209790 80386604 CACNA2D1 0.009804 0.16 0.133333 0.037037 0.296296 CACNA2D1 7 7q21.11 81417354 81910968 SEMA3A 0.009804 0.12 0.16 0.037037 0.333333 SEMA3A 7 7q21.11 83425595 83662154 MTERF 0.009804 0.186667 0.026667 0.037037 0 MTERF 7 7q21.2 91339957 91347953 AKAP9 0.009804 0.213333 0 0.037037 0 AKAP9 7 7q21.2 91408125 91577923 CYP51A1 0.009804 0.173333 0 0.037037 0 CYP51A1 7 7q21.2 91579399 91601777 LOC40138

0.009804 0.173333 0 0.037037 0 LOC40138

7 7q21.2 91612134 91632527 KRIT1 0.009804 0.173333 0.013333 0.037037 0 KRIT1 7 7q21.2 91666219 91713165 CCDC132 0.009804 0.08 0.146667 0.037037 0.037037 CCDC132 7 7q21.3 92699589 92826275 GNGT1 0.009804 0.08 0.16 0.074074 0.037037 GNGT1 7 7q21.3 93373756 93378422 NRCAM 0.009804 0.133333 0.08 0.037037 0.037037 NRCAM 7 7q31.1 1.08E+08 1.08E+08 IFRD1 0.009804 0.12 0.04 0.037037 0.074074 IFRD1 7 7q31.1 1.12E+08 1.12E+08 MET 0.009804 0.066667 0.106667 0.074074 0.037037 MET 7 7q31.2 1.16E+08 1.16E+08 ST7 0.009804 0.106667 0.066667 0.037037 0.111111 ST7 7 7q31.2 1.16E+08 1.17E+08 ST7OT3 0.009804 0.106667 0.066667 0.037037 0.111111 ST7OT3 7 7q31.2 1.17E+08 1.17E+08 MBOAT1 0.009804 0.106667 0.013333 0.037037 0 MBOAT1 6 6p22.3 20208914 20320650 E2F3 0.009804 0.12 0.013333 0.037037 0 E2F3 6 6p22.3 20510116 20601925 CDKAL1 0.009804 0.146667 0.013333 0.037037 0 CDKAL1 6 6p22.3 20642667 21339744 SOX4 0.009804 0.173333 0.013333 0.037037 0 SOX4 6 6p22.3 21701951 21706829 FLJ22536 0.009804 0.16 0.013333 0.037037 0 FLJ22536 6 6p22.3 21774654 22302594 ZNRD1 0.009804 0.266667 0.106667 0.444444 0.037037 ZNRD1 6 6p21.33 30137015 30140666 DNAH8 0.009804 0.186667 0.133333 0.555556 0.037037 DNAH8 6 6p21.2 38798530 39106546 MIR206 0.009804 0.013333 0.106667 0.037037 0.037037 MIR206 6 6p12.2 52117106 52117192 MIR133B 0.009804 0.013333 0.106667 0.037037 0.037037 MIR133B 6 6p12.2 52121680 52121798 PAQR8 0.009804 0.12 0.013333 0.037037 0.037037 PAQR8 6 6p12.2 52334885 52380535 BACH2 0.009804 0.16 0.2 0.037037 0.185185 BACH2 6 6q15 90692969 91063349 SOBP 0.009804 0.12 0.16 0.037037 0.074074 SOBP 6 6q21 1.08E+08 1.08E+08 SCML4 0.009804 0.146667 0.146667 0.037037 0.074074 SCML4 6 6q21 1.08E+08 1.08E+08 SEC63 0.009804 0.146667 0.146667 0.037037 0.074074 SEC63 6 6q21 1.08E+08 1.08E+08 OSTM1 0.009804 0.146667 0.146667 0.037037 0.074074 OSTM1 6 6q21 1.08E+08 1.09E+08 NR2E1 0.009804 0.146667 0.146667 0.037037 0.074074 NR2E1 6 6q21 1.09E+08 1.09E+08 SNX3 0.009804 0.146667 0.146667 0.037037 0.074074 SNX3 6 6q21 1.09E+08 1.09E+08 LACE1 0.009804 0.146667 0.146667 0.037037 0.074074 LACE1 6 6q21 1.09E+08 1.09E+08 FOXO3 0.009804 0.146667 0.146667 0.037037 0.074074 FOXO3 6 6q21 1.09E+08 1.09E+08 ARMC2 0.009804 0.146667 0.146667 0.037037 0.074074 ARMC2 6 6q21 1.09E+08 1.09E+08 SESN1 0.009804 0.133333 0.146667 0.037037 0.074074 SESN1 6 6q21 1.09E+08  1.1E+08 PPIL6 0.009804 0.146667 0.146667 0.037037 0.074074 PPIL6 6 6q21  1.1E+08  1.1E+08 SLC22A16 0.009804 0.133333 0.133333 0.037037 0.111111 SLC22A16 6 6q21 1.11E+08 1.11E+08 CDK19 0.009804 0.146667 0.133333 0.037037 0.111111 CDK19 6 6q21 1.11E+08 1.11E+08 SLC16A10 0.009804 0.133333 0.133333 0.037037 0.111111 SLC16A10 6 6q21 1.12E+08 1.12E+08 KIAA1919 0.009804 0.146667 0.133333 0.037037 0.111111 KIAA1919 6 6q21 1.12E+08 1.12E+08 REV3L 0.009804 0.133333 0.146667 0.037037 0.111111 REV3L 6 6q21 1.12E+08 1.12E+08 TRAF3IP2 0.009804 0.146667 0.145667 0.037037 0.111111 TRAF3IP2 6 6q21 1.12E+08 1.12E+08 FYN 0.009804 0.133333 0.133333 0.037037 0.148148 FYN 6 6q21 1.12E+08 1.12E+08 SGK1 0.009804 0.133333 0.026667 0.037037 0 SGK1 6 6q23.2 1.35E+08 1.35E+08 ALDH8A1 0.009804 0.12 0.026667 0.037037 0 ALDH8A1 6 6q23.3 1.35E+08 1.35E+08 C6orf217 0.009804 0 0.16 0 0.037037 C6orf217 6 6q23.3 1.36E+08 1.36E+08 PDE7B 0.009804 0 0.173333 0 0.037037 PDE7B 6 6q23.3 1.36E+08 1.37E+08 NHSL1 0.009804 0.146667 0.04 0.037037 0 NHSL1 6 6q23.3 1.39E+08 1.39E+08 CCDC28A 0.009804 0.146667 0.04 0.037037 0 CCDC28A 6 6q24.1 1.39E+08 1.39E+08 ECT2L 0.009804 0.146667 0.04 0.037037 0 ECT2L 6 6q24.1 1.39E+08 1.39E+08 C6orf115 0.009804 0.146667 0.04 0.037037 0 C6orf115 6 6q24.1 1.39E+08 1.39E+08 HECA 0.009804 0.146667 0.04 0.037037 0 HECA 6 6q24.1 1.39E+08  1.4E+08 TXLNB 0.009804 0.146667 0.04 0.037037 0 TXLNB 6 6q24.1  1.4E+08  1.4E+08 LOC15391

0.009804 0 0.146667 0.037037 0.037037 LOC15391

6 6q24.1 - 6c 1.43E+08 1.43E+08 MLLT4 0.009804 0.186667 0.106667 0.37037 0.037037 MLLT4 6 6q27 1.68E+08 1.68E+08 BASP1 0.009804 0.146667 0.013333 0.037037 0.037037 BASP1 5 5p15.1 17270750 17329944 TTC33 0.009804 0.173333 0 0.037037 0 TTC33 5 5p13.1 40747435 40791830 PRKAA1 0.009804 0.173333 0 0.037037 0 PRKAA1 5 5p13.1 40795238 40834055 RPL37 0.009804 0.173333 0 0.037037 0 RPL37 5 5p13.1 40867187 40871145 SNORD72 0.009804 0.173333 0 0.037037 0 SNORD72 5 5p13.1 40868515 40868595 CARD6 0.009804 0.173333 0 0.037037 0 CARD6 5 5p13.1 40877167 40891214 C7 0.009804 0.04 0.12 0 0.037037 C7 5 5p13.1 40945356 41018799 HEATR7B2 0.009804 0.013333 0.12 0 0.037037 HEATR7B2 5 5p13.1 41033879 41107202 C6 0.009804 0.013333 0.133333 0 0.037037 C6 5 5p13.1 41178093 41249425 PLCXD3 0.009804 0.013333 0.133333 0 0.037037 PLCXD3 5 5p13.1 41342805 41546488 OXCT1 0.009804 0.013333 0.12 0 0.037037 OXCT1 5 5p13.1 41765924 41906549 C5orf51 0.009804 0.013333 0.12 0 0.037037 C5orf51 5 5p13.1 41940227 41957496 FBXO4 0.009804 0.013333 0.12 0 0.037037 FBXO4 5 5p13.1 41961113 41977430 GHR 0.009804 0.013333 0.133333 0 0.037037 GHR 5 5p12 42459783 42757684 SEPP1 0.009804 0.04 0.12 0 0.037037 SEPP1 5 5p12 42835739 42847782 MGC42105 0.009804 0.146667 0 0.037037 0 MGC42105 5 5p12 43228084 43316710 HMGCS1 0.009804 0.146667 0 0.037037 0 HMGCS1 5 5p12 43325250 43349353 C5orf28 0.009804 0.16 0.013333 0.037037 0 C5orf28 5 5p12 43480111 43519750 PAIP1 0.009804 0.133333 0.04 0.037037 0 PAIP1 5 5p12 43562127 43592953 ARL15 0.009804 0.04 0.16 0 0.037037 ARL15 5 5q11.2 53216371 53642161 HSPB3 0.009804 0.026667 0.146667 0 0.037037 HSPB3 5 5q11.2 53787202 53787965 GZMA 0.009804 0.04 0.16 0.037037 0.057037 GZMA 5 5q11.2 54434231 54441838 CDC20B 0.009804 0.04 0.16 0.037037 0.037037 CDC20B 5 5q11.2 54444556 54504763 CCNO 0.009804 0.08 0.133333 0.037037 0.037037 CCNO 5 5q11.2 54562738 54565266 DHX29 0.009804 0.08 0.133333 0.037037 0.037037 DHX29 5 5q11.2 54587830 54639279 SKIV2L2 0.009804 0.08 0.133333 0.037037 0.037037 SKIV2L2 5 5q11.2 54639333 54757167 PPAP2A 0.009804 0.08 0.146667 0.037037 0.037037 PPAP2A 5 5q11.2 54756440 54866631 SLC38A9 0.009804 0.093333 0.146667 0.037037 0.037037 SLC38A9 5 5q11.2 54957433 55043921 BDP1 0.009804 0.146667 0.12 0.037037 0.074074 BDP1 5 5q13.2 70787198 70899406 MCCC2 0.009804 0.133333 0.12 0.037037 0.074074 MCCC2 5 5q13.2 70918871 70990287 TMEM174 0.009804 0.08 0.12 0.037037 0.037037 TMEM174 5 5q13.2 72504779 72506725 FOXD1 0.009804 0.066667 0.106667 0.037037 0.037037 FOXD1 5 5q13.2 72777841 72780109 SV2C 0.009804 0.013333 0.16 0.037037 0.037037 SV2C 5 5q13.3 75415061 75657173 F2R 0.009804 0.146667 0.08 0.037037 0.037037 F2R 5 5q13.3 76047624 76067352 F2R11 0.009804 0.133333 0.08 0.037037 0.037037 F2RL1 5 5q13.3 76150589 76166896 S100Z 0.009804 0.133333 0.08 0.037037 0.037037 S100Z 5 5q13.3 76181882 76252813 LHFPL2 0.009804 0.106667 0.08 0.037037 0.037037 LHFPL2 5 5q14.1 77816794 77980405 DMGDH 0.009804 0.08 0.133333 0.037037 0.037037 DMGDH 5 5q14.1 78329185 78401206 BHMT2 0.009804 0.133333 0.08 0.037037 0.037037 BHMT2 5 5q14.1 78401339 78421032 BHMT 0.009804 0.133333 0.08 0.037037 0.037037 BHMT 5 5q14.1 78443360 78463870 JMY 0.009804 0.133333 0.08 0.037037 0.037037 JMY 5 5q14.1 78567710 78658793 HOMER1 0.009804 0.133333 0.08 0.037037 0.037037 HOMER1 5 5q14.1 78705542 78845457 CMYA5 0.009804 0.12 0.08 0.037037 0.037037 CMYA5 5 5q14.1 79021415 79131806 THBS4 0.009804 0.146667 0.08 0.037037 0.037037 THBS4 5 5q14.1 79366747 79414864 SERINC5 0.009804 0.146667 0.08 0.037037 0.037037 SERINC5 5 5q14.1 79443230 79587627 FAM151B 0.009804 0.146667 0.093333 0.037037 0.037037 FAM151B 5 5q14.1 79819556 79873963 MSH3 0.009804 0.08 0.12 0.037037 0.037037 MSH3 5 5q14.1 79986050 80208391 3-Mar 0.009804 0.106667 0.08 0.037037 0.074074 3-Mar 5 5q23.2 1.26E+08 1.26E+08 STK32A 0.009804 0.013333 0.133333 0 0.037037 STK32A 5 5q32 1.47E+08 1.47E+08 TTC1 0.009804 0.133333 0.026667 0.037037 0.074074 TTC1 5 5q33.3 1.59E+08 1.59E+08 HSP90AB2

0.009804 0.013333 0.146667 0 0.037037 HSP90AB2

4 4p15.33 12944135 12949024 RAB28 0.009804 0.013333 0.16 0 0.037037 RAB28 4 4p15.33 12978445 13095088 KCNIP4 0.009804 0.026667 0.213333 0 0.037037 KCNIP4 4 4p15.31 20339337 21308417 PPARGC1A 0.009804 0.026667 0.226667 0 0.037037 PPARGC1A 4 4p15.2 23402742 23500799 LGI2 0.009804 0.106667 0.053333 0.037037 0 LGI2 4 4p15.2 24609569 24641513 SEPSECS 0.009804 0.12 0.066667 0.037037 0 SEPSECS 4 4p15.2 24730726 24771303 PI4K2B 0.009804 0.12 0.053333 0.037037 0 PI4K2B 4 4p15.2 24844751 24889930 ZCCHC4 0.009804 0.12 0.053333 0.037037 0 ZCCHC4 4 4p15.2 24923494 24981104 TLR10 0.009804 0.053333 0.186667 0.037037 0.037037 TLR10 4 4p14 38450647 38460985 UCHL1 0.009804 0.106667 0.053333 0.037037 0 UCHL1 4 4p13 40953655 40965203 LIMCH1 0.009804 0.106667 0.053333 0.037037 0 LIMCH1 4 4p13 41057561 41396819 PHOX2B 0.009804 0.133333 0.066667 0.037037 0 PHOX2B 4 4p13 41440856 41445745 TMEM33 0.009804 0.146667 0.053333 0.037037 0 TMEM33 4 4p13 41631894 41657582 SLC30A9 0.009804 0.16 0.053333 0.037037 0.037037 SLC30A9 4 4p13 41687280 41784309 BEND4 0.009804 0.16 0.053333 0.037037 0.037037 BEND4 4 4p13 41807629 41849653 RASL11B 0.009804 0.12 0 0.037037 0 RASL11B 4 4q12 53423252 53427760 SCFD2 0.009804 0.12 0 0.037037 0 SCFD2 4 4q12 53433908 53927000 PDGFRA 0.009804 0.106667 0.013333 0.037037 0 PDGFRA 4 4q12 54790021 54859170 AFP 0.009804 0.04 0.133333 0 0.037037 AFP 4 4q13.3 74520797 74540357 AFM 0.009804 0.04 0.133333 0 0.037037 AFM 4 4q13.3 74566326 74588583 RASSF6 0.009804 0.04 0.12 0 0.037037 RASSF6 4 4q13.3 74657726 74704999 CXCL6 0.009804 0.04 0.146667 0 0.037037 CXCL6 4 4q13.3 74921137 74923342 PPBPL1 0.009804 0.04 0.146667 0 0.037037 PPBPL1 4 4q13.3 74932447 74933418 PF4 0.009804 0.04 0.146667 0 0.037037 PF4 4 4q13.3 75065660 75066580 PPBP 0.009804 0.04 0.146667 0 0.037037 PPBP 4 4q13.3 75071620 75072765 CXCL3 0.009804 0.04 0.146667 0 0.037037 CXCL3 4 4q13.3 75121176 75123355 CXCL2 0.009804 0.04 0.146667 0 0.037037 CXCL2 4 4q13.3 75181618 75183862 MTHFD2L 0.009804 0.04 0.16 0 0.037037 MTHFD2L 4 4q13.3 75242693 75387677 AREG 0.009804 0.04 0.146667 0 0.037037 AREG 4 4q13.3 75699653 75709510 BTC 0.009804 0.066667 0.133333 0 0.037037 BTC 4 4q13.3 75890472 75938907 C4orf26 0.009804 0.133333 0.013333 0.037037 0 C4orf26 4 4q21.1 76700232 76708952 CDKL2 0.009804 0.106667 0.026667 0.037037 0 CDKL2 4 4q21.1 76720728 76774746 G3BP2 0.009804 0.12 0.013333 0.037037 0 G3BP2 4 4q21.1 76786977 76817368 ARD1B 0.009804 0.026667 0.226667 0 0.037037 ARD1B 4 4q21.21 80457296 80466196 GDEP 0.009804 0.026667 0.213333 0 0.037037 GDEP 4 4q21.21 80967649 81003424 PRDM8 0.009804 0.04 0.16 0 0.037037 PRDM8 4 4q21.21 81325448 81344507 C4orf22 0.009804 0.026667 0.16 0 0.037037 C4orf22 4 4q21.21 81475898 82103927 BMP3 0.009804 0.026667 0.186667 0 0.037037 BMP3 4 4q21.21 82171143 82197710 PRKG2 0.009804 0.026667 0.173333 0 0.037037 PRKG2 4 4q21.21 82228861 82345240 RASGEF1B 0.009804 0.053333 0.12 0 0.037037 RASGEF1B 4 4q21.21 82567243 82612086 TMEM150

0.009804 0.173333 0.04 0.037037 0 TMEM150

4 4q21.22 83624628 83702151 SCD5 0.009804 0.173333 0.04 0.037037 0 SCD5 4 4q21.22 83769714 83939035 SEC31A 0.009804 0.173333 0.04 0.037037 0 SEC31A 4 4q21.22 83958838 84031425 COPS4 0.009804 0.173333 0.04 0.037037 0 COPS4 4 4q21.22 84175263 84215996 PLAC8 0.009804 0.173333 0.04 0.037037 0 PLAC8 4 4q21.22 84230235 84250037 COQ2 0.009804 0.173333 0.04 0.037037 0 COQ2 4 4q21.23 84404002 84425092 HPSE 0.009804 0.173333 0.04 0.037037 0 HPSE 4 4q21.23 84435492 84475059 HELQ 0.009804 0.173333 0.04 0.037037 0 HELQ 4 4q21.23 84547523 84596050 MRPS18C 0.009804 0.173333 0.04 0.037037 0 MRPS18C 4 4q21.23 84596142 84601954 FAM175A 0.009804 0.173333 0.04 0.037037 0 FAM175A 4 4q21.23 84601120 84625315 AGPAT9 0.009804 0.173333 0.04 0.037037 0 AGPAT9 4 4q21.23 84676677 84746051 C4orf12 0.009804 0.026667 0.133333 0 0.037037 C4orf12 4 4q21.23 86106995 86147193 MAPK10 0.009804 0.026667 0.146667 0 0.037037 MAPK10 4 4q21.3 87155300 87593308 PKD2 0.009804 0.12 0.013333 0.037037 0 PKD2 4 4q22.1 89147844 89217954 ABCG2 0.009804 0.12 0.013333 0.037037 0 ABCG2 4 4q22.1 89230440 89299036 PPM1K 0.009804 0.133333 0.013333 0.037037 0 PPM1K 4 4q22.1 89400556 89424913 HERC6 0.009804 0.12 0.013333 0.037037 0 HERC6 4 4q22.1 89518915 89583272 HERC5 0.009804 0.12 0.013333 0.037037 0 HERC5 4 4q22.1 89597291 89646338 PIGY 0.009804 0.12 0.013333 0.037037 0 PIGY 4 4q22.1 89661158 89663979 ANK2 0.009804 0.16 0.053333 0.037037 0.074074 ANK2 4 4q25 1.14E+08 1.15E+08 CEP170L 0.009804 0.12 0.16 0.037037 0.185185 CEP170L 4 4q26  1.2E+08  1.2E+08 MFSD8 0.009804 0.146667 0.08 0.037037 0.111111 MFSD8 4 4q28.1 - 4c 1.29E+08 1.29E+08 C4orf29 0.009804 0.146667 0.08 0.037037 0.111111 C4orf29 4 4q28-2 1.29E+08 1.29E+08 LARP1B 0.009804 0.146667 0.066667 0.037037 0.111111 LARP1B 4 4q28.2 1.29E+08 1.29E+08 USP38 0.009804 0.013333 0.186667 0 0.037037 USP38 4 4q31.21 1.44E+08 1.44E+08 GYPA 0.009804 0.013333 0.16 0 0.037037 GYPA 4 4q31.22 1.45E+08 1.45E+08 TMEM184

0.009804 0.12 0 0.037037 0 TMEM184

4 4q31.23 1.49E+08 1.49E+08 PRMT10 0.009804 0.12 0 0.037037 0 PRMT10 4 4q31.23 1.49E+08 1.49E+08 ARHGAP10 0.009804 0.133333 0 0.037037 0 ARHGAP10 4 4q31.23 1.49E+08 1.49E+08 NR3C2 0.009804 0.106667 0 0.037037 0 NR3C2 4 4q31.23 1.49E+08  1.5E+08 DCLK2 0.009804 0.12 0.026667 0.037037 0.037037 DCLK2 4 4q31.3 1.51E+08 1.51E+08 LRBA 0.009804 0.013333 0.133333 0.037037 0.037037 LRBA 4 4q31.3 1.51E+08 1.52E+08 ANXA2P1 0.009804 0.186667 0.013333 0.037037 0.037037 ANXA2P1 4 4q31.3 1.54E+08 1.54E+08 MND1 0.009804 0.186667 0.013333 0.037037 0.037037 MND1 4 4q31.3 1.54E+08 1.55E+08 KIAA0922 0.009804 0.186667 0.013333 0.037037 0.037037 KIAA0922 4 4q31.3 1.55E+08 1.55E+08 DCHS2 0.009804 0.026667 0.12 0 0.037037 DCHS2 4 4q32.1 1.55E+08 1.56E+08 FGB 0.009804 0.026667 0.12 0 0.037037 FGB 4 4q32.1 1.56E+08 1.56E+08 FGA 0.009804 0.026667 0.12 0 0.037037 FGA 4 4q32.1 1.56E+08 1.56E+08 FGG 0.009804 0.026667 0.12 0 0.037037 FGG 4 4q32.1 1.56E+08 1.56E+08 RBM46 0.009804 0.026667 0.12 0 0.037037 RBM46 4 4q32.1 1.56E+08 1.56E+08 RXFP1 0.009804 0.08 0.106667 0 0.037037 RXFP1 4 4q32.1  1.6E+08  1.6E+08 SH3RF1 0.009804 0.12 0.026667 0.037037 0.037037 SH3RF1 4 4q32.3  1.7E+08  1.7E+08 NEK1 0.009804 0.12 0.026667 0.037037 0.037037 NEK1 4 4q33 1.71E+08 1.71E+08 CLCN3 0.009804 0.12 0.04 0.037037 0.037037 CLCN3 4 4q33 1.71E+08 1.71E+08 C4orf27 0.009804 0.12 0.04 0.037037 0.037037 C4orf27 4 4q33 1.71E+08 1.71E+08 MFAP3L 0.009804 0.12 0.04 0.037037 0.037037 MFAP3L 4 4q33 1.71E+08 1.71E+08 AADAT 0.009804 0.106667 0.053333 0.037037 0.037037 AADAT 4 4q33 1.71E+08 1.71E+08 IL5RA 0.009804 0.106667 0.026667 0.037037 0.037037 IL5RA 3 3p26.3 3086401 3127059 TRNT1 0.009804 0.106667 0.026667 0.037037 0.037037 TRNT1 3 3p26.3 3143600 3155707 GRM7 0.009804 0.013333 0.146667 0.037037 0.037037 GRM7 3 3p26.1 6877802 7758219 DVWA 0.009804 0.093333 0.133333 0.296296 0.037037 DVWA 3 3p24.3 15181875 15222471 RAB5A 0.009804 0.186667 0.026667 0.037037 0.037037 RAB5A 3 3p24.3 19963576 20001663 C3orf48 0.009804 0.186667 0.026667 0.037037 0.037037 C3orf48 3 3p24.3 19996458 20028770 KAT2B 0.009804 0.173333 0.04 0.037037 0.037037 KAT2B 3 3p24.3 20056528 20170901 THRB 0.009804 0.026667 0.146667 0.037037 0.037037 THRB 3 3p24.2 24133649 24511318 FAM19A1 0.009804 0.013333 0.133333 0 0.037037 FAM19A1 3 3p14.1 68136144 68677462 ARL13B 0.009804 0.106667 0.173333 0.037037 0.333333 ARL13B 3 3q11.2 95181672 95256814 STX19 0.009804 0.106667 0.173333 0.037037 0.333333 STX19 3 3q11.2 95215905 95230145 DHFRL1 0.009804 0.106667 0.173333 0.037037 0.333333 DHFRL1 3 3q11.2 95259456 95264351 RG9MTD1 0.009804 0.186667 0 0.037037 0.148148 RG9MTD1 3 3q12.3 1.03E+08 1.03E+08 PCNP 0.009804 0.186667 0 0.037037 0.148148 PCNP 3 3q12.3 1.03E+08 1.03E+08 ZBTB11 0.009804 0.186667 0 0.037037 0.148148 ZBTB11 3 3q12.3 1.03E+08 1.03E+08 LOC10000

0.009804 0.186667 0 0.037037 0.148148 LOC10000

3 3q12.3 1.03E+08 1.03E+08 RPL24 0.009804 0.186667 0 0.037037 0.148148 RPL24 3 3q12.3 1.03E+08 1.03E+08 CEP97 0.009804 0.173333 0 0.037037 0.148148 CEP97 3 3q12.3 1.03E+08 1.03E+08 FAM55C 0.009804 0.173333 0 0.037037 0.148148 FAM55C 3 3q12.3 1.03E+08 1.03E+08 NFKBIZ 0.009804 0.16 0 0.037037 0.148148 NFKBIZ 3 3q12.3 1.03E+08 1.03E+08 LOC15222

0.009804 0.16 0 0.037037 0.148148 LOC15222

3 3q12.3 1.03E+08 1.03E+08 BOC 0.009804 0.146667 0 0.037037 0.074074 BOC 3 3q13.2 1.14E+08 1.14E+08 NAT13 0.009804 0.173333 0 0.037037 0.074074 NAT13 3 3q13.2 1.15E+08 1.15E+08 GRAMD1C 0.009804 0.186667 0 0.037037 0.074074 GRAMD1C 3 3q13.31 1.15E+08 1.15E+08 KIAA1407 0.009804 0.106667 0.08 0.037037 0.074074 KIAA1407 3 3q13.31 1.15E+08 1.15E+08 QTRTD1 0.009804 0.106667 0.08 0.037037 0.074074 QTRTD1 3 3q13.31 1.15E+08 1.15E+08 DRD3 0.009804 0.133333 0.053333 0.037037 0.074074 DRD3 3 3q13.31 1.15E+08 1.15E+08 ZNF80 0.009804 0.12 0.053333 0.037037 0.074074 ZNF80 3 3q13.31 1.15E+08 1.15E+08 COL6A6 0.009804 0.093333 0.12 0.074074 0.037037 COL6A6 3 3q22.1 1.32E+08 1.32E+08 ATP2C1 0.009804 0.093333 0.12 0.074074 0.037037 ATP2C1 3 3q22.1 1.32E+08 1.32E+08 ASTE1 0.009804 0.106667 0.106667 0.074074 0.037037 ASTE1 3 3q22.1 1.32E+08 1.32E+08 NEK11 0.009804 0.106667 0.106667 0.074074 0.037037 NEK11 3 3q22.1 1.32E+08 1.33E+08 MRPL3 0.009804 0.093333 0.12 0.074074 0.037037 MRPL3 3 3q22.1 1.33E+08 1.33E+08 CPNE4 0.009804 0.093333 0.133333 0.074074 0.037037 CPNE4 3 3q22.1 1.33E+08 1.33E+08 AADACL2 0.009804 0.04 0.106667 0 0.037037 AADACL2 3 3q25.1 1.53E+08 1.53E+08 LOC40109

0.009804 0.04 0.106667 0 0.037037 LOC40109

3 3q25.1 1.53E+08 1.53E+08 MBNL1 0.009804 0.04 0.106667 0 0.037037 MBNL1 3 3q25.1 1.53E+08 1.54E+08 P2RY1 0.009804 0.04 0.12 0 0.037037 P2RY1 3 3q25.2 1.54E+08 1.54E+08 C3orf79 0.009804 0.04 0.106667 0.037037 0.037037 C3orf79 3 3q25.2 1.55E+08 1.55E+08 SGEF 0.009804 0.04 0.12 0.037037 0.037037 SGEF 3 3q25.2 1.55E+08 1.55E+08 DHX36 0.009804 0.04 0.106667 0.037037 0.037037 DHX36 3 3q25.2 1.55E+08 1.56E+08 MME 0.009804 0.04 0.106667 0.037037 0.037037 MME 3 3q25.31 1.56E+08 1.56E+08 SLC33A1 0.009804 0.186667 0 0.037037 0 SLC33A1 3 3q25.31 1.57E+08 1.57E+08 GMPS 0.009804 0.186667 0 0.037037 0 GMPS 3 3q25.31 1.57E+08 1.57E+08 CCNL1 0.009804 0.12 0.04 0.037037 0 CCNL1 3 3q25.32 1.58E+08 1.58E+08 GFM1 0.009804 0.106667 0.04 0.037037 0 GFM1 3 3q25.32  1.6E+08  1.6E+08 LXN 0.009804 0.106667 0.04 0.037037 0 LXN 3 3q25.32  1.6E+08  1.6E+08 SKIL 0.009804 0.226667 0 0.037037 0.037037 SKIL 3 3q26.2 1.72E+08 1.72E+08 CLDN11 0.009804 0.226667 0 0.037037 0.037037 CLDN11 3 3q26.2 1.72E+08 1.72E+08 SLC7A14 0.009804 0.226667 0 0.037037 0.037037 SLC7A14 3 3q26.2 1.72E+08 1.72E+08 TMEM212 0.009804 0.146667 0 0.037037 0 TMEM212 3 3q26.31 1.73E+08 1.73E+08 FNDC3B 0.009804 0.133333 0.013333 0.037037 0 FNDC3B 3 3q26.31 1.73E+08 1.74E+08 GHSR 0.009804 0.16 0.013333 0.037037 0 GHSR 3 3q26.31 1.74E+08 1.74E+08 TNFSF10 0.009804 0.2 0 0.037037 0 TNFSF10 3 3q26.31 1.74E+08 1.74E+08 ECT2 0.009804 0.04 0.12 0.037037 0.037037 ECT2 3 3q26.31 1.74E+08 1.74E+08 ZMAT3 0.009804 0.2 0.026667 0.037037 0.037037 ZMAT3 3 3q26.32  1.8E4+08  1.8E+08 PEX5L 0.009804 0.04 0.12 0.074074 0.037037 PEX5L 3 3q26.33 1.81E+08 1.81E+08 CCDC39 0.009804 0.04 0.133333 0.074074 0.037037 CCDC39 3 3q26.33 1.82E+08 1.82E+08 TPRG1 0.009804 0.066667 0.12 0 0.037037 TPRG1 3 3q28  1.9E+08 1.91E+08 IL1RAP 0.009804 0.053333 0.173333 0 0.037037 IL1RAP 3 3q28 1.92E+08 1.92E+08 FAM157A 0.009804 0.48 0.106667 0.62963 0.037037 FAM157A 3 3q29 1.99E+08 1.99E+08 VSNL1 0.009804 0.026667 0.133333 0.111111 0.037037 VSNL1 2 2p24.2 17585288 17701188 LCLAT1 0.009804 0.093333 0.12 0.333333 0.037037 LCLAT1 2 2p23.1 30523627 30720596 HNRPLL 0.009804 0.013333 0.146667 0.074074 0.037037 HNRPLL 2 2p22.1 38643832 38683683 MTIF2 0.009804 0.12 0.013333 0.037037 0 MTIF2 2 2p16.1 55317260 55349820 CCDC88A 0.009804 0.12 0.053333 0.037037 0 CCDC88A 2 2p16.1 55368484 55500562 VRK2 0.009804 0.013333 0.213333 0 0.037037 VRK2 2 2p16.1 58127233 58240560 C2orf86 0.009804 0.106667 0.026667 0.037037 0.037037 C2orf86 2 2p15 63202039 63518591 SLC5A7 0.009804 0.053333 0.173333 0.185185 0.037037 SLC5A7 2 2q12.3 1.08E+08 1.08E+08 EPB41L5 0.009804 0.16 0.106667 0.259259 0.037037 EPB41L5 2 2q14.2  1.2E+08 1.21E+08 NXPH2 0.009804 0.04 0.266667 0.037037 0.037037 NXPH2 2 2q22.1 1.39E+08 1.39E+08 LYPD6B 0.009804 0.08 0.133333 0.111111 0.037037 LYPD6B 2 2q23.2  1.5E+08  1.5E+08 LYPD6 0.009804 0.026667 0.186667 0.037037 0.037037 LYPD6 2 2q23.2  1.5E+08  1.5E+08 RND3 0.009804 0.025667 0.173333 0.037037 0.037037 RND3 2 2q23.3 1.51E+08 1.51E+08 FMNL2 0.009804 0.04 0.12 0.037037 0.037037 FMNL2 2 2q23.3 1.53E+08 1.53E+08 PRPF40A 0.009804 0.026667 0.12 0.037037 0.037037 PRPF40A 2 2q23.3 1.53E+08 1.53E+08 ACVR1 0.009804 0.066667 0.133333 0.074074 0.037037 ACVR1 2 2q24.1 1.58E+08 1.58E+08 UPP2 0.009804 0.053333 0.133333 0.074074 0.037037 UPP2 2 2q24.1 1.59E+08 1.59E+08 RBMS1 0.009804 0.013333 0.106667 0.074074 0.037037 RBMS1 2 2q24.2 1.61E+08 1.61E+08 SF3B1 0.009804 0.16 0.013333 0.037037 0.037037 SF3B1 2 2q33.1 1.98E+08 1.98E+08 COQ10B 0.009804 0.16 0.013333 0.037037 0.037037 COQ10B 2 2q33.1 1.98E+08 1.98E+08 HSPD1 0.009804 0.16 0.013333 0.037037 0.037037 HSPD1 2 2q33.1 1.98E+08 1.98E+08 PIKFYVE 0.009804 0.173333 0.053333 0.037037 0.037037 PIKFYVE 2 2q33.3 2.09E+08 2.09E+08 PTH2R 0.009804 0.12 0.093333 0.037037 0 PTH2R 2 2q33.3 2.09E+08 2.09E+08 KIAA1486 0.009804 0.013333 0.146567 0.074074 0.037037 KIAA1486 2 2q36.3 2.26E+08 2.26E+08 PRKAA2 0.009804 0.106667 0.106667 0.222222 0.037037 PRKAA2 1 1p32.2 56883578 56953597 PGM1 0.009804 0.106667 0.066667 0.037037 0 PGM1 1 1p31.3 63831535 63898506 PDE4B 0.009804 0 0.186667 0 0.037037 PDE4B 1 1p31.3 66030781 66612851 SGIP1 0.009804 0 0.2 0 0.037037 SGIP1 1 1p31.3 66772413 66983357 TCTEX1D1 0.009804 0 0.2 0 0.037037 TCTEX1D1 1 1p31.3 66990728 67017318 SLC35D1 0.009804 0 0.12 0 0.037037 SLC35D1 1 1p31.3 67237604 67292669 IL12RB2 0.009804 0.106667 0.053333 0.037037 0 IL12RB2 1 1p31.3 67545635 67635172 SERBP1 0.009804 0.12 0.053333 0.037037 0 SERBP1 1 1p31.3 67646081 67668712 DEPDC1 0.009804 0.013333 0.24 0 0.037037 DEPDC1 1 1p31.2 68712423 68735388 PTGER3 0.009804 0.013333 0.186667 0 0.037037 PTGER3 1 1p31.1 71090624 71286080 MSH4 0.009804 0.026667 0.146667 0 0.037037 MSH4 1 1p31.1 76035218 76151512 ASB17 0.009804 0.026667 0.146667 0 0.037037 ASB17 1 1p31.1 76157148 76170705 ST6GALNA

0.009804 0.013333 0.173333 0 0.037037 ST6GALNA

1 1p31.1 76312977 75815479 GIPC2 0.009804 0.013333 0.2 0 0.037037 GIPC2 1 1p31.1 78284177 78375701 MGC27382 0.009804 0.013333 0.24 0 0.037037 MGC27382 1 1p31.1 78467871 78607734 TTLL7 0.009804 0.013333 0.226667 0 0.037037 TTLL7 1 1p31.1 84107645 84237422 PRKACB 0.009804 0.013333 0.2 0 0.037037 PRKACB 1 1p31.1 84316333 84476770 SAMD13 0.009804 0.013333 0.186667 0.037037 0.037037 SAMD13 1 1p31.1 84536637 84589069 UOX 0.009804 0.013333 0.186667 0.037037 0.037037 UOX 1 1p31.1 84603229 84636165 DNASE2B 0.009804 0.026667 0.173333 0.037037 0.037037 DNASE2B 1 1p31.1 84636803 84653280 LOC33952

0.009804 0.16 0.08 0.037037 0 LOC33952

1 1p22.3 87368036 87407473 PKN2 0.009804 0.04 0.173333 0 0.037037 PKN2 1 1p22.2 88922510 89074527 GTF2B 0.009804 0.16 0.093333 0.037037 0 GTF2B 1 1p22.2 89090909 89129890 ABCD3 0.009804 0.04 0.146667 0.111111 0.037037 ABCD3 1 1p21.3 94656521 94716849 AGL 0.009804 0.12 0.08 0.037037 0.074074 AGL 1 1p21.2   1E+08   1E+08 SPRR2F 0.009804 0.133333 0.146667 0.481481 0.037037 SPRR2F 1 1q21.3 1.51E+08 1.51E+08 SPRR2C 0.009804 0.16 0.106667 0.481481 0.037037 SPRR2C 1 1q21.3 1.51E+08 1.51E+08 SPRR2G 0.009804 0.16 0.106667 0.481481 0.037037 SPRR2G 1 1q21.3 1.51E+08 1.51E+08 PYHIN1 0.009804 0.04 0.106667 0.037037 0.037037 PYHIN1 1 1q23.1 1.57E+08 1.57E+08 IFI16 0.009804 0.04 0.106667 0.074074 0.037037 IFI16 1 1q23.1 1.57E+08 1.57E+08 AIM2 0.009804 0.04 0.106667 0.074074 0.037037 AIM2 1 1q23.1 - 1c 1.57E+08 1.57E+08 CD84 0.009804 0.093333 0.12 0.185185 0.037037 CD84 1 1q23.2 - 1c 1.59E+08 1.59E+08 SLAMF1 0.009804 0.093333 0.12 0.185185 0.037037 SLAMF1 1 1q23.3 1.59E+08 1.59E+08 SLAMF7 0.009804 0.133333 0.106667 0.185185 0.037037 SLAMF7 1 1q23.3 1.59E+08 1.59E+08 C1orf111 0.009804 0.2 0.026667 0.037037 0 C1orf111 1 1q23.3 1.61E+08 1.61E+08 UHMK1 0.009804 0.146667 0.026667 0.037037 0 UHMK1 1 1q23.3 1.61E+08 1.61E+08 RGS5 0.009804 0.013333 0.133333 0 0.037037 RGS5 1 1q23.3 1.61E+08 1.61E+08 SFT2D2 0.009804 0.12 0.04 0.037037 0 SFT2D2 1 1q24.2 1.66E+08 1.66E+08 ANKRD36B 0.009804 0.12 0.04 0.037037 0 ANKRD36B 1 1q24.2 1.66E+08 1.66E+08 TBX19 0.009804 0.12 0.04 0.037037 0 TBX19 1 1q24.2 1.67E+08 1.67E+08 KIFAP3 0.009804 0 0.186667 0.037037 0.037037 KIFAP3 1 1q24.2 1.68E+08 1.68E+08 METTL11B 0.009804 0 0.16 0.037037 0.037037 METTL11B 1 1q24.2 1.68E+08 1.68E+08 FMO3 0.009804 0 0.2 0.037037 0.037037 FMO3 1 1q24.3 1.69E+08 1.69E+08 MIR1295 0.009804 0 0.2 0.037037 0.037037 MIR1295 1 1q24.3 1.69E+08 1.69E+08 FMO2 0.009804 0 0.186667 0.037037 0.037037 FMO2 1 1q24.3 1.69E+08 1.69E+08 DNM3 0.009804 0.025667 0.106667 0.037037 0.037037 DNM3 1 1q24.3  1.7E+08 1.71E+08 C1orf105 0.009804 0 0.133333 0.037037 0.037037 C1orf105 1 1q24.3 1.71E+08 1.71E+08 RC3H1 0.009804 0.133333 0.013333 0.037037 0 RC3H1 1 1q25.1 1.72E+08 1.72E+08 RABGAP1L 0.009804 0.12 0.013333 0.037037 0.037037 RABGAP1L 1 1q25.1 1.72E+08 1.73E+08 NMNAT2 0.009804 0.146667 0 0.037037 0.074074 NMNAT2 1 1q25.3 1.81E+08 1.82E+08 NCF2 0.009804 0.106667 0.013333 0.037037 0.074074 NCF2 1 1q25.3 1.82E+08 1.82E+08 KCNK2 0.009804 0.066667 0.16 0.074074 0.037037 KCNK2 1 1q41 2.13E+08 2.13E+08 GPATCH2 0.009804 0.026667 0.12 0.037037 0.037037 GPATCH2 1 1q41 2.16E+08 2.16E+08 LOC40080

0.009804 0.053333 0.146667 0.074074 0.037037 LOC40080

1 1q41  2.2E+08  2.2E+08 RYR2 0.009804 0.146667 0.053333 0.037037 0 RYR2 1 1q43 2.35E+08 2.36E+08 AKT3 0.009804 0.026667 0.146667 0.074074 0.037037 AKT3 1 1q44 2.42E+08 2.42E+08 LOC14832

0.009804 0.106667 0.106667 0.222222 0.037037 LOC14882

1 1q44 2.46E+08 2.46E+08 OR2C3 0.009804 0.106667 0.106667 0.222222 0.037037 OR2C3 1 1q44 2.46E+08 2.46E+08 OR2L13 0.009804 0.066667 0.186667 0.185185 0.037037 OR2L13 1 1q44 2.46E+08 2.46E+08 OR2M5 0.009804 0.066667 0.2 0.185185 0.037037 OR2M5 1 1q44 2.46E+08 2.46E+08

indicates data missing or illegible when filed

TABLE 3 Gene list for predicting prostate cancer fast relapse using prostate cancer tissues Symbol freq.use freq.amp.c freq.del.ca

freq.amp.o freq.del.co

Gene.Symt chromoson cytoband Transcript.

Transcript.end VAPA 1 0.242424 0.121212 0.26087 0 VAPA 18 18p11.22 9903955 9950019 C18orf19 1 0.181818 0.121212 0.217391 0 C18orf19 18 18p11.21 13653346 13716592 RNMT 1 0.181818 0.121212 0.217391 0 RNMT 18 18p11.21 13716704 13754555 ZNF267 1 0.181818 0.121212 0.434783 0 ZNF267 16 16p11.2 31792580 31836129 COCH 1 0.121212 0.060606 0 0.115942 COCH 14 14q12 30413492 30429574 BRMS1L 1 0.151515 0.060606 0 0.057971 BRMS1L 14 14q13.2 35365348 35410921 OTX2OS1 1 0.121212 0.060606 0 0.014493 OTX2OS1 14 14q23.1 56349654 56467302 TMEM30B 1 0.090909 0.121212 0.086957 0 TMEM30B 14 14q23.1 60813842 60818284 PRKCH 1 0.090909 0.121212 0.086957 0 PRKCH 14 14q23.1 60858268 61087452 HIF1A 1 0.090909 0.121212 0.072464 0 HIF1A 14 14q23.2 61231872 61284731 FAM71D 1 0.181818 0.121212 0.188406 0 FAM71D 14 14q23.3 66725899 66765021 MPP5 1 0.181818 0.121212 0.188406 0 MPP5 14 14q23.3 66777774 66872290 VTI1B 1 0.212121 0.121212 0.217391 0 VTI1B 14 14q24.1 67187619 67211356 RDH11 1 0.212121 0.121212 0.217391 0 RDH11 14 14q24.1 67213271 67232264 RDH12 1 0.212121 0.121212 0.217391 0 RDH12 14 14q24.1 67238356 67270922 ZFYVE26 1 0.212121 0.121212 0.217391 0 ZFYVE26 14 14q24.1 67282990 67353060 ACTN1 1 0.30303 0.121212 0.289855 0 ACTN1 14 14q24.1 68410593 68515837 GALNTL1 1 0.242424 0.151515 0.289855 0 GALNTL1 14 14q24.1 68796434 68890944 FLJ44817 1 0.242424 0.151515 0.289855 0 FLJ44817 14 14q24.1 69021224 69064969 KIAA0247 1 0.212121 0.151515 0.289855 0 KIAA0247 14 14q24.1 69148063 69251613 LOC10028

1 0.212121 0.151515 0.289855 0 LOC10028

14 14q24.1-1 69302753 69304184 SFRS5 1 0.212121 0.151515 0.289855 0 SFRS5 14 14q24.1-1 69303582 69308476 SLC10A1 1 0.212121 0.151515 0.289855 0 SLC10A1 14 14q24.2 69312305 69333760 SLC8A3 1 0.151515 0.151515 0.26087 0 SLC8A3 14 14q24.2 69580687 69616677 SYNJ2BP 1 0.121212 0.121212 0.246377 0 SYNJ2BP 14 14q24.2 69902966 69953561 MED6 1 0.151515 0.121212 0.275362 0 MED6 14 14q24.2 70120710 70137138 TTC9 1 0.151515 0.121212 0.289855 0 TTC9 14 14q24.2 70178257 70211831 MAP3K9 1 0.151515 0.121212 0.289855 0 MAP3K9 14 14q24.2 70264607 70345642 PCNX 1 0.151515 0.121212 0.289855 0 PCNX 14 14q24.2 70443875 70651853 SNORD56B 1 0.212121 0.151515 0.289855 0 SNORD56B 14 14q24.2 70934807 70934878 LOC14547

1 0.212121 0.121212 0.289855 0 LOC14547

14 14q24.2 71024331 71026172 SIPA1L1 1 0.212121 0.121212 0.289855 0 SIPA1L1 14 14q24.2 71065795 71275874 RGS6 1 0.181818 0.121212 0.289855 0 RGS6 14 14q24.2 71469539 72102992 DPF3 1 0.333333 0.121212 0.376812 0 DPF3 14 14q24.2 72206413 72430563 DCAF4 1 0.333333 0.121212 0.391304 0 DCAF4 14 14q24.2 72462793 72496110 ZFYVE1 1 0.333333 0.121212 0.391304 0 ZFYVE1 14 14q24.2 72505912 72563593 ENTPD5 1 0.333333 0.121212 0.449275 0 ENTPD5 14 14q24.3 73502936 73555780 C14orf45 1 0.333333 0.121212 0.449275 0 C14orf45 14 14q24.3 73555812 73602549 ALDH6A1 1 0.333333 0.121212 0.449275 0 ALDH6A1 14 14q24.3 73596625 73620950 ABCD4 1 0.363636 0.121212 0.376812 0 ABCD4 14 14q24.3 73821733 73839521 TMEM90A 1 0.363636 0.121212 0.376812 0 TMEM90A 14 14q24.3 73942349 73962559 BCYRN1 1 0.30303 0.121212 0.347826 0 BCYRN1 14 14q24.3 75406358 75658554 TGFB3 1 0.30303 0.121212 0.347826 0 TGFB3 14 14q24.3 75494195 75517846 C14orf179 1 0.30303 0.121212 0.347826 0 C14orf179 14 14q24.3 75521849 75619846 ESRRB 1 0.363636 0.121212 0.376812 0 ESRRB 14 14q24.3 75907443 76037932 VASH1 1 0.363636 0.121212 0.376812 0 VASH1 14 14q24.3 76297988 76319117 ANGEL1 1 0.363636 0.121212 0.376812 0 ANGEL1 14 14q24.3 76323339 76349037 C14orf166

1 0.363636 0.121212 0.376812 0 C14orf166

14 14q24.3 76362478 76406399 C14orf4 1 0.333333 0.121212 0.347826 0 C14orf4 14 14q24.3 76560639 76564788 KIAA1737 1 0.333333 0.121212 0.347826 0 KIAA1737 14 14q24.3 76634331 76653384 ZDHHC22 1 0.333333 0.121212 0.347826 0 ZDHHC22 14 14q24.3 76667366 76677888 TMEM63C 1 0.333333 0.121212 0.347826 0 TMEM63C 14 14q24.3 76717855 76795592 NGB 1 0.333333 0.121212 0.347826 0 NGB 14 14q24.3 76801587 76807409 MIR1260 1 0.333333 0.121212 0.347826 0 MIR1260 14 14q24.3 76802314 76802385 POMT2 1 0.333333 0.121212 0.347826 0 POMT2 14 14q24.3 76811054 76856979 GSTZ1 1 0.333333 0.121212 0.347826 0 GSTZ1 14 14q24.3 76856983 76867694 TMED8 1 0.333333 0.121212 0.347826 0 TMED8 14 14q24.3 76877867 76913150 C14orf174 1 0.333333 0.121212 0.347826 0 C14orf174 14 14q24.3 76913515 76927341 C14orf148 1 0.333333 0.121212 0.347826 0 C14orf148 14 14q24.3 76930177 76959133 C14orf133 1 0.30303 0.121212 0.347826 0 C14orf133 14 14q24.3 76962771 76993658 AHSA1 1 0.30303 0.121212 0.347826 0 AHSA1 14 14q24.3 76994126 77005561 ISM2 1 0.30303 0.121212 0.347826 0 ISM2 14 14q24.3 77010493 77034964 SPTLC2 1 0.272727 0.121212 0.333333 0 SPTLC2 14 14q24.3 77043023 77152864 C14orf156 1 0.272727 0.121212 0.318841 0 C14orf156 14 14q24.3 77244178 77253697 SNW1 1 0.272727 0.121212 0.318841 0 SNW1 14 14q24.3 77253597 77297251 C14orf178 1 0.272727 0.121212 0.318841 0 C14orf178 14 14q24.3 77296646 77305839 ADCK1 1 0.272727 0.121212 0.318841 0 ADCK1 14 14q24.3 77336179 77470050 KCNK10 1 0.090909 0.121212 0.318841 0 KCNK10 14 14q31.3 87716207 87863010 PTPN21 1 0.121212 0.121212 0.333333 0 PTPN21 14 14q31.3 88001875 88090877 ZC3H14 1 0.121212 0.121212 0.333333 0 ZC3H14 14 14q31.3 88099006 88149606 EML5 1 0.121212 0.121212 0.333333 0 EML5 14 14q31.3 88150956 88328911 TTC8 1 0.121212 0.121212 0.333333 0 TTC8 14 14q31.3 88360731 88414089 LOC28423

1 0.060606 0.121212 0.173913 0 LOC28423

13 13q11 18306543 18344110 EFHA1 1 0.181818 0.121212 0.173913 0 EFHA1 13 13q12.11 20964839 21076308 FGF9 1 0.181818 0.121212 0.15942 0 FGF9 13 13q12.11 21143215 21176641 SGCG 1 0.181818 0.121212 0.173913 0 SGCG 13 13q12.12 22653060 22797305 SACS 1 0.181818 0.121212 0.188406 0 SACS 13 13q12.12 22800965 22905842 TNFRSF19 1 0.212121 0.121212 0.173913 0 TNFRSF19 13 13q12.12 23042723 23148233 MIPEP 1 0.121212 0.121212 0.173913 0 MIPEP 13 13q12.12 23202328 23361560 SPATA13 1 0.181818 0.121212 0.202899 0 SPATA13 13 13q12.12 23632861 23779213 MIR2276 1 0.181818 0.121212 0.202899 0 MIR2276 13 13q12.12 23634555 23634644 C1QTNF9 1 0.212121 0.121212 0.202899 0 C1QTNF9 13 13q12.12 23781716 23794670 PARP4 1 0.181818 0.121212 0.217391 0 PARP4 13 13q12.12 23893069 23984949 RNF17 1 0.151515 0.121212 0.318841 0 RNF17 13 13q12.12 24236301 24352059 CENPJ 1 0.151515 0.121212 0.318841 0 CENPJ 13 13q12.12 24354412 24395086 PABPC3 1 0.151515 0.151515 0.318841 0 PABPC3 13 13q12.13 24568276 24570705 MTMR6 1 0.151515 0.151515 0.318841 0 MTMR6 13 13q12.13 24718341 24759705 ATP8A2 1 0.121212 0.151515 0.318841 0 ATP8A2 13 13q12.13 24844209 25493421 SHISA2 1 0.090909 0.121212 0.26087 0 SHISA2 13 13q12.13 25516735 25523199 RNF6 1 0.090909 0.121212 0.26087 0 RNF6 13 13q12.13 25684905 25694509 WASF3 1 0.121212 0.121212 0.333333 0 WASF3 13 13q12.13 26029840 26161081 USP12 1 0.151515 0.121212 0.333333 0 USP12 13 13q12.13 26540438 26644030 PAN3 1 0.060606 0.121212 0.231884 0 PAN3 13 13q12.2 27610643 27767476 MTUS2 1 0.090909 0.121212 0.246377 0 MTUS2 13 13q12.3 28496748 28978085 KCNMB4 1 0.151515 0.030303 0 0.028986 KCNMB4 12 12q15 69046329 69111246 PTPRR 1 0.121212 0.060606 0 0.043478 PTPRR 12 12q15 69318129 69600852 TPH2 1 0.121212 0.181818 0 0.202899 TPH2 12 12q21.1 70618893 70712489 TRHDE 1 0.121212 0.212121 0 0.231884 TRHDE 12 12q21.1 70952796 71345689 C12orf12 1 0.121212 0.212121 0 0.217391 C12orf12 12 12q21.33 89870123 89873085 EPYC 1 0.121212 0.212121 0 0.217391 EPYC 12 12q21.33 89881589 89922935 NAV2 1 0.030303 0.151515 0.130435 0 NAV2 11 11p15.1 19328847 20099724 FLJ32810 1 0.121212 0.181818 0 0.101449 FLJ32810 11 11q22.1   1E+08   1E+08 MMP20 1 0.121212 0.181818 0 0.101449 MMP20 11 11q22.2 1.02E+08 1.02E+08 SLC35F2 1 0.242424 0.121212 0.246377 0 SLC35F2 11 11q22.3 1.07E+08 1.07E+08 RAB39 1 0.242424 0.121212 0.246377 0 RAB39 11 11q22.3 1.07E+08 1.07E+08 CUL5 1 0.212121 0.121212 0.246377 0 CUL5 11 11q22.3 1.07E+08 1.07E+08 C11orf65 1 0.181818 0.121212 0.188406 0 C11orf65 11 11q22.3 1.08E+08 1.08E+08 KDELC2 1 0.181818 0.121212 0.188406 0 KDELC2 11 11q22.3 1.08E+08 1.08E+08 EXPH5 1 0.181818 0.121212 0.188406 0 EXPH5 11 11q22.3 1.08E+08 1.08E+08 ZC3H12C 1 0.151515 0.151515 0.144928 0 ZC3H12C 11 11q22.3 1.09E+08  1.1E+08 FDX1 1 0.181818 0.151515 0.130435 0 FDX1 11 11q22.3  1.1E+08  1.1E+08 ARHGAP20 1 0.181818 0.151515 0.130435 0 ARHGAP20 11 11q22.3  1.1E+08  1.1E+08 POU2AF1 1 0.212121 0.121212 0.217391 0 POU2AF1 11 11q23.1 1.11E+08 1.11E+08 C11orf88 1 0.121212 0.151515 0.217391 0 C11orf88 11 11q23.1 1.11E+08 1.11E+08 LAYN 1 0.121212 0.151515 0.217391 0 LAYN 11 11q23.1 1.11E+08 1.11E+08 SIK2 1 0.212121 0.121212 0.217391 0 SIK2 11 11q23.1 1.11E+08 1.11E+08 PPP2R1B 1 0.212121 0.121212 0.217391 0 PPP2R1B 11 11q23.1 1.11E+08 1.11E+08 ALG9 1 0.181818 0.121212 0.217391 0 ALG9 11 11q23.1 1.11E+08 1.11E+08 IL18 1 0.181818 0.121212 0.217391 0 IL18 11 11q23.1 1.12E+08 1.12E+08 BCO2 1 0.151515 0.121212 0.217391 0 BCO2 11 11q23.1 1.12E+08 1.12E+08 PTS 1 0.121212 0.121212 0.202899 0 PTS 11 11q23.1 1.12E+08 1.12E+08 C11orf34 1 0.121212 0.121212 0.202899 0 C11orf34 11 11q23.1 1.12E+08 1.12E+08 TTC12 1 0.212121 0.121212 0.289855 0 TTC12 11 11q23.1 1.13E+08 1.13E+08 DRD2 1 0.212121 0.121212 0.304348 0 DRD2 11 11q23.1 1.13E+08 1.13E+08 TMPRSS5 1 0.212121 0.121212 0.304348 0 TMPRSS5 11 11q23.2 1.13E+08 1.13E+08 CLDN25 1 0.212121 0.121212 0.289855 0 CLDN25 11 11q23.2 1.13E+08 1.13E+08 USP28 1 0.212121 0.121212 0.289855 0 USP28 11 11q23.2 1.13E+08 1.13E+08 BUD13 1 0.242424 0.121212 0.449275 0 BUD13 11 11q23.3 1.16E+08 1.16E+08 ZNF259 1 0.242424 0.121212 0.449275 0 ZNF259 11 11q23.3 1.16E+08 1.16E+08 APOA5 1 0.242424 0.121212 0.449275 0 APOA5 11 11q23.3 1.16E+08 1.16E+08 SIK3 1 0.272727 0.121212 0.449275 0 SIK3 11 11q23.3 1.16E+08 1.16E+08 PAFAH1B2 1 0.242424 0.121212 0.449275 0 PAFAH1B2 11 11q23.3 1.17E+08 1.17E+08 TAGLN 1 0.30303 0.121212 0.449275 0 TAGLN 11 11q23.3 1.17E+08 1.17E+08 PCSK7 1 0.30303 0.121212 0.449275 0 PCSK7 11 11q23.3 1.17E+08 1.17E+08 RNF214 1 0.30303 0.121212 0.449275 0 RNF214 11 11q23.3 1.17E+08 1.17E+08 BACE1 1 0.30303 0.121212 0.449275 0 BACE1 11 11q23.3 1.17E+08 1.17E+08 HYOU1 1 0.393939 0.121212 0.507246 0 HYOU1 11 11q23.3 1.18E+08 1.18E+08 VPS11 1 0.393939 0.121212 0.507246 0 VPS11 11 11q23.3 1.18E+08 1.18E+08 HMBS 1 0.393939 0.121212 0.507246 0 HMBS 11 11q23.3 1.18E+08 1.18E+08 H2AFX 1 0.393939 0.121212 0.507246 0 H2AFX 11 11q23.3 1.18E+08 1.18E+08 DPAGT1 1 0.393939 0.121212 0.507246 0 DPAGT1 11 11q23.3 1.18E+08 1.18E+08 TRPM3 1 0.060606 0.121212 0.014493 0 TRPM3 9 9q21.11 72339786 72926335 MIR548A1 1 0.151515 0.090909 0 0.028986 MIR548A1 6 6p22.3 18679994 18680091 ORC3L 1 0.151515 0.242424 0 0.202899 ORC3L 6 6q15 88356562 88433888 C5orf33 1 0.121212 0.060606 0 0.028986 C5orf33 5 5p13.2 36228451 36277658 RANBP3L 1 0.121212 0.060606 0 0.028986 RANBP3L 5 5p13.2 36284862 36337769 EGFLAM 1 0.121212 0 0 0 EGFLAM 5 5p13.2 38294290 38500408 LIFR 1 0.121212 0 0 0 LIFR 5 5p13.1 38510822 38592506 OSMR 1 0.121212 0 0 0 OSMR 5 5p13.1 38881717 38922516 RICTOR 1 0.121212 0 0 0 RICTOR 5 5p13.1 38973780 39110259 DAB2 1 0.121212 0.030303 0 0.072464 DAB2 5 5p13.1 39407537 39461093 SDAD1 1 0.181818 0.030303 0 0.014493 SDAD1 4 4q21.1 77090092 77131138 CXCL9 1 0.181818 0.030303 0 0.014493 CXCL9 4 4q21.1 77141647 77147666 ART3 1 0.181818 0.030303 0 0.014493 ART3 4 4q21.1 77151361 77252980 CXCL10 1 0.181818 0.030303 0 0.014493 CXCL10 4 4q21.1 77161295 77163675 CXCL11 1 0.181818 0.030303 0 0.014493 CXCL11 4 4q21.1 77173864 77176258 CCNG2 1 0.121212 0.030303 0 0.043478 CCNG2 4 4q21.1 78297381 78310238 RASGEF1B 1 0.121212 0.060606 0 0.115942 RASGEF1B 4 4q21.21 82567243 82612086 SMAD1 1 0.121212 0.030303 0 0 SMAD1 4 4q31.22 1.47E+08 1.47E+08 MMAA 1 0.121212 0 0 0 MMAA 4 4q31.22 1.47E+08 1.47E+08 C4orf51 1 0.121212 0 0 0 C4orf51 4 4q31.22 1.47E+08 1.47E+08 ZNF827 1 0.121212 0 0 0 ZNF827 4 4q31.22 1.47E+08 1.47E+08 MPP4 1 0.060606 0.121212 0.15942 0 MPP4 2 2q33.1 2.02E+08 2.02E+08 ALS2 1 0.060606 0.121212 0.15942 0 ALS2 2 2q33.1 2.02E+08 2.02E+08 CD28 1 0.060606 0.151515 0.086957 0 CD28 2 2q33.2 2.04E+08 2.04E+08 ERO1LB 1 0.181818 0.121212 0.202899 0 ERO1LB 1 1q42.3 2.34E+08 2.35E+08 PLD5 1 0.090909 0.121212 0.086957 0 PLD5 1 1q43  2.4E+08 2.41E+08 LOC100101 0.970588 0.212121 0.090909 0.231884 0 LOC100101 Y Yp11.2 6318442 6339606 TTTY1 0.970588 0.212121 0.090909 0.231884 0 TTTY1 Y Yp11.2 6318472 6339606 LOC100101 0.970588 0.212121 0.090909 0.231884 0 LOC100101 Y Yp11.2 6334285 6356486 TTTY2 0.970588 0.212121 0.090909 0.231884 0 TTTY2 Y Yp11.2 6334285 6356486 LOC10019

0.970588 0.090909 0.090909 0.217391 0 LOC10019

18 18p11.23 8350818 8357033 RAB12 0.970588 0.242424 0.090909 0.246377 0 RAB12 18 18p11.22 8599443 8629381 KIAA0802 0.970588 0.242424 0.090909 0.246377 0 KIAA0802 18 18p11.22 8707369 8822776 RALBP1 0.970588 0.272727 0.090909 0.26087 0 RALBP1 18 18p11.22 9465530 9528107 APCDD1 0.970588 0.242424 0.090909 0.246377 0 APCDD1 18 18p11.22 10444625 10478699 NAPG 0.970588 0.242424 0.090909 0.246377 0 NAPG 18 18p11.22 10515873 10542763 FAM38B 0.970588 0.272727 0.090909 0.231884 0 FAM38B 18 18p11.22 10660244 11138762 GNAL 0.970588 0.272727 0.090909 0.217391 0 GNAL 18 18p11.21 11679136 11873145 CHMP1B 0.970588 0.333333 0.090909 0.217391 0 CHMP1B 18 18p11.21 11841389 11844449 IMPA2 0.970588 0.30303 0.090909 0.289855 0 IMPA2 18 18p11.21 11971455 12020877 CIDEA 0.970588 0.272727 0.090909 0.231884 0 CIDEA 18 18p11.21 12244318 12267595 AFG3L2 0.970588 0.272727 0.090909 0.231884 0 AFG3L2 18 18p11.21 12319108 12367195 SLMO1 0.970588 0.272727 0.090909 0.231884 0 SLMO1 18 18p11.21 12397895 12422235 SPIRE1 0.970588 0.212121 0.090909 0.202899 0 SPIRE1 18 18p11.21 12436511 12647913 PTPN2 0.970588 0.212121 0.090909 0.217391 0 PTPN2 18 18p11.21 12775480 12874335 SEH1L 0.970588 0.181818 0.090909 0.217391 0 SEH1L 18 18p11.21 12937983 12977537 CEP192 0.970588 0.181818 0.090909 0.217391 0 CEP192 18 18p11.21 12981361 13115050 C18orf1 0.970588 0.272727 0.090909 0.231884 0 C18orf1 18 18p11.21 13208786 13642754 MC2R 0.970588 0.212121 0.090909 0.231884 0 MC2R 18 18p11.21 13872043 13905536 ZNF519 0.970588 0.090909 0.090909 0.101449 0 ZNF519 18 18p11.21 14094724 14122430 GP2 0.970588 0.242424 0.090909 0.492754 0 GP2 16 16p12.3 20229312 20246337 GSG1L 0.970588 0.424242 0.090909 0.565217 0 GSG1L 16 16p11.2 27706351 27982332 NOVA1 0.970588 0.090909 0.181818 0 0.217391 NOVA1 14 14q12 25984929 26136801 PRKD1 0.970588 0.090909 0.121212 0 0.173913 PRKD1 14 14q12 29115438 29466651 ARHGAP5 0.970588 0.090909 0 0 0.043478 ARHGAP5 14 14q12 31615246 31698686 AKAP6 0.970588 0.090909 0.121212 0 0.101449 AKAP6 14 14q13.1 31868230 32372020 RALGAPA1 0.970588 0.090909 0.030303 0 0.115942 RALGAPA1 14 14q13.2 35077309 35348184 PTGDR 0.970588 0.030303 0.090909 0.028986 0 PTGDR 14 14q22.1 51804181 51813193 KIAA0586 0.970588 0.121212 0.090909 0.014493 0 KIAA0586 14 14q23.1 57964463 58085303 DACT1 0.970588 0.121212 0.090909 0.014493 0 DACT1 14 14q23.1 58174510 58184792 SGPP1 0.970588 0.242424 0.090909 0.217391 0 SGPP1 14 14q23.2 63220688 63264510 SYNE2 0.970588 0.242424 0.090909 0.217391 0 SYNE2 14 14q23.2 63389436 63762923 ATP6V1D 0.970588 0.242424 0.090909 0.217391 0 ATP6V1D 14 14q23.3 66874342 66896345 EIF2S1 0.970588 0.242424 0.090909 0.217391 0 EIF2S1 14 14q23.3 66896787 66922987 PLEK2 0.970588 0.242424 0.090909 0.217391 0 PLEK2 14 14q23.3 66923453 66948582 PLEKHH1 0.970588 0.242424 0.090909 0.217391 0 PLEKHH1 14 14q24.1 67069761 67126009 PIGH 0.970588 0.212121 0.090909 0.217391 0 PIGH 14 14q24.1 67125776 67136771 ARG2 0.970588 0.212121 0.090909 0.217391 0 ARG2 14 14q24.1 67156332 67188190 LTBP2 0.970588 0.333333 0.090909 0.376812 0 LTBP2 14 14q24.3 74034639 74148788 KIAA0317 0.970588 0.333333 0.090909 0.376812 0 KIAA0317 14 14q24.3 74197708 74249561 FCF1 0.970588 0.333333 0.090909 0.362319 0 FCF1 14 14q24.3 74249603 74273144 YLPM1 0.970588 0.333333 0.090909 0.362319 0 YLPM1 14 14q24.3 74299822 74373767 PROX2 0.970588 0.333333 0.090909 0.362319 0 PROX2 14 14q24.3 74391588 74400291 DLST 0.970588 0.333333 0.090909 0.362319 0 DLST 14 14q24.3 74418347 74440204 RPS6KL1 0.970588 0.363636 0.090909 0.362319 0 RPS6KL1 14 14q24.3 74442099 74458899 PGF 0.970588 0.363636 0.090909 0.362319 0 PGF 14 14q24.3 74478291 74492045 EIF2B2 0.970588 0.333333 0.090909 0.362319 0 EIF2B2 14 14q24.3 74539365 74546047 MLH3 0.970588 0.333333 0.090909 0.362319 0 MLH3 14 14q24.3 74550220 74587989 ACYP1 0.970588 0.333333 0.090909 0.362319 0 ACYP1 14 14q24.3 74589681 74600490 FAM164C 0.970588 0.333333 0.090909 0.362319 0 FAM164C 14 14q24.3 74606052 74614553 NEK9 0.970588 0.333333 0.090909 0.362319 0 NEK9 14 14q24.3 74618572 74663532 TMED10 0.970588 0.333333 0.090909 0.362319 0 TMED10 14 14q24.3 74667924 74713103 JDP2 0.970588 0.333333 0.090909 0.362319 0 JDP2 14 14q24.3 74964262 75009156 BATF 0.970588 0.30303 0.090909 0.362319 0 BATF 14 14q24.3 75058537 75083081 FLVCR2 0.970588 0.30303 0.090909 0.318841 0 FLVCR2 14 14q24.3 75114693 75184266 FOXN3 0.970588 0.151515 0.090909 0.333333 0 FOXN3 14 14q31.3 88692269 89155248 C14orf143 0.970588 0.212121 0.090909 0.376812 0 C14orf143 14 14q32.11 89333222 89490843 C14orf64 0.970588 0.060606 0.090909 0.26087 0 C14orf64 14 14q32.2 97461700 97514215 GPR12 0.970588 0.181818 0.090909 0.333333 0 GPR12 13 13q12.13 26227341 26232923 RPL21 0.970588 0.181818 0.090909 0.333333 0 RPL21 13 13q12.2 26723692 26728703 RPL21P28 0.970588 0.181818 0.090909 0.333333 0 RPL21P28 13 13q12.2 26723693 26728699 SNORD102 0.970588 0.181818 0.090909 0.333333 0 SNORD102 13 13q12.2 26727201 26727273 SNORA27 0.970588 0.181818 0.090909 0.333333 0 SNORA27 13 13q12.2 26727538 26727664 RASL11A 0.970588 0.181818 0.090909 0.333333 0 RASL11A 13 13q12.2 26742464 26745828 GTF3A 0.970588 0.151515 0.090909 0.333333 0 GTF3A 13 13q12.2 26896681 26907847 MTIF3 0.970588 0.151515 0.090909 0.333333 0 MTIF3 13 13q12.2 26907776 26922335 GSX1 0.970588 0.121212 0.090909 0.347826 0 GSX1 13 13q12.2 27264780 27266090 PDX1 0.970588 0.121212 0.090909 0.333333 0 PDX1 13 13q12.2 27392168 27398452 ATP5EP2 0.970588 0.121212 0.090909 0.333333 0 ATP5EP2 13 13q12.2 27417343 27417711 CDX2 0.970588 0.121212 0.090909 0.333333 0 CDX2 13 13q12.2 27434278 27441318 PRHOXNB 0.970588 0.121212 0.090909 0.333333 0 PRHOXNB 13 13q12.2 27450243 27460775 FLT3 0.970588 0.121212 0.090909 0.333333 0 FLT3 13 13q12.2 27475411 27572730 FLT1 0.970588 0.090909 0.090909 0.231884 0 FLT1 13 13q12.2 27772483 27967266 POMP 0.970588 0.121212 0.090909 0.231884 0 POMP 13 13q12.3 28131241 28151092 SLC46A3 0.970588 0.121212 0.090909 0.231884 0 SLC46A3 13 13q12.3 28172220 28191151 SLC7A1 0.970588 0.151515 0.090909 0.26087 0 SLC7A1 13 13q12.3 28981552 29067826 KATNAL1 0.970588 0.151515 0.090909 0.246377 0 KATNAL1 13 13q12.3 29674767 29779164 LOC10018

0.970588 0.151515 0.090909 0.246377 0 LOC10018

13 13q12.3 29812409 29846037 HMGB1 0.970588 0.181818 0.090909 0.246377 0 HMGB1 13 13q12.3 29930879 29938082 ALOX5AP 0.970588 0.181818 0.090909 0.275362 0 ALOX5AP 13 13q12.3 30207669 30236557 KRT3 0.970588 0.212121 0.090909 0.478261 0 KRT3 12 12q13.13 51469736 51476160 TSPAN8 0.970588 0.090909 0.090909 0 0.15942 TSPAN8 12 12q21.1 69805144 69838047 LGR5 0.970588 0.090909 0.121212 0 0.15942 LGR5 12 12q21.1 70120080 70264889 KITLG 0.970588 0.090909 0.181818 0 0.246377 KITLG 12 12q21.32 87410698 87498370 VEZT 0.970588 0.181818 0.090909 0.188406 0 VEZT 12 12q22 94135653 94220698 TMEM132

0.970588 0.060606 0.090909 0.275362 0 TMEM132

12 12q24.32 1.27E+08 1.28E+08 EIF3F 0.970588 0.121212 0.090909 0.15942 0 EIF3F 11 11p15.4 7965443 7974295 SBF2 0.970588 0.181818 0.090909 0.188406 0 SBF2 11 11p15.4 9756790 10272331 MICALCL 0.970588 0.121212 0.090909 0.231884 0 MICALCL 11 11p15.3 12265023 12337268 LDLRAD3 0.970588 0.121212 0.090909 0.130435 0 LDLRAD3 11 11p13 35922188 35209418 COMMD9 0.970588 0.151515 0.090909 0.130435 0 COMMD9 11 11p13 36250418 36267576 PRR5L 0.970588 0.151515 0.090909 0.130435 0 PRR5L 11 11p13 36274301 36443330 FAM181B 0.970588 0.090909 0.121212 0 0.057971 FAM181B 11 11q14.1 82120694 82122555 DLG2 0.970588 0.090909 0.181818 0 0.115942 DLG2 11 11q14.1 82843706 85015963 RAB38 0.970588 0.090909 0.181818 0 0.101449 RAB38 11 11q14.2 87486079 87548248 CTSC 0.970388 0.090909 0.151515 0 0.130435 CTSC 11 11q14.2 87666408 87710590 GRM5 0.970588 0.090909 0.181818 0 0.115942 GRM5 11 11q14.2 87877393 88436465 TRPC6 0.970588 0.090909 0.272727 0 0.188406 TRPC6 11 11q22.1 1.01E+08 1.01E+08 KIAA1377 0.970588 0.090909 0.212121 0 0.173913 KIAA1377 11 11q22.1 1.01E+08 1.01E+08 YAP1 0.970588 0.090909 0.181818 0 0.130435 YAP1 11 11q22.1 1.01E+08 1.02E+08 MMP27 0.970588 0.090909 0.151515 0 0.057971 MMP27 11 11q22.2 1.02E+08 1.02E+08 MMP8 0.970588 0.090909 0.151515 0 0.057971 MMP8 11 11q22.2 1.02E+08 1.02E+08 MMP10 0.970588 0.090909 0.151515 0 0.043478 MMP10 11 11q22.2 1.02E+08 1.02E+08 MMP1 0.970588 0.090909 0.151515 0 0.043478 MMP1 11 11q22.2 1.02E+08 1.02E+08 PDGFD 0.970588 0.090909 0.212121 0 0.144928 PDGFD 11 11q22.3 1.03E+08 1.04E+08 CASP4 0.970588 0.090909 0.272727 0 0.188406 CASP4 11 11q22.3 1.04E+08 1.04E+08 CASP5 0.970588 0.090909 0.272727 0 0.188406 CASP5 11 11q22.3 1.04E+08 1.04E+08 CARD16 0.970588 0.090909 0.272727 0 0.188406 CARD16 11 11q22.3 1.04E+08 1.04E+08 GRIA4 0.970588 0.090909 0.242424 0 0.15942 GRIA4 11 11q22.3 1.05E+08 1.05E+08 SLN 0.970588 0.242424 0.090909 0.217391 0 SLN 11 11q22.3 1.07E+08 1.07E+08 ACAT1 0.970588 0.212121 0.090909 0.246377 0 ACAT1 11 11q22.3 1.07E+08 1.08E+08 NPAT 0.970588 0.212121 0.090909 0.246377 0 NPAT 11 11q22.3 1.08E+08 1.08E+08 ATM 0.970588 0.212121 0.090909 0.231884 0 ATM 11 11q22.3 1.08E+08 1.08E+08 FDXACB1 0.970588 0.212121 0.090909 0.217391 0 FDXACB1 11 11q23.1 1.11E+08 1.11E+08 C11orf1 0.970588 0.212121 0.090909 0.217391 0 C11orf1 11 11q23.1 1.11E+08 1.11E+08 CRYAB 0.970588 0.212121 0.090909 0.217391 0 CRYAB 11 11q23.1 1.11E+08 1.11E+08 HSPB2 0.970588 0.212121 0.090909 0.217391 0 HSPB2 11 11q23.1 1.11E+08 1.11E+08 C11orf52 0.970588 0.212121 0.090909 0.217391 0 C11orf52 11 11q23.1 1.11E+08 1.11E+08 DIXDC1 0.970588 0.212121 0.090909 0.217391 0 DIXDC1 11 11q23.1 1.11E+08 1.11E+08 PIH1D2 0.970588 0.212121 0.090909 0.217391 0 PIH1D2 11 11q23.1 1.11E+08 1.11E+08 C11orf57 0.970588 0.212121 0.090909 0.217391 0 C11orf57 11 11q23.1 1.11E+08 1.11E+08 TIMM8B 0.970588 0.212121 0.090909 0.217391 0 TIMM8B 11 11q23.1 1.11E+08 1.11E+08 SDHD 0.970588 0.212121 0.090909 0.217391 0 SDHD 11 11q23.1 1.11E+08 1.11E+08 CEP164 0.970588 0.30303 0.090909 0.449275 0 CEP164 11 11q23.3 1.17E+08 1.17E+08 DSCAML1 0.970588 0.30303 0.090909 0.463768 0 DSCAML1 11 11q23.3 1.17E+08 1.17E+08 FXYD6 0.970588 0.30303 0.090909 0.478261 0 FXYD6 11 11q23.3 1.17E+08 1.17E+08 TMPRSS13 0.970588 0.30303 0.090909 0.478261 0 TMPRSS13 11 11q23.3 1.17E+08 1.17E+08 IL10RA 0.970588 0.30303 0.090909 0.478261 0 IL10RA 11 11q23.3 1.17E+08 1.17E+08 TMPRSS4 0.970588 0.30303 0.090909 0.478261 0 TMPRSS4 11 11q23.3 1.17E+08 1.17E+08 SCN4B 0.970588 0.30303 0.090909 0.478261 0 SCN4B 11 11q23.3 1.18E+08 1.18E+08 MPZL2 0.970588 0.30303 0.090909 0.478261 0 MPZL2 11 11q23.3 1.18E+08 1.18E+08 MLL 0.970588 0.333333 0.090909 0.478261 0 MLL 11 11q23.3 1.18E+08 1.18E+08 TMEM25 0.970588 0.393939 0.090909 0.507246 0 TMEM25 11 11q23.3 1.18E+08 1.18E+08 C11orf60 0.970588 0.393939 0.090909 0.507246 0 C11orf60 11 11q23.3 1.18E+08 1.18E+08 ARCN1 0.970588 0.393939 0.090909 0.507246 0 ARCN1 11 11q23.3 1.18E+08 1.18E+08 PHLDB1 0.970588 0.393939 0.090909 0.507246 0 PHLDB1 11 11q23.3 1.18E+08 1.18E+08 TREH 0.970588 0.393939 0.090909 0.507246 0 TREH 11 11q23.3 1.18E+08 1.18E+08 CXCR5 0.970588 0.393939 0.090909 0.507246 0 CXCR5 11 11q23.3 1.18E+08 1.18E+08 BCL9L 0.970588 0.393939 0.090909 0.507246 0 BCL9L 11 11q23.3 1.18E+08 1.18E+08 THY1 0.970588 0.393939 0.090909 0.507246 0 THY1 11 11q23.3 1.19E+08 1.19E+08 PVRL1 0.970588 0.363636 0.090909 0.507246 0 PVRL1 11 11q23.3 1.19E+08 1.19E+08 GRIK4 0.970588 0.30303 0.090909 0.463768 0 GRIK4 11 11q23.3  1.2E+08  1.2E+08 OPCML 0.970588 0.090909 0.090909 0.173913 0 OPCML 11 11q25 1.32E+08 1.33E+08 ZNF33A 0.970588 0.090909 0.090909 0.15942 0 ZNF33A 10 10p11.21 38339584 38389002 LOC72864

0.970588 0.090909 0.242424 0 0.202899 LOC72864

10 10q21.1 60244781 60147298 LOC38970

0.970588 0.090909 0.030303 0 0.014493 LOC38970

9 9p22.3 14983325 15009723 CNTLN 0.970588 0.090909 0.121212 0 0.057971 CNTLN 9 9p22.2 17125038 17292050 SH3GL2 0.970588 0.090909 0.090909 0 0.043478 SH3GL2 9 9p22.2 17568953 17787121 IFNW1 0.970588 0.090909 0.121212 0 0.115942 IFNW1 9 9p21.3 21130631 21332145 IFNA21 0.970588 0.090909 0.121212 0 0.115942 IFNA21 9 9p21.3 21155636 21156660 IFNA13 0.970588 0.090909 0.090909 0 0.115942 IFNA13 9 9p21.3 21357371 21358076 C9orf135 0.970588 0.060606 0.090909 0.014493 0 C9orf135 9 9q21.11 71625551 71710969 MAMDC2 0.970588 0.090909 0.090909 0.014493 0 MAMDC2 9 9921.11 71848317 72031709 RHEB 0.970588 0.30303 0.090909 0.434783 0 RHEB 7 7q36.1 1.51E+08 1.51E+08 RHACTR1 0.970588 0.060606 0.090909 0.072464 0 PHACTR1 6 6p24.1 12825819 13395508 SNHG5 0.970588 0.090909 0.30303 0 0.333333 SNHG5 6 6q14.3 86443444 86445171 SNORD50A 0.970588 0.090909 0.30303 0 0.333333 SNORD50A 6 6q14.3 86443731 86443806 SNORD50B 0.970588 0.090909 0.30303 0 0.333333 SNORD50B 6 6q14.3 86444026 86444097 GJB7 0.970588 0.090909 0.242424 0 0.202899 GJB7 6 6q15 88049416 88095716 C6orf162 0.970588 0.090909 0.242424 0 0.202899 C6orf162 6 6q15 88089025 88108763 C6orf163 0.970588 0.090909 0.242424 0 0.202899 C6orf163 6 6q15 88111290 88131900 C6orf164 0.970588 0.090909 0.242424 0 0.202899 C6orf164 6 6q15 88163561 88166179 C6orf165 0.970588 0.090909 0.242424 0 0.202899 C6orf165 6 6q15 88174409 88230911 SLC35A1 0.970588 0.090909 0.242424 0 0.202899 SLC35A1 6 6q15 88239362 88278771 RARS2 0.970588 0.090909 0.242424 0 0.202899 RARS2 6 6q15 88280816 88356455 TAAR8 0.970588 0.090909 0.060606 0 0.043478 TAAR8 6 6q23.2 1.33E+08 1.33E+08 FYB 0.970588 0.090909 0 0 0.014493 FYB 5 5p13.1 39141114 39255425 UGT2B10 0.970588 0.090909 0.272727 0 0.289855 UGT2B10 4 4q13.2 69716302 69732329 UGT2A3 0.970588 0.090909 0.272727 0 0.289855 UGT2A3 4 4q13.2 69828766 69852099 MUC7 0.970588 0.090909 0.181818 0 0.202899 MUC7 4 4q13.3 71330798 71383303 ADAMTS3 0.970588 0.090909 0.181818 0 0.289855 ADAMTS3 4 4q13.3 73365551 73653381 AFP 0.970588 0.090909 0.121212 0 0.101449 AFP 4 4q13.3 74520797 74540357 AFM 0.970588 0.090909 0.121212 0 0.101449 AFM 4 4q13.3 74566326 74588583 RASSF6 0.970588 0.090909 0.121212 0 0.086957 RASSF6 4 4q13.3 74657726 74704999 CXCL6 0.970588 0.090909 0.151515 0 0.101449 CXCL6 4 4q13.3 74921137 74923342 PPBPL1 0.970588 0.090909 0.151515 0 0.101449 PPBPL1 4 4q13.3 74932447 74933418 PF4 0.970588 0.090909 0.151515 0 0.101449 PF4 4 4q13.3 75065660 75066580 PPBP 0.970588 0.090909 0.151515 0 0.101449 PPBP 4 4q13.3 75071620 75072765 CXCL3 0.970588 0.090909 0.151515 0 0.101449 CXCL3 4 4q13.3 75121176 75123355 CXCL2 0.970588 0.090909 0.151515 0 0.101449 CXCL2 4 4q13.3 75181618 75183862 MTHFD2L 0.970588 0.090909 0.151515 0 0.115942 MTHFD2L 4 4q13.3 75242693 75387677 AREG 0.970588 0.090909 0.121212 0 0.115942 AREG 4 4q13.3 75699653 75709510 PARM1 0.970588 0.090909 0.151515 0 0.086957 PARM1 4 4q13.3 76077322 76194348 FAM47E 0.970588 0.090909 0.030303 0 0.014493 FAM47E 4 4q21.1 77391877 77423948 ANKRD56 0.970588 0.090909 0.060606 0 0.014493 ANKRD56 4 4q21.1 78035106 78038027 11-Sep 0.970588 0.090909 0.030303 0 0.014493 11-Sep 4 4q21.1 78089919 78178793 ANXA3 0.970588 0.090909 0.060606 0 0.028986 ANXA3 4 4q21.21 79691766 79750630 BMP2K 0.970588 0.090909 0.090909 0 0.028986 BMP2K 4 4q21.21 79916556 80019619 PRDM8 0.970588 0.090909 0.121212 0 0.130435 PRDM8 4 4q21.21 81325448 81344507 CDS1 0.970588 0.090909 0.151515 0 0.043478 CDS1 4 4q21.23 85723081 85791518 WDFY3 0.970588 0.090909 0.121212 0 0.043478 WDFY3 4 4q21.23 85809723 86106569 MANBA 0.970588 0.090909 0.030303 0 0.101449 MANBA 4 4q24 1.04E+08 1.04E+08 TET2 0.970588 0.090909 0.151515 0 0.231884 TET2 4 4q24 1.06E+08 1.06E+08 HHIP 0.970588 0.090909 0.090909 0 0.086957 HHIP 4 4q31.22 1.46E+08 1.46E+08 CLSTN2 0.970588 0.090909 0.090909 0.26087 0 CLSTN2 3 3q23 1.41E+08 1.42E+08 CDC42EP3 0.970588 0 0.090909 0.072464 0 CDC42EP3 2 2p22.2 37724247 37752831 C2orf89 0.970588 0.151515 0.090909 0.318841 0 C2orf89 2 2p11.2 84902307 84961764 IL1RL2 0.970588 0.151515 0.090909 0.202899 0 IL1RL2 2 2q12.1 1.02E+08 1.02E+08 PKN2 0.970588 0.090909 0.212121 0 0.101449 PKN2 1 1p22.2 88922510 89074527 PHGDH 0.970588 0.060606 0.090909 0.086957 0 PHGDH 1 1p12  1.2E+08  1.2E+08 REG4 0.970588 0.030303 0.090909 0.086957 0 REG4 1 1p12  1.2E+08  1.2E+08 NBPF7 0.970588 0.030303 0.090909 0.086957 0 NBPF7 1 1p12  1.2E+08  1.2E+08 ADAM30 0.970588 0.030303 0.090909 0.086957 0 ADAM30 1 1p12  1.2E+08  1.2E+08 NOTCH2 0.970588 0.030303 0.090909 0.086957 0 NOTCH2 1 1p12  1.2E+08  1.2E+08 NENF 0.970588 0.121212 0.090909 0.246377 0 NENF 1 1q32.3 2.11E+08 2.11E+08 CNIH4 0.970588 0.181818 0.090909 0.304348 0 CNIH4 1 1q42.11 2.23E+08 2.23E+08 SNAP47 0.970588 0.272727 0.090909 0.42029 0 SNAP47 1 1q42.13 2.26E+08 2.26E+08 SIPA1L2 0.970588 0.212121 0.090909 0.275362 0 SIPA1L2 1 1q42.2 2.31E+08 2.31E+08 KIAA1383 0.970588 0.151515 0.090909 0.246377 0 KIAA1383 1 1q42.2 2.31E+08 2.31E+08 C1orf57 0.970588 0.151515 0.090909 0.231884 0 C1orf57 1 1q42.2 2.31E+08 2.31E+08 PCNXL2 0.970588 0.151515 0.090909 0.231884 0 PCNXL2 1 1q42.2 2.31E+08 2.31E+08 KIAA1804 0.970588 0.151515 0.090909 0.231884 0 KIAA1804 1 1q42.2 2.32E+08 2.32E+08 KCNK1 0.970588 0.121212 0.090909 0.217391 0 KCNK1 1 1q42.2 2.32E+08 2.32E+08 SLC35F3 0.970588 0.121212 0.090909 0.217391 0 SLC35F3 1 1q42.2 2.32E+08 2.33E+08 TARBP1 0.970588 0.242424 0.090909 0.246377 0 TARBP1 1 1q42.2 2.33E+08 2.33E+08 B3GALNT2 0.970588 0.242424 0.090909 0.275362 0 B3GALNT2 1 1q42.3 2.34E+08 2.34E+08 GNG4 0.970588 0.242424 0.090909 0.275362 0 GNG4 1 1q42.3 2.34E+08 2.34E+08 LYST 0.970588 0.212121 0.090909 0.275362 0 LYST 1 1q42.3 2.34E+08 2.34E+08 NID1 0.970588 0.242424 0.090909 0.26087 0 NID1 1 1q42.3 2.34E+08 2.34E+08 GPR137B 0.970588 0.272727 0.090909 0.26087 0 GPR137B 1 1q42.3 2.34E+08 2.34E+08 EDARADD 0.970588 0.272727 0.090909 0.246377 0 EDARADD 1 1q43 2.35E+08 2.35E+08 HEATR1 0.970588 0.242424 0.090909 0.188406 0 HEATR1 1 1q43 2.35E+08 2.35E+08 SMC5 0.019608 0.090909 0.090909 0.014493 0.014493 SMC5 9 9q21.11 72063698 72159610 TTTY8 0.009804 0.212121 0.121212 0.202899 0.014493 TTTY8 Y Yp11.2 10138709 10141309 TTTY8B 0.009804 0.212121 0.121212 0.202899 0.014493 TTTY8B Y Yp11.2 10138709 10141309 TTTY7 0.009804 0.212121 0.121212 0.202899 0.014493 TTTY7 Y Yp11.2 10154433 10162872 TTTY7B 0.009804 0.212121 0.121212 0.202899 0.014493 TTTY7B Y Yp11.2 10154433 10162872 LOC100101 0.009804 0.212121 0.121212 0.202899 0.014493 LOC10010

Y Yp11.2 10165262 10168906 TTTY21 0.009804 0.212121 0.121212 0.202899 0.014493 TTTY21 Y Yp11.2 10165262 10168906 TTTY22 0.009804 0.212121 0.121212 0.202899 0.014493 TTTY22 Y Yp11.2 10248762 10260855 C22orf25 0.009804 0.424242 0.121212 0.681159 0.014493 C22orf25 22 22q11.21 18388631 18433448 MIR185 0.009804 0.424242 0.121212 0.681159 0.014493 MIR185 22 22q11.21 18400662 18400743 DGCR8 0.009804 0.424242 0.090909 0.681159 0.014493 DGCR8 22 22q11.21 18447834 18479401 ZNF74 0.009804 0.393939 0.090909 0.666667 0.014493 ZNF74 22 22q11.21 19078480 19092753 SCARF2 0.009804 0.393939 0.090909 0.666667 0.014493 SCARF2 22 22q11.21 19108875 19122147 KLHL22 0.009804 0.393939 0.090909 0.666667 0.014493 KLHL22 22 22q11.21 19125806 19180123 MED15 0.009804 0.393939 0.090909 0.666667 0.014493 MED15 22 22q11.21 19191886 19271920 POM121L4 0.009804 0.393939 0.090909 0.666667 0.014493 POM121L4 22 22q11.21 19373843 19376010 TMEM191

0.009804 0.393939 0.090909 0.666667 0.014493 TMEM191

22 22q11.21 19385402 19388892 PI4KA 0.009804 0.393939 0.090909 0.666667 0.014493 PI4KA 22 22q11.21 19391979 19418956 SERPIND1 0.009804 0.363636 0.090909 0.637681 0.014493 SERPIND1 22 22q11.21 19458383 19472009 SNAP29 0.009804 0.333333 0.090909 0.623188 0.014493 SNAP29 22 22q11.21 19543292 19575500 CRKL 0.009804 0.333333 0.090909 0.623188 0.014493 CRKL 22 22q11.21 19601714 19638039 FLI39582 0.009804 0.363636 0.090909 0.623188 0.014493 FLI39582 22 22q11.21 19686211 19694663 MGC16703 0.009804 0.363636 0.090909 0.623188 0.014493 MGC16703 22 22q11.21 19692496 19698577 P2RX6 0.009804 0.363636 0.090909 0.623188 0.014493 P2RX6 22 22q11.21 19699442 19712303 SLC7A4 0.009804 0.363636 0.090909 0.623188 0.014493 SLC7A4 22 22q11.21 19713007 19716848 PRAME 0.009804 0.30303 0.090909 0.623188 0.014493 PRAME 22 22q11.22 21220123 21231697 LOC648691 0.009804 0.30303 0.090909 0.623188 0.014493 LOC648691 22 22q11.22 21231756 21239007 RTDR1 0.009804 0.333333 0.090909 0.652174 0.014493 RTDR1 22 22q11.22 21731593 21814242 GNAZ 0.009804 0.333333 0.090909 0.652174 0.014493 GNAZ 22 22q11.22 21742669 21797222 RAB36 0.009804 0.333333 0.090909 0.652174 0.014493 RAB36 22 22q11.23 21817513 21836532 BCR 0.009804 0.333333 0.090909 0.652174 0.014493 BCR 22 22q11.23 21852552 21990225 ZDHHC8P 0.009804 0.333333 0.090909 0.652174 0.014493 ZDHHC8P 22 22q11.23 22062792 22074800 IGLL1 0.009804 0.363636 0.090909 0.637681 0.014493 IGLL1 22 22q11.23 22245313 22252496 LOC91316 0.009804 0.30303 0.121212 0.623188 0.014493 LOC91316 22 22q11.23 22310676 22389611 ZNF70 0.009804 0.363636 0.090909 0.637681 0.014493 ZNF70 22 22q11.23 22413772 22423280 MMP11 0.009804 0.363636 0.090909 0.637681 0.014493 MMP11 22 22q11.23 22445036 22456504 SMARCB1 0.009804 0.363636 0.090909 0.637681 0.014493 SMARCB1 22 22q11.23 22459150 22506706 CABIN1 0.009804 0.363636 0.121212 0.637681 0.014493 CABIN1 22 22q11.23 22737765 22904597 GGT5 0.009804 0.30303 0.121212 0.637681 0.014493 GGT5 22 22q11.23 22945622 22971111 UPB1 0.009804 0.272727 0.121212 0.623188 0.014493 UPB1 22 22q11.23 23221251 23252554 C22orf13 0.009804 0.272727 0.121212 0.623188 0.014493 C22orf13 22 22q11.23 23266408 23281276 SNRPD3 0.009804 0.272727 0.121212 0.623188 0.014493 SNRPD3 22 22q11.23 23281618 23298510 GGT1 0.009804 0.272727 0.121212 0.623188 0.014493 GGT1 22 22q11.23 23309718 23354973 C22orf36 0.009804 0.30303 0.121212 0.623188 0.014493 C22orf36 22 22q11.23 23311591 23319036 LOC64416

0.009804 0.30303 0.121212 0.623188 0.014493 LOC64416

22 22q11.23 23358882 23379327 SGSM1 0.009804 0.333333 0.121212 0.652174 0.014493 SGSM1 22 22q11.23 23532136 23652814 KIAA1671 0.009804 0.333333 0.121212 0.652174 0.014493 KIAA1671 22 22q11.23 23753941 23923414 CRYBB2 0.009804 0.333333 0.121212 0.652174 0.014493 CRYBB2 22 22q11.23 23945612 23957837 ADRBK2 0.009804 0.30303 0.090909 0.623188 0.014493 ADRBK2 22 22q11.23 24290861 24455259 MYO18B 0.009804 0.30303 0.090909 0.623188 0.014493 MYO188 22 22q12.1 24468120 24757008 MIR1302-1 0.009804 0.212121 0.121212 0.57971 0.014493 MIR1302-1 22 22q12.1 24513501 25125580 HPS4 0.009804 0.30303 0.090909 0.608696 0.014493 HPS4 22 22q12.1 25177446 25209821 SRRD 0.009804 0.30303 0.090909 0.608696 0.014493 SRRD 22 22q12.1 25209850 25217905 TFIP11 0.009804 0.30303 0.090909 0.608696 0.014493 TFIP11 22 22q12.1 25217895 25238438 TPST2 0.009804 0.30303 0.090909 0.57971 0.014493 TPST2 22 22q12.1 25251714 25291371 MIR548J 0.009804 0.30303 0.090909 0.57971 0.014493 MIR548J 22 22q12.1 25281178 25281290 CRYBA4 0.009804 0.30303 0.090909 0.565217 0.014493 CRYBA4 22 22q12.1 25347928 25356637 MIAT 0.009804 0.272727 0.090909 0.550725 0.014493 MIAT 22 22q12.1 25383484 25402439 RFPL3 0.009804 0.242424 0.090909 0.608696 0.014493 RFPL3 22 22q12.3 31080872 31087149 RFP135 0.009804 0.242424 0.090909 0.608696 0.014493 RFPL3S 22 22q12.3 31085893 31097064 C22orf28 0.009804 0.242424 0.090909 0.608696 0.014493 C22orf28 22 22q12.3 31113562 31138275 SYN3 0.009804 0.242424 0.090909 0.608696 0.014493 SYN3 22 22q12.3 31238540 31784378 TIMP3 0.009804 0.242424 0.090909 0.608696 0.014493 TIMP3 22 22q12.3 31526802 31589029 LARGE 0.009804 0.242424 0.090909 0.594203 0.014493 LARGE 22 22q12.3 31999062 32646417 ISX 0.009804 0.151515 0.090909 0.57971 0.014493 ISX 22 22q12.3 33792130 33813381 TOM1 0.009804 0.30303 0.090909 0.608696 0.014493 TOM1 22 22q12.3 34025268 34073986 HMOX1 0.009804 0.333333 0.090909 0.623188 0.014493 HMOX1 22 22q12.3 34107087 34120195 MCM5 0.009804 0.333333 0.090909 0.623188 0.014493 MCM5 22 22q12.3 34126116 34150496 RASD2 0.009804 0.333333 0.090909 0.623188 0.014493 RASD2 22 22q12.3 34267298 34279992 MB 0.009804 0.30303 0.090909 0.637681 0.014493 MB 22 22q12.3 34332757 34343331 ABCC13 0.009804 0.090909 0.121212 0.014493 0.115942 ABCC13 21 21q11.2 14567991 14595564 KRTAP11-1 0.009804 0.121212 0.090909 0.101449 0.014493 KRTAP11-1 21 21q22.11 31174835 31175746 KRTAP19-8 0.009804 0.151515 0.090909 0.144928 0.014493 KRTAP19-8 21 21q22.11 31332349 31332667 CLDN14 0.009804 0.30303 0.090909 0.463768 0.014493 CLDN14 21 21q22.13 36754790 36760596 SMCHD1 0.009804 0.090909 0.090909 0.173913 0.014493 SMCHD1 18 18p11.32 2645886 2795016 EMILIN2 0.009804 0.151515 0.090909 0.202899 0.014493 EMILIN2 18 18p11.32 2837028 2904091 LPIN2 0.009804 0.212121 0.090909 0.188406 0.014493 LPIN2 18 18p11.32 2906992 3001946 LOC72789

0.009804 0.060606 0.090909 0.15942 0.014493 LOC72789

18 18p11.31 2933215 2936622 TGIF1 0.009804 0.181818 0.090909 0.188406 0.014493 TGIF1 18 18p11.31 3402072 3448407 DLGAP1 0.009804 0.151515 0.090909 0.188406 0.014493 DLGAP1 18 18p11.31 3488837 3835297 FLJ35776 0.009804 0.151515 0.090909 0.188406 0.014493 FLJ35776 18 18p11.31 3584112 3587377 EPB41L3 0.009804 0.060606 0.121212 0.086957 0.014493 EPB41L3 18 18p11.31 5382388 5533987 L3MBTL4 0.009804 0.030303 0.121212 0.072464 0.014493 L3MBTL4 18 18p11.31 5944705 6404911 ARHGAP28 0.009804 0.090909 0.090909 0.144928 0.014493 ARHGAP28 18 18p11.31 6824484 6905713 LAMA1 0.009804 0.121212 0.090909 0.173913 0.014493 LAMA1 18 18p11.31 6931886 7107814 LRRC30 0.009804 0.121212 0.090909 0.173913 0.014493 LRRC30 18 18p11.23 7221137 7222043 ANKRD12 0.009804 0.242424 0.090909 0.246377 0.014493 ANKRD12 18 18p11.22 9126758 9275207 RAB31 0.009804 0.272727 0.090909 0.26087 0.014493 RAB31 18 18p11.22 9698228 9852554 ROCK1 0.009804 0.151515 0.121212 0.130435 0.014493 ROCK1 18 18q11.1 16783701 16945811 GREB1L 0.009804 0.151515 0.121212 0.173913 0.014493 GREB1L 18 18q11.1 17076201 17356788 ESCO1 0.009804 0.151515 0.121212 0.173913 0.014493 ESCO1 18 18q11.2 17363260 17434692 SNRPD1 0.009804 0.151515 0.121212 0.173913 0.014493 SNRPD1 18 18q11.2 17446258 17464207 ABHD3 0.009804 0.151515 0.121212 0.173913 0.014493 ABHD3 18 18q11.2 17484856 17538765 MIR320C1 0.009804 0.151515 0.121212 0.173913 0.014493 MIR320C1 18 18q11.2 17517469 17517557 MIB1 0.009804 0.151515 0.121212 0.173913 0.014493 MIB1 18 18q11.2 17575543 17704911 CTAGE1 0.009804 0.030303 0.121212 0.130435 0.014493 CTAGE1 18 18q11.2 18247562 18251877 EPN2 0.009804 0.393939 0.090909 0.594203 0.014493 EPN2 17 17p11.2 19081283 19180622 B9D1 0.009804 0.393939 0.090909 0.594203 0.014493 B9D1 17 17p11.2 19187076 19206640 MIR1180 0.009804 0.393939 0.090909 0.594203 0.014493 MIR1180 17 17p11.2 19188412 19188481 MAPK7 0.009804 0.393939 0.090909 0.594203 0.014493 MAPK7 17 17p11.2 19221627 19227450 MFAP4 0.009804 0.393939 0.090909 0.594203 0.014493 MFAP4 17 17p11.2 19227348 19231087 RNF112 0.009804 0.393939 0.090909 0.594203 0.014493 RNF112 17 17p11.2 19255084 19261180 PCTP 0.009804 0.030303 0.090909 0.217391 0.014493 PCTP 17 17q22 51183355 51209748 EIF3CL 0.009804 0.424242 0.090909 0.565217 0.014493 EIF3CL 16 16p11.2 28298401 28322664 EIF3C 0.009804 0.424242 0.090909 0.565217 0.014493 EIF3C 16 16p11.2 28298404 28322667 CLN3 0.009804 0.424242 0.090909 0.565217 0.014493 CLN3 16 16p11.2 28396101 28410905 APOB48R 0.009804 0.424242 0.090909 0.565217 0.014493 APOB48R 16 16p11.2 28413494 28417784 IL27 0.009804 0.424242 0.090909 0.565217 0.014493 IL27 16 16p11.2 28418184 28425657 NUPR1 0.009804 0.424242 0.090909 0.565217 0.014493 NUPR1 16 16p11.2 28456163 28457997 CCDC101 0.009804 0.424242 0.090909 0.565217 0.014493 CCDC101 16 16q11.2 28472750 28510612 ATXN2L 0.009804 0.424242 0.090909 0.565217 0.014493 ATXN2L 16 16p11.2 28741915 28756060 SH2B1 0.009804 0.424242 0.090909 0.565217 0.014493 SH2B1 16 16p11.2 28782579 28793035 ATP2A1 0.009804 0.424242 0.090909 0.565217 0.014493 ATP2A1 16 16p11.2 28797310 28823332 SPNS1 0.009804 0.424242 0.090909 0.565217 0.014493 SPNS1 16 16p11.2 28893597 28903370 LAT 0.009804 0.424242 0.090909 0.565217 0.014493 LAT 16 16p11.2 28903648 28909606 RUNDC2C 0.009804 0.424242 0.090909 0.565217 0.014493 RUNDC2C 16 16p11.2 29210042 29293099 SLC7A5P1 0.009804 0.424242 0.090909 0.565217 0.014493 SLC7A5P1 16 16p11.2 29531925 29532540 SPN 0.009804 0.424242 0.090909 0.565217 0.014493 SPN 16 16p11.2 29581801 29589325 QPRT 0.009804 0.424242 0.090909 0.565217 0.014493 QPRT 16 16p11.2 29597942 29616816 C16orf54 0.009804 0.424242 0.090909 0.565217 0.014493 C16orf54 16 16p11.2 29661287 29664842 MAZ 0.009804 0.424242 0.090909 0.565217 0.014493 MAZ 16 16p11.2 29725356 29730006 PRRT2 0.009804 0.424242 0.090909 0.565217 0.014493 PRRT2 16 16p11.2 29730910 29734704 C16orf53 0.009804 0.424242 0.090909 0.565217 0.014493 C16orf53 16 16p11.2 29735029 29741318 MVP 0.009804 0.424242 0.090909 0.565217 0.014493 MVP 16 16p11.2 29739288 29766843 CDIPT 0.009804 0.424242 0.090909 0.565217 0.014493 CDIPT 16 16p11.2 29777179 29782080 LOC44035

0.009804 0.424242 0.090909 0.565217 0.014493 LOC44035

16 16p11.2 29782505 29786876 SEZ6L2 0.009804 0.424242 0.090909 0.565217 0.014493 SEZ6L2 16 16p11.2 29789981 29818082 ASPHD1 0.009804 0.424242 0.090909 0.565217 0.014493 ASPHD1 16 16p11.2 29819648 29824879 KCTD13 0.009804 0.424242 0.090909 0.565217 0.014493 KCTD13 16 16p11.2 29825162 29845047 TMEM219 0.009804 0.424242 0.090909 0.565217 0.014493 TMEM219 16 16p11.2 29880852 29891875 TAOK2 0.009804 0.424242 0.090909 0.565217 0.014493 TAOK2 16 16p11.2 29892723 29911083 C16orf92 0.009804 0.424242 0.090909 0.565217 0.014493 C16orf92 16 16p11.2 29942156 29943525 FAM57B 0.009804 0.424242 0.090909 0.565217 0.014493 FAM57B 16 16p11.2 29943249 29949688 ALDOA 0.009804 0.424242 0.090909 0.565217 0.014493 ALDOA 16 16p11.2 29971992 29989237 ITGAM 0.009804 0.393939 0.090909 0.565217 0.014493 ITGAM 16 16p11.2 31178789 31251715 RASGRP1 0.009804 0 0.121212 0.057971 0.014493 RASGRP1 15 15q14 36567594 36644300 C15orf53 0.009804 0 0.121212 0.057971 0.014493 C15orf53 15 15q14 36776091 36779532 THBS1 0.009804 0.030303 0.121212 0.086957 0.014493 THBS1 15 15q14 37660572 37676961 SCG3 0.009804 0 0.090909 0.115942 0.014493 SCG3 15 15q21.2 49760842 49800515 TMOD3 0.009804 0.030303 0.090909 0.130435 0.014493 TMOD3 15 15q21.2 49909181 49989139 RAB27A 0.009804 0.030303 0.121212 0.057971 0.014493 RAB27A 15 15q21.3 53283092 53349878 STXBP6 0.009804 0.090909 0.121212 0.014493 0.130435 STXBP6 14 14q12 24351144 24588936 HEATR5A 0.009804 0.121212 0 0.014493 0.043478 HEATR5A 14 14q12 30830745 30927933 C14orf126 0.009804 0.121212 0 0.014493 0.043478 C14orf126 14 14q12 30984994 30996432 NUBPL 0.009804 0.121212 0 0.014493 0.043478 NUBPL 14 14q12 31100342 31400181 NPAS3 0.009804 0.181818 0.090909 0.014493 0.101449 NPAS3 14 14q13.1 32478210 33343133 SSTR1 0.009804 0.090909 0.151515 0.014493 0.130435 SSTR1 14 14q21.1 37746955 37752020 MAP4K5 0.009804 0.181818 0 0.014493 0.028986 MAP4K5 14 14q22.1 49954993 50069127 ATL1 0.009804 0.181818 0 0.014493 0.028986 ATL1 14 14q22.1 50069550 50169535 FRMD6 0.009804 0.030303 0.090909 0 0.014493 FRMD6 14 14q22.1 51025605 51267195 DDHD1 0.009804 0.090909 0.030303 0.014493 0 DDHD1 14 14q22.2 52573210 52689797 PELI2 0.009804 0.030303 0.090909 0 0.014493 PELI2 14 14q22.3 55654846 55837785 DAAM1 0.009804 0.060606 0.151515 0.014493 0.014493 DAAM1 14 14q23.1 58725152 58906225 JKAMP 0.009804 0.060606 0.151515 0.028986 0.014493 JKAMP 14 14q23.1 59020914 59041835 C14orf38 0.009804 0.060606 0.151515 0.028986 0.014493 C14orf38 14 14q23.1 59041539 59113303 RHOJ 0.009804 0.121212 0.121212 0.101449 0.014493 RHOJ 14 14q23.2 62740898 62828313 GPHB5 0.009804 0.121212 0.121212 0.101449 0.014493 GPHB5 14 14q23.2 62849395 62854317 PPP2R5E 0.009804 0.151515 0.090909 0.101449 0.014493 PPP2R5E 14 14q23.2 62911108 63079833 SMOC1 0.009804 0.121212 0.242424 0.275362 0.014493 SMOC1 14 14q24.2 69415896 69568837 COX16 0.009804 0.121212 0.151515 0.231884 0.014493 COX16 14 14q24.2 69861552 69896198 HEATR4 0.009804 0.363636 0.121212 0.42029 0.014493 HEATR4 14 14q24.3 73014945 73095405 DNAL1 0.009804 0.363636 0.121212 0.434783 0.014493 DNAL1 14 14q24.3 73181331 73238403 PNMA1 0.009804 0.363636 0.121212 0.434783 0.014493 PNMA1 14 14q24.3 73248239 73250882 C14orf43 0.009804 0.363636 0.121212 0.434783 0.014493 C14orf43 14 14q24.3 73251578 73323650 PTGR2 0.009804 0.333333 0.121212 0.434783 0.014493 PTGR2 14 14q24.3 73388287 73421920 ZNF410 0.009804 0.333333 0.121212 0.434783 0.014493 ZNF410 14 14q24.3 73423339 73468557 LIN52 0.009804 0.333333 0.121212 0.376812 0.014493 LIN52 14 14q24.3 73621409 73736871 TTLL5 0.009804 0.272727 0.121212 0.304348 0.014493 TTLL5 14 14q24.3 75197374 75491176 STON2 0.009804 0.121212 0.121212 0.043478 0.014493 STON2 14 14q31.1 80806662 80934681 GJA3 0.009804 0.272727 0.121212 0.304348 0.014493 GJA3 13 13q12.11 19610395 19633184 GJB2 0.009804 0.272727 0.121212 0.304348 0.014493 GJB2 13 13q12.11 19659606 19665115 GJB6 0.009804 0.272727 0.121212 0.304348 0.014493 GJB6 13 13q12.11 19694101 19704535 CRYL1 0.009804 0.272727 0.121212 0.304348 0.014493 CRYL1 13 13q12.11 19875806 19998013 IFT88 0.009804 0.242424 0.121212 0.289855 0.014493 IFT88 13 13q12.11 20039208 20163577 IL17D 0.009804 0.272727 0.121212 0.289855 0.014493 IL17D 13 13q12.11 20175482 20195238 N6AMT2 0.009804 0.272727 0.121212 0.289855 0.014493 N6AMT2 13 13q12.11 20201073 20246058 LATS2 0.009804 0.212121 0.121212 0.246377 0.014493 LATS2 13 13q12.11 20445176 20533723 SAP18 0.009804 0.212121 0.121212 0.217391 0.014493 SAP18 13 13q12.11 20612653 20621224 SKA3 0.009804 0.212121 0.121212 0.217391 0.014493 SKA3 13 13q12.11 20625735 20648742 ZDHHC20 0.009804 0.181818 0.121212 0.173913 0.014493 ZDHHC20 13 13q12.11 20848508 20931424 NUPL1 0.009804 0.121212 0.181818 0.304348 0.014493 NUPL1 13 13q12.13 24773666 24814562 B3GALTL 0.009804 0.121212 0.090909 0.217391 0.014493 B3GALTL 13 13q12.3 30672112 30804412 TPP2 0.009804 0.090909 0.333333 0.014493 0.086957 TPP2 13 13q33.1 1.02E+08 1.02E+08 COL4A1 0.009804 0.272727 0.181818 0.347826 0.014493 COL4A1 13 13q34  1.1E+08  1.1E+08 COL4A2 0.009804 0.272727 0.181818 0.347826 0.014493 COL4A2 13 13q34  1.1E+08  1.1E+08 RAB20 0.009804 0.333333 0.181818 0.376812 0.014493 RAB20 13 13q34  1.1E+08  1.1E+08 CARKD 0.009804 0.333333 0.181818 0.405797 0.014493 CARKD 13 13q34  1.1E+08  1.1E+08 CARS2 0.009804 0.333333 0.181818 0.405797 0.014493 CARS2 13 13q34  1.1E+08  1.1E+08 C13orf29 0.009804 0.30303 0.181818 0.391304 0.014493 C13orf29 13 13q34  1.1E+08  1.1E+08 ARHGEF7 0.009804 0.333333 0.181818 0.453768 0.014493 ARHGEF7 13 13q34 1.11E+08 1.11E+08 LEMD3 0.009804 0.030303 0.121212 0.014493 0.014493 LEMD3 12 12q14.3 63849618 63928407 PTPRB 0.009804 0.090909 0.060606 0.014493 0.028986 PTPRB 12 12q15 69196899 69317487 ZFC3H1 0.009804 0.090909 0.121212 0.014493 0.144928 ZFC3H1 12 12q21.1 70289649 70344017 KCNC2 0.009804 0.121212 0.242424 0.014493 0.289855 KCNC2 12 12q21.1 73720163 73889779 CAPS2 0.009804 0.121212 0.242424 0.014493 0.246377 CAPS2 12 12q21.1 73956026 74010104 GLIPR1L2 0.009804 0.121212 0.242424 0.014493 0.246377 GLIPR1L2 12 12q21.1 74071156 74104088 NAP1L1 0.009804 0.151515 0.060606 0.014493 0.101449 NAP1L1 12 12q21.2 74724939 74765006 NAV3 0.009804 0.090909 0.212121 0.014493 0.318841 NAV3 12 12q21.2 76749200 77130922 SYT1 0.009804 0.090909 0.212121 0.014493 0.304348 SYT1 12 12q21.2 77781904 78369919 LiN7A 0.009804 0.090909 0.212121 0.014493 0.289855 LIN7A 12 12q21.31 79715302 79855826 MIR618 0.009804 0.090909 0.181818 0.014493 0.289855 MIR618 12 12q21.31 79853647 79853744 PPFIA2 0.009804 0.090909 0.242424 0.014493 0.318841 PPFIA2 12 12q21.31 80177487 80677241 RASSF9 0.009804 0.090909 0.181818 0.014493 0.333333 RASSF9 12 12q21.31 84722462 84754450 LUM 0.009804 0.121212 0.212121 0.014493 0.231884 LUM 12 12q21.33 90021363 90029674 BTG1 0.009804 0.121212 0.090909 0.014493 0.028986 BTG1 12 12q21.33 91058187 91063805 PLEKHG7 0.009804 0.121212 0.090909 0.014493 0.028986 PLEKHG7 12 12q22 91654396 91690000 PLXNC1 0.009804 0.151515 0.090909 0.115942 0.014493 PLXNC1 12 12q22 93066630 93223357 SRRM4 0.009804 0.121212 0.090909 0.42029 0.014493 SRRM4 12 12q24.23 1.18E+08 1.18E+08 OR52B4 0.009804 0.030303 0.090909 0.144928 0.014493 OR52B4 11 11p15.4 4345157 4346102 OR52K2 0.009804 0 0.090909 0.130435 0.014493 OR52K2 11 11p15.4 4427146 4428091 OR52N2 0.009804 0.060606 0.090909 0.072464 0.014493 OR52N2 11 11p15.4 5798142 5799108 OR2AG2 0.009804 0.030303 0.121212 0.057971 0.014493 OR2AG2 11 11p15.4 6745814 6746765 PDHX 0.009804 0.030303 0.151515 0.057971 0.014493 PDHX 11 11p13 34894253 34974251 SLC1A2 0.009804 0.090909 0.090909 0.043478 0.014493 SLC1A2 11 11p13 35229328 35397682 PAMR1 0.009804 0.030303 0.151515 0.028986 0.014493 PAMR1 11 11p13 35409952 35503753 FJX1 0.009804 0.030303 0.181818 0.028986 0.014493 FJX1 11 11p13 35596311 35598996 TRIM44 0.009804 0.030303 0.181818 0.028986 0.014493 TRIM44 11 11p13 35640929 35787507 TRAF6 0.009804 0.121212 0.090909 0.101449 0.014493 TRAF6 11 11p12 36467299 36488399 PRCP 0.009804 0.121212 0.090909 0.028986 0.014493 PRCP 11 11q14.1 82213057 82289206 C11orf82 0.009804 0.121212 0.090909 0.028986 0.014493 C11orf82 11 11q14.1 82290385 82323348 CCDC90B 0.009804 0.090909 0.151515 0.014493 0.057971 CCDC90B 11 11q14.1 82650150 82675026 C11orf75 0.009804 0.090909 0.121212 0.130435 0.014493 C11orf75 11 11q21 92851287 92916195 PANX1 0.009804 0.090909 0.151515 0.043478 0.014493 PANX1 11 11q21 93501742 93554786 GPR83 0.009804 0.121212 0.090909 0.043478 0.014493 GPR83 11 11q21 93750125 93774234 MAML2 0.009804 0.090909 0.121212 0.014493 0.086957 MAML2 11 11q21 95351088 95715993 DYNC2H1 0.009804 0.090909 0.151515 0.014493 0.188406 DYNC2H1 11 11q22.3 1.02E+08 1.03E+08 DDI1 0.009804 0.151515 0.151515 0.014493 0.144928 DDI1 11 11q22.3 1.03E+08 1.03E+08 ZW10 0.009804 0.212121 0.121212 0.275362 0.014493 ZW10 11 11q23.2 1.13E+08 1.13E+08 AMICA1 0.009804 0.242424 0.151515 0.449275 0.014493 AMICA1 11 11q23.3 1.18E+08 1.18E+08 CD3G 0.009804 0.333333 0.090909 0.478261 0.014493 CD3G 11 11q23.3 1.18E+08 1.18E+08 UBE4A 0.009804 0.333333 0.090909 0.478261 0.014493 UBE4A 11 11q23.3 1.18E+08 1.18E+08 DDX6 0.009804 0.393939 0.090909 0.492754 0.014493 DDX6 11 11q23.3 1.18E+08 1.18E+08 LOC10021

0.009804 0.030303 0.090909 0.15942 0.014493 LOC10021

10 10p15.1 4682378 4710263 LOC33858

0.009804 0.030303 0.090909 0.15942 0.014493 LOC33858

10 10p15.1 4688348 4694605 tAKR 0.009804 0 0.090909 0.188406 0.014493 tAKR 10 10p15.1 4903861 4948466 C10orf18 0.009804 0.151515 0.090909 0.304348 0.014493 C10orf18 10 10p15.1 5766807 5846950 GDI2 0.009804 0.242424 0.090909 0.318841 0.014493 GDI2 10 10p15.1 5847192 5895519 ARHGAP12 0.009804 0.090909 0.090909 0.086957 0.014493 ARHGAP12 10 10p11.22 32135231 32257777 LOC10012

0.009804 0 0.151515 0.115942 0.014493 LOC10012

10 10p11.21 38504605 38543279 HSD17B7P

0.009804 0 0.151515 0.115942 0.014493 HSD17B7P

10 10p11.21 38685314 38707440 TFAM 0.009804 0.090909 0.181818 0.014493 0.231884 TFAM 10 10q21.1 59815182 59825904 BICC1 0.009804 0.090909 0.242424 0.014493 0.231884 BICC1 10 10q21.1 59942910 60258852 PGM5 0.009804 0.060606 0.121212 0.057971 0.014493 PGM5 9 9q13 70161635 70335798 LOC44017

0.009804 0.121212 0.090909 0.318841 0.014493 LOC44017

9 9q21.33 88813187 88846862 SLC7A2 0.009804 0.090909 0.393939 0.014493 0.333333 SLC7A2 8 8p22 17398975 17472349 MTUS1 0.009804 0.090909 0.393939 0.014493 0.318841 MTUS1 8 8p22 17545584 17702707 FGL1 0.009804 0.121212 0.393939 0.014493 0.333333 FGL1 8 8p22 17766180 17797328 TMEM106

0.009804 0.090909 0.151515 0.014493 0.173913 TMEM106

7 7p21.3 12217373 12243415 MEOX2 0.009804 0.121212 0.030303 0.014493 0.231884 MEOX2 7 7p21.1 15617362 15692834 AGR3 0.009804 0.121212 0.030303 0.014493 0.101449 AGR3 7 7p21.1 16865555 16888139 SNX13 0.009804 0.121212 0.030303 0.014493 0.15942 SNX13 7 7p21.1 17796911 17946657 PRPS1L1 0.009804 0.090909 0.060606 0.014493 0.15942 PRPS1L1 7 7p21.1 18032925 18034012 HDAC9 0.009804 0.090909 0.121212 0.014493 0.173913 HDAC9 7 7p21.1 18501894 18674991 CHN2 0.009804 0.030303 0.090909 0.072464 0.014493 CHN2 7 7p15.1 29200646 29520470 POU6F2 0.009804 0.030303 0.121212 0.057971 0.014493 POU6F2 7 7p14.1 38984134 39470916 GLI3 0.009804 0.030303 0.151515 0.043478 0.014493 GLI3 7 7p14.1 41967075 42243144 CDK6 0.009804 0.151515 0.121212 0.014493 0.130435 CDK6 7 7q21.2 92072173 92303878 CALD1 0.009804 0.121212 0.090909 0.115942 0.014493 CALD1 7 7q33 1.34E+08 1.34E+08 LY86 0.009804 0.181818 0.121212 0.289855 0.014493 LY86 6 6p25.1 6533933 6600216 BMP6 0.009804 0.181818 0.090909 0.304348 0.014493 BMP6 6 6p24.3 7672010 7826961 RNF144B 0.009804 0.090909 0.151515 0.014493 0.043478 RNF144B 6 6p22.3 18495573 18576830 GPR116 0.009804 0 0.090909 0.072464 0.014493 GPR116 6 6p12.3 46928204 46997674 GPR110 0.009804 0 0.090909 0.072464 0.014493 GPR110 6 6p12.3 47075772 47118042 COL9A1 0.009804 0.090909 0.212121 0.014493 0.26087 COL9A1 6 6q13 70982464 71069508 SNX14 0.009804 0.121212 0.272727 0.014493 0.289855 SNX14 6 6q14.3 86271934 86360349 SYNCRIP 0.009804 0.121212 0.272727 0.014493 0.289855 SYNCRIP 6 6q14.3 86374222 86409360 ZNF292 0.009804 0.090909 0.242424 0.014493 0.217391 ZNF292 6 6q15 87921988 88030126 RSPH4A 0.009804 0.090909 0.333333 0.014493 0.26087 RSPH4A 6 6q22.1 1.17E+08 1.17E+08 SLC22A3 0.009804 0.151515 0.030303 0.014493 0.014493 SLC22A3 6 6q25.3 1.61E+08 1.61E+08 LPA 0.009804 0.030303 0.090909 0.014493 0.014493 LPA 6 6q25.3 1.61E+08 1.61E+08 DNAH5 0.009804 0.151515 0.030303 0.014493 0.014493 DNAH5 5 5p15.2 13743437 13997590 PRLR 0.009804 0.090909 0.060606 0.014493 0.072464 PRLR 5 5p13.2 35091559 35266552 ERBB2IP 0.009804 0.090909 0.151515 0.014493 0.130435 ERBB2IP 5 5q12.3 65258140 65412607 LOC10030

0.009804 0.090909 0.151515 0.014493 0.130435 LOC10030

5 5q12.3 65276391 65277158 ENC1 0.009804 0.090909 0.121212 0.014493 0.057971 ENC1 5 5q13.3 73958990 73973006 HEXB 0.009804 0.090909 0.121212 0.014493 0.057971 HEXB 5 5q13.3 74016725 74052870 ZNF608 0.009804 0.090909 0.090909 0.014493 0.130435 ZNF608 5 5q23.2 1.24E+08 1.24E+08 YIPF7 0.009804 0.090909 0.212121 0.014493 0.289855 YIPF7 4 4p13 44319111 44348416 ATP10D 0.009804 0.121212 0.121212 0.014493 0.188406 ATP10D 4 4p12 47182167 47290261 LRRC66 0.009804 0.060506 0.121212 0.028986 0.014493 LRRC66 4 4q12 52554623 52578544 SPATA18 0.009804 0.060606 0.151515 0.028986 0.014493 SPATA18 4 4q12 52612350 52658216 USP46 0.009804 0.090909 0.090909 0.072464 0.014493 USP46 4 4q12 53151886 53217517 ANKRD17 0.009804 0.181818 0.060606 0.014493 0.072464 ANKRD17 4 4q13.3 74159366 74343367 BTC 0.009804 0.121212 0.121212 0.014493 0.101449 BTC 4 4q13.3 75890472 75938907 PPEF2 0.009804 0.181818 0.030303 0.014493 0 PPEF2 4 4q21.1 77000050 77042706 NAAA 0.009804 0.181818 0.030303 0.014493 0 NAAA 4 4q21.1 77050832 77081191 SCARB2 0.009804 0.090909 0.030303 0.014493 0.014493 SCARB2 4 4q21.1 77298918 77354060 CCNI 0.009804 0.121212 0.030303 0.014493 0.014493 CCNI 4 4q21.1 78188199 78216150 MRPL1 0.009804 0.121212 0.090909 0.014493 0.043478 MRPL1 4 4q21.1 79002829 79092969 PTPN13 0.009804 0.121212 0.090909 0.057971 0.014493 PTPN13 4 4q21.3 87734492 87955353 UBE2D3 0.009804 0.090909 0.030303 0.014493 0.086957 UBE2D3 4 4q24 1.04E+08 1.04E+08 CISD2 0.009804 0.090909 0.030303 0.014493 0.086957 CISD2 4 4q24 1.04E+08 1.04E+08 NHEDC1 0.009804 0.090909 0.030303 0.014493 0.086957 NHEDC1 4 4q24 1.04E+08 1.04E+08 HADH 0.009804 0.090909 0.030303 0.014493 0.028986 HADH 4 4q25 1.09E+08 1.09E+08 LEF1 0.009804 0.090909 0.030303 0.014493 0.028986 LEF1 4 4q25 1.09E+08 1.09E+08 CCDC109B 0.009804 0.121212 0.030303 0.014493 0.014493 CCDC109B 4 4q25 1.11E+08 1.11E+08 CFI 0.009804 0.121212 0.030303 0.014493 0.014493 CFI 4 4q25 1.11E+08 1.11E+08 LOC285501 0.009804 0.090909 0.030303 0.014493 0.202899 LOC285501 4 4q34.3 1.79E+08 1.79E+08 ADAMTS9 0.009804 0 0.090909 0.101449 0.014493 ADAMTS9 3 3p14.1 64476371 64648406 ROBO2 0.009804 0.090909 0.212121 0.014493 0.333333 ROBO2 3 3p12.3 77171984 77779354 GABRR3 0.009804 0.090909 0.272727 0.014493 0.26087 GABRR3 3 3q11.2 99188217 99236522 GUCA1C 0.009804 0.090909 0.030303 0.014493 0.057971 GUCA1C 3 3q13.13  1.1E+08  1.1E+08 MORC1 0.009804 0.090909 0.030303 0.014493 0.057971 MORC1 3 3q13.13  1.1E+08  1.1E+08 TNIK 0.009804 0.060606 0.090909 0.072464 0.014493 TNIK 3 3q26.2 1.72E+08 1.73E+08 ETV5 0.009804 0.151515 0.090909 0.333333 0.014493 ETV5 3 3q27.2 1.87E+08 1.87E+08 HRG 0.009804 0.181818 0.090909 0.362319 0.014493 HRG 3 3q27.3 1.88E+08 1.88E+08 MASP1 0.009804 0.121212 0.090909 0.246377 0.014493 MASP1 3 3q27.3 1.88E+08 1.88E+08 SST 0.009804 0.090909 0.121212 0.246377 0.014493 SST 3 3q27.3 1.89E+08 1.89E+08 CRIM1 0.009804 0.060606 0.090909 0.086957 0.014493 CRIM1 2 2p22.2 36436901 36631783 TACR1 0.009804 0.090909 0.090909 0.144928 0.014493 TACR1 2 2p13.1 75127098 75280154 UNC50 0.009804 0.121212 0.090909 0.246377 0.014493 UNC50 2 2q11.2 98591474 98601410 MGAT4A 0.009804 0.121212 0.090909 0.246377 0.014493 MGAT4A 2 2q11.2 98602001 98714022 PLA2R1 0.009804 0.030303 0.090909 0.043478 0.014493 PLA2R1 2 2q24.2 1.61E+08 1.61E+08 STK39 0.009804 0.090909 0.060606 0.014493 0.043478 STK39 2 2q24.3 1.69E+08 1.69E+08 C2orf77 0.009804 0.151515 0.121212 0.086957 0.014493 C2orf77 2 2q31.1  1.7E+08  1.7E+08 PHOSPHO2 0.009804 0.151515 0.090909 0.086957 0.014493 PHOSPHO2 2 2q31.1  1.7E+08  1.7E+08 KLHL23 0.009804 0.151515 0.090909 0.086957 0.014493 KLHL23 2 2q31.1  1.7E+08  1.7E+08 SSB 0.009804 0.151515 0.090909 0.115942 0.014493 SSB 2 2q31.1  1.7E+08  1.7E+08 METTL5 0.009804 0.151515 0.090909 0.115942 0.014493 METTL5 2 2q31.1  1.7E+08  1.7E+08 UBR3 0.009804 0.151515 0.090909 0.115942 0.014493 UBR3 2 2q31.1  1.7E+08 1.71E+08 ZAK 0.009804 0.090909 0.090909 0.115942 0.014493 ZAK 2 2q31.1 1.74E+08 1.74E+08 COL5A2 0.009804 0.090909 0.121212 0.014493 0.130435 COL5A2 2 2q32.2  1.9E+08  1.9E+08 SLC40A1 0.009804 0.090909 0.090909 0.014493 0.130435 SLC40A1 2 2q32.2  1.9E+08  1.9E+08 ASNSD1 0.009804 0.121212 0.090909 0.014493 0.130435 ASNSD1 2 2q32.2  1.9E+08  1.9E+08 ANKAR 0.009804 0.090909 0.090909 0.014493 0.101449 ANKAR 2 2q32.2  1.9E+08  1.9E+08 OSGEPL1 0.009804 0.090909 0.090909 0.0144193 0.101449 OSGEPL1 2 2q32.2  1.9E+08  1.9E+08 ORMDL1 0.009804 0.090909 0.090909 0.014493 0.101449 ORMDL1 2 2q32.2  1.9E+08  1.9E+08 PMS1 0.009804 0.090909 0.090909 0.014493 0.101449 PMS1 2 2q32.2  1.9E+08  1.9E+08 STAT1 0.009804 0.090909 0.030303 0.014493 0.043478 STAT1 2 2q32.2 1.92E+08 1.92E+08 MYO1B 0.009804 0.090909 0.090909 0.014493 0.043478 MYO1B 2 2q32.3 1.92E+08 1.92E+08 TMEFF2 0.009804 0.090909 0.151515 0.014493 0.144928 TMEFF2 2 2q32.3 1.93E+08 1.93E+08 ANKRD44 0.009804 0.090909 0.060606 0.014493 0.028986 ANKRD44 2 2q33.1 1.98E+08 1.98E+08 MAP2 0.009804 0.090909 0.212121 0.014493 0.144928 MAP2 2 2q34  2.1E+08  2.1E+08 UNC80 0.009804 0.090909 0.181818 0.014493 0.15942 UNC80 2 2q34  2.1E+08 2.11E+08 ACADL 0.009804 0.090909 0.090909 0.014493 0.130435 ACADL 2 2q34 2.11E+08 2.11E+08 MYL1 0.009804 0.151515 0.090909 0.014493 0.130435 MYL1 2 2q34 2.11E+08 2.11E+08 LANCL1 0.009804 0.090909 0.181818 0.014493 0.130435 LANCL1 2 2q34 2.11E+08 2.11E+08 CPS1 0.009804 0.090909 0.212121 0.014493 0.217391 CPS1 2 2q34 2.11E+08 2.11E+08 ERBB4 0.009804 0.090909 0.212121 0.014493 0.246377 ERBB4 2 2q34 2.12E+08 2.13E+08 LOC72832

0.009804 0.363636 0.121212 0.608696 0.014493 LOC72832

2 2q37.3 2.43E+08 2.43E+08 PPAP2B 0.009804 0.090909 0.121212 0.217391 0.014493 PPAP2B 1 1p32.2 56733021 56817846 TACSTD2 0.009804 0.060606 0.181818 0.188406 0.014493 TACSTD2 1 1p32.1 58813683 58815755 NFIA 0.009804 0.060606 0.121212 0.115942 0.014493 NFIA 1 1p31.3 61315534 61701048 TM2D1 0.009804 0.121212 0.121212 0.173913 0.014493 TM2D1 1 1p31.3 61919307 61963684 INADL 0.009804 0.090909 0.121212 0.173913 0.014493 INADL 1 1p31.3 61980737 62402180 KANK4 0.009804 0.121212 0.121212 0.15942 0.014493 KANK4 1 1p31.3 62474425 62557672 USP1 0.009804 0.121212 0.121212 0.115942 0.014493 USP1 1 1p31.3 62674563 62690064 DOCK7 0.009804 0.121212 0.121212 0.115942 0.014493 DOCK7 1 1p31.3 62692985 62926558 ALG6 0.009804 0.060606 0.151515 0.115942 0.014493 ALG6 1 1p31.3 63605849 63676821 PGM1 0.009804 0.090909 0.121212 0.086957 0.014493 PGM1 1 1p31.3 63831535 63898506 ROR1 0.009804 0.090909 0.181818 0.086957 0.014493 ROR1 1 1p31.3 64012278 64381641 JAK1 0.009804 0.151515 0.090909 0.173913 0.014493 JAK1 1 1p31.3 65071494 65204776 MIR101-1 0.009804 0.121212 0.090909 0.130435 0.014493 MIR101-1 1 1p31.3 65296705 65296780 AK3L1 0.009804 0.121212 0.090909 0.130435 0.014493 AK3L1 1 1p31.3 65385820 65465764 LOC33952

0.009804 0.151515 0.151515 0.115942 0.014493 LOC33952

1 1p22.3 87368036 87407473 GTF2B 0.009804 0.151515 0.181818 0.115942 0.014493 GTF2B 1 1p22.2 89090909 89129890 CCBL2 0.009804 0.121212 0.181818 0.043478 0.014493 CCBL2 1 1p22.2 89174044 89231232 GBP7 0.009804 0.090909 0.151515 0.014493 0.057971 GBP7 1 1p22.2 89370022 89414312 GBP4 0.009804 0.090909 0.151515 0.014493 0.057971 GBP4 1 1p22.2 89419419 89437222 ZNF644 0.009804 0.090909 0.121212 0.072464 0.014493 ZNF644 1 1p22.2 91153445 91259619 HFM1 0.009804 0.030303 0.151515 0.057971 0.014493 HFM1 1 1p22.2 91498911 91643015 HSP90B3P 0.009804 0.121212 0.151515 0.072464 0.014493 HSP90B3P 1 1p22.2 91873156 91881923 TGFBR3 0.009804 0.060606 0.212121 0.057971 0.014493 TGFBR3 1 1p22.2 91918490 92124376 BRDT 0.009804 0.181818 0.121212 0.115942 0.014493 BRDT 1 1p22.1 92187516 92252574 EPHX4 0.009804 0.181818 0.121212 0.115942 0.014493 EPHX4 1 1p22.1 92268121 92301682 BTBD8 0.009804 0.181818 0.121212 0.115942 0.014493 BTBD8 1 1p22.1 92318450 92385984 KIAA1107 0.009804 0.181818 0.121212 0.115942 0.014493 KIAA1107 1 1p22.1 92405197 92422868 GFI1 0.009804 0.181818 0.121212 0.130435 0.014493 GFI1 1 1p22.1 92712906 92721945 RPL5 0.009804 0.121212 0.151515 0.101449 0.014493 RPL5 1 1p22.1 93070182 93080070 SNORD21 0.009804 0.121212 0.151515 0.101449 0.014493 SNORD21 1 1p22.1 93075434 93075529 FAM69A 0.009804 0.121212 0.121212 0.101449 0.014493 FAM69A 1 1p22.1 93080309 93199668 MTF2 0.009804 0.121212 0.121212 0.101449 0.014493 MTF2 1 1p22.1 93317380 93377225 DR1 0.009804 0.151515 0.181818 0.101449 0.014493 DR1 1 1p22.1 93584066 93600737 FNBP1L 0.009804 0.151515 0.151515 0.101449 0.014493 FNBP1L 1 1p22.1 93686427 93792807 BCAR3 0.009804 0.181818 0.151515 0.144928 0.014493 BCAR3 1 1p22.1 93799937 93919974 DNTTIP2 0.009804 0.181818 0.121212 0.15942 0.014493 DNTTIP2 1 1p22.1 94107924 94117331 GCLM 0.009804 0.181818 0.121212 0.15942 0.014493 GCLM 1 1p22.1 94125178 94147601 ABCA4 0.009804 0.181818 0.121212 0.173913 0.014493 ABCA4 1 1p22.1 94230982 94359294 TMEM56 0.009804 0.090909 0.151515 0.115942 0.014493 TMEM56 1 1p21.3 95355482 95435748 FAM102B 0.009804 0.030303 0.121212 0.086957 0.014493 FAM102B 1 1p13.3 1.09E+08 1.09E+08 C1orf59 0.009804 0.090909 0.090909 0.115942 0.014493 C1orf59 1 1p13.3 1.09E+08 1.09E+08 PRPF38B 0.009804 0.090909 0.090909 0.115942 0.014493 PRPF38B 1 1p13.3 1.09E+08 1.09E+08 FNDC7 0.009804 0.060606 0.090909 0.115942 0.014493 FNDC7 1 1p13.3 1.09E+08 1.09E+08 STXBP3 0.009804 0.060606 0.090909 0.115942 0.014493 STXBP3 1 1p13.3 1.09E+08 1.09E+08 AKNAD1 0.009804 0.060606 0.090909 0.130435 0.014493 AKNAD1 1 1p13.3 1.09E+08 1.09E+08 GPSM2 0.009804 0.090909 0.090909 0.173913 0.014493 GPSM2 1 1p13.3 1.09E+08 1.09E+08 CLCC1 0.009804 0.090909 0.090909 0.173913 0.014493 CLCC1 1 1p13.3 1.09E+08 1.09E+08 WDR47 0.009804 0.090909 0.090909 0.188406 0.014493 WDR47 1 1p13.3 1.09E+08 1.09E+08 MYBPHL 0.009804 0.151515 0.090909 0.202899 0.014493 MYBPHL 1 1p13.3  1.1E+08  1.1E+08 SORT1 0.009804 0.121212 0.090909 0.202899 0.014493 SORT1 1 1p13.3  1.1E+08  1.1E+08 ATXN7L2 0.009804 0.121212 0.090909 0.231884 0.014493 ATXN7L2 1 1p13.3  1.1E+08  1.1E+08 CYB561D1 0.009804 0.121212 0.090909 0.231884 0.014493 CYB561D1 1 1p13.3  1.1E+08  1.1E+08 AMIGO1 0.009804 0.121212 0.090909 0.231884 0.014493 AMIGO1 1 1p13.3  1.1E+08  1.1E+08 CD53 0.009804 0 0.090909 0.144928 0.014493 CD53 1 1p13.3 1.11E+08 1.11E+08 C1orf103 0.009804 0 0.121212 0.15942 0.014493 C1orf103 1 1p13.3 1.11E+08 1.11E+08 FAM46C 0.009804 0.121212 0.090909 0.173913 0.014493 FAM46C 1 1p12 1.18E+08 1.18E+08 WARS2 0.009804 0.090909 0.090909 0.072464 0.014493 WARS2 1 1p12 1.19E+08 1.19E+08 HAO2 0.009804 0 0.121212 0.057971 0.014493 HAO2 1 1p12  1.2E+08  1.2E+08 HSD3B2 0.009804 0 0.121212 0.057971 0.014493 HSD3B2 1 1p12  1.2E+08  1.2E+08 HSD3B1 0.009804 0.060606 0.121212 0.072464 0.014493 HSD3B1 1 1p12  1.2E+08  1.2E+08 ZNF697 0.009804 0.030303 0.121212 0.057971 0.014493 ZNF697 1 1p12  1.2E+08  1.2E+08 CHD1L 0.009804 0.060606 0.121212 0.188406 0.014493 CHD1L 1 1q21.1 1.45E+08 1.45E+08 NOS1AP 0.009804 0.030303 0.121212 0.086957 0.014493 NOS1AP 1 1q23.3  1.6E+08 1.61E+08 C1orf156 0.009804 0.090909 0.060606 0.014493 0.086957 C1orf156 1 1q24.2 1.68E+08 1.68E+08 C1orf112 0.009804 0.090909 0.060606 0.014493 0.086957 C1orf112 1 1q24.2 1.68E+08 1.68E+08 RGL1 0.009804 0.090909 0.030303 0.014493 0.043478 RGL1 1 1q25.3 1.82E+08 1.82E+08 APOBEC4 0.009804 0.090909 0.030303 0.014493 0.043478 APOBEC4 1 1q25.3 1.82E+08 1.82E+08 C1orf21 0.009804 0.121212 0.030303 0.014493 0.057971 C1orf21 1 1q25.3 1.83E+08 1.83E+08 TPR 0.009804 0.090909 0.060606 0.014493 0.115942 TPR 1 1q31.1 1.85E+08 1.85E+08 C1orf27 0.009804 0.090909 0.060606 0.014493 0.115942 C1or127 1 1q31.1 1.85E+08 1.85E+08 PDC 0.009804 0.090909 0.060606 0.014493 0.115942 PDC 1 1q31.1 1.85E+08 1.85E+08 CRB1 0.009804 0.121212 0.151515 0.014493 0.275362 CRB1 1 1q31.3 1.96E+08 1.96E+08 C4BPB 0.009804 0.181818 0.090909 0.362319 0.014493 C4BPB 1 1q32.2 2.05E+08 2.05E+08 DUSP10 0.009804 0.060606 0.181818 0.057971 0.014493 DUSP10 1 1q41  2.2E+08  2.2E+08 NVL 0.009804 0.181818 0.090909 0.304348 0.014493 NVL 1 1q42.11 2.22E+08 2.23E+08 H3F3A 0.009804 0.30303 0.090909 0.405797 0.014493 H3F3A 1 1q42.12 2.24E+08 2.24E+08 LOC44092

0.009804 0.30303 0.090909 0.405797 0.014493 LOC44092

1 1q42.12 2.24E+08 2.24E+08 GGPS1 0.009804 0.242424 0.090909 0.289855 0.014493 GGPS1 1 1q42.3 2.34E+08 2.34E+08 TBCE 0.009804 0.242424 0.090909 0.289855 0.014493 TBCE 1 1q42.3 2.34E+08 2.34E+08 ACTN2 0.009804 0.242424 0.090909 0.130435 0.014493 ACTN2 1 1q43 2.35E+08 2.35E+08 MTR 0.009804 0.242424 0.090909 0.15942 0.014493 MTR 1 1q43 2.35E+08 2.35E+08 RYR2 0.009804 0.121212 0.090909 0.115942 0.014493 RYR2 1 1q43 2.35E+08 2.36E+08 LOC10013

0.009804 0.060606 0.090909 0.014493 0.014493 LOC10013

1 1q43 2.36E+08 2.36E+08 ZP4 0.009804 0.060606 0.090909 0.014493 0.014493 ZP4 1 1q43 2.36E+08 2.36E+08

indicates data missing or illegible when filed

TABLE 4 Gene list for predicting prostate cancer relapse using AT Symbol freq.use freq.amp.c freq.del.ca freq.amp.o freq.del.co Gene.Symt chromoson cytoband Transcript. Transcript.end RNF160 1 0.142857 0.047619 0 0.037037 RNF160 21 21q21.3 29222337 29287149 BTBD3 1 0 0.142857 0 0 BTBD3 20 20p12.2 11819477 11855244 SPTLC3 1 0 0.142857 0 0 SPTLC3 20 20p12.1 12937627 13095412 ISM1 1 0 0.142857 0 0 ISM1 20 20p12.1 13150418 13229298 TASP1 1 0 0.142857 0 0 TASP1 20 20p12.1 13318036 13567584 MACROD2 1 0 0.142857 0 0 MACROD2 20 20p12.1 13924146 15981842 PSGl 1 0.333333 0.142857 0.481481 0 PSGl 19 19q13.31 48063198 48075712 ST8SIA3 1 0.238095 0 0 0 ST8SIA3 18 18q21.31 53170719 53187160 ONECUT2 1 0.238095 0 0 0 ONECUT2 18 18q21.31 53253915 53309529 TNFRSF11

1 0.190476 0 0 0 TNFRSF11

18 18q21.33 58143528 58204485 ZCCHC2 1 0.238095 0 0 0 ZCCHC2 18 18q21.33 58341638 58396799 ZNF407 1 0.190476 0 0 0 ZNF407 18 18q22.3 70471907 70762000 TSHZ1 1 0.190476 0 0 0 TSHZ1 18 18q22.3 71051719 71130890 RBL2 1 0.190476 0 0 0.037037 R8L2 16 16q12.2 52025852 52083062 CDH11 1 0.142857 0.095238 0 0.037037 CDH11 16 16q21 63538184 63713421 LOC28386

1 0.142857 0.047619 0 0 LOC28386

16 16q21 63875903 64167705 MAGEL2 1 0.142857 0 0 0 MAGEL2 15 15q11.2 21439791 21444087 NDN 1 0.142857 0 0 0 NDN 15 15q11.2 21481647 21483544 MIR548A3 1 0.047619 0.190476 0 0 MIR548A3 15 15q21.1 44584617 45037888 NEDD4 1 0.142857 0 0 0 NEDD4 15 15q21.3 53906414 54073128 CGNL1 1 0.190476 0 0 0 CGNL1 15 15q21.3 55455997 55630214 OR11G2 1 0.238095 0 0 0.074074 OR11G2 14 14q11.2 19735335 19736373 OR11H4 1 0.238095 0 0 0.074074 OR11H4 14 14q11.2 19780791 19781766 AP4S1 1 0.238095 0 0 0 AP451 14 14q12 30564434 30632390 HECTD1 1 0.238095 0 0 0 HECTD1 14 14q12 30639075 30746441 SSTR1 1 0 0.142857 0 0 SSTR1 14 14q21.1 37746955 37752020 PPIL5 1 0.142857 0 0 0 PPIL5 14 14q22.1 49135165 49151141 RPL36AL 1 0.142857 0 0 0 RPL36AL 14 14q22.1 49155157 49157100 MGAT2 1 0.142857 0 0 0 MGAT2 14 14q22.1 49157239 49159950 C14orf104 1 0.142857 0 0 0 C14orf104 14 14q22.1 49161642 49171699 POLE2 1 0.142857 0 0 0 POLE2 14 14q22.1 49180029 49224686 KLHDC1 1 0.142857 0 0 0 KLHDC1 14 14q22.1 49229635 49289615 ARF6 1 0.142857 0 0 0 ARF6 14 14q22.1 49429486 49433523 C14orf182 1 0.142857 0 0 0 C14orf182 14 14q22.1 49518180 49543989 CGRRF1 1 0.142857 0 0 0 CGRRF1 14 14q22.2 54046337 54075085 SAMD4A 1 0.142857 0 0 0 SAMD4A 14 14q22.2 54104387 54329784 TMEM30B 1 0.142857 0 0 0 TMEM30B 14 14q23.1 60813842 60818284 PRKCH 1 0.142857 0 0 0 PRKCH 14 14q23.1 60858268 61087452 ZDHHC20 1 0.142857 0 0 0 ZDHHC20 13 13q12.11 20848508 20931424 EFHA1 1 0.142857 0 0 0 EFHA1 13 13q12.11 20964839 21076308 FGF9 1 0.142857 0 0 0 FGF9 13 13q12.11 21143215 21176641 FAM48A 1 0 0.190476 0 0 FAM48A 13 13q13.3 36481451 36531851 FREM2 1 0 0.142857 0 0 FREM2 13 13q13.3 38159173 38359268 C13orf23 1 0 0.142857 0 0 C13orf23 13 13q13.3 38482002 38510253 DHRS12 1 0.142857 0 0 0 DHRS12 13 13q14.3 51240132 51276295 FU37307 1 0.142857 0 0 0 FU37307 13 13q14.3 51285484 51317288 ATP7B 1 0.142857 0 0 0 ATP7B 13 13q14.3 51404806 51483632 ALG11 1 0.142857 0 0 0 ALG11 13 13q14.3 51484551 51501782 UTP14C 1 0.142857 0 0 0 UTP14C 13 13q14.3 51496828 51505736 NEKS 1 0.142857 0 0 0 NEKS 13 13q14.3 51536901 51601216 NEK3 1 0.142857 0 0 0 NEK3 13 13q14.3 51604780 51631998 THSD1 1 0.142857 0 0 0 THSD1 13 13q14.3 51849305 51878631 LOC64728

1 0 0.142857 0 0 LOC64728

13 13q22.2 74709890 74712519 ABCC4 1 0.190476 0 0 0 ABCC4 13 13q32.1 94470084 94751689 DZIP1 1 0.380952 0 0 0 DZIP1 13 13q32.1 95028457 95094959 DNAJC3 1 0.190476 0 0 0 DNAJC3 13 13q32.1 95127403 95245243 TM9SF2 1 0.190476 0 0 0 TM9SF2 13 13q32.3 98951729 99013278 PCCA 1 0.190476 0 0 0 PCCA 13 13q32.3 99539338 99980690 ITGBL1 1 0 0.142857 0 0 ITGBL1 13 13q33.1 1.01E+08 1.01E+08 FGF14 1 0 0.142857 0 0 FGF14 13 13q33.1 1.01E+08 1.01E+08 IRS2 1 0.190476 0 0 0 IRS2 13 13q34 1.09E+08 1.09E+08 KLRC1 1 0 0.142857 0.037037 0 KLRC1 12 12p13.2 10489904 10497247 PRR4 1 0 0.142857 0.037037 0 PRR4 12 12p13.2 10889715 11215481 PRH1 1 0 0.142857 0.037037 0 PRH1 12 12p13.2 10924827 11215478 TAS2R30 1 0 0.142857 0.037037 0 TAS2R30 12 12p13.2 11177151 11178111 PRB3 1 0 0.142857 0.037037 0 PRB3 12 12p13.2 11310124 11313909 FAR2 1 0 0.142857 0 0 FAR2 12 12p11.22 29267865 29378274 OVCH1 1 0 0.142857 0 0 OVCH1 12 12p11.22 29471756 29541887 PRICKLE1 1 0.142857 0 0 0 PRICKLE1 12 12q12 41138408 41269840 NEUROD4 1 0.047619 0.190476 0.259259 0 NEUROD4 12 12q13.2 53699996 53710069 CDK17 1 0.142857 0 0 0 CDK17 12 12q23.1 95196173 95318437 ANKS1B 1 0.190476 0 0 0 ANKS1B 12 12q23.1 97653202 98072604 UBQLN3 1 0 0.142857 0 0 UBQLN3 11 11P15.4 5485106 5487730 UBQLNL 1 0 0.142857 0 0 UBQLNL 11 11p15.4 5492199 5494533 TRIM6 1 0.142857 0 0 0 TRIM6 11 11p15.4 5573923 5590765 TRIM6-TR1

1 0.142857 0 0 0 TRIM6-T1

11 11p15.4 5574460 5622200 TRIM34 1 0.142857 0 0 0 TRIM34 11 11p15.4 5597750 5622202 SERGEF 1 0.142857 0 0 0 SERGEF 11 11p15.1 17766172 17991214 TPH1 1 0.142857 0 0 0 TPH1 11 11p15.1 17998660 18018912 MRGPRX3 1 0.142857 0 0 0 MRGPRX3 11 11p15.1 18099078 18116602 MRGPRX4 1 0.142857 0 0 0 MRGPRX4 11 11p15.1 18150960 18152404 ELP4 1 0.190476 0.047619 0 0.037037 ELP4 11 11p13 31487873 31761906 PAX6 1 0.190476 0.047619 0 0.037037 PAX6 11 11p13 31762916 31789456 LOC441601 1 0 0.238095 0.037037 0 LOC441601 11 11p11.12 50195575 50214200 PRCP 1 0.142857 0 0 0.074074 PRCP 11 11q14.1 82213057 82289206 C11orf82 1 0.142857 0 0 0.074074 C11orf82 11 11q14.1 82290385 82323348 RAB30 1 0.142857 0 0 0.037037 RAB30 11 11q14.1 82370126 82460533 CCDC82 1 0 0.142857 0 0 CCDC82 11 11q21 95725577 95762732 JRKL 1 0 0.142857 0 0 JRKL 11 11q21 95762806 95766376 LOC25431

1 0.190476 0 0 0 LOC25431

10 10p14 11016910 11034133 CUGBP2 1 0.190476 0 0 0 CUGBP2 10 10p14 11087265 11418679 PTER 1 0.142857 0 0 0 PTER 10 10p13 16518973 16595743 MLLT10 1 0.142857 0 0 0 MLLT10 10 10p12.31 21863108 22072561 DNAJC1 1 0.142857 0 0 0 DNAJC1 10 10p12.31 22085483 22332657 PRINS 1 0.142857 0 0 0 PRINS 10 10p12.1 24576060 24584982 MIR603 1 0.142857 0 0 0 MIR603 10 10p12.1 24604620 24604717 ARHGAP21 1 0.142857 0 0 0 ARHGAP21 10 10p12.1 24912544 25052604 PRTFDC1 1 0.142857 0 0 0 PRTFDC1 10 10p12.1 25177560 25281540 GPR158 1 0 0.190476 0 0 GPR158 10 10p12.1 25504296 25931164 ZEB1 1 0 0.142857 0.037037 0 ZEB1 10 10p11.22 31647430 31858134 FAM13C 1 0 0.142857 0 0 FAM13C 10 10q21.1 60675896 60792359 RNLS 1 0 0.142857 0 0 RNLS 10 10q23.31 90023601 9D333063 UPN 1 0 0.142857 0 0 UPN 10 10q23.31 90511143 90527980 KDM4C 1 0.238095 0 0 0 KDM4C 9 9p24.1 6710863 7067265 PGM5 1 0.142857 0.047619 0 0 PGM5 9 9q13 70161635 70335798 C9orf71 1 0.142857 0 0 0 C9orf71 9 9q13 70341318 70345604 PIP5K1B 1 0.142857 0 0 0 P5P5K1B 9 9q21.11 70510436 70813912 FAM108B1 1 0.142857 0 0 0 FAM108B1 9 9q21.13 73667188 73715969 PAPPA 1 0.047619 0.142857 0 0 PAPPA 9 9q33.1 1.18E+08  1.18E+08 ZDHHC2 1 0.142857 0 0 0 ZDHHC2 8 8p22 17058207 17124612 CSGALNAC 1 0.142857 0 0 0 CSGALNAC 8 8p21.3 19305952 19504337 INTS10 1 0.142857 0 0 0 INTS10 8 8p21.3 19719198 19753867 LPL 1 0.142857 0 0 0 LPL 8 8p21.3 19840862 19869051 FUT10 1 0.190476 0.047619 0 0.037037 FUT10 8 8p12 33347886 33450207 FAM150A 1 0.142857 0 0 0 FAM150A 8 8q11.23 53609151 53640575 OPRK1 1 0.142857 0 0 0 OPRK1 8 8q11.23 54300829 54326748 ATP6V1H 1 0.142857 0 0 0 ATP6V1H 8 8q11.23 54790668 54918404 RGS20 1 0.142857 0 0 0 RGS20 8 8q11.23 54926921 55034415 TGS1 1 0.142857 0 0 0 TGS1 8 8q12.1 56848345 56900560 LYN 1 0.142857 0 0 0 LYN 8 8q12.1 56954940 57086495 RPS20 1 0.142857 0 0 0 RPS20 8 8q12.1 57143293 57149695 SNORD54 1 0.142857 0 0 0 SNORD54 8 8q12.1 57148952 57149015 MOS 1 0.142857 0 0 0 MOS 8 8q12.1 57188055 57189096 PLAG1 1 0.142857 0 0 0 PLAG1 8 8q12.1 57236022 57286414 CHCHD7 1 0.142857 0 0 0 CHCHD7 8 8q12.1 57286869 57293731 CSPP1 1 0.190476 0 0 0 CSPP1 8 8q13.2 68139157 68271051 ARFGEF1 1 0.142857 0 0 0 ARFGEF1 8 8q13.2 68272451 68418467 CPA6 1 0.142857 0 0 0 CPA6 8 8q13.2 68496959 68821175 TERF1 1 0.142857 0.047619 0 0 TERF1 8 8q21.11 74083651 74122542 MRPS28 1 0.142857 0.047619 0 0.111111 MRPS28 8 8q21.13 80993650 81105062 TPD52 1 0.142857 0.047619 0 0.111111 TPD52 8 8q21.13 81109660 81155566 ZNF704 1 0.190476 0 0 0.111111 ZNF704 8 8q21.13 81713324 81949572 PAG1 1 0.142857 0 0 0.111111 PAG1 8 8q21.13 82042601 82186859 PDP1 1 0.190476 0 0 0 PDP1 8 8q22.1 94998259 95007471 PTDSS1 1 0.190476 0 0 0 PTDSS1 8 8q22.1 97343343 97415951 SDC2 1 0.190476 0 0 0 SDC2 8 8q22.1 97575058 97693214 PGCP 1 0.142857 0.047619 0 0 PGCP 8 8q22.1 97726675 98224899 LAPTM4B 1 0.190476 0 0 0 LAPTM4B 8 8q22.1 98856985 98934007 MATN2 1 0.190476 0 0 0 MATN2 8 8q22.1 98950487 99118123 C8orf47 1 0.190476 0 0 0 C8orf47 8 8q22.2 99145926 99175015 NIPAL2 1 0.142857 0.047619 0 0 NIPAL2 8 8q22.2 99273563 99375798 STK3 1 0.142857 0.047619 0 0 STK3 8 8q22.2 99536037 99907086 VPS13B 1 0.142857 0.047619 0 0 VPS13B 8 8q22.2   1E+08   1E+08 HAS2 1 0.142857 0 0 0 HAS2 8 3q24.13 1.23E+08 1.23E+08 ZHX2 1 0.285714 0 0 0 ZHX2 8 8q24.13 1.24E+08 1.24E+08 DERL1 1 0.285714 0 0 0 DERL1 8 8q24.13 1.24E+08 1.24E+08 WDR67 1 0.285714 0 0 0 WDR67 8 8q24.13 1.24E+08 1.24E+08 ASAP1 1 0.142857 0 0 0 ASAP1 8 8q24.21 1.31E+08 1.31E+08 ADCY8 1 0.142857 0 0 0 ADCY8 8 8q24.22 1.32E+08 1.32E+08 ZFAT 1 0.190476 0 0 0 ZFAT 8 8q24.22 1.36E+08 1.36E+08 ZFATAS 1 0.190476 0 0 0 ZFATAS 8 8q24.22 1.36E+08 1.36E+08 KHDRBS3 1 0.142857 0 0 0 KHDRBS3 8 8q24.23 1.37E+08 1.37E+08 FAM135B 1 0.142857 0.047619 0 0 FAM135B 8 8q24.23 1.39E+08  1.4E+08 COL22A1 1 0.333333 0 0 0 COL22A1 8 8q24.23  1.4E+08  1.4E+08 GPNMB 1 0.142857 0 0 0 GPNMB 7 7p15.3 23252841 23281255 RPS2P32 1 0.190476 0 0 0 RPS2P32 7 7p153 23496532 23497555 C7orf46 1 0.190476 0 0 0 C7orf46 7 7p15.3 23686274 23708795 HOXA3 1 0.190476 0 0 0 HOXA3 7 7p15.2 27112334 27125740 HOXA4 1 0.190476 0 0 0 HOXA4 7 7p15.2 27134651 27136925 EVX1 1 0.190476 0 0 0 EVX1 7 7p15.2 27248689 27252718 HIBADH 1 0.190476 0 0 0 HIBADH 7 7p15.2 27531586 27669128 C7orf25 1 0.190476 0 0 0 C7orf25 7 7p14.1 42915397 42918215 PSMA2 1 0.190476 0 0 0 PSMA2 7 7p14.1 42922987 42938331 HECW1 1 0.190476 0 0 0 HECW1 7 7p14.1 43118723 43569464 C7orf44 1 0.190476 0 0 0 C7orf44 7 7p13 43645384 43735609 BLVRA 1 0.190476 0 0 0 BLVRA 7 7p13 43754797 43813467 PEX1 1 0.190476 0 0 0 PEX1 7 7q21.2 91954273 91995782 C7orf64 1 0.190476 0 0 0 C7orf64 7 7q21.2 91996023 92004760 MGC16142 1 0.190476 0 0 0 MGC16142 7 7q21.2 92005725 92007014 FAM133B 1 0.190476 0 0 0 FAM133B 7 7q21.2 92028008 92057643 SLC26A5 1 0.142857 0 0 0 SLC26A5 7 7q22.1 1.03E+08 1.03E+08 RELN 1 0.142857 0 0 0 RELN 7 7q22.1 1.03E+08 1.03E+08 ORC5L 1 0.142857 0 0 0 ORC5L 7 7q22.1 1.04E+08 1.046E+08  LHFPL3 1 0.142857 0 0 0 LHFPL3 7 7q22.1 1.04E+08 1.04E+08 STRA8 1 0.142857 0 0 0 STRA8 7 7q33 1.35E+08 1.35E+08 CNOT4 1 0.142857 0 0 0 CNOT4 7 7q33 1.35E+08 1.35E+08 MRPS33 1 0.142857 0 0 0 MRPS33 7 7q34  1.4E+08  1.4E+08 HIVEP1 1 0.142857 0 0 0 HIVEP1 6 6p24.1 12120710 12273219 MRS2 1 0.142857 0 0 0 MRS2 6 6p22.2 24511132 24533796 GPLD1 1 0.142857 0 0 0 GPLD1 6 6p22.2 24536384 24597830 ALDH5A1 1 0.142857 0 0 0 ALDH5A1 6 6p22.2 24603176 24645415 SUPT3H 1 0 0.190476 0.074074 0 SUPT3H 6 6p21.1 44904448 45453649 AHI1 1 0 0.142857 0 0 AHI1 6 6q23.3 1.36E+08 1.36E+08 C6orf217 1 0 0.142857 0 0 C6orf217 6 6q23.3 1.36E+08 1.36E+08 PDE7B 1 0 0.142857 0 0 PDE7B 6 6q23.3 1.36E+08 1.37E+08 UTRN 1 0.142857 0 0 0 UTRN 6 6q24.2 1.45E+08 1.45E+08 GRM1 1 0 0.142857 0 0 GRM1 6 6q24.3 1.46E+08 1.47E+08 OPRM1 1 0 0.190476 0 0 OPRM1 6 6q25.2 1.54E+08 1.54E+08 CNKSR3 1 0.190476 0 0 0 CNKSR3 6 6q25.2 1.55E+08 1.55E+08 RBM16 1 0.190476 0 0 0 RBM16 6 6q25.2 1.55E+08 1.55E+08 TIAM2 1 0.190476 0 0 0 TIAM2 6 6q25.2 1.55E+08 1.56E+08 TFB1M 1 0.190476 0 0 0 TFB1M 6 6q25.3 1.56E+08 1.56E+08 CLDN20 1 0.190476 0 0 0 CLDN20 6 6q25.3 1.56E+08 1.56E+08 ARID1B 1 0.190476 0 0 0 ARID1B 6 6q25.3 1.57E+08 1.58E+08 ZDHHC14 1 0.190476 0 0 0 ZDHHC14 6 6q25.3 1.58E+08 1.58E+08 SLC22A2 1 0.142857 0 0 0 SLC22A2 6 6q25.3 1.61E+08 1.61E+08 PLG 1 0.142857 0 0 0 PLG 6 6q26 1.61E+08 1.61E+08 BASP1 1 0.142857 0 0 0.037037 BASP1 5 5p15.1 17270750 17329944 C5orf22 1 0.190476 0 0 0 C5orf22 5 5p13.3 31568130 31590923 ZFR 1 0.190476 0 0 0 ZFR 5 5p13.3 32390213 32480602 CSorf42 1 0.142857 0 0 0 CSorf42 5 5p13.2 37142087 37285288 WDR70 1 0.190476 0 0 0 WDR70 5 5p13.2 37415169 37788532 F2RL2 1 0 0.142857 0.037037 0 F2RL2 5 5q13.3 75947063 75954997 TRIM36 1 0.047619 0.142857 0 0 TRIM36 5 5q22.3 1.14E+08 1.15E+08 DMXL1 1 0.190476 0.047619 0 0 DMXL1 5 5q23.1 1.18E+08 1.19E+08 SGCD 1 0 0.190476 0 0 SGCD 5 5q33.3 1.56E+08 1.56E+08 HTRA3 1 0.47619 0.142857 0.703704 0 HTRA3 4 4p16.1 8322392 8359735 NCAPG 1 0 0.238095 0 0 NCAPG 4 4p15.32 17421623 17455586 LCORL 1 0 0.238095 0 0 LCORL 4 4p15.32 17453938 17532582 TLR1 1 0.190476 0 0 0 TLR1 4 4p14 38474271 38482808 TLR6 1 0.190476 0 0 0 TLR6 4 4p14 38501728 38534833 FAM114A1 1 0.190476 0 0 0 FAM114A1 4 4p14 38545832 38621822 MIR574 1 0.190476 0 0 0 MIR574 4 4p14 38546048 38546144 TMEM156 1 0.190476 0 0 0 TMEM156 4 4p14 38644836 38710437 KLHLS 1 0.190476 0 0 0 KLHLS 4 4p14 38723054 38800225 WDR19 1 0.190476 0 0 0 WDR19 4 4p14 38860419 38963826 RFC1 1 0.190476 0 0 0 RFC1 4 4p14 38965471 39044391 KLB 1 0.238095 0 0 0 KLB 4 4p14 39084868 39129547 RPL9 1 0.238095 0 0 0 RPL9 4 4p14 39132140 39136964 LIAS 1 0.238095 0 0 0 LIAS 4 4p14 39137060 39155667 LOC40112

1 0.238095 0 0 0 LOC40112

4 4p14 39158270 39159917 UGDH 1 0.238095 0 0 0 UGDH 4 4p14 39176770 39205607 C4orf34 1 0.238095 0 0 0 C4orf34 4 4p14 39228941 39316877 EPGN 1 0 0.142857 0 0 EPGN 4 4q13.3 75393068 75398172 AREG 1 0 0.142857 0 0 AREG 4 4q13.3 75699653 75709510 BTC 1 0 0.142857 0 0 BTC 4 4q13.3 75890472 75938907 BMP3 1 0 0.142857 0 0 BMP3 4 4q21.21 82171143 82197710 PRKG2 1 0 0.142857 0 0 PRKG2 4 4q21.21 82228861 82345240 RASGEF1B 1 0 0.142857 0 0 RASGEF1B 4 4q21.21 82567243 82612086 TBC1D9 1 0 0.142857 0 0 TBC1D9 4 4q31.21 1.42E+08 1.42E+08 RNF150 1 0 0.142857 0 0 RNF150 4 4q31.21 1.42E+08 1.42E+08 IL15 1 0 0.142857 0 0 IL15 4 4q31.21 1.43E+08 1.43E+08 INPP4B 1 0 0.142857 0 0 INPP4B 4 4q31.21 1.43E+08 1.44E+08 RPS3A 1 0.142857 0 0 0 RPS3A 4 4q31.3 1.52E+08 1.52E+08 SNORD73A 1 0.142857 0 0 0 SNORD73A 4 4q31.3 1.52E+08 1.52E+08 SH3D19 1 0.142857 0 0 0 SH3D19 4 4q31.3 1.52E+08 1.52E+08 SUMF1 1 0 0.142857 0 0 SUMF1 3 3p25.2 4377829 4483967 EGOT 1 0.190476 0 0 0 EGOT 3 3p26.2 4765878 4768275 BHLHE40 1 0.333333 0 0 0 BHLHE40 3 3p26.2 4996097 5001864 TPRXL 1 0.190476 0.142857 0.259259 0 TPRXL 3 3p25.1 13953808 14082481 TBC1D5 1 0 0.142857 0 0 TBC1D5 3 3p24.3 17173659 17759245 RAB5A 1 0.142857 0.095238 0 0.037037 RAB5A 3 3p24.3 19963576 20001663 C3orf48 1 0.142857 0.095238 0 0.037037 C3orf48 3 3p24.3 19996458 20028770 KAT2B 1 0.142857 0.095238 0 0.037037 KAT2B 3 3p24.3 20056528 20170901 NGLY1 1 0.047619 0.142857 0 0 NGLY1 3 3p24.2 25735440 25799994 OSBPL10 1 0.190476 0.095238 0 0.037037 OSBPL10 3 3p23 31677321 31998243 MITF 1 0 0.142857 0 0 MITF 3 3p14.1 69871323 70100178 MIR1284 1 0.142857 0.047619 0 0 MIR1284 3 3p14.1 71673811 71673931 CEP97 1 0.142857 0.047619 0 0.074074 CEP97 3 3q12.3 1.03E+08 1.03E+08 FAM55C 1 0.142857 0.047619 0 0.074074 FAM55C 3 3q12.3 1.03E+08 1.03E+08 LOC15165

1 0 0.142857 0 0 LOC15165

3 3q13.12 1.09E+08 1.09E+08 LOC28520

1 0 0.142857 0 0 LOC28520

3 3q13.12 1.09E+08 1.09E+08 HHLA2 1 0 0.142857 0 0 HHLA2 3 3q13.13  1.1E+08  1.1E+08 MYH15 1 0 0.142857 0 0 MYH15 3 3q13.13  1.1E+08  1.1E+08 KIAA1524 1 0 0.142857 0 0 KIAA1524 3 3q13.13  1.1E+08  1.1E+08 DZIP3 1 0 0.142857 0 0 DZIP3 3 3q13.13  1.1E+08  1.1E+08 STXBP5L 1 0 0.142857 0 0 STXBP5L 3 3q13.33 1.22E+08 1.23E+08 SPSB4 1 0.142857 0 0 0 SPSB4 3 3q23 1.42E+08 1.42E+08 ACPL2 1 0.142857 0 0 0 ACPL2 3 3q23 1.42E+08 1.42E+08 ZBTB38 1 0.142857 0 0 0 ZBTB38 3 3q23 1.43E+08 1.43E+08 RNF7 1 0.238095 0 0 0 RNF7 3 3q23 1.43E+08 1.43E+08 GRK7 1 0.238095 0 0 0 GRK7 3 3q23 1.43E+08 1.43E+08 ATP1B3 1 0.238095 0 0 0 ATP1B3 3 3q23 1.43E+08 1.43E+08 TFDP2 1 0.238095 0 0 0 TFDP2 3 3q23 1.43E+08 1.43E+08 GK5 1 0.238095 0 0 0 GK5 3 3q23 1.43E+08 1.43E+08 XRN1 1 0.238095 0 0 0 XRN1 3 3q23 1.44E+08 1.44E+08 ATR 1 0.238095 0 0 0 ATR 3 3q23 1.44E+08 1.44E+08 PLS1 1 0.190476 0 0 0 PLS1 3 3q23 1.44E+08 1.44E+08 PCOLCE2 1 0.190476 0 0 0 PCOLCE2 3 3q23 1.44E+08 1.44E+08 LOC201651 1 0 0.142857 0 0 LOC201651 3 3q25.1 1.53E+08 1.53E+08 AADAC 1 0 0.142857 0 0 AADAC 3 3q25.1 1.53E+08 1.53E+08 LOC40109

1 0 0.142857 0 0 LOC40109

3 3q25.1 1.53E+08 1.53E+08 MBNL1 1 0 0.142857 0 0 MBNL1 3 3q25.1 1.53E+08 1.54E+08 P2RY1 1 0 0.142857 0 0 P2RY1 3 3q25.2 1.54E+08 1.54E+08 LEKR1 1 0 0.142857 0 0 LEKR1 3 3q25.31 1.58E+08 1.58E+08 GFM1 1 0 0.142857 0 0 GFM1 3 3q25.32  1.6E+08  1.6E+08 LXN 1 0 0.142857 0 0 LXN 3 3q25.32  1.6E+08  1.6E+08 KPNA4 1 0 0.190476 0 0 KPNA4 3 3q26.1 1.62E+08 1.62E+08 PPM1L 1 0 0.142857 0 0 PPM1L 3 3q26.1 1.62E+08 1.62E+08 KCNMB2 1 0 0.190476 0 0 KCNMB2 3 3q26.32  1.8E+08  1.8E+08 ZMAT3 1 0 0.190476 0 0 ZMAT3 3 3q26.32  1.8E+08  1.8E+08 PIK3CA 1 0 0.190476 0 0 PIK3CA 3 3q26.32  1.8E+08  1.8E+08 PEX5L 1 0 0.142857 0 0 PEX5L 3 3q26.33 1.81E+08 1.81E+08 CCDC39 1 0.047619 0.142857 0 0 CCDC39 3 3q26.33 1.82E+08 1.82E+08 FXR1 1 0.142857 0.047619 0 0 FXR1 3 3q26.33 1.82E+08 1.82E+08 ATP11B 1 0.142857 0 0 0 ATP11B 3 3q26.33 1.84E+08 1.84E+08 UTS2D 1 0 0.142857 0 0 UTS2D 3 3q28 1.92E+08 1.93E+08 PYDC2 1 0 0.142857 0 0 PYDC2 3 3q28 1.93E+08 1.93E+08 VSNL1 1 0.047619 0.142857 0 0 VSNL1 2 2p24.2 17585288 17701188 KLHL29 1 0.190476 0 0 0 KLHL29 2 2p24.1 23461803 23784986 MTIF2 1 0.190476 0 0 0 MTIF2 2 2p16.1 55317260 55349820 CCDC88A 1 0.190476 0 0 0 CCDC88A 2 2p16.1 55368484 55500562 MIR217 1 0 0.142857 0 0 MIR217 2 2p16.1 56063606 56063716 MIR216A 1 0 0.142857 0 0 MIR216A 2 2p16.1 56069590 56069699 MIR216B 1 0 0.142857 0 0 MIR216B 2 2p16.1 56081354 56081435 CCDC85A 1 0 0.142857 0 0 CCDC85A 2 2p16.1 56264762 56466814 BCL11A 1 0.238095 0 0 0 BCL11A 2 2p16.1 60531806 60634138 FAM161A 1 0.142857 0 0 0 FAM161A 2 2p15 61905487 61934783 CCT4 1 0.142857 0 0 0 CCT4 2 2p15 61948766 61969296 COMMD1 1 0.142857 0 0 0 COMMD1 2 2p15 61986307 62216710 B3GNT2 1 0.142857 0 0 0 B3GNT2 2 2p15 62276766 62305371 IL18RAP 1 0.142857 0 0 0 IL18RAP 2 2q12.1 1.02E+08 1.02E+08 SLC9A4 1 0.142857 0 0 0 SLC9A4 2 2q12.1 1.02E+08 1.03E+08 TNFA1P6 1 0.190475 0 0 0 TNFA1P6 2 2q23.3 1.52E+08 1.52E+08 STAM2 1 0 0.142857 0 0 STAM2 2 2q23.3 1.53E+08 1.53E+08 EVX2 1 0.142857 0 0 0 EVX2 2 2q31.1 1.77E+08 1.77E+08 HOXD13 1 0.142857 0 0 0 HOXD13 2 2q31.1 1.77E+08 1.77E+08 HOXD12 1 0.142857 0 0 0 HOXD12 2 2q31.1 1.77E+08 1.77E+08 HOXD11 1 0.142857 0 0 0 HOXD11 2 2q31.1 1.77E+08 1.77E+08 HOXD10 1 0.142857 0 0 0 HOXD10 2 2q31.1 1.77E+08 1.77E+08 HOXD9 1 0.142857 0 0 0 HOXD9 2 2q31.1 1.77E+08 1.77E+08 HOXD8 1 0.142857 0 0 0 HOXD8 2 2q31.1 1.77E+08 1.77E+08 CD28 1 0.142857 0 0 0 CD28 2 2q33.2 2.04E+08 2.04E+08 CTLA4 1 0.142857 0 0 0 CTLA4 2 2q33.2 2.04E+08 2.04E+08 ICOS 1 0.142857 0 0 0 ICOS 2 2q33.2 2.05E+08 2.05E+08 PLEKHM3 1 0.142857 0 0 0.037037 PLEKHM3 2 2q33.3 2.08E+08 2.09E+08 CRYGD 1 0.142857 0 0 0 CRYGD 2 2q33.3 2.09E+08 2.09E+08 CRYGC 1 0.142857 0 0 0 CRYGC 2 2q33.3 2.09E+08 2.09E+08 PIKFYVE 1 0.142857 0 0 0 PIKFYVE 2 2q33.3 2.09E+08 2.09E+08 KIAA1486 1 0 0.142857 0 0 KIAA1486 2 2q36.3 2.26E+08 2.26E+08 PDE48 1 0 0.142857 0 0 PDE48 1 1p31.3 66030781 66612851 IL23R 1 0.142857 0 0 0 IL23R 1 1p31.3 67404757 67498239 IL12RB2 1 0.142857 0 0 0 IL12RB2 1 1p31.3 67545635 67635172 CCBL2 1 0.142857 0 0 0 CCBL2 1 1p22.2 89174044 89231232 RPL5 1 0.142857 0 0 0 RPL5 1 1p22.1 93070182 93080070 SNORD21 1 0.142857 0 0 0 SNORD21 1 1p22.1 93075434 93075529 FAM69A 1 0.142857 0 0 0 FAM69A 1 1p22.1 93080309 93199668 MTF2 1 0.142857 0 0 0 MTF2 1 1p22.1 93317380 93377225 DR1 1 0.142857 0 0 0 DR1 1 1p22.1 93584066 93600737 FNBP1L 1 0.142857 0 0 0 FNBP1L 1 1p22.1 93686427 93792807 RC3H1 1 0.142857 0 0 0 RC3H1 1 1q25.1 1.72E+08 1.72E+08 GPR52 1 0 0.142857 0 0 GPR52 1 1q25.1 1.73E+08 1.73E+08 C1orf49 1 0.142857 0 0 0 C1orf49 1 1q25.2 1.77E+08 1.77E+08 Clorf220 1 0.142857 0 0 0 Clorf220 1 1q25.2 1.77E+08 1.77E+08 FAM20B 1 0.238095 0 0 0 FAM20B 1 1q25.2 1.77E+08 1.77E+08 ABL2 1 0.238095 0 0 0 ABL2 1 1q25.2 1.77E+08 1.77E+08 SOAT1 1 0.190476 0 0 0 SOAT1 1 1q25.2 1.78E+08 1.78E+08 C1orf125 1 0.190476 0 0 0 C1orf125 1 1425.2 1.78E+08 1.78E+08 NPHS2 1 0.190476 0 0 0 NPHS2 1 1q25.2 1.78E+08 1.78E+08 TDRD5 1 0.142857 0.047619 0 0 TDRD5 1 1q25.2 1.78E+08 1.78E+08 FAM163A 1 0.190476 0 0 0 FAM163A 1 1q25.2 1.78E+08 1.78E+08 TOR1AIP2 1 0.190476 0 0 0 TOR1AIP2 1 1q25.2 1.78E+08 1.78E+08 CEP350 1 0.142857 0.047619 0 0 CEP350 1 1q25.2 1.78E+08 1.78E+08 STX6 1 0.142857 0 0 0 STX6 1 1q25.3 1.79E+08 1.79E+08 MR1 1 0.142857 0 0 0 MR1 1 1q25.3 1.79E+08 1.79E+08 OR2M5 1 0.095238 0.190476 0.111111 0 OR2M5 1 1q44 2.46E+08 2.46E+08 OR2M2 1 0.095238 0.190476 0.111111 0 OR2M2 1 1q44 2.46E+08 2.46E+08 OR2T6 1 0.095238 0.190476 0.111111 0 OR2T6 1 1q44 2.47E+08 2.47E+08 RFX7 0.4375 0.095238 0.095238 0 0 RFX7 15 15q21.3 54170023 54322776 ZNF462 0.4375 0.095238 0.095238 0 0 ZNF462 9 9q31.2 1.09E+08 1.09E+08 IPCEF1 0.4375 0.095238 0.095238 0 0 IPCEF1 6 6q25.2 1.55E+08 1.55E+08 TLR10 0.4375 0.095238 0.095238 0 0 TLR10 4 4p14 38450647 38460985 PDZRN3 0.4375 0.095238 0.095238 0 0 PDZRN3 3 3p13 73514342 73756763 SR140 0.4375 0.095238 0.095238 0 0 SR140 3 3q23 1.44E+08 1.44E+08 CCDC50 0.4375 0.095238 0.095238 0 0 CCDC50 3 3q28 1.93E+08 1.93E+08 FCRLB 0.4375 0.095238 0.095238 0 0 FCRLB 1 1q23.3  1.6E+08  1.6E+08 ALG5 0.416667 0.142857 0.095238 0.037037 0 ALG5 13 13q13.3 36421910 36471505 NEDD9 0.416667 0.190476 0.095233 0.037037 0 NEDD9 6 6p24.1 11291518 11490568 SGOL1 0.416667 0.095238 0.142857 0 0.037037 SGOL1 3 3p24.3 20177089 20202688 RASA2 0.416667 0.095238 0.142857 0 0.037037 RASA2 3 3q23 1.43E+08 1.43E+08 VAMP7 0.395833 0.285714 0.095238 0.333333 0 VAMP7 X Xq28 1.55E+08 1.55E+08 IL9R 0.395833 0.285714 0.095238 0.333333 0 IL9R X Xq28 1.55E+08 1.55E+08 RPL23AP8

0.395833 0.809524 0.095238 0.777778 0 RPL23AP8

22 22q13.33 49542380 49584931 RABL2B 0.395833 0.809524 0.095238 0.777778 0 RABL2B 22 22q13.33 49552786 49568954 C21orf7 0.395833 0.095238 0.047619 0 0 C21orf7 21 21q21.3 29374744 29470074 CLDN17 0.395833 0.047619 0.095238 0 0 CLDN17 21 21q21.3 30460132 30460807 KRTAP19-3 0.395833 0.047619 0.095238 0 0 KRTAP19-3 21 21q22.11 30785653 30786147 KRTAP19-4 0.395833 0.047619 0.095238 0 0 KRTAP19-4 21 21q22.11 30791045 30791300 KRTAP19-5 0.395833 0.047619 0.095238 0 0 KRTAP19-5 21 21q22.11 30796061 30796280 KRTAP19-7 0.395833 0.047619 0.095238 0 0 KRTAP19-7 21 21q22.11 30855288 30855480 KRTAP20-2 0.395833 0.047619 0.095238 0.037037 0 KRTAP20-2 21 21q22.11 30929454 30929652 KRTAP20-3 0.395833 0.047619 0.095238 0.037037 0 KRTAP20-3 21 21q22.11 30937054 30937327 HAO1 0.395833 0 0.095238 0 0 HAO1 20 20p12.3 7811631 7869094 TMX4 0.395833 0 0.095238 0 0 TMX4 20 20p12.3 7909716 7948394 PLCB1 0.395833 0 0.095238 0 0 PLCB1 20 20p12.3 8061296 8813548 PLCB4 0.395833 0 0.095238 0 0 PLCB4 20 20p12.2 9024932 9409463 PAK7 0.395833 0 0.095238 0 0 PAK7 20 20p12.2 9466037 9767688 SNAP25 0.395833 0 0.095238 0 0 SNAP25 20 20p12.2 10147477 10236066 C20orf94 0.395833 0 0.095238 0 0 C20orf94 20 20p12.2 10363951 10552028 JAG1 0.395833 0 0.095238 0 0 JAG1 20 20p12.2 10566332 10602695 ESF1 0.395833 0.095238 0.047619 0 0 ESF1 20 20p12.1 13642969 13713533 C20orf7 0.395833 0.095238 0.047619 0 0 C20orf7 20 20p12.1 13713672 13747066 KIF16B 0.395833 0 0.095238 0 0 KIF16B 20 20p12.1 16200749 16502079 DOK5 0.395833 0.095238 0.095238 0.148148 0 DOK5 20 20q13.2 52525673 52701118 CETN1 0.395833 0.095238 0 0 0 CETN1 18 18p11.32 570369 571525 CLUL1 0.395833 0.095238 0 0 0 CLUL1 18 18p11.32 586998 640294 TYMS 0.395333 0.095238 0 0 0 TYMS 18 18p11.32 647604 663500 ENOSF1 0.395833 0.095233 0 0 0 ENOSF1 18 18p11.32 662544 702663 YES1 0.395833 0.095238 0 0 0 YES1 18 18p11.32 711592 802328 LOC64259

0.395833 0 0.095238 0 0 LOC64259

18 18p11.31 5133672 5187256 ZNF519 0.395833 0.095238 0.095238 0.074074 0 ZNF519 18 18p11.21 14094724 14122430 ANKRD30B 0.395833 0.095238 0.095238 0.074074 0 ANKRD30B 18 13p11.21 14738239 14842738 SERPINB13 0.395833 0.095238 0 0 0.037037 SERPINB13 18 18q21.33 59405514 59417413 SERPINB8 0.395833 0.095238 0 0 0.037037 SERPINB8 18 18q21.33 59788243 59804868 SOCS6 0.395833 0.095238 0 0 0.037037 SOCS6 18 18q22.2 66107117 66148415 KRT25 0.395833 0.190476 0.095238 0.259259 0 KRT25 17 17q21.2 36157800 36165111 KRT26 0.395833 0.190476 0.095238 0.259259 0 KRT26 17 17q21.2 36176018 36181938 CA10 0.395833 0.142857 0.095238 0.185185 0 CA10 17 17q21.33 47062673 47592161 TANC2 0.395833 0.238095 0.095238 0.333333 0 TANC2 17 17q23.3 58440630 58858800 KCNJ16 0.395833 0.047613 0.095238 0.222222 0 KCNJ16 17 17q24.3 65583021 65643342 TOX3 0.395833 0.047619 0.095238 0 0 TOX3 16 16q12.1 51029419 51138308 CNTNAP4 0.395833 0.095238 0.047619 0 0 CNTNAP4 16 16q23.1 74868677 75150637 SCG5 0.395833 0.095238 0 0 0 SCG5 15 15q13.3 30721162 30776591 AVEN 0.395833 0.095238 0 0 0 AVEN 15 15q14 31945720 32118596 CHRM5 0.395833 0.095238 0 0 0 CHRM5 15 15q14 32048381 32144580 PGBD4 0.395833 0.095238 0 0 0 PGBD4 15 15q14 32181566 32183884 C15orf29 0.395833 0.095238 0 0 0 C15orf29 15 15q14 32220167 32289590 TMEM85 0.395833 0.095238 0 0 0 TMEM85 15 15q14 32304537 32309645 SLC12A6 0.395833 0.095238 0 0 0 SLC12A6 15 15q14 32309489 32417254 NOP10 0.395833 0.095238 0 0 0 NOP10 15 15q14 32421209 32422655 C15orf55 0.395833 0.095238 0 0 0 C15orf55 15 15q14 32425358 32437224 MEIS2 0.395833 0.047619 0.095238 0 0 MEIS2 15 15q14 34970524 35180793 SPRED1 0.395833 0.047619 0.095238 0.037037 0 SPRED1 15 15q14 36332344 36436743 DMXL2 0.395833 0.095238 0.095238 0.037037 0 DMXL2 15 15q21.2 49527231 49702260 ONECUT1 0.395833 0.095238 0 0 0.037037 ONECUT1 15 15q21.2 50836645 50869502 RAB27A 0.395833 0.095238 0 0 0 RAB27A 15 15q21.3 53283092 53349878 PIGB 0.395833 0.095238 0 0 0 PIGB 15 15q21.3 53398425 53435139 CCPG1 0.395833 0.095238 0 0 0 CCPG1 15 15q21.3 53434730 53487835 MIR628 0.395833 0.095238 0 0 0 MIR628 15 15q21.3 53452430 53452525 DYX1C1 0.395833 0.095238 0 0 0 DYX1C1 15 15q21.3 53497246 53587725 PYGO1 0.395833 0.095238 0 0 0 PYGO1 15 15q21.3 53625513 53668343 PRTG 0.395833 0.095238 0 0 0 PRTG 15 15q21.3 53691042 53822470 TEX9 0.395833 0.095238 0.095238 0 0.037037 TEX9 15 15q21.3 54444935 54525365 ZNF280D 0.395833 0.095238 0 0 0 ZNF280D 15 15q21.3 54709666 54813080 TCF12 0.395833 0.095238 0.047619 0 0 TCF12 15 15q21.3 54998125 55368007 NEO1 0.395833 0.190476 0.095238 0.333333 0 NEO1 15 15q24.1 71131928 71384599 LOC91948 0.395833 0.047619 0.095238 0.074074 0 LOC91948 15 15q26.2 96086850 96218664 C15orf51 0.395833 0.190476 0.095238 0.185185 0 C15orf51 15 15q26.3 98147884 98164656 COCH 0.395833 0.095238 0 0 0.037037 COCH 14 14q12 30413492 30429574 EGLN3 0.395833 0.095238 0 0 0 EGLN3 14 14q13.1 33463172 33490036 MIPOL1 0.395833 0 0.095238 0 0 MIPOL1 14 14q21.1 36736869 37086619 RPS29 0.395833 0.095238 0 0 0 RPS29 14 14q22.1 49113792 49122845 C14orf183 0.395833 0.095238 0 0 0 C14orf183 14 14q22.1 49620119 49629112 SOS2 0.395833 0.095238 0 0 0 SOS2 14 14q22.1 49653596 49767850 L2HGDH 0.395833 0.095238 0 0 0 L2HGDH 14 14q22.1 49778902 49848698 ATP5S 0.395833 0.095238 0 0 0 ATP5S 14 14q22.1 49848797 49862419 CDKL1 0.395833 0.095238 0 0 0 CDKL1 14 14q22.1 49866470 49932368 MAP4K5 0.395833 0.095238 0 0 0 MAP4K5 14 14q22.1 49954993 50069127 ATL1 0.395833 0.095238 0 0 0 ATL1 14 14q22.1 50069550 50169535 SAV1 0.395833 0.095238 0 0 0 SAV1 14 14q22.1 50170110 50204774 NIN 0.395833 0.095238 0 0 0 NIN 14 14q22.1 50256231 50367590 ABHD12B 0.395833 0.095238 0 0 0 ABHD12B 14 14q22.1 50408628 50441439 PYGL 0.395833 0.095238 0 0 0 PYGL 14 14q22.1 50441686 50480999 TRIM9 0.395833 0.095238 0 0 0 TRIM9 14 14q22.1 50511731 50632173 FRMD6 0.395833 0.095238 0 0 0 FRMD6 14 14q22.1 51025605 51267195 CDKN3 0.395833 0.095238 0 0 0 CDKN3 14 14q22.2 53933423 53956683 ACTR10 0.395833 0.095238 0 0 0 ACTR10 14 14q23.1 57736586 57772107 PSMA3 0.395833 0.095238 0 0 0.037037 PSMA3 14 14q23.1 57781346 57808480 FL131306 0.395833 0.095238 0 0 0.037037 FL131306 14 14q23.1 57801837 57834609 ARID4A 0.395833 0.095238 0 0 0 ARID4A 14 14q23.1 57834975 57910205 NRXN3 0.395833 0.047619 0.095238 0.074074 0 NRXN3 14 14q24.3 77939846 79400514 ZMYM2 0.395833 0.190476 0.095238 0.111111 0 ZMYM2 13 13q12.11 19430810 19558940 KL 0.395833 0.095238 0 0 0 KL 13 13q13.1 32488571 32538282 STARD13 0.395833 0.095238 0 0 0 STARD13 13 13q13.1 32575273 32678188 NBEA 0.395833 0 0.095238 0 0 NBEA 13 13q13.2 34414456 35144874 C13orf36 0.395833 0.047619 0.095238 0 0 C13orf36 13 13q13.3 36146049 36169976 SMAD9 0.395833 0.095238 0.095238 0.037037 0 SMAD9 13 13q13.3 36320207 36392410 TSC22D1 0.395833 0.095238 0 0 0 TSC22D1 13 13q14.11 43905655 44048702 NUFIP1 0.395833 0.095238 0 0 0 NUFIP1 13 13q14.12 44411384 44461614 KIAA1704 0.395833 0.095238 0 0 0 KIAA1704 13 13q14.12 44461687 44500405 GTF2F2 0.395833 0.095238 0 0 0 GTF2F2 13 13q14.12 44592631 44756240 KCTD4 0.395833 0.095238 0 0 0 KCTD4 13 13q14.12 44664988 44673176 TPT1 0.395833 0.095238 0 0 0 TPT1 13 13q14.12 44809304 44813298 SNORA31 0.395833 0.095238 0 0 0 SNORA31 13 13q14.12 44809615 44809745 LOC10019

0.395833 0.095238 0 0 0 LOC10019

13 13q14.12 44813480 44853617 COG3 0.395833 0.095238 0 0 0 COG3 13 13q14.12 44937072 45008762 FAM194B 0.395833 0.095238 0 0 0 FAM194B 13 13q14.12 45013433 45087876 esd 0.395833 0 0.095238 0 0 esd 13 13q14.2 46243392 46269369 HTR2A 0.395833 0 0.095238 0 0 HTR2A 13 13q14.2 46305514 46369171 SUCLA2 0.395833 0.095238 0 0 0 SUCLA2 13 13q14.2 47414792 47473464 NUDT15 0.395833 0.095238 0 0 0 NUDT15 13 13q14.2 47509704 47519284 MED4 0.395833 0.095238 0 0 0 MED4 13 13q14.2 47548093 47567242 ITM2B 0.395833 0.095238 0 0 0 ITM2B 13 13q14.2 47705275 47734234 RNASEH2B 0.395833 0.095238 0 0 0 RNASEH2B 13 13q14.3 50381893 50442596 GUCY1B2 0.395833 0.095238 0 0 0 GUCY1B2 13 13q14.3 50466649 50538295 FAM124A 0.395833 0.095238 0 0 0 FAM124A 13 13q14.3 50694508 50753618 SERPINE3 0.395833 0.095238 0 0 0 SERPINE3 13 13q14.3 50813169 50834241 INTS6 0.395833 0.095238 0 0 0 INTS6 13 13q14.3 50833702 50925277 WDFY2 0.395833 0.095238 0 0 0 WDFY2 13 13q14.3 51056485 51234173 HNRNPA1L 0.395833 0.095238 0 0 0 HNRNPA1L 13 13q14.3 52089606 52115921 KLF12 0.395833 0 0.095238 0 0 KLF12 13 13q22.1 73158150 73606068 TBC1D4 0.395833 0 0.095238 0 0 TBC1D4 13 13q22.2 74756810 74954252 COMMD6 0.395833 0 0.095238 0 0 COMMD6 13 13q22.2 74997351 75009993 LM07 0.395833 0 0.095238 0 0 LM07 13 13q22.2 75092571 75332006 DCT 0.395833 0.095238 0.095238 0 0.111111 DCT 13 13q32.1 93889842 93929938 TMTC4 0.395833 0.095238 0 0 0 TMTC4 13 13q32.3   1E+08   1E+08 LOC37444

0.395833 0 0.095238 0.037037 0 LOC37444

12 12p13.31 9691910 9702276 CLECL1 0.395833 0 0.095238 0.037037 0 CLECL1 12 12p13.31 9766358 9777128 CD69 0.395833 0 0.095238 0.037037 0 CD69 12 12p13.31 9796351 9804765 CLEC2A 0.395833 0 0.095238 0.037037 0 CLEC2A 12 12p13.31 9957093 9976248 CLEC12A 0.395833 0 0.095238 0.037037 0 CLEC12A 12 12p13.2 10015275 10029462 CLEC1B 0.395833 0 0.095238 0.037037 0 CLEC1B 12 12p13.2 10036929 10043167 CLEC12B 0.395833 0 0.095238 0.037037 0 CLEC12B 12 12p13.2 10054498 10062667 CLEC9A 0.395833 0 0.095238 0.037037 0 CLEC9A 12 12p13.2 10074543 10109833 CLEC1A 0.395833 0 0.095238 0.037037 0 CLEC1A 12 12p13.2 10114347 10142873 STYK1 0.395833 0 0.095238 0.037037 0 STYK1 12 12p13.2 10662805 10718159 CSDA 0.395833 0 0.095238 0.037037 0 CSDA 12 12p13.2 10742945 10767221 KIAAD528 0.395833 0 0.095238 0 0 KIAAD528 12 12P12.1 22492785 22588720 ETNK1 0.395833 0 0.095238 0 0 ETNK1 12 12p12.1 22669343 22688617 TMTC1 0.395833 0 0.095238 0 0 TMTC1 12 12p11.22 29545024 29828960 GXYLT1 0.395833 0 0.095238 0 0 GXYLT1 12 12q12 40761915 40824941 ZCRB1 0.395833 0.095238 0 0 0 ZCRB1 12 12q12 40992155 41006200 PPHLN1 0.395833 0.095238 0 0 0 PPHLN1 12 12q12 41006214 41128690 ADAMTS2

0.395833 0 0.095238 0 0 ADAMTS2

12 12q12 42034279 42231992 NELL2 0.395833 0.047619 0.095238 0 0 NELL2 12 12q12 43188325 43556901 DBX2 0.395833 0.047619 0.095238 0 0 DBX2 12 12q12 43694806 43731150 KIAA0748 0.395833 0.095238 0.095238 0.259259 0 KIAA0748 12 12q13.2 53630132 53664724 MON2 0.395833 0.095238 0 0 0.037037 MON2 12 12q14.1 61146864 61277631 SRGAP1 0.395833 0.095238 0 0 0 SRGAP1 12 12q14.2 62524808 62827881 C12orf66 0.395833 0.095238 0 0 0 C12orf66 12 12q14.2 62872686 62902344 C12orf56 0.395833 0.095238 0 0 0 C12orf56 12 12q14.2 62947032 63070613 TBK1 0.395833 0.095238 0 0 0 TBK1 12 12q14.2 63132204 63182159 GNS 0.395833 0.095238 0 0 0 GNS 12 12q14.2-1 63393489 63439494 TBC1D15 0.395833 0.095238 0.095238 0 0.037037 TBC1D15 12 12q21.1 70519754 70606895 MRS2P2 0.395833 0.095238 0.095238 0 0.037037 MRS2P2 12 12q21.1 70528343 70531031 METAP2 0.395833 0.095238 0 0 0 METAP2 12 12q22 94391953 94433745 USP44 0.395833 0.095238 0 0 0 USP44 12 12q22 94435018 94466752 NTN4 0.395833 0.095238 0 0 0 NTN4 12 12q22 94575714 94708668 CCDC38 0.395833 0.095238 0 0 0 CCDC38 12 12q23.1 94784958 94860560 AMDHD1 0.395833 0.095238 0 0 0 AMDHD1 12 12q23.1 94861202 94886501 HAL 0.395833 0.095238 0 0 0 HAL 12 12q23.1 94891273 94914203 C12orf42 0.395833 0 0.095238 0.111111 0 C12orf42 12 12q23.2 1.02E+08 1.02 E+08 OR51F1 0.395833 0 0.095238 0 0 OR51F1 11 11p15.4 4746785 4747724 OR51S1 0.395833 0 0.095238 0 0 OR51S1 11 11p15.4 4826043 4827015 OR51A7 0.395833 0 0.095238 0 0 OR51A7 11 11p15.4 4885176 4886115 OR51G2 0.395833 0 0.095238 0 0 OR51G2 11 11p15.4 4892525 4893470 OR51L1 0.395833 0 0.095238 0 0 OR51L1 11 11p15.4 4976789 4977737 OR52J3 0.395833 0 0.095238 0 0 OR52J3 11 11p15.4 5024332 5025268 OR52E2 0.395833 0 0.095238 0 0 OR52E2 11 11p15.4 5036456 5037434 OR52A1 0.395833 0 0.095238 0 0 OR52A1 11 11p15.4 5129237 5130176 OR51V1 0.395833 0 0.095238 0 0 OR51V1 11 11p15.4 5177541 5178507 OR51B4 0.395833 0 0.095238 0 0 OR51B4 11 11p15.4 5278820 5279753 OR51B5 0.395833 0 0.095238 0 0 OR51B5 11 11p15.4 5320392 5321331 OR51B6 0.395833 0 0.095238 0 0 OR51B6 11 11P15.4 5329314 5330253 OR5P3 0.395833 0 0.095238 0.074074 0 OR5P3 11 11p15.4 7803160 7804096 PSMA1 0.395833 0 0.095238 0 0 PSMA1 11 11p15.2 14482999 14621757 PDE3B 0.395833 0 0.095238 0 0 PDE3B 11 11p15.2 14621845 14850179 INSC 0.395833 0.095238 0 0 0 INSC 11 11p15.2 15090546 15225331 LDLRAD3 0.395833 0.095238 0 0 0 LDLRAD3 11 11p13 35922188 36209418 COMMDS 0.395833 0.095238 0 0 0 COMMDS 11 11p13 36250418 36267576 PRR5L 0.395833 0.095238 0 0 0 PRR5L 11 11p13 36274301 36443330 PCF11 0.395833 0.095238 0.047619 0 0.074074 PCF11 11 11q14.1 82545785 82574484 ANKRD42 0.395833 0.095238 0.047619 0 0.074074 ANKRD42 11 11q14.1 82582939 82637662 MMP7 0.395833 0.095238 0 0 0.037037 MMP7 11 11q22.2 1.02E+08 1.02E+08 FAM55A 0.395833 0.190476 0.095238 0.148148 0 FAM55A 11 11q23.2 1.14E+08 1.14E+08 FAM55B 0395833 0.190476 0.095238 0.148148 0 FAM55B 11 11q23.2 1.14E+08 1.14E+08 RSU1 0.395833 0.095238 0 0 0 RSU1 10 10p13 16672623 16899460 ST8SIA6 0.395833 0.095238 0 0 0 ST8SIA6 10 10p12.33 17402682 17536261 PTPLA 0.395833 0.095238 0 0 0 PTPLA 10 10p12.33 17671964 17699380 STAM 0.395833 0.095238 0 0 0 STAM 10 10p12.33 17726130 17797914 SLC39A12 0.395833 0.095238 0 0 0 SLC39A12 10 10p12.33 18280774 18372228 CACNB2 0.395833 0.095238 0 0 0 CACNB2 10 10p12.33 18469612 18870695 NSUN6 0.395833 0.095238 0 0 0 NSUN6 10 10p12.33 18874270 18980557 ARL5B 0.395833 0.095238 0 0 0 ARL5B 10 10p12.33 18988319 19006947 GAD2 0.395833 0.095238 0 0 0 GAD2 10 10p12.1 26545242 26633498 APB1IP 0395833 0.095238 0 0 0 APB1IP 10 10p12.1 26767272 26896739 C10orf50 0.395833 0.095238 0 0 0 C10orf50 10 10p12.1 26918800 26923256 LOC73178

0.395833 0.095238 0 0 0 LOC73178

10 10p12.1 26972043 26982389 PDSS1 0.395833 0.095238 0 0 0 PDSS1 10 10p12.1 27026601 27075733 ABI1 0.395833 0.095238 0 0 0 ABI1 10 10p12.1 27075531 27189966 KIF5B 0.395833 0.095238 0 0 0 KIF5B 10 10p11.22 32337944 32385378 EPC1 0.395833 0.095238 0 0 0 EPC1 10 10p11.22 32597865 32676120 CCDC7 0.395833 0.047619 0.095238 0 0 CCDC7 10 10p11.22 32775047 32903499 LOC10012

0.395833 0 0.095238 0 0 LOC10012

10 10p11.21 38504605 38543279 HSD17B7P

0.395833 0 0.095238 0 0 HSD17B7P

10 10p11.21 38685314 38707440 LRIT2 0.395833 0.095238 0 0 0 LRIT2 10 10q23.1 85970229 85975265 LRIT1 0.395833 0.095238 0 0 0 LRIT1 10 10q23.1 85981256 85991198 RGR 0.395833 0.095238 0 0 0 RGR 10 10q23.1 85994789 86008925 PTEN 0.395833 0 0.095238 0 0 PTEN 10 10q23.31 89613175 89718513 LIPK 0.395833 0.047619 0.095238 0.037037 0 LIPK 10 10q23.31 90474281 90502494 STAMBPL1 0.395833 0 0.095238 0 0 STAMBPL1 10 10q23.31 90630006 90673225 ACTA2 0.395833 0 0.095238 0 0 ACTA2 10 10q23.31 90684813 90741128 LIPA 0.395833 0 0.095238 0 0 LIPA 10 10q23.31 90963306 91001641 IFIT3 0.395833 0 0.095238 0 0 IFIT3 10 10q23.31 91077582 91090705 IFIT5 0.395333 0 0.095238 0 0 IFIT5 10 10q23.31 91164305 91170739 SLC16A12 0.395833 0 0.095238 0 0 SLC16A12 10 10q23.31 91180036 91285294 PANK1 0.395833 0 0.095238 0 0 PANK1 10 10q23.31 91332729 91393628 MIR107 0.395833 0 0.095238 0 0 MIR107 10 10q23.31 91342485 91342565 TM9SF3 0.395833 0.285714 0.095238 0.259259 0 TM9SF3 10 10q24.1 98267857 98336800 PIK3AP1 0.395833 0.285714 0.095238 0.259259 0 PIK3AP1 10 10q24.1 98343059 98470270 CCDC147 0.395833 0.095238 0.095238 0.037037 0 CCDC147 10 10q25.1 1.06E+08 1.06E+08 SLC1A1 0.395833 0.095238 0 0 0 SLC1A1 9 9p24.2 4480444 4577470 UHRF2 0.395833 0.095238 0 0 0 UHRF2 9 9p24.1 6403151 6497052 PTPLAD2 0.395833 0 0.095238 0 0 PTPLAD2 9 9p21.3 20996365 21021636 IFNW1 0.395833 0 0.095238 0 0 IFNW1 9 9p21.3 21130631 21132145 IFNA21 0.395833 0 0.095238 0 0 IFNA21 9 9p21.3 21155636 21156660 MOBKL2B 0.395833 0.095238 0.047619 0 0.111111 MOBKL2B 9 9p21.2 27315207 27519851 KLF9 0.395833 0.095238 0 0 0 KLF9 9 9q21.11 72189333 72219394 TRPM3 0.395833 0.095238 0 0 0 TRPM3 9 9q21.11 72339786 72926335 TMEM2 0.395833 0.095238 0 0 0 TMEM2 9 9q21.13 73488102 73573621 GDA 0.395833 0.095238 0 0 0 GDA 9 9q21.13 73954113 74056961 ZFAND5 0.395833 0.095238 0 0 0 ZFAND5 9 9q21.13 74156161 74169984 TMC1 0.395833 0.095238 0 0 0 TMC1 9 9q21.13 74326537 74641088 ALDH1A1 0.395833 0 0.095238 0 0 ALDH1A1 9 9q21.13 74705407 74757790 PRUNE2 0.395833 0.095238 0 0 0 PRUNE2 9 9q21.13 78416112 78710824 GAS1 0.395833 0.142857 0.095238 0.222222 0 GAS1 9 9q21.33 88749097 88751925 CKS2 0.395833 0.333333 0.095238 0.296296 0 CKS2 9 9q22.2 91115933 91121439 5ECISBP2 0.395833 0.333333 0.095238 0.296296 0 5ECISBP2 9 9q22.2 91123232 91164382 LPPR1 0.395833 0 0.095238 0.037037 0 LPPR1 9 9q31.1 1.03E+08 1.03E+08 MRPL50 0.395833 0.047619 0.095238 0.037037 0 MRPL50 9 9q31.1 1.03E+08 1.03E+08 ZNF189 0.395833 0.047619 0.095238 0.037037 0 ZNF189 9 9q31.1 1.03E+08 1.03E+08 ALDOB 0.395833 0.047619 0.095238 0.037037 0 ALDOB 9 9q31.1 1.03E+08 1.03E+08 RNF20 0.395833 0.047619 0.095238 0.037037 0 RNF20 9 9q31.1 1.03E+08 1.03E+08 GRIN3A 0.395833 0.047619 0.095238 0.037037 0 GRIN3A 9 9q31.1 1.03E+08 1.04E+08 NIPSNAP3

0.395833 0.095238 0.047619 0 0.037037 NIPSNAP3

9 9q31.1 1.07E+08 1.07E+08 FSD1L 0.395833 0.047619 0.095238 0 0 FSD1L 9 9q31.2 1.07E+08 1.07E+08 FKTN 0.395833 0.047619 0.095238 0 0 FKTN 9 9q31.2 1.07E+08 1.07E+08 TAL2 0.395833 0.095238 0.047619 0 0 TAL2 9 9q31.2 1.07E+08 1.07E+08 IKBKAP 0.395833 0.095238 0 0 0 IKBKAP 9 9q31.3 1.11E+08 1.11E+08 CTNNAL1 0.395833 0.095238 0 0 0 CTNNAL1 9 9q31.3 1.11E+08 1.11E+08 C9orf5 0.395833 0.095238 0 0 0 C9orf5 9 9q31.3 1.11E+08 1.11E+08 TNFSF15 0.395833 0.095238 0.095238 0.037037 0 TNFSF15 9 9q32 1.17E+08 1.17E+08 TNFSF8 0.395833 0.095238 0.095238 0.037037 0 TNFSF8 9 9q33.1 1.17E+08 1.17E+08 TNC 0.395833 0.095238 0.095238 0.037037 0 TNC 9 9q33.1 1.17E+08 1.17E+08 ASTN2 0.395833 0.095238 0.047619 0 0 ASTN2 9 9q33.1 1.18E+08 1.19E+08 DBC1 0.395833 0.047619 0.095238 0 0 DBC1 9 9q33.1 1.21E+08 1.21E+08 SH2D4A 0.395833 0.095238 0 0 0 SH2D4A 8 8p21.3 19215487 19297597 ADAM7 0.395833 0 0.095238 0.037037 0 ADAM7 8 8p21.2 24354454 24422166 ADAM9 0.395833 0 0.095238 0.037037 0 ADAM9 8 8p11.23 38973662 39081937 ADAM32 0.395833 0 0.095238 0.037037 0 ADAM32 8 8p11.23 39084207 39261594 POTEA 0.395833 0.047619 0.095238 0.148148 0 POTEA 8 8p11.1 43266742 43337486 SNTG1 0.395833 0.095238 0.047619 0 0.037037 SNTG1 8 8q11.22 50987150 51867981 PXDNL 0.395833 0.095238 0 0 0 PXDNL 8 8q11.22 52394690 52884559 ST18 0.395833 0.047619 0.095238 0 0 ST18 8 8q11.23 53185945 53484993 RB1CC1 0.395833 0.095238 0 0 0 RB1CC1 8 8q11.23 53697571 53789580 XKR4 0.395833 0.095238 0 0 0 XKR4 8 8q12.1 56177571 56601265 SDR16C6 0.395833 0.095238 0 0 0 SDR16C6 8 8q12.1 57448181 57470479 FAM110B 0.395833 0.095238 0 0 0 FAM110B 8 8q12.1 59069667 59224832 UBXN2B 0.395833 0.095238 0.047619 0 0 UBXN2B 8 8q12.1 59486377 59526615 NSMAF 0.395833 0.095238 0.047619 0 0 NSMAF 8 8q12.1 59658620 59734521 TOX 0.395833 0.095238 0.047619 0 0 TOX 8 8q12.1 59880531 60194322 CA8 0.395833 0.095238 0 0 0 CA8 8 8q12.1 61263977 61356509 RAB2A 0.395833 0.095238 0 0 0 RAB2A 8 8q12.1 61592113 61696184 CHD7 0.395833 0.095238 0 0 0 CHD7 8 8q12.2 61753893 61942022 CLVS1 0.395833 0.095238 0 0 0 CLVS1 8 8q12.2 62363079 62576757 ASPH 0.395833 0.095238 0 0 0 ASPH 8 8q12.3 62575670 62764963 NKAIN3 0.395833 0.095238 0.047619 0 0.037037 NKAIN3 8 8q12.3 63324055 64066183 ARMC1 0.395833 0.095238 0 0 0 ARMC1 8 8q13.1 66677628 66708987 MTFR1 0.395833 0.095238 0 0 0 MTFR1 8 8q13.1 66719442 66783127 PDE7A 0.395833 0.095238 0 0 0 PDE7A 8 8q13.1 66792460 66863876 DNAJC5B 0.395833 0.095238 0 0 0 DNAJC5B 8 8q13.1 67096345 67175310 TRIM55 0.395833 0.095238 0 0 0 TRIM55 8 8q13.1 67201832 67250273 STAU2 0.395833 0.095238 0.095238 0 0.037037 STAU2 8 8q21.11 74495160 74821717 TMEM70 0.395833 0.095238 0.095238 0 0.037037 TMEM70 8 8q21.11 75050984 75057568 FABP5 0.395833 0.095238 0.095238 0 0.148148 FABP5 8 8q21.13 82355340 82359564 RGS22 0.395833 0.095238 0 0 0 RGS22 8 8q22.2 1.01E+08 1.01E+08 FBXO43 0.395833 0.095238 0 0 0 FBXO43 8 8q22.2 1.01E+08 1.01E+08 POLR2K 0.395833 0.095238 0 0 0 POLR2K 8 8q22.2 1.01E+08 1.01E+08 SPAG1 0.395833 0.095238 0 0 0 SPAG1 8 8q22.2 1.01E+08 1.01E+08 DPYS 0.395833 0.095238 0 0 0.148148 DPYS 8 8q22.3 1.05E+08 1.06E+08 COL14A1 0.395833 0.095238 0.047619 0 0 COL14A1 8 8q24.12 1.21E+08 1.21E+08 MRPL13 0.395833 0 0.095238 0 0 MRPL13 8 8q24.12 1.21E+08 1.22E+08 MTBP 0.395833 0 0.095238 0 0 MTBP 8 8q24.12 1.22E+08 1.22E+08 LOC72767

0.395833 0.095238 0.047619 0 0 LOC72767

8 8q24.21 1.29E+08 1.29E+08 GSDMC 0.395833 0.095238 0 0 0.037037 GSDMC 8 8q24.21 1.31E+08 1.31E+08 FAM49B 0.395833 0.095238 0 0 0.037037 FAM49B 8 8q24.21 1.31E+08 1.31E+08 OC90 0.395333 0.095238 0 0 0 OC90 8 8q24.22 1.33E+08 1.33E+08 HHLA1 0.395833 0.095238 0 0 0 HHLA1 8 8q24.22 1.33E+08 1.33E+08 KCNQ3 0.395833 0.095238 0 0 0 KCNQ3 8 8q24.22 1.33E+08 1.34E+08 HPYR1 0.395833 0.095238 0 0 0 HPYR1 8 8q24.22 1.34E+08 1.34E+08 TMEM71 0.395833 0.095238 0 0 0 TMEM71 8 8q24.22 1.34E+08 1.34E+08 COL28A1 0.395833 0.095238 0.047619 0 0.111111 COL28A1 7 7p21.3 7364769 7541986 RPA3 0.395833 0.095238 0.047619 0 0.074074 RPA3 7 7p21.3 7643100 7724764 GLCCI1 0.395833 0.095238 0.047619 0 0.074074 GLCCI1 7 7p21.3 7974948 8095235 TOMM7 0.395833 0.095238 0 0 0 TOMM7 7 7p15.3 22818777 22828947 KLHL7 0.395833 0.095238 0 0 0 KLHL7 7 7p15.3 23111878 23181564 NUPL2 0.395833 0.095238 0 0 0 NUPL2 7 7p15.3 23187971 23207155 C7orf30 0.395833 0.095238 0.047619 0 0 C7orf30 7 7p15.3 23305465 23315706 IGF2BP3 0.395833 0.095238 0.047619 0 0 IGF2BP3 7 7p15.3 23316353 23476521 STK31 0.395833 0.095238 0 0 0 STK31 7 7p15.3 23716363 23838653 CPVL 0.395833 0.095238 0 0 0 CPVL 7 7p15.1 29001772 29152679 CHN2 0.395833 0.095238 0 0 0 CHN2 7 7p15.1 29200646 29520470 NEUROD6 0.395833 0.095238 0 0 0 NEUROD6 7 7p15.1 31343605 31347064 AVL9 0.395833 0.095238 0 0 0 AVL9 7 7p14.3 32501701 32590305 KBTBD2 0.395833 0.095238 0 0 0 KBTBD2 7 7p14.3 32874303 32897994 NT5C3 0.395833 0.095238 0 0 0 NT5C3 7 7p14.3 33020267 33068935 RP9 0.395833 0.095238 0 0 0 RP9 7 7p14.3 33100935 33115528 BMPER 0.395833 0.095238 0 0 0 BMPER 7 7p14.3 33911637 34160637 EEPD1 0.395833 0.095238 0 0 0 EEPD1 7 7p14.2 36159361 36307678 ANLN 0.395833 0.095238 0 0 0 ANLN 7 7p14.2 36395957 36459926 AOAH 0.395833 0.095238 0 0 0 AOAH 7 7p14.2 36519133 36730679 ABCA13 0.395833 0.095238 0.047619 0 0.037037 ABCA13 7 7p12.3 48208389 48657638 MTERF 0.395833 0.095238 0 0 0 MTERF 7 7q21.2 91339957 91347953 AKAP9 0.395833 0.095238 0 0 0 AKAP9 7 7q21.2 91408125 91577923 CYP51A1 0.395833 0.095238 0 0 0 CYP51A1 7 7q21.2 91579399 91601777 LOC40138

0.395833 0.095238 0 0 0 LOC40138

7 7q21.2 91612134 91632527 KRIT1 0.395833 0.095238 0 0 0 KRIT1 7 7q21.2 91566219 91713165 LMTK2 0.395833 0.333333 0.095238 0.296296 0 LMTK2 7 7q21.3 97574133 97676879 LAMB1 0.395833 0.095238 0 0 0 LAMB1 7 7q31.1 1.07E+08 1.07E+08 AKR1B1 0.395833 0.095238 0 0 0 AKR1B1 7 7q33 1.34E+08 1.34E+08 AKR1B10 0.395833 0.095238 0 0 0 AKR1B10 7 7q33 1.34E+08 1.34E+08 C6orf105 0.395833 0.095238 0 0 0 C6orf105 6 6p24.1 11821876 11887267 RNF144B 0.395833 0.095238 0 0 0.037037 RNF144B 6 6p22.3 18495573 18576830 SOX4 0.395833 0.095238 0 0 0 SOX4 6 6p22.3 21701951 21706829 FLJ22536 0.395833 0.095238 0 0 0 FLJ22536 6 6p22.3 21774654 22302594 DCDC2 0.395833 0.095238 0.047619 0 0 DCDC2 6 6p22.2 24279962 24466260 KIAA0319 0.395833 0.095238 0 0 0 KIAA0319 6 6p22.2 24652311 24754363 ACOT13 0.395833 0.095238 0 0 0 ACOT13 6 6p22.2 24775242 24813273 C6orf62 0.395833 0.095238 0 0 0 C6orf62 6 6p22.2 24813070 24827383 FAM65B 0.395833 0.095238 0 0 0 FAM65B 6 6p22.2 24912492 25019175 SCGN 0.395833 0.047619 0.095238 0.037037 0 SCGN 6 6p22.2 25760408 25809988 SLC17A1 0.395833 0.047619 0.095238 0.037037 0 SLC17A1 6 6p22.2 25891105 25940267 NCRNA001 0.395833 0.285714 0.095238 0.259259 0 NCRNA001 6 6p21.33 30076768 30135941 ZNRD1 0.395833 0.285714 0.095238 0.259259 0 ZNRD1 6 6p21.33 30137015 30140666 C6orf141 0.395833 0.095238 0.190476 0 0.074074 C6orf141 6 6p12.3 49626072 49627766 GCM1 0.395833 0.095238 0 0 0 GCM1 6 6p12.1 53099721 53121584 SMAP1 0.395833 0.095238 0.095238 0 0.148148 SMAP1 6 6q13 71434200 71628438 MY06 0.395833 0.095238 0.095238 0 0.111111 MY06 6 6q14.1 76515629 76685975 HTR1E 0.395833 0 0.095238 0 0 HTR1E 6 6q15 87703743 87783110 GJA1 0.395833 0.095238 0.095238 0 0.111111 GJA1 6 6q22.31 1.22E+08 1.22E+08 EPM2A 0.395833 0 0.095238 0 0 EPM2A 6 6q24.3 1.46E+08 1.46E+08 NOX3 0.395833 0.095238 0 0 0 NOX3 6 6q25.3 1.56E+08 1.56E+08 SLC22A3 0.395833 0.095238 0 0 0 SLC22A3 6 6q25.3 1.61E+08 1.61E+08 LPA 0.395833 0.095238 0 0 0 LPA 6 6q25.3 1.61E+08 1.61E+08 ADCY2 0.395833 0.095238 0 0 0 ADCY2 5 5p15.31 7449343 7883195 NPR3 0.395833 0.095238 0 0 0 NPR3 5 5p13.3 32747422 32823012 DAB2 0.395833 0 0.095238 0 0 DAB2 5 5p13.1 39407537 39461093 TTC33 0.395833 0.095238 0 0 0 TTC33 5 5p13.1 40747435 40791830 PRKAA1 0.395833 0.095238 0 0 0 PRKAA1 5 5p13.1 40795238 40834055 RPL37 0.395833 0.095238 0 0 0 RPL37 5 5p13.1 40867187 40871145 SNORD72 0.395833 0.095238 0 0 0 SNORD72 5 5p13.1 40868515 40868595 CARD6 0.395833 0.095238 0 0 0 CARD6 5 5p13.1 40877167 40891214 C7 0.395833 0 0.095238 0.037037 0 C7 5 5p13.1 40945356 41018799 ACTBL2 0.395833 0.095238 0.047619 0 0 ACTBL2 5 5q11.2 56811600 56814394 IPO11 0.395833 0.095238 0 0 0.037037 IPO11 5 5q12.1 61744330 61960172 LHFPL2 0.395833 0.095238 0 0 0 LHFPL2 5 5q14.1 77816794 77980405 ARSB 0.395833 0.095238 0 0 0 ARSB 5 5q14.1 78108793 78318114 RASGRF2 0.395833 0.095238 0 0 0.037037 RASGRF2 5 5q14.1 80292314 80557710 CKMT2 0.395833 0.095238 0 0 0.037037 CKMT2 5 5q14.1 80564895 80597974 ZCCHC9 0.395833 0.095238 0 0 0.037037 ZCCHC9 5 5q14.1 80633158 80644720 ACOT12 0.395833 0.095238 0 0 0.037037 ACOT12 5 5q14.1 80661703 80725745 MEF2C 0.395833 0.095238 0.238095 0 0.185185 MEF2C 5 5q14.3 88049815 88235626 RHOBTB3 0.395833 0.095238 0.047619 0 0.148148 RHOBTB3 5 5q15 95092606 95157828 GLRX 0.395833 0.095238 0.047619 0 0.148148 GLRX 5 5q15 95175309 95184334 C5orf27 0.395833 0.095238 0.047619 0 0.148148 C5orf27 5 5q15 95213592 95221591 TSSK1B 0.395833 0 0.095238 0 0 TSSK1B 5 5q22.2 1.13E+08 1.13E+08 3-Mar 0.395833 0.095238 0.047619 0 0.037037 3-Mar 5 5q23.2 1.26E+08 1.26E+08 CDC42SE2 0.395833 0.095238 0 0 0 CDC42SE2 5 5q31.1 1.31E+08 1.31E+08 RAPGEF6 0.395833 0.095238 0 0 0 RAPGEF6 5 5q31.1 1.31E+08 1.31E+08 FNIP1 0.395833 0.095238 0 0 0 FNIP1 5 5q31.1 1.31E+08 1.31E+08 GRIA1 0.395833 0 0.095238 0 0 GRIA1 5 5q33.2 1.53E+08 1.53E+08 GEMIN5 0.395833 0.047619 0.095238 0.148148 0 GEMIN5 5 5q33.2 1.54E+08 1.54E+08 KIF4B 0.395833 0 0.095238 0.111111 0 KIF4B 5 5q33.2 1.54E+08 1.54E+08 EBF1 0.395833 0 0.095238 0 0 EBF1 5 5q33.3 1.58E+08 1.58E+08 TTC1 0.395833 0.095238 0 0 0 TTC1 5 5q33.3 1.59E+08 1.59E+08 C5orf54 0.395833 0.095238 0.095238 0.037037 0 C5orf54 5 5q33.3  1.6E+08  1.6E+08 QDPR 0.395833 0.095238 0 0 0 QDPR 4 4p15.32 17097118 17122956 CLRN2 0.395833 0.095238 0 0 0 CLRN2 4 4p15.32 17125886 17137826 LAP3 0.395833 0.095238 0 0 0 LAP3 4 4p15.32 17188025 17218689 FAM184B 0.395833 0.095238 0 0 0 FAM184B 4 4p15.32 17242809 17392234 DCAF16 0.395833 0.095238 0 0 0 DCAF16 4 4p15.32 17411376 17421480 C4orf19 0.395833 0.095238 0 0 0.037037 C4orf19 4 4p14 37131947 37271528 RELL1 0.395833 0.095238 0 0 0 RELL1 4 4p14 37268817 37364395 PGM2 0.395833 0.095238 0 0 0 PGM2 4 4p14 37504677 37540955 T8C1D1 0.395833 0.095238 0 0 0 T8C1D1 4 4p14 37569115 37817190 FLI13197 0.395833 0.095238 0 0 0 FLI13197 4 4p14 38290717 38342645 ANKRD17 0.395833 0 0.095238 0 0 ANKRD17 4 4q13.3 74159366 74343367 AFP 0.395833 0 0.095238 0 0 AFP 4 4q13.3 74520797 74540357 AFM 0.395833 0 0.095238 0 0 AFM 4 4q13.3 74566326 74588583 RA5SF6 0.395833 0 0.095238 0 0 RA5SF6 4 4q13.3 74657726 74704999 DCLK2 0.395833 0.047619 0.095238 0 0 DCLK2 4 4q31.3 1.51E+08 1.51E+08 FAM160A1 0.395833 0.095238 0 0 0 FAM160A1 4 4q31.3 1.53E+08 1.53E+08 ITPR1 0.395833 0.095238 0.047819 0 0 ITPR1 3 3p26.2 4510032 4864523 DVWA 0.395833 0.238095 0.095238 0.185185 0 DVWA 3 3p24.3 15181875 15222471 PLCL2 0.395833 0 0.095238 0 0 PLCL2 3 3p24.3 16901456 17107102 UBE2E2 0.395833 0 0.095238 0 0 UBE2E2 3 3p24.3 23219788 23607301 UBE2E1 0.395833 0.095238 0.047619 0 0 UBE2E1 3 3p24.2 23822443 23907812 PDCD6IP 0.395833 0.095238 0.047619 0 0.037037 PDCD6IP 3 3p22.3 33815070 33886199 FOXPI 0.395833 0.095238 0.047619 0 0 FOXPI 3 3p14.1 71087426 71715831 GXYLT2 0.395833 0.095238 0.047619 0 0 GXYLT2 3 3p13 73020075 73107213 PPP4R2 0.395833 0.095238 0.047619 0 0 PPP4R2 3 3p13 73128809 73197702 RETNLB 0.395833 0 0.095238 0 0 RETNLB 3 3q13.13  1.1E+08  1.1E+08 TRAT1 0.395833 0 0.095238 0 0 TRAT1 3 3q13.13  1.1E+08  1.1E+08 GUCA1C 0.395833 0 0.095238 0 0 GUCA1C 3 3q13.13  1.1E+08  1.1E+08 MORC1 0.395833 0 0.095238 0 0 MORC1 3 3q13.13  1.1E+08  1.1E+08 BOC 0.395833 0.095238 0.047619 0 0.037037 BOC 3 3q13.2 1.14E+08 1.14E+08 NAT13 0.395833 0.095238 0.047619 0 0 NAT13 3 3q13.2 1.15E+08 1.15E+08 POLQ 0.395833 0.095238 0.047619 0 0 POLQ 3 3q13.33 1.23E+08 1.23E+08 ARGFX 0.395833 0.095238 0.047619 0 0 ARGFX 3 3q13.33 1.23E+08 1.23E+08 FBXO40 0.395833 0.095238 0.047619 0 0 FBXO40 3 3q13.33 1.23E+08 1.23E+08 GOLGB1 0.395833 0.047619 0.095238 0 0 GOLGB1 3 3q13.33 1.23E+08 1.23E+08 ACAD11 0.395833 0 0.095238 0 0 ACAD11 3 3q22.1 1.34E+08 1.34E+08 CCRL1 0.395833 0 0.095238 0 0 CCRL1 3 3q22.1 1.34E+08 1.34E+08 UBA5 0.395833 0 0.095238 0 0 UBA5 3 3q22.1 1.34E+08 1.34E+08 NCRNA001 0.395833 0 0.095238 0 0 NCRNA001 3 3q22.1 1.34E+08 1.34E+08 TMEM108 0.395833 0 0.095238 0 0 TMEM108 3 3q22.1 1.34E+08 1.35E+08 C3orf79 0.395833 0 0.095238 0 0 C3orf79 3 3q25.2 1.55E+08 1.55E+08 PLCH1 0.395833 0 0.095238 0 0 PLCH1 3 3q25.31 1.57E+08 1.57E+08 SHOX2 0.395833 0 0.095238 0 0 SHOX2 3 3q25.32 1.59E+08 1.59E+08 RSRC1 0.395833 0 0.095238 0 0 RSRC1 3 3q25.32 1.59E+08  1.6E+08 MFSD1 0.395833 0 0.095238 0 0 MFSD1 3 3q25.33  1.6E+08  1.6E+08 IQCI 0.395833 0 0.095238 0 0 IQCI 3 3q25.33  1.6E+08  1.6E+08 SCHIP1 0.395833 0 0.095238 0 0 SCHIP1 3 3q25.33  1.6E+08 1.61E+08 C3orf57 0.395833 0 0.095238 0 0 C3orf57 3 3q26.1 1.63E+08 1.63E+08 TBL1XR1 0.395833 0.095238 0 0 0 TBL1XR1 3 3q26.32 1.78E+08 1.78E+08 ZNF639 0.395833 0.095238 0 0 0 ZNF639 3 3q26.32 1.81E+08 1.81E+08 GN84 0.395833 0.095238 0 0 0 GN84 3 3q26.33 1.81E+08 1.81E+08 ACTL6A 0.395833 0.095238 0 0 0 ACTL6A 3 3q26.33 1.81E+08 1.81E+08 MRPL47 0.395833 0.095238 0.047619 0 0 MRPL47 3 3q26.33 1.81E+08 1.81E+08 USP13 0.395833 0.095238 0 0 0 USP13 3 3q26.33 1.81E+08 1.81E+08 SOX2OT 0.395833 0.095238 0.095238 0 0.037037 SOX2OT 3 3q26.33 1.83E+08 1.83E+08 TPRG1 0.395833 0 0.095238 0.037037 0 TPRG1 3 3q28  1.9E+08 1.91E+08 TP63 0.395833 0 0.095238 0.037037 0 TP63 3 3q28 1.91E+08 1.91E+08 LEPREL1 0.395833 0 0.095233 0 0 LEPREL1 3 3q28 1.91E+08 1.91E+08 CLDN1 0.395833 0 0.095238 0 0 CLDN1 3 3q28 1.92E+08 1.92E+08 IL1RAP 0.395833 0 0.095238 0 0 IL1RAP 3 3q28 1.92E+08 1.92E+08 LOC64730

0.395833 0 0.095238 0 0 LOC64730

3 3q28 1.92E+08 1.92E+08 SNAR-I 0.395833 0 0.095238 0 0 SNAR-I 3 3q28 1.92E+08 1.92E+08 HRASLS 0.395833 0.047619 0.095238 0 0 HRASLS 3 3q29 1.94E+08 1.94E+08 ATP13A5 0.395833 0.047619 0.095238 0 0 ATP13A5 3 3q29 1.94E+08 1.95E+08 ROCK2 0.395833 0.333333 0.095238 0.259259 0 ROCK2 2 2p25.1 11239229 11402163 C2orf43 0.395833 0.047619 0.095238 0 0 C2orf43 2 2p24.1 20748299 20886309 CRIM1 0.395833 0.095238 0 0 0 CRIM1 2 2p22.2 36436901 36631783 CDKL4 0.395833 0.095238 0 0 0 CDKL4 2 2p22.1 39259192 39310178 MAP4K3 0.395833 0.095238 0 0 0 MAP4K3 2 2p22.1 39329926 39517724 SLC9A2 0.395833 0.095238 0.047619 0 0 SLC9A2 2 2q12.1 1.03E+08 1.03E+08 SLC5A7 0.395833 0.047619 0.095238 0.074074 0 SLC5A7 2 2q12.3 1.08E+08 1.08E+08 DDX18 0.395833 0.095238 0 0 0.037037 DDX18 2 2q14.1 1.18E+08 1.18E+08 CCDC93 0.395833 0.095238 0 0 0.037037 CCDC93 2 2q14.1 1.18E+08 1.18E+08 MGAT5 0.395833 0.095238 0 0 0 MGAT5 2 2q21.3 1.35E+08 1.35E+08 KIFSC 0.395833 0.095238 0.047619 0 0.037037 KIFSC 2 2q23.1 1.49E+08  1.5E+08 MIR1978 0.395833 0.095238 0.047619 0 0.037037 MIR1978 2 2q23.1 1.49E+08 1.49E+08 RND3 0.395833 0 0.095238 0 0 RND3 2 2q23.3 1.51E+08 1.51E+08 DPP4 0.395833 0.095238 0 0 0.111111 DPP4 2 2q24.2 1.63E+08 1.63E+08 DYNC1I2 0.395833 0.047619 0.095238 0.074074 0 DYNC1I2 2 2q31.1 1.72E+08 1.72E+08 OLA1 0.395833 0.095238 0.047619 0 0 OLA1 2 2q31.1 1.75E+08 1.75E+08 GPR155 0.395833 0.095238 0 0 0 GPR155 2 2q31.1 1.75E+08 1.75E+08 WIPF1 0.395833 0.095238 0 0 0 WIPF1 2 2q31.1 1.75E+08 1.75E+08 CHRNA1 0.395833 0.095238 0 0 0 CHRNA1 2 2q31.1 1.75E+08 1.75E+08 KCTD18 0.395833 0.095238 0 0 0 KCTD18 2 2q33.1 2.01E+08 2.01E+08 SGOL2 0.395833 0.095238 0 0 0 SGOL2 2 2q33.1 2.01E+08 2.01E+08 AOX1 0.395833 0.095238 0 0 0 AOX1 2 2q33.1 2.01E+08 2.01E+08 PARD3B 0.395833 0 0.095238 0 0 PARD3B 2 2q33.2 2.05E+08 2.06E+08 TMEM57 0.395833 0.47619 0.095238 0.592593 0 TMEM57 1 1p36.11 25629975 25699284 LDLRAP1 0.395833 0.47619 0.095238 0.592593 0 LDLRAP1 1 1p36.11 25742663 25767965 SKINTL 0.395833 0.047619 0.095238 0.222222 0 SKINTL 1 1p33 48339974 48420688 DNAJC6 0.395833 0.095238 0 0 0 DNAJC6 1 1p31.3 65503018 65654141 LEPR 0.395833 0.095238 0 0 0 LEPR 1 1p31.3 65558836 65873699 LEPROT 0.395833 0.095238 0 0 0 LEPROT 1 1p31.3 65658836 65674277 TCTEX1D1 0.395833 0 0.095238 0 0 TCTEX1D1 1 1p31.3 66990728 67017318 WDR78 0.395833 0 0.095238 0 0 WDR78 1 1p31.3 67051161 67163159 SLC35D1 0.395833 0 0.095238 0 0 SLC35D1 1 1p31.3 67237604 67292669 SERBP1 0.395833 0.095238 0 0 0 SERBP1 1 1p31.3 67646081 67668712 HFM1 0.395833 0.095238 0 0 0 HFM1 1 1p22.2 91498911 91643015 CDC7 0.395833 0.095238 0 0 0 CDC7 1 1p22.2 91738992 91763909 HSP90B3P 0.395833 0.095238 0 0 0 HSP90B3P 1 1p22.2 91873156 91881923 TGFBR3 0.395833 0.095238 0 0 0 TGFBR3 1 1p22.2 91918490 92124376 BRDT 0.395833 0.095238 0 0 0 BRDT 1 1p22.1 92187516 92252574 EPHX4 0.395833 0.095238 0 0 0 EPHX4 1 1p22.1 92268121 92301682 BTBD8 0.395833 0.095238 0 0 0 BTBD8 1 1p22.1 92318450 92385984 KIAA1107 0.395833 0.095238 0 0 0 KIAA1107 1 1p22.1 92405197 92422868 GFI1 0.395833 0.095238 0 0 0 GFI1 1 1p22.1 92712906 92721945 EV15 0.395833 0.095238 0 0 0 EV15 1 1p22.1 92746841 93030550 ABCD3 0.395833 0.095238 0.047619 0 0 ABCD3 1 1p21.3 94656521 94716849 SLC44A3 0.395833 0.095238 0 0 0 SLC44A3 1 1p21.3 95058489 35133391 CNN3 0.395833 0.095238 0 0 0 CNN3 1 1p21.3 95135095 95165324 ALG14 0.395833 0.095238 0 0 0 ALG14 1 1p21.3 95220867 95311096 TMEM56 0.395833 0.095238 0.047619 0 0.037037 TMEM56 1 1p21.3 95355482 95435748 GDAP2 0.395833 0 0.095238 0.037037 0 GDAP2 1 1p12 1.18E+08 1.18E+08 SPAG17 0.395833 0 0.095238 0.037037 0 SPAG17 1 1p12 1.18E+08 1.19E+08 TBX15 0.395833 0 0.095238 0 0 TBX15 1 1p12 1.19E+08 1.19E+08 SPRR2F 0.395833 0.095238 0.095238 0.185185 0 SPRR2F 1 1q21.3 1.51E+08 1.51E+08 SPRR2C 0.395833 0.095238 0.095238 0.185185 0 SPRR2C 1 1q21.3 1.51E+08 1.51E+08 SPRR2G 0.395833 0.095238 0.095238 0.185185 0 SPRR2G 1 1q21.3 1.51E+08 1.51E+08 CD1D 0.395833 0.047619 0.095238 0.074074 0 CD1D 1 1q23.1 1.56E+08 1.56E+08 CD1A 0.395833 0.047619 0.095238 0.074074 0 CD1A 1 1q23.1 1.56E+08 1.56E+08 SPTA1 0.395833 0.047619 0.095238 0.074074 0 SPTA1 1 1q23.1 1.57E+08 1.57E+08 OR6K6 0.395833 0.047619 0.095238 0.074074 0 OR6K6 1 1q23.1 1.57E+08 1.57E+08 PYHIN1 0.395833 0.047619 0.095238 0.074074 0 PYHIN1 1 1q23.1 1.57E+08 1.57E+08 IFI16 0.395833 0.047519 0.095238 0.074074 0 IFI16 1 1q23.1 1.57E+08 1.57E+08 AIM2 0.395833 0.047619 0.095238 0.074074 0 AIM2 1 1q23.1-1c 1.57E+08 1.57E+08 DUSP12 0.395833 0.047619 0.095238 0 0 DUSP12 1 1q23.3  1.6E+08  1.6E+08 ATF6 0.395833 0.047619 0.095238 0 0 ATF6 1 1q23.3  1.6E+08  1.6E+08 M1R556 0.395833 0.095233 0 0 0 M1R556 1 1q23.3 1.61E+08 1.61E+08 UHMK1 0.395833 0.095238 0 0 0 UHMK1 1 1q23.3 1.61E+08 1.61E+08 FAM78B 0.395833 0.095238 0 0 0 FAM78B 1 1q24.1 1.64E+08 1.64E+08 GPA33 0.395833 0.095238 0 0 0 GPA33 1 1q24.1 1.65E+08 1.65E+08 DUSP27 0.395833 0.095238 0 0 0 DUSP27 1 1q24.1 1.65E+08 1.65E+08 POU2F1 0.395833 0.095238 0 0 0 POU2F1 1 1q24.2 1.65E+08 1.66E+08 CD247 0.395833 0.095238 0 0 0 CD247 1 1q24.2 1.66E+08 1.66E+08 CREG1 0.395833 0.095238 0 0 0 CREG1 1 1q24.2 1.66E+08 1.06E+08 RCSD1 0.395833 0.095238 0 0 0 RCSD1 1 1q24.2 1.66E+08 1.66E+08 MPZL1 0.395833 0.095238 0 0 0 MPZL1 1 1q24.2 1.66E+08 1.66E+08 ADCY10 0.395833 0.095238 0 0 0 ADCY10 1 1q24.2 1.66E+08 1.66E+08 BRP44 0.395833 0.095238 0 0 0 BRP44 1 1q24.2 1.66E+08 1.66E+08 DCAF6 0.395833 0.095238 0 0 0 DCAF6 1 1q24.2 1.66E+08 1.66E+08 GPR161 0.395833 0.095238 0 0 0 GPR161 1 1q24.2 1.66E+08 1.66E+08 ANKRD36B 0.395833 0.095238 0 0 0 ANKRD36B 1 1q24.2 1.66E+08 1.66E+08 MIR557 0.395833 0.095238 0 0 0 MIR557 1 1q24.2 1.67E+08 1.67E+08 KIFAP3 0.395833 0 0.095238 0 0 KIFAP3 1 1q24.2 1.68E+08 1.68E+08 METTL11B 0.395833 0 0.095238 0 0 METTL11B 1 1q24.2 1.68E+08 1.68E+08 FMO3 0.395833 0 0.095238 0 0 FMO3 1 1q24.3 1.69E+08 1.69E+08 MIR1295 0.395833 0 0.095238 0 0 MIR1295 1 1q24.3 1.69E+08 1.69E+08 FMO2 0.395833 0 0.095238 0 0 FMO2 1 1q24.3 1.69E+08 1.69E+08 FMO1 0.395833 0 0.095238 0 0 FMO1 1 1q24.3 1.69E+08  1.7E+08 FMO4 0.395833 0.095238 0 0 0 FMO4 1 1q24.3  1.7E+08  1.7E+08 TOP1P1 0.395833 0.095238 0 0 0 TOP1P1 1 1q24.3  1.7E+08  1.7E+08 BAT2L2 0.395833 0.095238 0 0 0 BAT2L2 1 1q24.3  1.7E+08  1.7E+08 MYOC 0.395833 0.095238 0 0 0 MYOC 1 1q24.3  1.7E+08  1.7E+08 C1orf105 0.395833 0 0.095238 0 0 C1orf105 1 1q24.3 1.71E+08 1.71E+08 C1orf9 0.395833 0 0.095238 0 0 C1orf9 1 1q24.3 1.71E+08 1.71E+08 RABGAP1L 0.395833 0.095238 0.047619 0 0 RABGAP1L 1 1q25.1 1.72E+08 1.73E+08 XPR1 0.395833 0.095238 0 0 0 XPR1 1 1q25.3 1.79E+08 1.79E+08 CACNA1E 0.395833 0.095238 0 0 0 CACNA1E 1 1q25.3  1.8E+08  1.8E+08 LAMC1 0.395833 0.095238 0 0 0 LAMC1 1 1q25.3 1.81E+08 1.81E+08 LAMC2 0.395833 0.095238 0 0 0 LAMC2 1 1q25.3 1.81E+08 1.81E+08 C4BPA 0.395833 0.095238 0.095238 0.259259 0 C4BPA 1 1q32.2 2.05E+08 2.05E+08 SYT14 0.395833 0.095238 0.095238 0.111111 0 SYT14 1 1q32.2 2.08E+08 2.08E+08 LOC40080

0.395833 0 0.095238 0 0 LOC40080

1 1q41  2.2E+08  2.2E+08 AKT3 0.395833 0 0.095238 0 0 AKT3 1 1q44 2.42E+08 2.42E+08 OR2L13 0.395833 0.095238 0.095238 0.111111 0 OR2L13 1 1q44 2.46E+08 2.46E+08 C21orf34 0.020833 0 0.142857 0 0.037037 C21orf34 21 21q21.1 16364713 16903966 SMCHD1 0.020833 0.190476 0 0.037037 0 SMCHD1 18 18p11.3 2645886 2795016 LOC72789

0.020833 0.238095 0 0.037037 0 LOC72789

18 18p11.3 2933215 2936622 ARHGAP28 0.020833 0.190475 0 0.037037 0 ARHGAP28 18 18p11.31 6824484 6905713 PTPRM 0.020833 0.190476 0 0.037037 0 PTPRM 18 18p11.23 7557314 8396860 CTAGE1 0.020833 0.190476 0 0.037037 0 CTAGE1 18 18q11.2 18247562 18251877 RBBP8 0.020833 0.285714 0 0.037037 0.111111 RBBP8 18 18q11.2 18767293 18860448 MAPRE2 0.020833 0 0.142857 0 0.037037 MAPRE2 18 18q12.1 30810890 30976376 FHOD3 0.020833 0.142857 0 0.037037 0 FHOD3 18 18q12.2 32131700 32614017 KIAA1328 0.020833 0 0.142857 0.037037 0.037037 KIAA1328 18 18q12.2 32663078 33059287 DYM 0.020833 0.047619 0.142857 0.148148 0.037037 DYM 18 18q21.1 44824170 45241078 ALPK2 0.020833 0.238095 0 0.037037 0 ALPK2 18 18q21.31 54299462 54447170 MALT1 0.020833 0.238095 0 0.037037 0 MALT1 18 18q21.32 54489598 54568351 ZNF532 0.020833 0.238095 0 0.037037 0 ZNF532 18 18q21.32 54681041 54804690 LOC39085

0.020833 0.238095 0 0.037037 0 LOC39085

18 18q21.32 54853951 54871427 SEC11C 0.020833 0.238095 0 0.037037 0 SEC11C 18 18q21.32 54958105 54977044 CPLX4 0.020833 0.238095 0 0.037037 0 CPLX4 18 18q21.32 55113618 55136862 LMAN1 0.020833 0.238095 0 0.037037 0 LMAN1 18 18q21.32 55146037 55177489 CCBE1 0.020833 0.238095 0 0.037037 0 CCBE1 18 18q21.32 55252129 55515625 PHLPP1 0.020833 0.190476 0 0.037037 0 PHLPP1 18 18q21.33 58533714 58798647 SERPINB3 0.020833 0 0.190476 0 0.037037 SERPINB3 18 18q21.33 59473411 59480178 CYB5A 0.020833 0.238095 0 0.037037 0 CYB5A 18 18q22.3 70071507 70110202 FAM69C 0.020833 0.238095 0 0.037037 0 FAM69C 18 18q22.3 70253943 70275484 CNDP2 0.020833 0.238095 0 0.037037 0 CNDP2 18 18q22.3 70314480 70341668 CHD9 0.020833 0.190476 0 0.037037 0 CHD9 16 16q12.2 51646446 51918916 AKTIP 0.020833 0.142857 0 0.037037 0 AKTIP 16 16q12.2 52082693 52094672 IRX3 0.020833 0.142857 0 0.037037 0 IRX3 16 16q12.2 52574713 52877880 WWOX 0.020833 0.142857 0.047619 0.037037 0 WWOX 16 16q23.1 76691052 77804066 SNRPN 0.020833 0.190476 0 0.037037 0 SNRPN 15 15q11.2 22619887 22774823 ATPBD4 0.020833 0.047619 0.142857 0.037037 0.037037 ATPBD4 15 15q14 33450462 33625697 C15orf41 0.020833 0.047619 0.142857 0 0.037037 C15orf41 15 15q14 34659104 34889742 CSNK1A1P 0.020833 0.047619 0.142857 0 0.037037 CSNK1A1P 15 15q14 34878594 34898000 LOC14584

0.020833 0.047619 0.142857 0 0.037037 LOC14584

15 15q14 34943936 34966027 GLDN 0.020833 0.190476 0 0.037037 0 GLDN 15 15q21.2 49421005 49487502 GCOM1 0.020833 0.190476 0 0.037037 0 GCOM1 15 15q21.3 55671406 55797046 GRINL1A 0.020833 0.190476 0 0.037037 0 GRINL1A 15 15q21.3 55786193 55797046 AQP9 0.020833 0.142857 0.047619 0.037037 0 AQP9 15 15q22.1 56217700 56265403 SCAPER 0.020833 0.238095 0.142857 0.481481 0.037037 SCAPER 15 15q24.3 74427584 74941341 TTC5 0.020833 0.238095 0 0.037037 0.037037 TTC5 14 14q11.2 19827141 19843994 CCNB1IP1 0.020833 0.238095 0 0.037037 0.037037 CCNB1IP1 14 14q11.2 19849369 19871298 SNORD126 0.020833 0.238095 0 0.037037 0.037037 SNORD126 14 14q11.2 19864440 19864539 MIR1201 0.020833 0.238095 0 0.037037 0.037037 MIR1201 14 14q11.2 19864449 19864531 RPPH1 0.020833 0.238095 0 0.037037 0.037037 RPPH1 14 14q11.2 19881070 19881411 PARP2 0.020833 0.238095 0 0.037037 0.037037 PARP2 14 14q11.2 19881613 19895904 METT11D1 0.020833 0.285724 0 0.037037 0 METT11D1 14 14q11.2 20527805 20535035 S1C39A2 0.020833 0.285714 0 0.037037 0 S1C39A2 14 14q11.2 20537259 20539871 NDRG2 0.020833 0.285714 0 0.037037 0 NDRG2 14 14q11.2 20554762 20563776 TPPP2 0.020833 0.285714 0 0.037037 0 TPPP2 14 14q11.2 20568185 20570171 RNASE13 0.020833 0.285714 0 0.037037 0 RNASE13 14 14q11.2 20570819 20572785 RNASE7 0.020833 0.285714 0 0.037037 0 RNASE7 14 14q11.2 20580225 20582233 RNASE8 0.020833 0.285714 0 0.037037 0 RNASE8 14 14q11.2 20595892 20596357 FLI10357 0.020833 0.285714 0 0.037037 0 FLI10357 14 14q11.2 20608367 20627877 ZNF219 0.020833 0.285714 0 0.037037 0 ZNF219 14 14q11.2 20628045 20637014 C14orf176 0.020833 0.285714 0 0.037037 0 C14orf176 14 14q11.2 20636936 20641723 OR5AU1 0.020833 0.285714 0 0.037037 0 OR5AU1 14 14q11.2 20692936 20694025 HNRNPC 0.020833 0.285714 0 0.037037 0 HNRNPC 14 14q11.2 20747136 20807473 RPGRIP1 0.020833 0.285714 0 0.037037 0 RPGRIP1 14 14q11.2 20825976 20889301 SUPT16H 0.020833 0.285714 0 0.037037 0 SUPT16H 14 14q11.2 20889472 20922266 RAB2B 0.020833 0.285714 0 0.037037 0 RAB2B 14 14q11.2 20997020 21014673 TOX4 0.020833 0.285714 0 0.037037 0 TOX4 14 14q11.2 21015175 21037160 METTL3 0.020833 0.285714 0 0.037037 0 METTL3 14 14q11.2 21036122 21049298 SALL2 0.020833 0.285714 0 0.037037 0 SALL2 14 14q11.2 21059072 21075178 OR10G3 0.020833 0.285714 0 0.037037 0 OR10G3 14 14q11.2 21107774 21108716 STRN3 0.020833 0.285714 0 0.037037 0 STRN3 14 14q12 30432756 30565359 MIA2 0.020833 0.142857 0.047619 0.037037 0.074074 MIA2 14 14q21.1 38772876 38792327 CTAGE5 0.020833 0.142857 0.047619 0.037037 0.074074 CTAGE5 14 14q21.1 38804227 38890149 GCH1 0.020833 0.190476 0 0.037037 0 GCH1 14 14q22.2 54378474 54439293 WDHD1 0.020833 0.190476 0 0.037037 0 WDHD1 14 14q22.3 54476692 54563558 MAPK1IP1

0.020833 0.190476 0 0.037037 0 MAPK1IP1

14 14q22.3 54588115 54606666 DLGAP5 0.020833 0.190476 0 0.037037 0 DLGAP5 14 14q22.3 54684589 54728150 FBXO34 0.020833 0.190476 0 0.037037 0 FBXO34 14 14q22.3 54807774 54890081 KIAA0831 0.020833 0.190476 0 0.037037 0 KIAA0831 14 14q22.3 54902863 54948330 TBPL2 0.020833 0.190476 0 0.037037 0 TBPL2 14 14q22.3 54950683 54977017 HIF1A 0.020833 0.142857 0 0.037037 0 HIF1A 14 14q23.2 61231872 61284731 DIO2 0.020833 0 0.142857 0 0.037037 DIO2 14 14q31.1 79733622 79748279 LOC28423

0.020833 0.142857 0 0.037037 0.074074 LOC28423

13 13q11 18306543 18344110 SGCG 0.020833 0.238095 0 0.037037 0 SGCG 13 13q12.12 22653060 22797305 MIPEP 0.020833 0.238095 0 0.037037 0 MIPEP 13 13q12.12 23202328 23361560 TRPC4 0.020833 0 0.190476 0 0.037037 TRPC4 13 13q13.3 37108775 37341940 CLDN10 0.020833 0.380952 0 0.037037 0 CLDN10 13 13q32.1 94883854 95030012 UBAC2 0.020833 0.238095 0 0.037037 0 UBAC2 13 13q32.3 98650680 98836753 MIR623 0.020833 0.190476 0 0.037037 0 MIR623 13 13q32.3 98806386 98806484 CLYBL 0.020833 0.190476 0 0.037037 0 CLYBL 13 13q32.3 99056920 99347389 A2LD1 0.020833 0.142857 0 0.037037 0 A2LD1 13 13q32.3 99981811 99983999 CCDC91 0.020833 0 0.190476 0 0.037037 CCDC91 12 12p11.22 28301400 28594367 LRIG3 0.020833 0 0.190476 0 0.037037 LRIG3 12 12q14.1 57552204 57600530 TPH2 0.020833 0 0.190476 0 0.037037 TPH2 12 12q21.1 70618893 70712489 LOC10012

0.020833 0.333333 0 0.037037 0 LOC10012

12 12q23.1 97430884 97434136 TMPO 0.020833 0.333333 0 0.037037 0 TMPO 12 12q23.1 97433540 97466867 SLC25A3 0.020833 0.333333 0 0.037037 0 SLC25A3 12 12q23.1 97511534 97519909 APAF1 0.020833 0.285714 0 0.037037 0 APAF1 12 12q23.1 97563209 97653343 SOX6 0.020833 0.047619 0.190476 0 0.037037 SOX6 11 11p15.2-1 15944572 16387007 ABCC8 0.020833 0.285714 0 0.037037 0 ABCC8 11 11p15.1 17371008 17455026 USH1C 0.020833 0.285714 0 0.037037 0 USH1C 11 11p15.1 17472019 17522540 LOC49414

0.020833 0.142857 0 0.037037 0 LOC49414

11 11p15.1 18187261 18189631 SAA4 0.020833 0.142857 0 0.037037 0 SAA4 11 11p15.1 18209480 18214932 SAA2 0.020833 0.142857 0 0.037037 0 SAA2 11 11p15.1 18217164 18226759 SAA1 0.020833 0.142857 0 0.037037 0 SAA1 11 11p15.1 18244348 18248103 HPS5 0.020833 0.142857 0 0.037037 0 HPS5 11 11p15.1 18256793 18300298 GTF2H1 0.020833 0.142857 0 0.037037 0 GTF2H1 11 11p15.1 18300392 18345167 CCDC73 0.020833 0.285714 0 0.037037 0 CCDC73 11 11p13 32580202 32772764 QSER1 0.020833 0.285714 0 0.037037 0 QSER1 11 11p13 32871368 32958391 DEPDC7 0.020833 0.285714 0 0.037037 0.037037 DEPDC7 11 11p13 32993986 33011705 TCP11L1 0.020833 0.285714 0 0.037037 0.037037 TCP11L1 11 11p13 33017539 33051685 LOC28326

0.020833 0.285714 0 0.037037 0 LOC28326

11 11p13 33054272 33057576 CSTF3 0.020833 0.238095 0.047619 0.037037 0 CSTF3 11 11p13 33062706 33139614 ABTB2 0.020833 0.238095 0 0.037037 0 ABTB2 11 11p13 34129111 34335379 CAT 0.020833 0.238095 0 0.037037 0 CAT 11 11p13 34417048 34450183 ZDHHC5 0.020833 0.285714 0 0.037037 0 ZDHHC5 11 11q12.1 57192050 57225236 MED19 0.020833 0.285714 0 0.037037 0 MED19 11 11q12.1 57227763 57236250 TMX2 0.020833 0.285714 0 0.037037 0 TMX2 11 11q12.1 57236618 57265021 C11orf31 0.020833 0.285714 0 0.037037 0 C11orf31 11 11q12.1 57265298 57267460 BTBD18 0.020833 0.285714 0 0.037037 0 BTBD18 11 11q12.1 57267563 57275830 CTNND1 0.020833 0.285714 0 0.037037 0 CTNND1 11 11q12.1 57285810 57343229 OR9Q1 0.020833 0.190476 0 0.037037 0 OR9Q1 11 11q12.1 57547929 57705615 OR6Q1 0.020833 0.190476 0 0.037037 0 OR6Q1 11 11q12.1 57555001 57555955 KIAA1377 0.020833 0 0.190476 0 0.037037 KIAA1377 11 11q22.1 1.01E+08 1.01E+08 CADM1 0.020833 0.142857 0.190476 0.185185 0.037037 CADM1 11 11q23.2 1.15E+08 1.15E+08 LOC39995

0.020833 0.047619 0.142857 0.111111 0.037037 LOC39995

11 11q24.1 1.21E+08 1.22E+08 MKX 0.020833 0.190476 0 0.037037 0 MKX 10 10p12.1 28001809 28074785 ARMC4 0.020833 0.190476 0 0.037037 0 ARMC4 10 10p12.1 28141103 28327984 MPP7 0.020833 0.190476 0 0.037037 0 MPP7 10 10p11.23 28379929 28611074 CREM 0.020833 0.238095 0 0.037037 0 CREM 10 10p11.21 35455507 35508782 CCNY 0.020833 0.238095 0 0.037037 0 CCNY 10 10p11.21 35575959 35900854 LOC72864

0.020833 0 0.238095 0 0.037037 LOC72864

10 10q21.1 60144781 60147298 C10orf107 0.020333 0 0.142857 0 0.037037 C10orf107 10 10q21.2 63092725 63196096 ANXA2P3 0.020833 0 0.190476 0 0.037037 ANXA2P3 10 10q21.3 66255291 66256641 LIPF 0.020833 0 0.142857 0 0.037037 LIPF 10 10q23.31 90414074 90428553 TCF7L2 0.020833 0.190476 0 0.037037 0 TCF7L2 10 10q25.2 1.15E+08 1.15E+08 HABP2 0.020833 0.142857 0.047619 0.037037 0 HABP2 10 10q25.3 1.15E+08 1.15E+08 NRAP 0.020833 0.190476 0.047619 0.037037 0 NRAP 10 10q25.3 1.15E+08 1.15E+08 CASP7 0.020833 0.190476 0 0.037037 0 CASP7 10 10q25.3 1.15E+08 1.15E+08 C10orf81 0.020833 0.190476 0 0.037037 0 C10orf81 10 10q25.3 1.16E+08 1.16E+08 NHLRC2 0.020833 0.190476 0 0.037037 0 NHLRC2 10 10q25.3 1.16E+08 1.16E+08 ADRB1 0.020833 0.190476 0 0.037037 0 ADRB1 10 10q25.3 1.16E+08 1.16E+08 C10orf118 0.020833 0.238095 0 0.037037 0 C10orf118 10 10q25.3 1.16E+08 1.16E+08 MIR2110 0.020833 0.238095 0 0.037037 0 MIR2110 10 10q25.3 1.16E+08 1.16E+08 TDRD1 0.020833 0.238095 0 0.037037 0 TDRD1 10 10q25.3 1.16E+08 1.16E+08 ATRNL1 0.020833 0.047619 0.238095 0.074074 0.037037 ATRNL1 10 10q25.3 1.17E+08 1.18E+08 DOCK8 0.020833 0.285714 0 0.037037 0 DOCK8 9 9p24.3 204865 455250 KANK1 0.020833 0.333333 0 0.037037 0 KANK1 9 9p24.3 494703 736104 SNAPC3 0.020833 0.142857 0 0.037037 0 SNAPC3 9 9p22.3 15412782 15451628 C9orf93 0.020833 0.142857 0 0.037037 0 C9orf93 9 9p22.3 15543097 15961898 IFNA14 0.020833 0 0.142857 0 0.037037 IFNA14 9 9p21.3 21229201 21229979 C9orf82 0.020833 0.142857 0.047619 0.037037 0.074074 C9orf82 9 9p21.2 26830684 26882827 IFT74 0.020833 0.142857 0.047619 0.037037 0.037037 IFT74 9 9p21.2 26937037 27052932 FXN 0.020833 0.238095 0 0.037037 0 FXN 9 9q21.11 70840299 70883814 TJP2 0.020833 0.238095 0 0.037037 0 TJP2 9 9q21.11 70926044 71059945 FAM189A2 0.020833 0.142857 0 0.037037 0 FAM189A2 9 9q21.11 71129308 71197191 APBA1 0.020833 0.238095 0 0.037037 0 APBA1 9 9q21.11 71232269 71477096 RASEF 0.020833 0 0.142857 0.037037 0.037037 RASEF 9 9q21.32 84787137 84867864 SLC44A1 0.020833 0.238095 0 0.037037 0 SLC44A1 9 9q31.1 1.07E+08 1.07E+08 KLF4 0.020833 0.190476 0 0.037037 0 KLF4 9 9q31.2 1.09E+08 1.09E+08 EPB4114B 0.020833 0.190476 0 0.037037 0 EPB4114B 9 9q31.3 1.11E+08 1.11E+08 PALM2 0.020833 0.142857 0 0.037037 0 PALM2 9 9q31.3 1.11E+08 1.12E+08 PALM2-AK

0.020833 0.142857 0 0.037037 0 PALM2-AK

9 9q31.3 1.12E+08 1.12E+08 AKAP2 0.020833 0.142857 0 0.037037 0 AKAP2 9 9q31.3 1.12E+08 1.12E+08 C9orf152 0.020833 0.142857 0 0.037037 0 C9orf152 9 9q31.3 1.12E+08 1.12E+08 FGF20 0.020833 0 0.142857 0 0.037037 FGF20 8 8p22 16894705 16904046 MAK16 0.020833 0.238035 0 0.037037 0.037037 MAK16 8 8p12 33462227 33478320 TCEA1 0.020833 0.142857 0 0.037037 0 TCEA1 8 8q11.23 55041669 55097562 RRS1 0.020833 0.190476 0 0.037037 0 RRS1 8 8q13.1 67503817 67505523 ADHFE1 0.020833 0.190476 0 0.037037 0 ADHFE1 8 8q13.1 67507272 67543599 C8orf46 0.020833 0.190476 0 0.037037 0 C8orf46 8 8q13.1 67568045 67593312 VCPIP1 0.020833 0.238095 0 0.037037 0 VCPIP1 8 8q13.1 67705042 67742007 C8orf44 0.020833 0.238095 0 0.037037 0 C8orf44 8 8q13.1 67751008 67755790 SGK3 0.020833 0.190476 0 0.037037 0 SGK3 8 8q13.1 67787445 67936812 NCOA2 0.020833 0.190476 0 0.037037 0 NCOA2 8 8q13.3 71186821 71478575 KCNB2 0.020833 0.047619 0.142857 0 0.037037 KCNB2 8 8q13.3 73612180 74013139 C8orf84 0.020833 0.142857 0.047619 0.037037 0 C8orf84 8 8q21.11 74139334 74168062 RDH10 0.020833 0.142857 0.047619 0.037037 0 RDH10 8 8q21.11 74369819 74400069 UBE2W 0.020833 0.190476 0.047619 0.037037 0 UBE2W 8 8q21.11 74865394 74953665 TCEB1 0.020833 0.190476 0.047619 0.037037 0 TCEB1 8 8q21.11 75021188 75046901 HEY1 0.020833 0.142857 0.047619 0.037037 0.111111 HEY1 8 8q21.13 80838800 80842654 RUNX1T1 0.020833 0.047619 0.142857 0 0.037037 RUNX1T1 8 8q21.3 93040328 93144368 C8orf83 0.020833 0 0.333333 0 0.037037 C8orf83 8 8q22.1 93965039 94047516 CDH17 0.020833 0.238095 0 0.037037 0 CDH17 8 8q22.1 95208570 95298708 GEM 0.020833 0.238095 0 0.037037 0 GEM 8 8q22.1 95330663 95343724 TSPYL5 0.020833 0.190476 0 0.037037 0 TSPYL5 8 8q22.1 98354890 98359353 MTDH 0.020833 0.190476 0 0.037037 0 MTDH 8 8q22.1 98725583 98811664 ANKRD46 0.020833 0.238095 0 0.037037 0 ANKRD46 8 8q22.2-8c 1.02E+08 1.02E+08 SNX31 0.020833 0.238095 0 0.037037 0 SNX31 8 8q22.3 1.02E+08 1.02E+08 NACAP1 0.020833 0.190476 0 0.037037 0 NACAP1 8 8q22.3 1.02E+08 1.02E+08 GRHL2 0.020833 0.190476 0 0.037037 0 GRHL2 8 8q22.3 1.03E+08 1.03E+08 ATAD2 0.020833 0.285714 0 0.037037 0 ATAD2 8 8q24.13 1.24E+08 1.24E+08 WDYHV1 0.020833 0.285714 0 0.037037 0 WDYHV1 8 8q24.13 1.24E+08 1.25E+08 FBXO32 0.020833 0.285714 0 0.037037 0 FBXO32 8 8q24.13 1.25E+08 1.25E+08 ANXA13 0.020833 0.285714 0 0.037037 0 ANXA13 8 8q24.13 1.25E+08 1.25E+08 FAM91A1 0.020833 0.285714 0 0.037037 0 FAM91A1 8 8q24.13 1.25E+08 1.25E+08 FER1L6 0.020833 0.238095 0 0.037037 0 FER1L6 8 8q24.13 1.25E+08 1.25E+08 TRMT12 0.020833 0.285714 0 0.037037 0 TRMT12 8 8q24.13 1.26E+08 1.26E+08 RNF139 0.020833 0.285714 0 0.037037 0 RNF139 8 8q24.13 1.26E+08 1.26E+08 TATDN1 0.020833 0.285714 0 0.037037 0 TATDN1 8 8q24.13 1.26E+08 1.26E+08 NDUFB9 0.020833 0.285714 0 0.037037 0 NDUFB9 8 8q24.13 1.26E+08 1.26E+08 MTSS1 0.020833 0.285714 0 0.037037 0 MTSS1 8 8q24.13 1.26E+08 1.26E+08 LOC15738

0.020833 0.285714 0 0.037037 0 LOC15738

8 8q24.13 1.26E+08 1.26E+08 ZNF572 0.020833 0.285714 0 0.037037 0 ZNF572 8 8q24.13 1.26E+08 1.26E+08 SQLE 0.020833 0.285714 0 0.037037 0 SQLE 8 8q24.13 1.26E+08 1.26E+08 KIAA0196 0.020833 0.285714 0 0.037037 0 KIAA0196 8 8q24.13 1.26E+08 1.26E+08 NSMCE2 0.020833 0.285714 0 0.037037 0 NSMCE2 8 8q24.13 1.26E+08 1.25E+08 ASAP1IT1 0.020833 0.142857 0 0.037037 0 ASAP1IT1 8 8q24.21 1.31E+08 1.31E+08 TG 0.020833 0.238095 0 0.037037 0 TG 8 8q24.22 1.34E+08 1.34E+08 SLA 0.020833 0.285714 0 0.037037 0 SLA 8 8q24.22 1.34E+08 1.34E+08 CLK2P 0.020833 0.190476 0 0.037037 0 CLK2P 7 7p15.3 23590860 23592672 CCDC126 0.020833 0.190476 0 0.037037 0 CCDC126 7 7p15.3 23603523 23650853 WIPF3 0.020833 0.142857 0 0.037037 0 WIPF3 7 7p15.1 29840866 29912317 SCRN1 0.020833 0.142857 0 0.037037 0 SCRN1 7 7p15.1 29326245 29996260 C7orf41 0.020833 0.342857 0 0.037037 0 C7orf41 7 7p15.1 30141077 30168907 NOD1 0.020833 0.142857 0 0.037037 0 NOD1 7 7p15.1 30430668 30484919 CRHR2 0.020833 0.190476 0 0.037037 0 CRHR2 7 7p15.1 30659388 30588666 INMT 0.020833 0.190476 0 0.037037 0 INMT 7 7p15.1 30758276 30763744 FAM188B 0.020833 0.190476 0 0.037037 0 FAM188B 7 7p15.1 30777558 30898528 AQP1 0.020833 0.190476 0 0.037037 0 AQP1 7 7p15.1 30917993 30931657 GHRHR 0.020833 0.190476 0 0.037037 0 GHRHR 7 7p15.1 30970161 30985669 ADCYAP1R 0.020833 0.190476 0 0.037037 0 ADCYAP1R 7 7p15.1 31058667 31112837 CDK13 0.020833 0.142857 0 0.037037 0 CDK13 7 7p14.1 39956484 40103257 C7orf10 0.020833 0.238095 0 0.037037 0 C7orf10 7 7p14.1 40141100 40866883 HUS1 0.020833 0.285714 0 0.037037 0 HUS1 7 7p12.3 47970308 47985772 UPP1 0.020833 0.238095 0 0.037037 0 UPP1 7 7p12.3 48094880 48114856 RSBN1L 0.020833 0.190476 0 0.037037 0.074074 RSBN1L 7 7q11.23 77163679 77247057 CCDC132 0.020833 0 0.190476 0 0.037037 CCDC132 7 7q21.3 92699589 92826275 GNGT1 0.020833 0 0.190476 0 0.037037 GNGT1 7 7q21.3 93373756 93378422 COL1A2 0.020833 0 0.190476 0 0.037037 COL1A2 7 7q21.3 93861809 93898481 CASD1 0.020833 0 0.142857 0 0.037037 CASD1 7 7q21.3 93977106 94024265 SGCE 0.020333 0 0.142857 0 0.037037 SGCE 7 7q21.3 94052472 94123458 FAM185A 0.020833 0.142857 0 0.037037 0 FAM185A 7 7q22.1 1.02E+08 1.02E+08 FBXL13 0.020833 0.142857 0 0.037037 0 FBXL13 7 7q22.1 1.02E+08 1.03E+08 WDR91 0.020833 0.142857 0 0.037037 0 WDR91 7 7q33 1.35E+08 1.35E+08 NUP205 0.020833 0.190476 0 0.037037 0 NUP205 7 7q33 1.35E+08 1.35E+08 PL-5283 0.020833 0.190476 0 0.037037 0 PL-5283 7 7q33 1.35E+08 1.35E+08 SLC13A4 0.020833 0.190476 0 0.037037 0 SLC13A4 7 7q33 1.35E+08 1.35E+08 TRPV5 0.020833 0.142857 0 0.037037 0 TRPV5 7 7q34 1.42E+08 1.42E+08 C7orf34 0.020833 0.142857 0 0.037037 0 C7orf34 7 7q34 1.42E+08 1.42E+08 KEL 0.020833 0.142857 0 0.037037 0 KEL 7 7q34 1.42E+08 1.42E+08 TAS2R39 0.020833 0.142857 0 0.037037 0.037037 TAS2R39 7 7q34 1.43E+08 1.43E+08 TAS2R40 0.020833 0.142857 0 0.037037 0 TAS2R40 7 7q34 1.43E+08 1.43E+08 TMEM139 0.020833 0.142857 0 0.037037 0 TMEM139 7 7q34 1.43E+08 1.43E+08 CASP2 0.020833 0.142857 0 0.037037 0 CASP2 7 7q34 1.43E+08 1.43E+08 CLCN1 0.020833 0.142857 0 0.037037 0 CLCN1 7 7q34 1.43E+08 1.43E+08 FAM131B 0.020833 0.142857 0 0.037037 0 FAM131B 7 7q34 1.43E+08 1.43E+08 TFAP2A 0.020833 0.238095 0 0.037037 0 TFAP2A 6 6p24.3 10504902 10520594 C6orf218 0.020833 0.238095 0 0.037037 0 C6orf218 6 6p24.3 10536004 10543042 SLC17A2 0.020833 0.190476 0 0.037037 0 SLC17A2 6 6p22.2 26020963 26038819 TRIM38 0.020333 0.190476 0 0.037037 0 TRIM38 6 6p22.2 26071050 26093332 HIST1H4C 0.020833 0.190476 0 0.037037 0 HIST1H4C 6 6p22.1 26212155 26212545 HIST1H1T 0.020833 0.190476 0 0.037037 0 HIST1H1T 6 6p22.1 26215619 26216344 HIST1H2B

0.020833 0.238095 0 0.037037 0 HIST1H2B

6 6p22.1 26231674 26232112 HIST1H2A

0.020833 0.238095 0 0.037037 0 HIST1H2A

6 6p22.1 26232352 26232898 HIST1H1E 0.020833 0.238095 0 0.037037 0.037037 HIST1H1E 6 6p22.1 26264538 26265323 HIST1H2B

0.020833 0.238095 0 0.037037 0.037037 HIST1H2B

6 6p22.1 26266328 26266851 HIST1H1D 0.020833 0.190476 0 0.037037 0.037037 HIST1H1D 6 6p22.1 26342419 26343196 HIST1H4F 0.020833 0.190476 0 0.037037 0.037037 HIST1H4F 6 6p22.1 26348633 26349001 BTN3A2 0.020833 0.190476 0 0.037037 0 BTN3A2 6 6p22.1 26473377 26486528 BTN3A1 0.020833 0.190476 0 0.037037 0 BTN3A1 6 6p22.1 26510444 26523422 BTN2A3 0.020833 0.190476 0 0.037037 0 BTN2A3 6 6p22.1 26529598 26538796 BTN3A3 0.020833 0.190476 0 0.037037 0 BTN3A3 6 6p22.1 26548679 26561622 BTN2A1 0.020833 0.190476 0 0.037037 0 BTN2A1 6 6p22.1 26566168 26577845 BTN1A1 0.020833 0.190476 0 0.037037 0 BTN1A1 6 6p22.1 26509474 26618632 HCG11 0.020833 0.190476 0 0.037037 0 HCG11 6 6p22.1 26629913 26635590 HMGN4 0.020833 0.190476 0 0.037037 0 HMGN4 6 6p22.1 26646551 26655144 ABT1 0.020833 0.190476 0 0.037037 0 ABT1 6 6p22.1 26705159 26708257 ZNF322A 0.020833 0.190476 0 0.037037 0 ZNF322A 6 6p22.1 26742590 26767943 PRSS16 0.020833 0.238035 0 0.037037 0 PRSS16 6 6p22.1 27323481 27332378 POM121L2 0.020833 0.238095 0 0.037037 0 POM121L2 6 6p22.1 27384821 27387991 FKSG83 0.020833 0.238095 0 0.037037 0 FKSG83 6 6p22.1 27400557 27401721 ZNF204P 0.020833 0.238095 0 0.037037 0 ZNF204P 6 6p22.1 27433582 27447284 ZNF391 0.020833 0.285714 0 0.037037 0 ZNF391 6 6p22.1 27464503 27477207 GPR111 0.020833 0 0.190476 0 0.037037 GPR111 6 6p12.3 47732285 47773491 GPR115 0.020833 0 0.190476 0 0.037037 GPR115 6 6p12.3 47774248 47797717 OPN5 0.020833 0 0.190476 0 0.037037 OPN5 6 6p12.3 47857757 47902076 C6orf138 0.020833 0 0.190476 0 0.037037 C6orf138 6 6p12.3 47953723 48144385 PKHD1 0.020833 0 0.190476 0 0.037037 PKHD1 6 6p12.2 51588104 52050383 C6orf142 0.020833 0 0.190476 0 0.037037 C6orf142 6 6p12.1 53991673 54239038 GTF3C6 0.020833 0.190476 0 0.037037 0 GTF3C6 6 6q21 1.11E+08 1.11E+08 RPF2 0.020833 0.190476 0 0.037037 0 RPF2 6 6q21 1.11E+08 1.11E+08 RFX6 0.020833 0 0.238095 0 0.037037 RFX6 6 6q22.2 1.17E+08 1.17E+08 ROS1 0.020833 0 0.238095 0 0.037037 ROS1 6 6q22.2 1.18E+08 1.18E+08 DCBLD1 0.020833 0 0.238095 0 0.037037 DCBLD1 6 6q22.2 1.18E+08 1.18E+08 NUS1 0.020833 0 0.142857 0 0.037037 NUS1 6 6q22.2 1.18E+08 1.18E+08 LAMA2 0.020833 0 0.142857 0 0.037037 LAMA2 6 6q22.33 1.29E+08  1.3E+08 GPR126 0.020833 0 0.142857 0 0.037037 GPR126 6 6q24.1 1.43E+08 1.43E+08 UST 0.020833 0.142857 0 0.037037 0 UST 6 6q25.1 1.49E+08 1.49E+08 MAP3K7IP

0.020833 0.142857 0 0.037037 0 MAP3K7IP

6 6q25.1  1.5E+08  1.5E+08 SUMO4 0.020833 0.142857 0 0.037037 0 SUMO4 6 6q25.1  1.5E+08  1.5E+08 SNX9 0.020833 0.238095 0 0.037037 0 SNX9 6 6q25.3 1.58E+08 1.58E+08 GTF2H5 0.020833 0.238095 0 0.037037 0 GTF2H5 6 6q25.3 1.59E+08 1.59E+08 TAGAP 0.020833 0.238095 0 0.037037 0 TAGAP 6 6q25.3 1.59E+08 1.59E+08 FNDC1 0.020833 0.238095 0 0.037037 0 FNDC1 6 6q25.3  1.6E+08  1.6E+08 WTAP 0.020833 0.238095 0 0.037037 0 WTAP 6 6q25.3  1.6E+08  1.6E+08 ACAT2 0.020833 0.238095 0 0.037037 0 ACAT2 6 6q25.3  1.6E+08  1.6E+08 IGF2R 0.020833 0.238095 0 0.037037 0 IGF2R 6 6q25.3  1.6E+08  1.6E+08 LOC72960

0.020833 0.238095 0 0.037037 0 LOC72960

6 6q25.3  1.6E+08  1.6E+08 SLC22A1 0.020833 0.238095 0 0.037037 0 SLC22A1 6 6q25.3  1.6E+08  1.6E+08 MAP3K4 0.020833 0.190476 0 0.037037 0 MAP3K4 6 6q26 1.61E+08 1.61E+08 PARK2 0.020833 0.190476 0 0.037037 0 PARK2 6 6q26 1.62E+08 1.63E+08 LOC28579

0.020833 0.190476 0 0.037037 0 LOC28579

6 6q26 1.64E+08 1.64E+08 ADAMT51

0.020833 0.142857 0 0.037037 0 ADAMT51

5 5p15.32 5193443 5373413 FU33360 0.020833 0.285714 0 0.037037 0 FU33360 5 5p15.31 6363554 6390406 MED10 0.020833 0.285714 0 0.037037 0 MED10 5 5p15.31 6425039 6431640 UBE2QL1 0.020833 0.285714 0 0.037037 0 UBE2QL1 5 5p15.31 6501736 6545706 LOC25516

0.020833 0.285714 0 0.037037 0 LOC25516

5 5p15.31 6635287 6641613 NSUN2 0.020833 0.285714 0 0.037037 0 NSUN2 5 5p15.31 6652352 6686158 SRD5A1 0.020833 0.285714 0 0.037037 0 SRD5A1 5 5p15.31 6686500 6722676 POLS 0.020833 0.285714 0 0.037037 0 POLS 5 5p15.31 6767718 6810162 FBXL7 0.020833 0 0.190475 0 0.037037 FBXL7 5 5p15.1 15553305 15992901 11-Mar 0.020833 0 0.142857 0 0.037037 11-Mar 5 5p15.1 16120474 16232898 LOC28569

0.020833 0.238095 0 0.037037 0.037037 LOC28569

5 5p15.1 17183137 17270532 PDZD2 0.020833 0.238095 0 0.037037 0 PDZD2 5 5p13.3 31834788 32146796 MTMR12 0.020833 0.238095 0 0.037037 0 MTMR12 5 5p13.3 32262868 32348872 PLCXD3 0.020833 0 0.142857 0 0.037037 PLCXD3 5 5p13.1 41342805 41546488 OXCT1 0.020833 0 0.142857 0 0.037037 OXCT1 5 5p13.1 41765924 41906549 C5orf51 0.020833 0 0.142857 0 0.037037 C5orf51 5 5p13.1 41940227 41957496 FBXO4 0.020833 0 0.142857 0 0.037037 FBXO4 5 5p13.1 41961113 41977430 GHR 0.020833 0 0.142857 0 0.037037 GHR 5 5p12 42459783 42757684 SEPP1 0.020833 0 0.142857 0 0.037037 SEPP1 5 5p12 42835739 42847782 GAPT 0.020833 0 0.190476 0 0.037037 GAPT 5 5q11.2 57823087 57827943 RAB3C 0.020833 0 0.190476 0 0.037037 RAB3C 5 5q11.2 57914696 58183164 PDE4D 0.020833 0 0.142857 0 0.037037 PDE4D 5 5q11.2 58300623 59225379 S1C30A5 0.020833 0.190476 0 0.037037 0 S1C30A5 5 5q13.2 68425574 68436324 CCNB1 0.020833 0.190476 0 0.037037 0 CCNB1 5 5q13.2 58498669 68509827 CENPH 0.020833 0.190476 0 0.037037 0 CENPH 5 5q13.2 68521131 68541941 MRPS36 0.020833 0.190476 0 0.037037 0 MRPS36 5 5q13.2 68549329 68561742 CDK7 0.020833 0.190476 0 0.037037 0 CDK7 5 5q13.2 68566378 68609014 CCDC125 0.020833 0.190476 0 0.037037 0 CCDC125 5 5q13.2 68612275 68652167 TAF9 0.020833 0.190476 0 0.037037 0 TAF9 5 5q13.2 68683309 68701597 RAD17 0.020833 0.190476 0 0.037037 0 RAD17 5 5q13.2 68700880 68746388 LOC65339

0.020833 0.190476 0 0.037037 0 LOC65339

5 5q13.2 68713443 69917304 MARVELD

0.020833 0.190476 0 0.037037 0 MARVELD

5 5q13.2 68746699 68775593 OCLN 0.020833 0.190476 0 0.037037 0 OCLN 5 5q13.2 68823875 68885890 BDP1 0.020833 0.142857 0 0.037037 0 BDP1 5 5q13.2 70787198 70899406 MCCC2 0.020833 0.142857 0 0.037037 0 MCCC2 5 5q13.2 70918871 70990287 FBXL17 0.020833 0 0.142857 0 0.037037 FBXL17 5 5q21.3 1.07E+08 1.08E+08 C5orf13 0.020833 0 0.190476 0 0.037037 C5orf13 5 5q22.1 1.11E+08 1.11E+08 EPB41L4A 0.020833 0 0.142857 0 0.037037 EPB41L4A 5 5q22.2 1.12E+08 1.12E+08 KCNN2 0.020833 0 0.238095 0 0.037037 KCNN2 5 5q22.3 1.14E+08 1.14E+08 DTWD2 0.020833 0 0.285714 0 0.037037 DTWD2 5 5q23.1 1.18E+08 1.18E+08 SNCAIP 0.020833 0 0.142857 0 0.037037 SNCAIP 5 5q23.2 1.22E+08 1.22E+08 PRDM6 0.020833 0 0.142857 0 0.037037 PRDM6 5 5q23.2 1.22E+08 1.23E+08 CEP120 0.020833 0 0.285714 0 0.037037 CEP120 5 5q23.2 1.23E+08 1.23E+08 CSNK1G3 0.020833 0 0.285714 0 0.037037 CSNK1G3 5 5q23.2 1.23E+08 1.23E+08 ZNF608 0.020833 0 0.190476 0 0.037037 ZNF608 5 5q23.2 1.24E+08 1.24E+08 SLC27A6 0.020833 0 0.142857 0 0.037037 SLC27A6 5 5q23.3 1.28E+08 1.28E+08 ISOC1 0.020833 0 0.142857 0 0.037037 ISOC1 5 5q23.3 1.28E+08 1.28E+08 ADAMTS19 0.020833 0 0.190476 0 0.037037 ADAMTS19 5 5q23.3 1.29E+08 1.29E+08 CHSY3 0.020833 0 0.190476 0 0.037037 CHSY3 5 5q23.3 1.29E+08  1.3E+08 KCTD16 0.020833 0 0.142857 0 0.037037 KCTD16 5 5q32 1.44E+08 1.44E+08 TIMD4 0.020833 0.190476 0 0.037037 0 TIMD4 5 5q33.3 1.56E+08 1.56E+08 MIR146A 0.020833 0.047619 0.142857 0 0.037037 MIR146A 5 5q33.3  1.6E+08  1.6E+08 ATP10B 0.020833 0 0.190476 0 0.037037 ATP10B 5 5q34  2.6E+08  1.6E+08 HSP90AS2

0.020833 0 0.142857 0 0.037037 HSP90AS2

4 4p15.33 12944135 12949024 RAB28 0.020833 0 0.190476 0 0.037037 RAB28 4 4p15.33 12978445 13095088 ARAP2 0.020833 0.190476 0.190476 0.037037 0.111111 ARAP2 4 4p14 35744017 35922375 SPINK2 0.020833 0.142857 0 0.037037 0 SPINK2 4 4q12 57370791 57382651 REST 0.020833 0.142857 0 0.037037 0 REST 4 4q12 57468799 57493098 CSN1S2A 0.020833 0 0.285714 0 0.037037 CSN1S2A 4 4q13.3 70967692 70985578 CSN1S2B 0.020833 0 0.285714 0 0.037037 CSN1S2B 4 4q13.3 71033910 71047011 C4orf40 0.020833 0 0.285714 0 0.037037 C4orf40 4 4q13.3 71054493 71066916 ODAM 0.020833 0 0.285714 0 0.037037 ODAM 4 4q13.3 71096833 71104883 SMR3A 0.020833 0 0.285714 0 0.037037 SMR3A 4 4q13.3 71261082 71267413 MUC7 0.020833 0 0.238095 0 0.037037 MUC7 4 4q13.3 71330798 71383303 RUFY3 0.020833 0.190476 0.095238 0.037037 0.037037 RUFY3 4 4q13.3 71783518 71874478 MOBKL1A 0.020833 0.190476 0.095238 0.037037 0.037037 MOBKL1A 4 4q13.3 71986928 72072756 DCK 0.020833 0.190476 0.095238 0.037037 0.037037 DCK 4 4q13.3 72078129 72115494 CXCL6 0.020833 0 0.142857 0 0.037037 CXCL6 4 4q13.3 74921137 74923342 PPBPL1 0.020833 0 0.142857 0 0.037037 PPBPL1 4 4q13.3 74932447 74933418 PF4 0.020833 0 0.142857 0 0.037037 PF4 4 4q13.3 75065660 75066580 PPBP 0.020833 0 0.142857 0 0.037037 PPBP 4 4q13.3 75071620 75072765 CXCL3 0.020833 0 0.142857 0 0.037037 CXCL3 4 4q13.3 75121176 75123355 CXCL2 0.020833 0 0.142857 0 0.037037 CXCL2 4 4q13.3 75181618 75183862 MTHFD2L 0.020833 0 0.142857 0 0.037037 MTHFD2L 4 4q13.3 75242693 75387677 ARD1B 0.020833 0 0.142857 0 0.037037 ARD1B 4 4q21.21 80457296 80466196 GDEP 0.020833 0 0.190476 0 0.037037 GDEP 4 4q21.21 80967649 81003424 PRDM8 0.020833 0 0.190476 0 0.037037 PRDM8 4 4q21.21 81325448 81344507 C4orf22 0.020833 0 0.190476 0 0.037037 C4orf22 4 4q21.21 81475898 82103927 MANBA 0.020833 0.095238 0.142857 0.037037 0.037037 MANBA 4 4q24 1.04E+08 1.04E+08 SCOC 0.020833 0.142857 0 0.037037 0 SCOC 4 4q31.1 1.41E+08 1.42E+08 USP38 0.020833 0 0.142857 0 0.037037 USP38 4 4q31.21 1.44E+08 1.44E+08 TMEM154 0.020833 0.142857 0 0.037037 0 TMEM154 4 4q31.3 1.54E+08 1.54E+08 FHDC1 0.020833 0.142857 0 0.037037 0 FHDC1 4 4q31.3 1.54E+08 1.54E+08 TRIM2 0.020833 0.142857 0 0.037037 0 TRIM2 4 4q31.3 1.54E+08 1.54E+08 ANXA2P1 0.020833 0.142857 0 0.037037 0 ANXA2P1 4 4q31.3 1.54E+08 1.54E+08 MND1 0.020833 0.142857 0 0.037037 0 MND1 4 4q31.3 1.54E+08 1.55E+08 KIAA0922 0.020833 0.142857 0 0.037037 0 KIAA0922 4 4q31.3 1.55E+08 1.55E+08 RBM46 0.020333 0 0.142857 0 0.037037 RBM46 4 4q32.1 1.56E+08 1.56E+08 NPY2R 0.020833 0 0.190476 0 0.037037 NPY2R 4 4q32.1 1.56E+08 1.56E+08 MAP9 0.020833 0 0.190476 0 0.037037 MAP9 4 4q32.1 1.56E+08 1.57E+08 GUCY1A3 0.020833 0 0.190476 0 0.037037 GUCY1A3 4 4q32.1 1.57E+08 1.57E+08 GUCY1B3 0.020833 0 0.190476 0 0.037037 GUCY1B3 4 4q32.1 1.57E+08 1.57E+08 TD02 0.020833 0 0.190476 0 0.037037 TD02 4 4q32.1 1.57E+08 1.57E+08 CTSO 0.020833 0 0.190475 0 0.037037 CTSO 4 4q32.1 1.57E+08 1.57E+08 ZFP42 0.020833 0.238095 0 0.037037 0 ZFP42 4 4q35.2 1.89E+08 1.89E+08 TRIML2 0.020833 0.238095 0 0.037037 0 TRIML2 4 4q35.2 1.89E+08 1.89E+08 TRIML1 0.020833 0.285714 0 0.037037 0 TRIML1 4 4q35.2 1.89E+08 1.89E+08 CNTN4 0.020833 0 0.142857 0 0.037037 CNTN4 3 3p26.3 2117247 3074646 SATB1 0.020833 0 0.238095 0 0.037037 SATB1 3 3p24.3 18364270 18455257 KCNH8 0.020833 0 0.238095 0 0.037037 KCNH8 3 3p24.3 19165021 19552140 CMC1 0.020833 0.047619 0.190476 0 0.037037 CMC1 3 3p24.1 28258128 28336268 TGFBR2 0.020833 0.047619 0.238095 0 0.037037 TGFBR2 3 3p24.1 30622998 30710638 GADL1 0.020833 0.047619 0.238095 0 0.037037 GADL1 3 3p24.1-3p 30742696 30911158 CLASP2 0.020833 0.238095 0 0.037037 0 CLASP2 3 3p22.3 33512742 33734853 CCDC66 0.020833 0.333333 0 0.037037 0 CCDC66 3 3p14.3 56566224 56630887 C3orf63 0.020833 0.333333 0 0.037037 0 C3orf63 3 3p14.3 56629200 56692176 ARHGEF3 0.020833 0.333333 0 0.037037 0 ARHGEF3 3 3p14.3 56736486 57088377 SPATA12 0.020833 0.380952 0 0.037037 0 SPATA12 3 3p14.3 57069509 57084501 IL17RD 0.020833 0.380952 0 0.037037 0 IL17RD 3 3p14.3 57099050 57174444 DNAH12 0.020833 0.333333 0 0.037037 0.037037 DNAH12 3 3p14.3 57302767 57505112 EIF4E3 0.020833 0.142857 0.047619 0.037037 0 EIF4E3 3 3p13 71811132 71886223 GPR27 0.020833 0.142857 0.047619 0.037037 0 GPR27 3 3p13 71885891 71887019 PROK2 0.020833 0.142857 0.047619 0.037037 0 PROK2 3 3p13 71903496 71917048 RG9MTD1 0.020833 0.238095 0 0.037037 0.037037 RG9MTD1 3 3q12.3 1.03E+08 1.03E+08 PCNP 0.020833 0.238095 0 0.037037 0.037037 PCNP 3 3q12.3 1.03E+08 1.03E+08 ZBTB11 0.020833 0.285714 0 0.037037 0.037037 ZBTB11 3 3q12.3 1.03E+08 1.03E+08 LOC100009 0.020833 0.285714 0 0.037037 0.037037 LOC100009 3 3q12.3 1.03E+08 1.03E+08 RPL24 0.020833 0.285714 0 0.037037 0.037037 RPL24 3 3q12.3 1.03E+08 1.03E+08 LOC10030

0.020833 0 0.190476 0 0.037037 LOC10030

3 3q13.12 1.08E+08 1.08E+08 LOC34459

0.020833 0 0.190476 0 0.037037 LOC34459

3 3q13.12 1.08E+08 1.08E+08 CCDC54 0.020833 0 0.142857 0 0.037037 CCDC54 3 3q13.12 1.09E+08 1.09E+08 BBX 0.020833 0 0.142857 0 0.037037 BBX 3 3q13.12 1.09E+08 1.09E+08 FLI25363 0.020833 0.238095 0 0.037037 0.037037 FLI25363 3 3q13.13 1.11E+08 1.11E+08 TMPRSS7 0.020833 0 0.142857 0 0.037037 TMPRSS7 3 3q13.2 1.13E+08 1.13E+08 SLC9A10 0.020833 0 0.142857 0 0.037037 SLC9A10 3 3q13.2 1.13E+08 1.13E+08 CD200 0.020833 0 0.142857 0 0.037037 CD200 3 3q13.2 1.14E+08 1.14E+08 BTLA 0.020833 0 0.142857 0 0.037037 BTLA 3 3q13.2 1.14E+08 1.14E+08 SLC35A5 0.020833 0 0.142857 0 0.037037 SLC35A5 3 3q13.2 1.14E+08 1.14E+08 CCDC80 0.020833 0 0.142857 0 0.037037 CCDC80 3 3q13.2 1.14E+08 1.14E+08 CD200R1L 0.020833 0 0.142857 0 0.037037 CD200R1L 3 3q13.2 1.14E+08 1.14E+08 ZBTB20 0.020833 0 0.142857 0 0.037037 ZBTB20 3 3q13.31 1.16E+08 1.16E+08 COL29A1 0.020833 0 0.142857 0.074074 0.037037 COL29A1 3 3q22.1 1.32E+08 1.32E+08 COL6A6 0.020833 0 0.142857 0 0.037037 COL6A6 3 3q22.1 1.32E+08 1.32E+08 PIK3R4 0.020833 0 0.190476 0 0.037037 PIK3R4 3 3q22.1 1.32E+08 1.32E+08 ATP2C1 0.020833 0 0.190476 0 0.037037 ATP2C1 3 3q22.1 1.32E+08 1.32E+08 ASTE1 0.020833 0 0.190476 0 0.037037 ASTE1 3 3q22.1 1.32E+08 1.32E+08 NEK11 0.020833 0 0.190476 0 0.037037 NEK11 3 3q22.1 1.32E+08 1.33E+08 NUDT16 0.020833 0 0.142857 0 0.037037 NUDT16 3 3q22.1 1.33E+08 1.33E+08 MRPL3 0.020833 0 0.142857 0 0.037037 MRPL3 3 3q22.1 1.33E+08 1.33E+08 CPNE4 0.020833 0 0.142857 0 0.037037 CPNE4 3 3q22.1 1.33E+08 1.33E+08 BFSP2 0.020833 0.142857 0 0.037037 0 BFSP2 3 3q22.1 1.35E+08 1.35E+08 CDV3 0.020833 0.190476 0 0.037037 0 CDV3 3 3q22.1 1.35E+08 1.35E+08 TOPBP1 0.020833 0.190476 0 0.037037 0 TOPBP1 3 3q22.1 1.35E+08 1.35E+08 TF 0.020833 0.190476 0 0.037037 0 TF 3 3q22.1 1.35E+08 1.35E+08 DZIP1L 0.020833 0.190476 0 0.037037 0 DZIP1L 3 3q22.3 1.39E+08 1.39E+08 DBR1 0.020833 0.190476 0 0.037037 0 DBR1 3 3q22.3 1.39E+08 1.39E+08 ARMC8 0.020833 0.190476 0 0.037037 0 ARMC8 3 3q22.3 1.39E+08 1.39E+08 TXNDC6 0.020833 0.238095 0 0.037037 0 TXNDC6 3 3q22.3 1.39E+08  1.4E+08 MRAS 0.020833 0.238095 0 0.037037 0 MRAS 3 3q22.3  1.4E+08  1.4E+08 ESYT3 0.020833 0.238095 0 0.037037 0 ESYT3 3 3q22.3  1.4E+08  1.4E+08 CEP70 0.020833 0.190475 0 0.037037 0 CEP70 3 3q22.3  1.4E+08  1.4E+08 FAIM 0.020833 0.190476 0 0.037037 0 FAIM 3 3q22.3  1.4E+08  1.4E+08 PIK3CB 0.020833 0.190476 0 0.037037 0 PIK3CB 3 3q22.3  1.4E+08  1.4E+08 FOXL2 0.020833 0.190476 0 0.037037 0 FOXL2 3 3q22.3  1.4E+08  1.4E+08 C3orf72 0.020833 0.190476 0 0.037037 0 C3orf72 3 3q22.3  1.4E+08  1.4E+08 BPESC1 0.020833 0.190476 0 0.037037 0 BPESC1 3 3q22.3  1.4E+08  1.4E+08 AADACL2 0.020833 0 0.142857 0 0.037037 AADACL2 3 3q25.1 1.53E+08 1.53E+08 SLC33A1 0.020833 0.285714 0 0.037037 0 SLC33A1 3 3q25.31 1.57E+08 1.57E+08 GMPS 0.020833 0.285714 0 0.037037 0 GMPS 3 3q25.31 1.57E+08 1.57E+08 LRRIQ4 0.020833 0.238095 0 0.037037 0 LRRIQ4 3 3q26.2 1.71E+08 1.71E+08 LRRC31 0.020833 0.238095 0 0.037037 0 LRRC31 3 3q26.2 1.71E+08 1.71E+08 SAMD7 0.020833 0.238095 0 0.037037 0 SAMD7 3 3q26.2 1.71E+08 1.71E+08 LOC10012

0.020833 0.238095 0 0.037037 0 LOC10012

3 3q26.2 1.71E+08 1.71E+08 SEC62 0.020833 0.238095 0 0.037037 0 SEC62 3 3q26.2 1.71E+08 1.71E+08 MCCC1 0.020833 0.333333 0 0.037037 0 MCCC1 3 3q27.1 1.84E+08 1.84E+08 FGF12 0.020833 0 0.142857 0 0.037037 FGF12 3 3q28 1.93E+08 1.94E+08 DLG1 0.020833 0.238095 0.142857 0.407407 0.037037 DLG1 3 3q29 1.98E+08 1.99E+08 KIDINS220 0.020833 0.190476 0.142857 0.185185 0.037037 KIDINS220 2 2p25.1 8786438 8895207 KCNS3 0.020833 0.142857 0 0.037037 0 KCNS3 2 2p24.2 17923426 17977707 GALM 0.020833 0.142857 0 0.037037 0 GALM 2 2p22.1 38746556 38815413 GEMIN6 0.020833 0.142857 0 0.037037 0 GEMIN6 2 2p22.1 38858831 38862611 DHX57 0.020833 0.142857 0 0.037037 0 DHX57 2 2p22.1 38878379 38956525 MORN2 0.020833 0.142857 0 0.037037 0 MORN2 2 2p22.1 38956607 38963353 SLC8A1 0.020833 0 0.142857 0 0.037037 SLC8A1 2 2p22.1 40192790 40510949 MSH6 0.020833 0.142857 0 0.037037 0.074074 MSH6 2 2p16.3 47863725 47887597 FBXO11 0.020833 0.142857 0 0.037037 0.074074 FBXO11 2 2p16.3 47887563 47986319 VRK2 0.020833 0 0.142857 0 0.037037 VRK2 2 2p16.1 58127233 58240560 FANCL 0.020833 0 0.142857 0 0.037037 FANCL 2 2p16.1 58239882 58322020 PAPOLG 0.020833 0.238095 0 0.037037 0 PAPOLG 2 2p16.1 60836887 60879603 REL 0.020833 0.238095 0 0.037037 0 REL 2 2p16.1 60962256 61003683 PUS10 0.020833 0.238095 0 0.037037 0 PUS10 2 2p16.1 61021054 61098870 KIAA1841 0.020833 0.238095 0 0.037037 0 KIAA1841 2 2p15 61146510 61204918 C2orf74 0.020833 0.238095 0 0.037037 0 C2orf74 2 2p15 61225747 61245469 USP34 0.020833 0.238095 0 0.037037 0 USP34 2 2p15 61268094 61551354 XPO1 0.020833 0.285714 0 0.037037 0 XPO1 2 2p15 61558573 61618923 RAB1A 0.020833 0.142857 0 0.037037 0 RAB1A 2 2p14 65167493 65210940 MAP4K4 0.020833 0.190476 0 0.037037 0 MAP4K4 2 2q11.2 1.02E+08 1.02E+08 IL1R2 0.020833 0.190476 0 0.037037 0 IL1R2 2 2q11.2 1.02E+08 1.02E+08 IL1R1 0.020833 0.142857 0 0.037037 0 IL1R1 2 2q12.1 1.02E+08 1.02E+08 IL1RL2 0.020833 0.142857 0 0.037037 0 IL1RL2 2 2q12.1 1.02E+08 1.02E+08 IL1RL1 0.020833 0.142857 0 0.037037 0 IL1RL1 2 2q12.1 1.02E+08 1.02E+08 IL18R1 0.020833 0.142857 0 0.037037 0 IL18R1 2 2q12.1 1.02E+08 1.02E+08 MFSD9 0.020833 0 0.142857 0 0.037037 MFSD9 2 2q12.1 1.03E+08 1.03E+08 TMEM182 0.020833 0 0.142857 0 0.037037 TMEM182 2 2q12.1 1.03E+08 1.03E+08 MRPS9 0.020833 0.142857 0 0.037037 0 MRPS9 2 2q12.1 1.05E+08 1.05E+08 PLGLA 0.020833 0.190476 0 0.037037 0 PLGLA 2 2q12.2 1.06E+08 1.06E+08 RGPD3 0.020833 0.190476 0 0.037037 0 RGPD3 2 2q12.2 1.06E+08 1.06E+08 ACVR2A 0.020833 0 0.190476 0 0.037037 ACVR2A 2 2q22.3 1.48E+08 1.48E+08 MBD5 0.020833 0 0.142857 0 0.037037 MBD5 2 2q23.1 1.49E+08 1.49E+08 EPC2 0.020833 0 0.238095 0 0.037037 EPC2 2 2q23.1 1.49E+08 1.49E+08 DAPL1 0.020833 0.142857 0 0.037037 0 DAPL1 2 2q24.1 1.59E+08 1.59E+08 TANC1 0.020833 0.142857 0 0.037037 0 TANC1 2 2q24.1  1.6E+08  1.6E+08 TTN 0.020833 0 0.142857 0 0.037037 TTN 2 2q31.2 1.79E+08 1.79E+08 CCDC141 0.020833 0 0.142857 0 0.037037 CCDC141 2 2q31.2 1.79E+08 1.79E+08 SESTD1 0.020833 0 0.142857 0 0.037037 SESTD1 2 2q31.2  1.8E+08  1.8E+08 ZNF385B 0.020833 0 0.190475 0 0.037037 ZNF385B 2 2q31.2  1.8E+08  1.8E+08 MIR1258 0.020833 0 0.190476 0 0.037037 MIR1258 2 2q31.3  1.8E+08  1.8E+08 SF3B1 0.020833 0.238095 0 0.037037 0 SF3B1 2 2q33.1 1.98E+08 1.98E+08 COQ10B 0.020833 0.238095 0 0.037037 0 COQ10B 2 2q33.1 1.98E+08 1.98E+08 HSPD1 0.020833 0.238095 0 0.037037 0 HSPD1 2 2q33.1 1.98E+08 1.98E+08 RFTN2 0.020833 0 0.142857 0 0.037037 RFTN2 2 2q33.1 1.98E+08 1.98E+08 PLCL1 0.020833 0 0.142857 0 0.037037 PLCL1 2 2q33.1 1.98E+08 1.99E+08 BZW1 0.020833 0.142857 0 0.037037 0 BZW1 2 2q33.1 2.01E+08 2.01E+08 BZW1L1 0.020833 0.142857 0 0.037037 0 BZW1L1 2 2q33.1 2.01E+08 2.01E+08 PPIL3 0.020833 0.142857 0 0.037037 0 PPIL3 2 2q33.1 2.01E+08 2.01E+08 N1F3L1 0.020833 0.142857 0 0.037037 0 N1F3L1 2 2q33.1 2.01E+08 2.01E+08 ORC2L 0.020833 0.142857 0 0.037037 0 ORC2L 2 2q33.1 2.01E+08 2.02E+08 FAM126B 0.020833 0.190476 0 0.037037 0 FAM126B 2 2q33.1 2.02E+08 2.02E+08 NDUFB3 0.020833 0.190476 0 0.037037 0 NDUFB3 2 2q33.1 2.02E+08 2.02E+08 CFLAR 0.020833 0.190476 0 0.037037 0 CFLAR 2 2q33.1 2.02E+08 2.02E+08 CASP10 0.020833 0.142857 0 0.037037 0 CASP10 2 2q33.1 2.02E+08 2.02E+08 CASP8 0.020833 0.142857 0 0.037037 0 CASP8 2 2q33.1 2.02E+08 2.02E+08 ALS2CR12 0.020833 0.142857 0 0.037037 0 ALS2CR12 2 2q33.1 2.02E+08 2.02E+08 TRAK2 0.020833 0.142857 0.047619 0.037037 0 TRAK2 2 2q33.1 2.02E+08 2.02E+08 STRAD8 0.020833 0.142857 0.047619 0.037037 0 STRAD8 2 2q33.1 2.02E+08 2.02E+08 MPP4 0.020833 0.190476 0 0.037037 0 MPP4 2 2q33.1 2.02E+08 2.02E+08 ALS2 0.020833 0.190476 0 0.037037 0 ALS2 2 2q33.1 2.02E+08 2.02E+08 CDK15 0.020833 0.190476 0 0.037037 0 CDK15 2 2q33.1 2.02E+08 2.02E+08 FAM117B 0.020833 0.238095 0 0.037037 0 FAM117B 2 2q33.1 2.03E+08 2.03E+08 ALS2CR8 0.020833 0.190476 0 0.037037 0 ALS2CR8 2 2q33.2 2.03E+08 2.04E+08 NBEAL1 0.020833 0.190476 0 0.037037 0 NBEAL1 2 2q33.2 2.04E+08 2.04E+08 CYP20A1 0.020833 0.190476 0 0.037037 0 CYP20A1 2 2q33.2 2.04E+08 2.04E+08 ABI2 0.020833 0.190476 0 0.037037 0 ABI2 2 2q33.2 2.04E+08 2.04E+08 RAPH1 0.020833 0.190476 0 0.037037 0 RAPH1 2 2q33.2 2.04E+08 2.04E+08 INO80D 0.020833 0.142857 0 0.037037 0 INO80D 2 2q33.3 2.07E+08 2.07E+08 NDUFS1 0.020833 0.142857 0 0.037037 0 NDUFS1 2 2q33.3 2.07E+08 2.07E+08 EEF1B2 0.020833 0.142857 0 0.037037 0 EEF1B2 2 2q33.3 2.07E+08 2.07E+08 SNORD51 0.020833 0.142857 0 0.037037 0 SNORD51 2 2q33.3 2.07E+08 2.07E+08 SNORA41 0.020833 0.142857 0 0.037037 0 SNORA41 2 2q33.3 2.07E+08 2.07E+08 GPR1 0.020833 0.142857 0 0.037037 0 GPR1 2 2q33.3 2.07E+08 2.07E+08 CCNYL1 0.020833 0.142857 0 0.037037 0 CCNYL1 2 2q33.3 2.08E+08 2.08E+08 PECR 0.020833 0.142857 0 0.037037 0 PECR 2 2q35 2.17E+08 2.17E+08 4-Mar 0.020833 0.142857 0 0.037037 0 4-Mar 2 2q35 2.17E+08 2.17E+08 DEPDC1 0.020833 0 0.190476 0 0.037037 DEPDC1 1 1p31.2 68712423 68735388 LRRC7 0.020833 0 0.190476 0 0.037037 LRRC7 1 1p31.1 69998446 70361760 PIN1L 0.020833 0 0.190476 0 0.037037 PIN1L 1 1p31.1 70157593 70158589 ANKRD13C 0.020833 0 0.142857 0 0.037037 ANKRD13C 1 1p31.1 70497273 70593006 HHLA3 0.020833 0 0.142857 0 0.037037 HHLA3 1 1p31.1 70593081 70606294 CTH 0.020833 0 0.142857 0 0.037037 CTH 1 1p31.1 70649543 70677842 USP33 0.020833 0.142857 0 0.037037 0.074074 USP33 1 1p31.1 77934262 77998126 FAM73A 0.020833 0.190476 0 0.037037 0.074074 FAM73A 1 1p31.1 78017897 78116670 TTLL7 0.020833 0 0.142857 0 0.037037 TTLL7 1 1p31.1 84107645 84237422 PRKACB 0.020833 0 0.142857 0 0.037037 PRKACB 1 1p31.1 84316333 84476770 SAMD13 0.020833 0 0.142857 0 0.037037 SAMD13 1 1p31.1 84536637 84589069 UOX 0.020833 0 0.142857 0 0.037037 UOX 1 1p31.1 84603229 84636165 PKN2 0.020833 0 0.142857 0 0.037037 PKN2 1 1p22.2 88922510 89074527 GTF2B 0.020833 0.142857 0 0.037037 0 GTF2B 1 1p22.2 89090909 89129890 BCAR3 0.020833 0.142857 0 0.037037 0 BCAR3 1 1p22.1 93799937 93919974 TRIM33 0.020833 0.142857 0 0.037037 0 TRIM33 1 1p13.2 1.15E+08 1.15E+08 DENND2C 0.020833 0.142857 0 0.037037 0 DENND2C 1 1p13.2 1.15E+08 1.15E+08 AMPD1 0.020833 0.142857 0 0.037037 0 AMPD1 1 1p13.2 1.15E+08 1.15E+08 NRAS 0.020833 0.142857 0 0.037037 0 NRAS 1 1p13.2 1.15E+08 1.15E+08 CSDE1 0.020833 0.142857 0 0.037037 0 CSDE1 1 1p13.2 1.15E+08 1.15E+08 SIKE1 0.020833 0.142857 0 0.037037 0 SIKE1 1 1p13.2 1.15E+08 1.15E+08 FAM46C 0.020833 0.190476 0 0.037037 0 FAM46C 1 1p12 1.18E+08 1.18E+08 HFE2 0.020833 0.285714 0 0.037037 0 HFE2 1 1q11.1 1.44E+08 1.44E+08 PQLR3GL 0.020833 0.238095 0 0.037037 0 PQLR3GL 1 1q21.1 1.44E+08 1.44E+08 LIX1L 0.020833 0.238095 0 0.037037 0 LIX1L 1 1q21.1 1.44E+08 1.44E+08 RBM8A 0.020833 0.238095 0 0.037037 0 RBM8A 1 1q21.1 1.44E+08 1.44E+08 GNRHR2 0.020833 0.238095 0 0.037037 0 GNRHR2 1 1q21.1 1.44E+08 1.44E+08 PEX11B 0.020833 0.238095 0 0.037037 0 PEX11B 1 1q21.1 1.44E+08 1.44E+08 ITGA10 0.020833 0.238095 0 0.037037 0 ITGA10 1 1q21.1 1.44E+08 1.44E+08 ANKRD35 0.020833 0.238095 0 0.037037 0 ANKRD35 1 1q21.1 1.44E+08 1.44E+08 RNF115 0.020833 0.238095 0 0.037037 0 RNF115 1 1q21.1 1.44E+08 1.44E+08 SLAMF6 0.020833 0.190476 0 0.037037 0 SLAMF6 1 1q23.2 1.59E+08 1.59E+08 CD84 0.020833 0.190476 0 0.037037 0 CD84 1 1q23.2-1c 1.59E+08 1.59E+08 SLAMF7 0.020833 0.142857 0 0.037037 0 SLAMF7 1 1q23.3 1.59E+08 1.59E+08 CD244 0.020833 0.190476 0 0.037037 0 CD244 1 1q23.3 1.59E+08 1.59E+08 UFC1 0.020833 0.238095 0 0.037037 0.037037 UFC1 1 1q23.3 1.59E+08 1.59E+08 USP21 0.020833 0.238095 0 0.037037 0.037037 USP21 1 1q23.3 1.59E+08 1.59E+08 PPOX 0.020833 0.238095 0 0.037037 0.037037 PPOX 1 1q23.3 1.59E+08 1.59E+08 B4GALT3 0.020833 0.238095 0 0.037037 0.037037 B4GALT3 1 1q23.3 1.59E+08 1.59E+08 NR1I3 0.020833 0.238095 0 0.037037 0 NR1I3 1 1q23.3 1.59E+08 1.59E+08 PCP4L1 0.020833 0.238095 0 0.037037 0 PCP4L1 1 1q23.3 1.59E+08  1.6E+08 MPZ 0.020833 0.238095 0 0.037037 0 MPZ 1 1q23.3  1.6E+08  1.6E+08 SDHC 0.020833 0.238095 0 0.037037 0 SDHC 1 1q23.3  1.6E+08  1.6E+08 LOC64250

0.020833 0.238095 0 0.037037 0 LOC64250

1 1q23.3  1.6E+08  1.6E+08 C1orf192 0.020833 0.238095 0 0.037037 0 C1orf192 1 1q23.3  1.6E+08  1.6E+08 OLFML2B 0.020833 0.190476 0 0.037037 0 OLFML2B 1 1q23.3  1.6E+08  1.6E+08 NOS1AP 0.020833 0.142857 0 0.037037 0 NOS1AP 1 1q23.3  1.6E+08 1.61E+08 C1orf111 0.020833 0.190476 0 0.037037 0 C1orf111 1 1q23.3 1.61E+08 1.61E+08 RGS5 0.020833 0 0.142857 0 0.037037 RGS5 1 1q23.3 1.61E+08 1.61E+08 KIAA1614 0.020833 0.238095 0 0.037037 0 KIAA1614 1 1q25.3 1.79E+08 1.79E+08 HEATR1 0.020833 0.190476 0 0.037037 0 HEATR1 1 1q43 2.35E+08 2.35E+08 ACTN2 0.020833 0.190476 0 0.037037 0 ACTN2 1 1q43 2.35E+08 2.35E+08 RYR2 0.020833 0.142857 0 0.037037 0 RYR2 1 1q43 2.35E+08 2.36E+08 ZNF238 0.020833 0.238095 0 0.037037 0 ZNF238 1 1q44 2.42E+08 2.42E+08 C1orf100 0.020833 0.238095 0 0.037037 0 C1orf100 1 1q44 2.43E+08 2.43E+08 ADSS 0.020833 0.238095 0 0.037037 0 ADSS 1 1q44 2.43E+08 2.43E+08 C1orf101 0.020833 0.238095 0 0.037037 0 C1orf101 1 1q44 2.43E+08 2.43E+08 PPPDE1 0.020833 0.190476 0.047619 0.037037 0 PPPDE1 1 1q44 2.43E+08 2.43E+08 FAM36A 0.020833 0.238095 0 0.037037 0 FAM36A 1 1q44 2.43E+08 2.43E+08 EFCAB2 0.020833 0.238095 0 0.037037 0 EFCAB2 1 1q44 2.43E+08 2.43E+08 KIF26B 0.020833 0.238095 0 0.037037 0 KIF26B 1 1q44 2.43E+08 2.44E+08

indicates data missing or illegible when filed

TABLE 5 Gene list for predicting prostate cancer fast relapse using AT Symbol freq.use freq.amp.c 

  freq.del.cas 

freq.amp.c 

freq.del.co 

  Gene5ymb 

RPL23AP82 1 0.75 0.25 0.8 0 RPL234P82 RABL2B 1 0.75 0.25 0.8 0 RABL2B CA10 1 0.25 0.25 0.15 0 CA10 MAGEL2 1 0.375 0 0 0 MAGEL2 NDN 1 0.375 0 0 0 NDN C13orf36 1 0 0.25 0.025 0 C13orf36 SMAD9 1 0 0.25 0.075 0 SMAD9 ALG5 1 0.125 0.25 0.075 0 ALG5 RSU1 1 0.25 0 0 0 RSU1 ADCY2 1 0.25 0 0 0 ADCY2 UBE2E1 1 0.25 0 0 0.025 UBE2E1 RETNLB 1 0 0.25 0 0 RETNLB TRAT1 1 0 0.25 0 0 TRAT1 GUCA1C 1 0 0.25 0 0 GUCA1C MORC1 1 0 0.25 0 0 MORC1 TTTY8 0.979167 0.125 0.125 0.275 0 TTTY8 TTTY8B 0.979167 0.125 0.125 0.275 0 TTTY8B TTTY7 0.979167 0.125 0.125 0.275 0 TTTY7 TTTY7B 0.979167 0.125 0.125 0.275 0 TTTY7B LOC100101 0.979167 0.125 0.125 0.275 0 LOC100101 TTTY21 0.979167 0.125 0.125 0.275 0 TTTY21 YIPF6 0.979167 0.125 0.125 0.275 0 YIPF6 LOC96610 0.979167 0.625 0.125 0.575 0 LOC96610 STX16 0.979167 0.5 0.125 0.45 0 STX16 ZNF440 0.979167 0.875 0.125 0.625 0 ZNF440 FKBP8 0.979167 0.75 0.125 0.575 0 FKBP8 ZNF30 0.979167 0.875 0.125 0.5 0 ZNF30 PSMC4 0.979167 0.875 0.125 0.55 0 PSMC4 MAMSTR 0.979167 0.75 0.125 0.575 0 MAMSTR RASIP1 0.979167 0.75 0.125 0.575 0 RASIP1 IZUMO1 0.979167 0.75 0.125 0.575 0 IZUMO1 DSG2 0.979167 0.125 0 0 0.05 DSG2 ZNF287 0.979167 0.375 0.125 0.325 0 ZNF287 SLC4A1 0.979167 0.5 0.125 0.5 0 SLC4A1 SPAG9 0.979167 0.5 0.125 0.225 0 SPAG9 NME1 0.979167 0.5 0.125 0.275 0 NME1 NME1-NMI 0.979167 0.5 0.125 0.275 0 NME1-NMI NME2 0.979167 0.5 0.125 0.275 0 NME2 MBTD1 0.979167 0.375 0.125 0.2 0 MBTD1 UTP18 0.979167 0.375 0.125 0.2 0 UTP18 TOM1L1 0.979167 0 0.125 0.1 0 TOM1L1 COX11 0.979167 0 0.125 0.1 0 COX11 STXBP4 0.979167 0 0.125 0.1 0 STXBP4 RSL1D1 0.979167 0.5 0.125 0.425 0 RSL1D1 VPS4A 0.979167 0.625 0.125 0.375 0 VPS4A COG8 0.979167 0.625 0.125 0.375 0 COG8 PDF 0.979167 0.625 0.125 0.375 0 PDF NIP7 0.979167 0.625 0.125 0.375 0 NIP7 TMED6 0.979167 0.625 0.125 0.375 0 TMED6 PAR1 0.979167 0.125 0 0 0.075 PAR1 FSIP1 0.979167 0 0.125 0.125 0 FSIP1 NRG4 0.979167 0.5 0.125 0.45 0 NRG4 NTRK3 0.979167 0.375 0.125 0.25 0 NTRK3 FBXO33 0.979167 0.125 0.125 0 0.1 FBXO33 DDHD1 0.979167 0.125 0 0 0 DDHD1 FUT8 0.979167 0 0.125 0.175 0 FUT8 CYP46A1 0.979167 0.5 0.125 0.475 0 CYP46A1 RFC3 0.979167 0 0.125 0 0 RFC3 MIR548F5 0.979167 0 0.125 0.05 0 MIR548F5 DCLK1 0.979167 0 0.125 0 0 DCLK1 SOHLH2 0.979167 0 0.125 0 0 SOHLH2 CCNA1 0.979167 0 0.125 0 0 CCNA1 MYO16 0.979167 0.125 0 0 0.025 MYO16 YAF2 0.979167 0 0.125 0.025 0 YAF2 WDR51B 0.979167 0.125 0.25 0 0.05 WDR51B OR51E1 0.979167 0.125 0 0 0 OR51E1 OR51E2 0.979167 0.125 0 0 0 OR51E2 FLJ46111 0.979167 0.125 0.125 0.25 0 FLJ46111 DNAJC24 0.979167 0.125 0 0 0.075 DNAJC24 ASRGL1 0.979167 0.5 0.125 0.45 0 ASRGL1 SCGB1A1 0.979167 0.5 0.125 0.45 0 SCGB1A1 PAK1 0.979167 0.125 0.125 0.2 0 PAK1 AKR1C1 0.979167 0 0.125 0.1 0 AKR1C1 AKR1C2 0.979167 0 0.125 0.1 0 AKR1C2 CUBN 0.979167 0.125 0 0 0 CUBN MYO3A 0.979167 0.125 0 0 0 MYO3A CCDC6 0.979167 0.125 0 0 0 CCDC6 KCNMA1 0.979167 0.25 0.125 0.175 0 KCNMA1 PDCD4 0.979167 0 0.125 0.05 0 PDCD4 RLN1 0.979167 0 0.125 0 0 RLN1 SLC24A2 0.979167 0.125 0 0 0.025 SLC24A2 LOC440173 0.979167 0.25 0.125 0.175 0 LOC440173 ASTN2 0.979167 0 0.125 0.05 0 ASTN2 LHX3 0.979167 0.875 0.125 0.725 0 LHX3 QSOX2 0.979167 0.875 0.125 0.725 0 QSOX2 TNFRSF10C 0.979167 0.25 0.125 0.175 0 TNFRSF10C TERF1 0.979167 0 0.125 0.075 0 TERF1 C8orf84 0.979167 0 0.125 0.1 0 C8orf84 RDH10 0.979167 0 0.125 0.1 0 RDH10 UBE2W 0.979167 0.125 0.125 0.1 0 UBE2W TCEB1 0.979167 0.125 0.125 0.1 0 TCEB1 C7orf30 0.979167 0 0.125 0.05 0 C7orf30 IGF2BP3 0.979167 0 0.129 0.05 0 IGF2BP3 CALU 0.979167 0.25 0.125 0.3 0 CALU MIR548A1 0.979167 0.125 0 0 0.025 MIR548A1 HMGA1 0.979167 0.625 0.125 0.425 0 HMGA1 TCP11 0.979167 0.5 0.125 0.325 0 TCP11 KLHL31 0.979167 0 0.125 0 0 KLHL31 LRRC1 0.979167 0 0.125 0 0 LRRC1 SLC22A16 0.979167 0.125 0 0 0 SLC22A16 RICTOR 0.979167 0 0.125 0 0 RICTOR FYB 0.979167 0 0.125 0 0 FYB FAM169A 0.979167 0 0.125 0 0 FAM1694 SEMA6A 0.979167 0 0.125 0 0 SEMA6A DMXL1 0.979167 0.125 0.125 0.075 0 DMXL1 TNFAIP8 0.979167 0 0.125 0.025 0 TNFAIP8 SAR1B 0.979167 0.375 0.125 0.35 0 SAR1B RNF130 0.979167 0.5 0.125 0.525 0 RNF130 MIR340 0.979167 0.5 0.125 0.525 0 MIR340 SLC30A9 0.979167 0.125 0.125 0 0.05 SLC30A9 BEND4 0.979167 0.125 0.125 0 0.05 BEND4 POLR2B 0.979167 0 0.125 0 0 POLR2B IGFBP7 0.979167 0 0.125 0 0 IGFBP7 HELQ 0.979167 0.125 0.125 0.125 0 HELQ MRPS18C 0.979167 0.125 0.125 0.125 0 MRPS18C FAM175A 0.979167 0.125 0.125 0.125 0 FAM175A DCLK2 0.979167 0.125 0.125 0 0.025 DCLK2 TRIM61 0.979167 0.125 0.125 0 0.05 TRIM61 C4orf39 0.979167 0.125 0.125 0 0.05 C4orf39 NKTR 0.979167 0.25 0.125 0.275 0 NKTR DOCK3 0.979167 0.375 0.125 0.275 0 DOCK3 LRIG1 0.979167 0.125 0 0 0 LRIG1 GXYLT2 0.979167 0 0.125 0.05 0 GXYLT2 PPP4R2 0.979167 0 0.125 0.05 0 PPP4R2 WDR52 0.979167 0 0.125 0.025 0 WDR52 SIDT1 0.979167 0 0.125 0.025 0 SIDT1 NAT13 0.979167 0 0.125 0.05 0 NAT13 POLQ 0.979167 0 0.12.5 0.05 0 POLQ ARGFX 0.979167 0 0.125 0.05 0 ARGFX FBXO40 0.979167 0 0.125 0.05 0 FBXO40 PLSCR1 0.979167 0.125 0.375 0 0.175 PLSCR1 TM4SF4 0.979167 0.125 0 0 0.025 TM4SF4 WWTR1 0.979167 0.125 0 0 0.025 WWTR1 NMD3 0.979167 0 0.125 0.025 0 NMD3 MRPL47 0.979167 0.125 0.125 0.025 0 MRPL47 TMEM17 0.979167 0.125 0 0 0 TMEM17 EHBP1 0.979167 0 0.125 0 0 EHBP1 C2orf86 0.979167 0 0.125 0.025 0 C2orf86 MDH1 0.979167 0 0.125 0.025 0 MDH1 RPL31 0.979167 0.25 0.125 0.175 0 RPL31 SLC9A2 0.979167 0 0.125 0.05 0 SLC9A2 GCG 0.979167 0.125 0 0 0.125 GCG FAP 0.979167 0.125 0 0 0.125 FAP C2orf77 0.979167 0.125 0 0 0 C2orf77 PHOSPHO2 0.979167 0.125 0 0 0 PHOSPHO2 KLHL23 0.979167 0.125 0 0 0 KLHL23 SSB 0.979167 0.125 0 0 0 SSB METTL5 0.979167 0.125 0 0 0 METTL5 UBR3 0.979167 0.125 0 0 0 UBR3 C1orf64 0.979167 0.625 0.125 0.575 0 C1orf64 CYP4A22 0.979167 0.375 0.125 0.325 0 CYP4A22 C1orf141 0.979167 0 0.125 0.025 0 C1orf141 ABCD3 0.979167 0.125 0.125 0.025 0 ABCD3 RABGAP1L 0.979167 0 0.125 0.05 0 RABGAP1L RBBP5 0.979167 0.375 0.125 0.35 0 RBBP5 RFX7 0.041667 0.125 0.125 0.025 0.025 RFX7 IPCEF1 0.041667 0.125 0.125 0.025 0.025 IPCEF1 TLR10 0.041667 0.125 0.125 0.025 0.025 TLR10 PHOX2B 0.041667 0.125 0.125 0.025 0.025 PHOX2B PDCD6IP 0.041667 0.125 0.125 0.025 0.025 PDCD6IP SR140 0.041667 0.125 0.125 0.025 0.025 SR140 KIF5C 0.041667 0.125 0.125 0.025 0.025 KIF5C MIR1978 0.041667 0.125 0.125 0.025 0.025 MIR1978 VAMP7 0.020833 0.375 0.125 0.3 0.025 VAMP7 IL9R 0.020833 0.375 0.125 0.3 0.025 IL9R ATXN10 0.020833 0.625 0.125 0.575 0.025 ATXN10 RNF160 0.020833 0.125 0.125 0.05 0.025 RNF160 C21orf7 0.020833 0.125 0 0.025 0.025 C21orf7 CLDN17 0.020833 0 0.125 0.025 0.025 CLDN17 KRTAP19-3 0.020833 0 0.125 0.025 0.025 KRTAP19-3 KRTAP19-4 0.020833 0 0.125 0.025 0.025 KRTAP19-4 KRTAP19-5 0.020833 0 0.125 0.025 0.025 KRTAP19-5 KRTAP19-7 0.020833 0 0.125 0.025 0.025 KRTAP19-7 KRTAP20-2 0.020833 0 0.125 0.05 0.025 KRTAP20-2 KRTAP20-3 0.020833 0 0.125 0.05 0.025 KRTAP20-3 PSG1 0.020833 0.5 0.25 0.4 0.025 PSG1 ZNF519 0.020833 0.125 0.125 0.075 0.025 ZNF519 ANKRD30B 0.020833 0.125 0.125 0.075 0.025 ANKRD30B TTR 0.020833 0.125 0 0.025 0.025 TTR B4GALT6 0.020833 0.125 0 0.025 0.025 B4GALT6 MCART2 0.020833 0.125 0 0.025 0.025 MCART2 KIAA1012 0.020833 0.125 0 0.025 0.025 KIAA1012 SERPINB13 0.020833 0.125 0 0.025 0.025 SERPINB13 TANC2 0.020833 0.375 0.125 0.275 0.025 TANC2 CDH11 0.020833 0.25 0 0.025 0.075 CDH11 LOC283867 0.020833 0.25 0 0.025 0.025 LOC283867 CNTNAP4 0.020833 0.125 0 0.025 0.025 CNTNAP4 SCG5 0.020833 0.125 0 0.025 0 SCG5 MEIS2 0.020833 0 0.125 0.025 0.025 MEIS2 DMXL2 0.020833 0.125 0.125 0.05 0.025 DMXL2 RAB27A 0.020833 0.125 0 0.025 0 RAB27A PIGB 0.020833 0.125 0 0.025 0 PIGB CCPG1 0.020833 0.125 0 0.025 0 CCPG1 MIR628 0.020833 0.125 0 0.025 0 MIR628 DYX1C1 0.020833 0.125 0 0.025 0 DYX1C1 PYGO1 0.020833 0.125 0 0.025 0 PYGO1 PRTG 0.020833 0.125 0 0.025 0 PRTG NEDD4 0.020833 0.25 0 0.025 0 NEDD4 TEX9 0.020833 0.125 0.125 0.025 0.05 TEX9 ZNF280D 0.020833 0.125 0 0.025 0 ZNF280D TCF12 0.020833 0.125 0 0.025 0.025 TCF12 NEO1 0.020833 0.25 0.125 0.275 0.025 NEO1 MIPOL1 0.020833 0 0.125 0 0.025 MIPOL1 CDKN3 0.020833 0.125 0 0.025 0 CDKN3 C14orf145 0.020833 0 0.25 0 0.025 C14orf145 TSHR 0.020833 0 0.25 0 0.025 TSHR STON2 0.020833 0 0.25 0.025 0.025 STON2 SEL1L 0.020833 0 0.25 0.025 0.025 SEL1L ZMYM2 0.020833 0.125 0.125 0.15 0.025 ZMYM2 NBEA 0.020833 0 0.125 0 0.025 NBEA SPG20 0.020833 0 0.125 0 0.025 SPG20 COG6 0.020833 0 0.125 0 0.025 COG6 RNASEH2B 0.020833 0.125 0 0.025 0 RNASEH2B GUCY1B2 0.020833 0.125 0 0.025 0 GUCY1B2 FAM124A 0.020833 0.125 0 0.025 0 FAM124A SERPINE3 0.020833 0.125 0 0.025 0 SERPINE3 INTS6 0.020833 0.125 0 0.025 0 INTS6 DCT 0.020833 0.125 0.125 0.025 0.1 DCT DNAJC3 0.020833 0.375 0 0.025 0 DNAJC3 TMTC4 0.020833 0.125 0 0.025 0 TMTC4 AEBP2 0.020833 0.125 0 0.025 0.075 AEBP2 GXYLT1 0.020833 0 0.125 0 0.025 GXYLT1 SRGAP1 0.020833 0.125 0 0.025 0 SRGAP1 C12orf66 0.020833 0.125 0 0.025 0 C12orf66 C12orf56 0.020833 0.125 0 0.025 0 C12orf56 TBK1 0.020833 0.125 0 0.025 0 TBK1 GNS 0.020833 0.125 0 0.025 0 GNS ZFC3H1 0.020833 0 0.25 0 0.025 ZFC3H1 TBC1D15 0.020833 0 0.25 0.05 0.025 TBC1D15 MRS2P2 0.020833 0 0.25 0.05 0.025 MRS2P2 METAP2 0.020833 0.125 0 0.025 0 METAP2 USP44 0.020833 0.125 0 0.025 0 USP44 NTN4 0.020833 0.125 0 0.025 0 NTN4 CCDC38 0.020833 0.125 0 0.025 0 CCDC38 AMDHD1 0.020833 0.125 0 0.025 0 AMDHD1 HAL 0.020833 0.125 0 0.025 0 HAL OR52K2 0.020833 0.125 0 0.025 0.025 OR52K2 C11orf40 0.020833 0.125 0 0.025 0.025 C11orf40 API5 0.020833 0.25 0 0.025 0 API5 TTC17 0.020833 0.25 0 0.025 0 TTC17 MIR670 0.020833 0.25 0 0.025 0 MIR670 CCDC82 0.020833 0 0.25 0 0.025 CCDC82 JRKL 0.020833 0 0.25 0 0.025 JRKL OR8D1 0.020833 0.125 0 0.025 0.025 OR8D1 OR8D2 0.020833 0.125 0 0.025 0.025 OR8D2 C10orf18 0.020833 0.375 0.125 0.225 0.025 C10orf18 LOC254312 0.020833 0.375 0 0.025 0 LOC254312 CUGBP2 0.020833 0.375 0 0.025 0 CUGBP2 PTER 0.020833 0.25 0 0.025 0 PTER GAD2 0.020833 0.125 0 0.025 0 GAD2 APBB1IP 0.020833 0.125 0 0.025 0 APBB1IP C10orf50 0.020833 0.125 0 0.025 0 C10orf50 LOC731789 0.020833 0.125 0 0.025 0 LOC731789 PDSS1 0.020833 0.125 0 0.025 0 PDSS1 ABI1 0.020833 0.125 0 0.025 0 A8I1 CCDC7 0.020833 0 0.125 0.025 0.025 CCDC7 FAM13C 0.020833 0 0.25 0 0.025 FAM13C TM9SF3 0.020833 0.25 0.125 0.275 0.025 TM9SF3 PIK3AP1 0.020833 0.25 0.125 0.275 0.025 PIK3AP1 PLAA 0.020833 0.125 0.125 0.1 0.025 PLAA IFT74 0.020833 0.125 0.125 0.075 0.025 IFT74 ALDH1A1 0.020833 0 0.125 0 0.025 ALDH1A1 GAS1 0.020833 0.25 0.125 0.175 0.025 GAS1 LPPR1 0.020833 0 0.125 0.025 0.025 LPPR1 MRPL50 0.020833 0 0.125 0.05 0.025 MRPL50 ZNF189 0.020833 0 0.125 0.05 0.025 ZNF189 ALDOB 0.020833 0 0.125 0.05 0.025 ALDOB RNF20 0.020833 0 0.125 0.05 0.025 RNF20 GRIN3A 0.020833 0 0.125 0.05 0.025 GRIN3A TNFSF15 0.020833 0 0.125 0.075 0.025 TNFSF15 TNFSF8 0.020833 0 0.125 0.075 0.025 TNFSF8 TNC 0.020833 0 0.125 0.075 0.025 TNC PAPPA 0.020833 0 0.25 0.025 0.025 PAPPA DBC1 0.020833 0 0.125 0.025 0.025 DBC1 ADAM9 0.020833 0 0.125 0.025 0.025 ADAM9 ADAM32 0.020833 0 0.125 0.025 0.025 ADAM32 ADAM18 0.020833 0 0.125 0.025 0.025 ADAM18 ADAM2 0.020833 0 0.125 0.025 0.025 ADAM2 POTEA 0.020833 0 0.125 0.125 0.025 POTEA ST18 0.020833 0 0.125 0.025 0.025 ST18 ARMC1 0.020833 0.125 0 0.025 0 ARMC1 MTFR1 0.020833 0.125 0 0.025 0 MTFR1 PDE7A 0.020833 0.125 0 0.025 0 PDE7A DNAJC5B 0.020833 0.125 0 0.025 0 DNAJC5B TRIM55 0.020833 0.125 0 0.025 0 TRIM55 TMEM70 0.020833 0 0.25 0.05 0.025 TMEM70 JPH1 0.020833 0 0.25 0.025 0.025 JPH1 COL14A1 0.020833 0.125 0 0.025 0.025 COL14A1 MRPL13 0.020833 0 0.125 0 0.025 MRPL13 MTBP 0.020833 0 0.125 0 0.025 MTBP C1GALT1 0.020833 0.125 0.125 0.075 0.025 C1GALT1 COL28A1 0.020833 0.125 0.125 0.025 0.075 COL28A1 RPA3 0.020833 0.125 0.125 0.025 0.05 RPA3 GLCCI1 0.020833 0.125 0.125 0.025 0.05 GLCCI1 ABCA13 0.020833 0.125 0 0.025 0.05 ABCA13 PION 0.020833 0.125 0 0.025 0.075 PION CDK6 0.020833 0 0.125 0.075 0.025 CDK6 LAMB1 0.020833 0.125 0 0.025 0 LAMB1 AKR1B1 0.020833 0.125 0 0.025 0 AKR1B1 AKR1810 0.020833 0.125 0 0.025 0 AKR1B10 RNF144B 0.020833 0.125 0 0.025 0.025 RNF144B SOX4 0.020833 0.125 0 0.025 0 SOX4 Symbol chromoson 

cytoband Transcript. 

Transcript.end RPL23AP82 22 22q13.33 49542380 49584931 RABL2B 22 22q13.33 49552786 49568954 CA10 17 17q21.33 47062673 47592161 MAGEL2 15 15q11.2 21439791 21444087 NDN 15 15q11.2 21481647 21483544 C13orf36 13 13q13.3 36146049 36169976 SMAD9 13 13q13.3 36320207 36392410 ALG5 13 13q13.3 36421910 36471505 RSU1 10 10p13 16672623 16899460 ADCY2 5 5p15.31  7449343  7883195 UBE2E1 3 3p24.2 23822443 23907812 RETNLB 3 3q13.13  1.1E+08  1.1E+08 TRAT1 3 3q13.13  1.1E+08  1.1E+08 GUCA1C 3 3q13.13  1.1E+08  1.1E+08 MORC1 3 3q13.13  1.1E+08  1.1E+08 TTTY8 Y Yp11.2 10138709 10141309 TTTY8B Y Yp11.2 10138709 10141309 TTTY7 Y Yp11.2 10154433 10162872 TTTY7B Y Yp11.2 10154433 10162872 LOC100101 Y Yp11.2 10165262 10168906 TTTY21 Y Yp11.2 10165262 10168906 YIPF6 X Xq12 67635611 67669027 LOC96610 22 22q11.22 20982463 21007325 STX16 20 20q13.32 56659734 56687989 ZNF440 19 19p13.2 11786107 11807017 FKBP8 19 19p13.11 18503568 18515384 ZNF30 19 19q13.11 40109647 40127917 PSMC4 19 19q13.2 45168913 45179194 MAMSTR 19 19q13.33 53908067 53914789 RASIP1 19 19q13.33 53915654 53935783 IZUMO1 19 19q13.33 53935957 53941979 DSG2 18 18q12.1 27332025 27382813 ZNF287 17 17p11.2 16394356 16413246 SLC4A1 17 17q21.31 39681284 39701029 SPAG9 17 17q21.33 46394535 46553226 NME1 17 17q21.33 46585919 46594450 NME1-NMI 17 17q21.33 46585919 46604105 NME2 17 17q21.33 46597890 46604105 MBTD1 17 17q21.33 46609785 46692427 UTP18 17 17q21.33 46692896 46730292 TOM1L1 17 17q22 50333051 50394328 COX11 17 17q22 50384258 50401064 STXBP4 17 17q22 50401125 50596449 RSL1D1 16 16p13.13 11835556 11852944 VPS4A 16 16q22.1 67902788 67916448 COG8 16 16q22.1 67920025 67931028 PDF 16 16q22.1 67920025 67922000 NIP7 16 16q22.1 67931047 67934511 TMED6 16 16q22.1 67934650 67943214 PAR1 15 15q11.2 22931882 22934294 FSIP1 15 15q14 37679524 37862332 NRG4 15 15q24.2 74022899 74091841 NTRK3 15 15q25.3 86220992 86600666 FBXO33 14 14q21.1 38936628 38971456 DDHD1 14 14q22.2 52573210 52689797 FUT8 14 14q23.3 64947593 65279716 CYP46A1 14 14q32.2 99220508 99263392 RFC3 13 13q13.2 33290206 33438696 MIR548F5 13 13q13.3 34946406 35413383 DCLK1 13 13q13.3 35241123 35603465 SOHLH2 13 13q13.3 35640347 35686753 CCNA1 13 13q13.3 35903967 35915020 MYO16 13 13q33.3 1.08E+08 1.09E+08 YAF2 12 12q12 40837174 40918318 WDR51B 12 12q21.33 88337634 88443909 OR51E1 11 11p15.4  4621732  4633291 OR51E2 11 11p15.4  4657977  4675653 FLJ46111 11 11p15.4  9072486  9074314 DNAJC24 11 11p13 31347953 31410959 ASRGL1 11 11q12.3 61861350 61917464 SCGB1A1 11 11q12.3 61943099 61947244 PAK1 11 11q14.1 76710708 76862757 AKR1C1 10 10p15.1  4995454  5010159 AKR1C2 10 10p15.1  5021965  5050208 CUBN 10 10p13 16905971 17211823 MYO3A 10 10p12.1 26263008 26541472 CCDC6 10 10q21.2 61218527 61336825 KCNMA1 10 10q22.3 78299365 79067584 PDCD4 10 10q25.2 1.13E+08 1.13E+08 RLN1 9 9p24.1  5324969  5329874 SLC24A2 9 9p22.1 19505978 19776927 LOC440173 9 9q21.33 88813187 88846862 ASTN2 9 9q33.1 1.18E+08 1.19E+08 LHX3 9 9q34.3 1.38E+08 1.38E+08 QSOX2 9 9q34.3 1.38E+08 1.38E+08 TNFRSF10C 8 8p21.3 23016379 23030896 TERF1 8 8q21.11 74083651 74122542 C8orf84 8 8q21.11 74139334 74168062 RDH10 8 8q21.11 74369819 74400069 UBE2W 8 8q21.11 74865394 74953665 TCEB1 8 8q21.11 75021188 75046901 C7orf30 7 7p15.3 23305465 23315706 IGF2BP3 7 7p15.3 23316353 23476521 CALU 7 7q32.1 1.28E+08 1.28E+08 MIR548A1 6 6p22.3 18679994 18680091 HMGA1 6 6p21.31 34312555 34321986 TCP11 6 6p21.31 35193827 35217156 KLHL31 6 6p12.1 53620658 53638466 LRRC1 6 6q12.1 53767737 53896879 SLC22A16 6 6q21 1.11E+08 1.11E+08 RICTOR 5 5p13.1 38973780 39110259 FYB 5 5p13.1 39141114 39255425 FAM169A 5 5q13.3 74109155 74198372 SEMA6A 5 5q23.1 1.16E+08 1.16E+08 DMXL1 5 5q23.1 1.18E+08 1.19E+08 TNFAIP8 5 5q23.1 1.19E+08 1.19E+08 SAR1B 5 5q31.1 1.34E+08 1.34E+08 RNF130 5 5q35.3 1.79E+08 1.79E+08 MIR340 5 5q35.3 1.79E+08 1.79E+08 SLC30A9 4 4p13 41687280 41784309 BEND4 4 4p13 41807629 41849653 POLR2B 4 4q12 57539866 57592092 IGFBP7 4 4q12 57592001 57671297 HELQ 4 4q21.23 84547523 84596050 MRPS18C 4 4q21.23 84596142 84601954 FAM175A 4 4q21.23 84601120 84625315 DCLK2 4 4q31.3 1.51E+08 1.51E+08 TRIM61 4 4q32.3 1.66E+08 1.66E+08 C4orf39 4 4q32.3 1.66E+08 1.66E+08 NKTR 3 3p22.1 42617151 42665238 DOCK3 3 3p21.31 50687676 51396670 LRIG1 3 3p14.1 66511911 66633536 GXYLT2 3 3p13 73020075 73107213 PPP4R2 3 3p13 73128809 73197702 WDR52 3 3q13.2 1.14E+08 1.15E+08 SIDT1 3 3q13.2 1.15E+08 1.15E+08 NAT13 3 3q13.2 1.15E+08 1.15E+08 POLQ 3 3q13.33 1.23E+08 1.23E+08 ARGFX 3 3q13.33 1.23E+08 1.23E+08 FBXO40 3 3q13.33 1.23E+08 1.23E+08 PLSCR1 3 3q24 1.48E+08 1.48E+08 TM4SF4 3 3q25.1 1.51E+08 1.51E+08 WWTR1 3 3q25.1 1.51E+08 1.51E+08 NMD3 3 3q26.1 1.62E+08 1.62E+08 MRPL47 3 3q26.33 1.81E+08 1.81E+08 TMEM17 2 2p15 62580860 62587109 EHBP1 2 2p15 62754517 63127124 C2orf86 2 2p15 63202039 63518591 MDH1 2 2p15 63669626 63687833 RPL31 2 2q11.2 1.01E+08 1.01E+08 SLC9A2 2 2q12.1 1.03E+08 1.03E+08 GCG 2 2q24.2 1.63E+08 1.63E+08 FAP 2 2q24.2 1.63E+08 1.63E+08 C2orf77 2 2q31.1  1.7E+08  1.7E+08 PHOSPHO2 2 2q31.1  1.7E+08  1.7E+08 KLHL23 2 2q31.1  1.7E+08  1.7E+08 SSB 2 2q31.1  1.7E+08  1.7E+08 METTL5 2 2q31.1  1.7E+08  1.7E+08 UBR3 2 2q31.1  1.7E+08 1.71E+08 C1orf64 1 1p36.13 16203318 16205772 CYP4A22 1 1p33 47375694 47387114 C1orf141 1 1p31.3 67330447 67366809 ABCD3 1 1p21.3 94656521 94716849 RABGAP1L 1 1q25.1 1.72E+08 1.73E+08 RBBP5 1 1q32.1 2.03E+08 2.03E+08 RFX7 15 15q21.3 54170023 54322776 IPCEF1 6 6q25.2 1.55E+08 1.55E+08 TLR10 4 4p14 38450647 38460985 PHOX2B 4 4p13 41440856 41445745 PDCD6IP 3 3p22.3 33815070 33886199 SR140 3 3q23 1.44E+08 1.44E+08 KIF5C 2 2q23.1 1.49E+08  1.5E+08 MIR1978 2 2q23.1 1.49E+08 1.49E+08 VAMP7 X Xq28 1.55E+08 1.55E+08 IL9R X Xq28 1.55E+08 1.55E+08 ATXN10 22 22q13.31 44446342 44619851 RNF160 21 21q21.3 29222337 29287149 C21orf7 21 21q21.3 29374744 29470074 CLDN17 21 21q21.3 30460132 30460807 KRTAP19-3 21 21q22.11 30785653 30786147 KRTAP19-4 21 21q22.11 30791045 30791300 KRTAP19-5 21 21q22.11 30796061 30796280 KRTAP19-7 21 21q22.11 30855288 30855480 KRTAP20-2 21 21q22.11 30929454 30929652 KRTAP20-3 21 21q22.11 30937054 30937327 PSG1 19 19q13.31 48063198 48075712 ZNF519 18 18p11.21 14094724 14122430 ANKRD30B 18 18p11.21 14738239 14842738 TTR 18 18q12.1 27425728 27432983 B4GALT6 18 18q12.1 27456207 27518685 MCART2 18 18q12.1 27593657 27594842 KIAA1012 18 18q12.1 27663134 27777090 SERPINB13 18 18q21.33 59405514 59417413 TANC2 17 17q23.3 58440630 58858800 CDH11 16 16q21 63538184 63713421 LOC283867 16 16q21 63875903 64167705 CNTNAP4 16 16q23.1 74868677 75150637 SCG5 15 15q13.3 30721162 30776591 MEIS2 15 15q14 34970524 35180793 DMXL2 15 15q21.2 49527231 49702260 RAB27A 15 15q21.3 53283092 53349878 PIGB 15 15q21.3 53398425 53435139 CCPG1 15 15q21.3 53434730 53487835 MIR628 15 15q21.3 53452430 53452525 DYX1C1 15 15q21.3 53497246 53587725 PYGO1 15 15q21.3 53625513 53668343 PRTG 15 15q21.3 53691042 53822470 NEDD4 15 15q21.3 53906414 54073128 TEX9 15 15q21.3 54444936 54525365 ZNF280D 15 15q21.3 54709666 54813080 TCF12 15 15q21.3 54998125 55368007 NEO1 15 15q24.1 71131928 71384599 MIPOL1 14 14q21.1 36736869 37086619 CDKN3 14 14q22.2 53933423 53956683 C14orf145 14 14q31.1 80032574 80475638 TSHR 14 14q31.1 80491622 80682400 STON2 14 14q31.1 80806662 80934681 SEL1L 14 14q31.1 81008994 81069959 ZMYM2 13 13q12.11 19430810 19558940 NBEA 13 13q13.2 34414456 35144874 SPG20 13 13q13.3 35773777 35842318 COG6 13 13q13.3 39127764 39263803 RNASEH2B 13 13q14.3 50381893 50442596 GUCY1B2 13 13q14.3 50466649 50538295 FAM124A 13 13q14.3 50694508 50753618 SERPINE3 13 13q14.3 50813169 50834241 INTS6 13 13q14.3 50833702 50925277 DCT 13 13q32.1 93889842 93929938 DNAJC3 13 13q32.1 95127403 95245243 TMTC4 13 13q32.3   1E+08   1E+08 AEBP2 12 12p12.3 19483875 19566441 GXYLT1 12 12q12 40761915 40824941 SRGAP1 12 12q14.2 62524808 62827881 C12orf66 12 12q14.2 62872686 62902344 C12orf56 12 12q14.2 62947032 63070613 TBK1 12 12q14.2 63132204 63182159 GNS 12 12q14.2-1 63393489 63439494 ZFC3H1 12 12q21.1 70289649 70344017 TBC1D15 12 12q21.1 70519754 70606895 MRS2P2 12 12q21.1 70528343 70531031 METAP2 12 12q22 94391953 94433745 USP44 12 12q22 94435018 94466752 NTN4 12 12q22 94575714 94708668 CCDC38 12 12q23.1 94784958 94860560 AMDHD1 12 12q23.1 94861202 94886501 HAL 12 12q23.1 94891273 94914203 OR52K2 11 11p15.4  4427146  4428091 C11orf40 11 11p15.4  4549229  4555627 API5 11 11p12 43290081 43322659 TTC17 11 11p12 43337067 43472072 MIR670 11 11p11.2 43537782 43537880 CCDC82 11 11q21 95725577 95762732 JRKL 11 11q21 95762806 95766376 OR8D1 11 11q24.2 1.24E+08 1.24E+08 OR8D2 11 11q24.2 1.24E+08 1.24E+08 C10orf18 10 10p15.1  5766807  5846950 LOC254312 10 10p14 11016910 11034133 CUGBP2 10 10p14 11087265 11418679 PTER 10 10p13 16518973 16595743 GAD2 10 10p12.1 26545242 26633498 APBB1IP 10 10p12.1 26767272 26896739 C10orf50 10 10p12.1 26918800 26923256 LOC731789 10 10p12.1 26972043 26982389 PDSS1 10 10p12.1 27026601 27075733 ABI1 10 10p12.1 27075531 27189966 CCDC7 10 10q11.22 32775047 32903499 FAM13C 10 10q21.1 60675896 60792359 TM9SF3 10 10q24.1 98267857 98336800 PIK3AP1 10 10q24.1 98343059 98470270 PLAA 9 9p21.2 26893369 26937469 IFT74 9 9p21.2 26937037 27052932 ALDH1A1 9 9q21.13 74705407 74757790 GAS1 9 9q21.33 88749097 88751925 LPPR1 9 9q31.1 1.03E+08 1.03E+08 MRPL50 9 9q31.1 1.03E+08 1.03E+08 ZNF189 9 9q31.1 1.03E+08 1.03E+08 ALDOB 9 9q31.1 1.03E+08 1.03E+08 RNF20 9 9q31.1 1.03E+08 1.03E+08 GRIN3A 9 9q31.1 1.03E+08 1.04E+08 TNFSF15 9 9q32 1.17E+08 1.17E+08 TNFSF8 9 9q33.1 1.17E+08 1.17E+08 TNC 9 9q33.1 1.17E+08 1.17E+08 PAPPA 9 9q33.1 1.18E+08 1.18E+08 DBC1 9 9q33.1 1.21E+08 1.21E+08 ADAM9 8 8p11.23 38973662 39081937 ADAM32 8 8p11.23 39084207 39261594 ADAM18 8 8p11.22 39561299 39706645 ADAM2 8 8p11.22 39720412 39814937 POTEA 8 8p11.1 43266742 43337486 ST18 8 8q11.23 53185945 53484993 ARMC1 8 8q13.1 66677628 66708987 MTFR1 8 8q13.1 66719442 66783127 PDE7A 8 8q13.1 66792460 66863876 DNAJC5B 8 8q13.1 67096345 67175310 TRIM55 8 8q13.1 67201832 67250273 TMEM70 8 8q21.11 75050984 75057568 JPH1 8 8q21.11 75309493 75396118 COL14A1 8 8q24.12 1.21E+08 1.21E+08 MRPL13 8 8q24.12 1.21E+08 1.22E+08 MTBP 8 8q24.12 1.22E+08 1.22E+08 C1GALT1 7 7p21.3  7188771  7250507 COL28A1 7 7p21.3  7364769  7541986 RPA3 7 7p21.3  7643100  7724764 GLCCI1 7 7p21.3  7974948  8095235 ABCA13 7 7p12.3 48208389 48657638 PION 7 7q11.23 76778004 76883654 CDK6 7 7q21.2 92072173 92303878 LAMB1 7 7q31.1 1.07E+08 1.07E+08 AKR1B1 7 7q33 1.34E+08 1.34E+08 AKR1810 7 7q33 1.34E+08 1.34E+08 RNF144B 6 6p22.3 18495573 18576830 SOX4 6 6p22.3 21701951 21706829

indicates data missing or illegible when filed 

What is claimed is:
 1. A method of diagnosing a prostate cancer in a subject comprising determining the number and/or size of copy number variations in DNA from a tumor sample, a sample of tissue adjacent a tumor, and/or in a blood sample, where if the number and/or size of copy number variations exceeds a particular threshold, a diagnosis of prostate cancer is indicated.
 2. The method of claim 1, comprising determining the number and size of copy number variations in DNA from a tumor or prostate tissue sample, where if the number of copy number variations exceeds 90 loci, each locus being at least 10 kb in length, a diagnosis of prostate cancer is indicated
 3. The method of claim 1, where said subject is a male having one or more of the following clinical findings: increased serum prostate specific antigen, enlarged prostate on physical exam, difficulty urinating and/or urinary retention, comprising determining the number and/or size of copy number variations in DNA from a blood sample from the subject, where if the number of copy number variations exceeds 4 loci, each locus being at least 10 kb in length, a diagnosis of prostate cancer is indicated.
 4. The method of claim 1, comprising determining the presence of deletions in one or more of chromosome regions 8p, 13p, 16q, and/or 17p in DNA from a prostate tissue or a blood sample from the subject, where if there is a deletion of at least 3 megabases in one or more of these regions, a diagnosis of prostate cancer is indicated.
 5. The method of claim 1, comprising determining the presence of amplification in one or more of chromosome regions 8q and X in DNA from a prostate tissue or a blood sample from the subject, where if there is amplification of a locus in one or more of these regions, a diagnosis of prostate cancer is indicated.
 6. A method of determining that a prostate cancer patient is at decreased risk for relapse or rapid relapse comprising determining the size of copy number variations in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the size of copy number variations is below a particular threshold, the patient is deemed to be at decreased risk for relapse or rapid relapse.
 7. The method of claim 6, comprising determining the mean size of copy number variations in DNA from a blood sample from the patient, where if the mean size of copy number variations is 40 kb or less, the patient is deemed to be at decreased risk for relapse.
 8. The method of claim 6, comprising determining the mean size of copy number variations in DNA from a sample of tissue adjacent a prostate cancer from the patient, where if the mean size of copy number variations is 95 kb or less, the patient is deemed to be at decreased risk for relapse.
 9. The method of claim 6, comprising determining the mean size of copy number variations in DNA from a sample of prostate cancer tissue from the patient, where if the mean size of copy number variations is 385 kb or less, the patient is deemed to be at decreased risk for relapse.
 10. The method of claim 6, comprising determining the median size of copy number variations in a blood sample from the patient, where if the median size of copy number variations is 17 kb or less, the subject is deemed to be at decreased risk for relapse.
 11. The method of claim 6, comprising determining the median size of copy number variations in a sample of tissue adjacent a prostate cancer from the patient, where if the median size of copy number variations is 16 kb or less, the subject is deemed to be at decreased risk for relapse.
 12. The method of claim 6, comprising determining the median size of copy number variations in DNA from a sample of prostate cancer tissue from the patient, where if the median size of copy number variations is 185 kb or less, the patient is deemed to be at decreased risk for relapse.
 13. A method of determining that a prostate cancer patient is at increased risk for relapse or rapid relapse comprising determining the size of copy number variations in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the size of copy number variations exceeds a particular threshold, the patient is deemed to be at increased risk for relapse or rapid relapse.
 14. The method of claim 12, comprising determining the mean size of Copy number variations in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the mean size of copy number variations exceeds a particular threshold, the patient is deemed to be at increased risk for relapse or rapid relapse.
 15. The method of claim 13, comprising determining the mean size of copy number variations in DNA from a blood sample from the patient, where if the mean size of copy number variations is 70 kb or more, the patient is deemed to be at increased risk for relapse.
 16. The method of claim 14, comprising determining the mean size of copy number variations in DNA from a sample of tissue adjacent to prostate cancer from the patient, where if the mean size of copy number variations is 246 kb or more, the patient is deemed to be at increased risk for relapse.
 17. The method of claim 14, comprising determining the mean size of copy number variations in DNA from a sample of prostate cancer tissue from the patient, where if the mean size of copy number variations is 817 kb or more, the patient is deemed to be at increased risk for relapse.
 18. The method of claim 14, comprising determining the mean size of copy number variations in DNA from a sample of prostate cancer tissue from the patient, where if the mean size of copy number variations is 1060 kb or more, the patient is deemed to be at increased risk for rapid relapse.
 19. The method of claim 13, comprising determining the median size of copy number variations in a prostate tumor sample, tissue adjacent a prostate tumor, and/or blood, where if the median size of copy number variations exceeds a particular threshold, the patient is deemed to be at increased risk for relapse or rapid relapse.
 20. The method of claim 19, comprising determining the median size of copy number variations in DNA from a blood sample from the patient, where if the median size of copy number variations is 23 kb or more, the patient is deemed to be at increased risk for relapse.
 21. The method of claim 19, comprising determining the median size of copy number variations in DNA from a sample of tissue adjacent a prostate cancer from the patient, where if the median size of copy number variations is 18 kb or more, the patient is deemed to be at increased risk for relapse.
 22. The method of claim 19, comprising determining the median size of copy number variations in DNA from a sample of prostate cancer tissue from the patient, where if the median size of copy number variations is 647 kb or more, the patient is deemed to be at increased risk for relapse. 